Hair Loss: Androgenic Alopecia
Summary
TLDRThe video script explains the three-phase hair growth cycle: anagen, catagen, and telogen. Hair growth occurs in the anagen phase, with nutrients supplied by the dermal papilla. The catagen phase sees halted growth, and telogen is when the old hair is shed. Androgenetic alopecia shortens the anagen phase, leading to hair loss. Minoxidil, a treatment, may stimulate hair growth by increasing blood supply and follicle activity, potentially reversing hair loss. Visible results are expected after 2-4 months of treatment.
Takeaways
- 🌀 The hair growth cycle is a three-phase process occurring at the hair follicles.
- 🌱 During the anagen phase, hair matrix cells actively proliferate, producing new cells that form the hair shaft.
- 🔄 The catagen phase is a transitional stage where hair growth stops and the hair shaft keratinizes.
- 🍂 In the telogen phase, hair is shed as the follicle prepares for a new growth cycle.
- 🚿 Androgenetic alopecia is linked to higher levels of certain androgens, leading to shorter anagen and longer telogen phases.
- 📉 These hormonal changes result in progressively thinner and shallower hair follicles over time.
- 🌟 The typical pattern of hair loss due to androgenetic alopecia is observed at the vertex and frontotemporal regions.
- 💊 Minoxidil, a treatment for hair loss, may work by opening ATP-sensitive potassium channels and promoting hair growth.
- 🌡️ It might also increase vascular endothelial growth factor expression and enhance follicle vascularization.
- 🔁 The use of minoxidil can stimulate longer anagen phases, shorten telogen phases, and reactivate dormant follicles.
- ⏱️ It typically takes 2 to 4 months of minoxidil treatment to see noticeable improvements in hair growth.
Q & A
What is the three-phase cycle of hair growth?
-The three-phase cycle of hair growth includes the anagen, catagen, and telogen phases. It takes place at the hair follicles where cells in the hair matrix are responsible for hair growth.
How do cells in the hair matrix receive nutrients during the anagen phase?
-During the anagen phase, cells in the hair matrix receive nutrients from a capillary loop at the dermal papilla.
What happens during the anagen phase of hair growth?
-During the anagen phase, the hair matrix actively proliferates, new cells are continually produced, and pushed upward to differentiate and form the hair shaft.
How long does the anagen phase typically last?
-The anagen phase typically lasts for two to six years.
What occurs during the catagen phase of the hair growth cycle?
-In the catagen phase, matrix cells cease activity, hair growth stops, and the base of the hair shaft keratinizes and migrates upward away from the papillary blood supply.
What is the telogen phase and what happens during this phase?
-The telogen phase is the final stage of the hair growth cycle where hair transforms into club hairs, which then move up the hair sheath. At the start of a new anagen phase, the follicle re-grasps the papilla and a new hair grows.
How does androgenetic alopecia affect the hair growth cycle?
-Androgenetic alopecia is associated with increased levels of certain androgens that lead to shorter anagen phases and longer telogen phases, resulting in progressively shallower follicles and thinner hair fibers.
What is the typical hair loss pattern seen in androgenetic alopecia?
-The typical hair loss pattern in androgenetic alopecia is seen at the vertex and frontotemporal regions of the head.
How does minoxidil contribute to hair regrowth?
-Minoxidil may act as an ATP-sensitive potassium channel opener and may elevate the expression of vascular endothelial growth factor, supporting follicle vascularization and potentially stimulating longer anagen phases and shortening telogen phases.
What is the initial response some patients may notice when using minoxidil?
-Some patients may notice an initial increase in hair shedding due to an abbreviated telogen phase when they first start using minoxidil, which is temporary and indicative of a response to the treatment.
How long does it typically take to see visual improvement in hair growth with minoxidil?
-It typically takes two to four months of treatment with minoxidil to reverse the process of androgenetic alopecia enough for patients to see visual improvement in their hair.
