Reversing Skin Aging with Collagen Peptides [11 Studies Later]
Summary
TLDRThis video explores the anti-aging effects of collagen peptides, a popular supplement in the beauty industry. After analyzing 11 studies, the presenter discusses the scientific debate around collagen's efficacy due to its low levels of certain essential amino acids. However, recent research indicates that peptides are absorbed into the bloodstream, potentially aiding skin cell function. Despite varying study quality and industry funding, there's consistent evidence suggesting collagen peptides can reduce signs of aging. The presenter, now in their 70s,权衡s the research and decides to continue supplementation, citing its low cost and potential benefits, and invites viewers to join as a 'physionic Insider' for more in-depth analysis.
Takeaways
- 🔬 The speaker has analyzed 11 studies to determine the effectiveness of collagen peptides in reducing or reversing skin aging.
- 🥚 Collagen peptides are considered a poor source of essential amino acids, which are crucial for skin cell repair and growth.
- 🧬 Newer mechanistic studies suggest that the body absorbs amino acids not only as single units but also as di- and tri-peptides.
- 🔑 Collagen peptides may bind to cell receptors, influencing internal cell signaling and gene expression, which could lead to the production of new skin proteins.
- 🧪 Some studies show improvements in wrinkle volume, number of wrinkles, and skin elasticity with collagen peptide supplementation.
- 💸 Most of the studies analyzed are industry-funded, which may raise concerns about potential conflicts of interest.
- 📊 Non-industry funded studies also support the positive effects of collagen peptides on skin health.
- 🤔 The speaker is cautious but opts to supplement with collagen peptides due to their potential benefits and relatively low cost.
- 📉 The research on collagen peptides could be improved with more rigorous study designs and less potential for bias.
- 💊 A meta-analysis suggests that effective doses of collagen peptides for skin health range from 2.5 to 5 grams per day.
Q & A
What is the main topic discussed in the transcript?
-The main topic discussed in the transcript is the use of collagen peptides as a supplement for reducing and potentially reversing skin aging.
Why is there controversy over the use of collagen peptides?
-There is controversy because collagen peptides have low levels of some key amino acids, leading to the belief that consuming whole high-quality proteins might be more effective for skin repair and growth.
What does the transcript reveal about the absorption of amino acids in the body?
-The transcript reveals that contrary to previous assumptions, the body does not only absorb single amino acids. Instead, di- and tri-peptides, which are two and three amino acids still bound together, are also detectable in the blood after protein consumption.
How do collagen peptides potentially benefit the skin?
-Collagen peptides may bind to receptors on the surface of skin cells like keratinocytes and fibroblasts, leading to changes in cell signaling and gene expression that promote the production of new skin proteins, including full collagen fibers.
What does the human data show regarding the effectiveness of collagen peptides on skin aging?
-The human data, despite some studies having methodological issues, generally shows improvements in wrinkle volume, number of wrinkles, depth of wrinkles, and skin elasticity in those who supplement with collagen peptides compared to placebo.
Are there any concerns regarding the funding sources of the studies mentioned?
-Yes, most of the studies are industry-funded, which may raise concerns about conflicts of interest. However, there are some non-industry funded studies that corroborate the results.
What is the speaker's personal stance on collagen peptide supplementation?
-The speaker, despite acknowledging the potential for conflicts of interest and the need for better study designs, personally opts for supplementation due to the consistency of results across studies and the relatively low cost and potential benefits.
What is the recommended dosage of collagen peptides according to the meta-analysis mentioned?
-The most frequent effective dosages across the studies included in the meta-analysis were between 2.5 and 5 grams per day.
Does the speaker mention any additional questions about collagen peptide supplementation?
-Yes, the speaker mentions additional questions such as whether different sources of collagen are more or less effective and what happens when one stops taking collagen peptides.
How can one access the extended version of the video and other related content?
-The extended version of the video and other related content can be accessed by becoming a Physionic Insider, with the link to join provided below the transcript.
Outlines
🧬 Collagen Peptides: The Fountain of Youthful Skin?