Outlines
💇♂️ Hair Growth Cycle and Androgenetic Alopecia
The paragraph explains the hair growth cycle, which occurs in three phases: anagen, catagen, and telogen. During the anagen phase, hair cells actively divide and push upward to form the hair shaft. This phase lasts for two to six years. Following this, the catagen phase ensues, where hair growth halts, and the hair shaft keratinizes, moving away from the blood supply. The telogen phase is the final stage where the hair becomes a club hair and is shed as a new hair begins to grow. Androgenetic alopecia is linked to hormonal changes that shorten the anagen phase and prolong the telogen phase, resulting in thinner and shallower hair follicles over time. This condition typically manifests as hair loss at the vertex and frontotemporal regions.
Mindmap
Keywords
💡Follicles
💡Hair Matrix
💡Anagen Phase
💡Catagen Phase
💡Telogen Phase
💡Androgenetic Alopecia
💡Minoxidil
💡Vascular Endothelial Growth Factor (VEGF)
💡Fenestrations
💡Rogaine
💡Hair Shedding
Highlights
The hair growth cycle is a three-phase process occurring at the follicles.
Hair matrix cells are responsible for growth and receive nutrients from the dermal papilla.
During the anagen phase, the hair matrix actively proliferates, producing new cells.
The anagen phase lasts for two to six years, during which hair actively grows.
The catagen phase is a transition phase where hair growth stops and cells cease activity.
In the telogen phase, hair transforms into club hairs and moves up the hair sheath.
The follicle re-grasps the papilla at the start of a new anagen phase.
Androgenetic alopecia is linked to increased levels of certain androgens.
Androgenetic alopecia leads to shorter anagen phases and longer telogen phases.
The result of these changes is hair loss in the vertex and frontotemporal regions.
Minoxidil diffuses to the hair follicle and may act as an ATP-sensitive potassium channel opener.
Minoxidil may elevate the expression of vascular endothelial growth factor.
Minoxidil increases fenestrations in the parafollicular capillary network.
These mechanisms may stimulate longer anagen phases and shorten telogen phases.
Minoxidil can trigger dormant follicles into a new growth cycle.
An initial increase in hair shedding may occur due to an abbreviated telogen phase.
This initial shedding is temporary and indicative of a response to minoxidil treatment.
Treatment with minoxidil products typically takes two to four months to show visual improvement.
Transcripts
it's a three-phase cycle that takes
place at the follicles
the cells of the hair matrix are
responsible for hair growth
and receive nutrients from a capillary
loop at the dermal papilla
during the anagen phase the hair matrix
actively proliferates
new cells are continually produced and
pushed upward
where they differentiate to form the
hair shaft
after the two to six year antigen phase
is complete
the follicle moves into catagen
transition phase in this phase
matrix cells cease activity and hair
growth stops
the base of the hair shaft keratinizes
and migrates upward
away from the papillary blood supply
finally the follicle transitions into
the telogen phase
where hair transforms into club hairs
and migrate up the hair sheath
at the start of the new antigen phase
the follicle re-grasps the papilla
the blood supply reconnects and a new
hair grows
the old club hair naturally sheds as the
new hair grows to the same depth and
thickness as in the previous cycle
androgenetic alopecia is associated with
increased levels of certain androgens
and hair follicles
that ultimately lead to shorter antigen
phases and longer telogen phases
these changes lead to progressively
shallower follicles
and thinner hair fibers over time
[Music]
the combined result of these changes is
seen as the typical hair loss pattern at
the vertex
and frontotemporal regions of the head
minoxidil diffuses to the hair follicle
it may act in several ways to promote
hair regrowth
minoxidil is an atp sensitive potassium
channel opener
which may play a role in its ability to
stimulate hair growth
minoxidil may also elevate the
expression of vascular endothelial
growth factor
and increase fenestrations in the
parafollicular capillary network
thereby supporting follicle
vascularization
these collective mechanisms may
contribute to the stimulation of longer
antigen phases
and shorten telogen phases as well as
trigger dormant follicles into new
growth cycle
both lead to new hair fibers and
restored follicular function
some patients may notice an initial
increase in hair shedding caused by an
abbreviated telogen phase
this is temporary and indicative of
rogaine product response
it typically takes two to four months of
treatment with rogaine product
to reverse the process of androgenetic
alopecia enough for patients to see
visual improvement in their hair
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