The paragraph delves into the exploration of collagen peptides as a potential anti-aging solution in the beauty industry. The speaker has been intrigued by the claims of collagen's benefits for over 14 years and has conducted an analysis of 11 studies to determine the effectiveness of collagen peptides in reversing or slowing down skin aging. The controversy surrounding collagen's efficacy stems from its low levels of certain essential amino acids, which are crucial for skin cell repair and maintenance. However, recent studies have shown that the body absorbs not only single amino acids but also di- and tri-peptides, challenging the previous belief. The paragraph also touches on the mechanistic benefits of collagen peptides, such as their ability to bind to cell receptors and stimulate the production of new skin proteins, including collagen fibers. Despite some studies being poorly designed or funded by the industry, there is a consistent trend suggesting that collagen peptides may improve skin health. The speaker concludes with a personal note on the importance of considering supplements like collagen peptides, especially as one ages and experiences more noticeable signs of skin aging.
🧪 The Science and Effectiveness of Collagen Peptides
This paragraph continues the discussion on collagen peptides, focusing on the scientific evidence and effectiveness of supplementation. The speaker acknowledges that while the evidence is not mixed, there is a good consistency across studies showing the benefits of collagen peptides in reversing signs of aging. However, the speaker also points out the limitations in study designs and the potential conflicts of interest due to industry funding. Despite these concerns, there are non-industry funded studies that corroborate the positive effects of collagen peptides. The speaker, who is in their 70s and has noticed skin aging, expresses a personal preference for supplementation, citing the relatively low cost and potential benefits. The paragraph concludes with a mention of a meta-analysis indicating that doses between 2.5 and 5 grams of collagen peptides are most frequently studied, though the speaker personally opts for a higher dose. The speaker also hints at further discussion on topics such as the effectiveness of different collagen sources and the effects of discontinuing supplementation, which are covered in an extended version of the video available to subscribers.
Mindmap
Keywords
💡Collagen Peptides
💡Amino Acids
💡Keratinocytes
💡Fibroblasts
💡Die and Tri Peptides
💡Skin Aging
💡Supplementation
💡Clinical Human Science
💡Methodological Issues
💡Funding Sources and Conflicts of Interest
💡Meta-Analysis
Highlights
Collagen peptides are touted as age-reversing in the beauty industry.
The speaker analyzed 11 studies to determine the effect of collagen peptides on skin aging.
Collagen is a poor protein source due to low levels of essential amino acids.
Mechanistic studies show that not all amino acids are absorbed as single units.
Collagen peptides may bind to cell receptors, leading to changes in gene expression and new skin protein production.
Some studies show improvements in wrinkle volume and skin elasticity with collagen supplementation.
Most studies on collagen peptides are industry-funded, which may raise concerns about bias.
There are non-industry funded studies that corroborate the positive effects of collagen peptides.
The evidence suggests that collagen peptides can reverse some signs of aging.
The speaker personally uses a higher dose of collagen peptides than the average recommended.
A meta-analysis indicates that the most effective doses of collagen peptides are between 2.5 and 5 grams.
The speaker discusses the potential for different sources of collagen to have varying effects.
The speaker raises the question of what happens when one stops taking collagen peptides.
The speaker invites viewers to access an extended analysis for more detailed information.
The speaker humorously suggests that they look young for their age, despite being 'in the triple digits'.
Transcripts
in all 11 years I've been on this Earth
I've seen ingredient after ingredient
touted as age reversing in the beauty
industry Now One supplement that I've
heard about multiple times over the last
14 years is the use of collagen peptides
for reducing and even reversing skin
aging so I analyzed 11 studies to find
out if my previous 17 years of skin
aging can be reversed or at least slowed
what was the verdict I those first we
should understand why there's any
controversy over the use of collagen
peptides it really comes down to
collagen being a sucky protein Source
essentially for growth we rely on
essential amino acids those are the
building blocks of proteins and for our
skin cells like keratinocytes to repair
and bolster our skin like they easily do
in youth they need these highquality
proteins that are filled with these
essential amino acids similar to how our
body builds muscles are myocytes the
muscle cells require the same proteins
for growth unfortunately collagen
peptides have low levels of some of
these key amino acids so the rationale
was always that we should just consume
whole high quality proteins and that'll
do the trick because when we digest and
absorb these amino acids in our
intestines they come through as single
amino acids anyway so why not just eat
whole protein sources since they have
Superior amino acid profiles well that
may all be true but more mechanistic
Studies have uncovered that we actually
don't just absorb single amino acids for
example this study shows that when
people consume proteins and when
researchers measure blood levels of D
and tri peptides those are two and three
amino acids still bound to one another
there are detectable levels in the blood
we see that here we don't need to go
into the specifics just know that if the
lines go up that means that blood levels
of these die peptides have increased
which is deemed impossible based on the
argument laid out before clearly it is
incorrect to assume that amino acids are
only absorbed into the blood as single
amino acids so then what benefit is
there from these peptides I mean it's
great that peptides enter our
bloodstream but why do we care again
mechanistically and I promise we're
going to get to some more clinical human
science in a minute there are some
scientific reviews that make Arguments
for collagen peptides binding to a
series of different receptors on the
surface of the cell you know think uh
keratinocytes that I mentioned earlier
and fibroblasts those are cells involved
in keeping the structure of your skin
intact and Youthful once bound to these
receptors the cell's internal signaling
changes lead to proper gene expression
changes that allow for the production of
new skin proteins including the full
collagen fibers I could go on with this
far more in depth but I'll leave it uh
for my full length analysis on the topic
if you're interested anyway you're
interested in more than just mechanisms
I'm sure what does the human data
actually show well look ever since my
20s I've known that you have to put all
of the context out otherwise it may lead
to improper conclusions I'll add this
some of the studies are really shoddy
like having no blinding and some of the
studies
using a mixture of supplements not just
using collagen peptides and a few other
methodological no NOS that mentioned not
all the studies were poorly designed
some were fine so even if we limit our
analysis to those where does that land
us let's crack one of them open here we
see the data on wrinkle volume the
higher the bar the worse wrinkles a
person has obviously the lower the
better in white we see our collagen
condition and in gray we see our Placebo
or non-collagen condition no matter how
you read it Baseline versus a weeks
later or Placebo versus collagen there
seems to be an improvement in the
collagen condition only but is this
consistent Beyond one study well we see
similar results in other measures of
skin youthfulness like here these
researchers showed improvements in a
number of wrinkles depth of wrinkles
skin elasticity and several other
metrics now when I turned 33 I also came
to understand the importance of funding
sources in conflicts of interest
unfortunately most of the studies are
industry funded so if that rattles your
cage that may unnerve you fortunately
there are some non-industry funded
studies that corroborate these results
as well I'm not a big fan of the study
design on This research but at least it
corroborates the other research so where
exactly does that leave us should we be
supplementing with it or not well every
since I turned 46 I've thought it'd be
better to be safe than sorry so while
the evidence isn't mixed there is good
consistency across studies However the
fact that the study designs aren't
always a top tier and the potential
conflicts of interest certainly leave
significant room for pause but I also
don't want to be that 55-year-old guy
that I was and not take a relatively
cheap and potentially noticeably
effective supplement based on negative
suspicion
it's not like I'll get that last 67
years of my life back am I right in
short while the research could use some
bolstering in this area of Investigation
it does seem that supplementation with
collagen peptides is effective at
reversing some signs of aging which is
comforting to hear once you pass your
70s and experience noticeable signs of
skin aging like me now how much is shown
to be effective I'll get to that in a
second and there are some additional
questions questions that you may not
have considered either for example are
different sources of collagen more or
less effective and what happens when you
stop taking collagen I'm covering that
all in the extended version of this
video which you can get access to if
you're a physionic Insider which also
includes a whole library of other videos
just to point that out you can find the
link to join below would love to have
you aboard now exactly how much of this
collagen is shown to be effective
according to a meta analysis which took
into my 80s to read due to its density
the researchers pointed out that the
most frequent doses across all the
included studies were between 2.5 and 5
G however I have been using collagen for
a while myself and some studies go as
high as or higher than 10 G per day so I
opt for that higher threshold and hell I
think I still look pretty young
considering I'm pushing into the triple
digits don't you think
[Music]
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