💉VOLUFILINE FOR FACE: LIP FILLER IN A BOTTLE? 💉 Dermatologist @DrDrayzday
Summary
TLDRIn this skincare-focused video, board-certified dermatologist Andrea explores the claims of 'Volume Fill-In', a trademark ingredient by Soderma, said to naturally enhance bust and buttocks. She critically examines the ingredient's scientific basis, derived from plant extract, and its purported ability to stimulate adipocyte differentiation. Andrea expresses skepticism about its effectiveness, especially for facial use, citing concerns about safety and the lack of peer-reviewed studies. She concludes by suggesting that any perceived 'filling' effects may be due to skin hydration rather than actual fat cell changes.
Takeaways
- 📚 The video discusses 'Volume Fill-In', a trademark ingredient from Soderma, which is claimed to naturally fill the bust and buttocks.
- 👩⚕️ The speaker is Andrea, a board-certified dermatologist, who shares her professional opinion on the ingredient based on available information.
- 🌿 The main component of Volume Fill-In is a plant extract called Hena Asphodelus Root Extract, which is said to stimulate fat cells (adipocytes) to differentiate and fill in naturally.
- 🧪 The company claims are based on an industry study, not a peer-reviewed paper, but the study is available online for those interested.
- 🧬 In vitro studies showed that the ingredient could stimulate pre-adipocytes to differentiate into fat cells and increase fat uptake.
- 🔬 An in vivo clinical study was conducted with women applying the compound to one breast, showing an average increase of 2.2 percent in breast size.
- 🤔 The speaker expresses skepticism about the ingredient's ability to penetrate the skin and affect fat cell differentiation.
- 🚫 Concerns are raised about the potential for developing lipomas if the ingredient does indeed stimulate fat cell growth.
- 🧴 The ingredient is also found in other products, such as lip glosses, without claims of volumizing effects, suggesting it may not be unique in its purported effects.
- 🛒 The raw material of the ingredient is available for purchase online, which the speaker advises against using directly on the skin.
- 💡 The speaker concludes that while the ingredient may improve skin hydration, its claims of fat cell stimulation and volume increase are doubtful and require more research.
Q & A
What is the main topic of the video?
-The main topic of the video is the discussion of a cosmetic ingredient called 'Volume Fill-In' or 'Volufeline', which is claimed to fill the bust and buttocks naturally.
Who is the speaker in the video?
-The speaker is Andrea, a board-certified dermatologist who posts skincare content on YouTube and other social media platforms.
What does the ingredient 'Volume Fill-In' claim to do?
-The ingredient 'Volume Fill-In' claims to enhance the bust and buttocks by stimulating adipocytes, which are fat cells, to differentiate and fill in, creating a natural filling effect.
What is the scientific basis for the company's claim about 'Volume Fill-In'?
-The company's claim is based on an industry study involving in vitro and in vivo tests, where the ingredient was shown to stimulate pre-adipocytes to differentiate into fat cells and take up fat.
What is the chemical composition of 'Volume Fill-In'?
-The chemical composition of 'Volume Fill-In' includes hydrogenated polyisobutene and a plant extract called NMR Asphodeloides root extract, which contains saponins and phytosterols.
How was the effectiveness of 'Volume Fill-In' tested in the clinical study?
-The effectiveness of 'Volume Fill-In' was tested using a method called FOITS (Fast Optical In Vivo Topometry of Human Skin) to measure the 3D optical properties of the skin on women's breasts.
What was the average increase in breast size reported in the clinical study?
-The average increase in breast size reported in the clinical study was 2.2 percent after using 'Volume Fill-In'.
What are the speaker's concerns regarding the use of 'Volume Fill-In' on the face?
-The speaker is skeptical about the ability of 'Volume Fill-In' to penetrate the skin deeply enough to affect fat cell differentiation and is concerned about the potential for developing lipomas or other unintended side effects.
What is the speaker's opinion on the overall effectiveness and safety of 'Volume Fill-In'?
-The speaker expresses doubt about the effectiveness and safety of 'Volume Fill-In', stating that it sounds too good to be true and that more peer-reviewed research is needed to confirm its safety and efficacy.
What other products contain the 'Asphodeloides root extract' mentioned in the video?
-The 'Asphodeloides root extract' is found in other products as well, such as some Revlon lip glosses and several Asian skincare products, although they do not claim a volumizing effect.
Why does the speaker advise against buying and using the raw material of 'Volume Fill-In'?
-The speaker advises against using the raw material directly on the skin due to the potential for irritation and uneven distribution when mixed with other skincare products.
Outlines
🧪 Introduction to Volufiline and Its Claims
Dr. Andrea, a board-certified dermatologist, introduces the topic of Volufiline, a trademark ingredient from Soderma that is claimed to naturally fill the bust and buttocks. The video aims to explore the science behind this ingredient, which is marketed as an alternative to cosmetic fillers. The main component of Volufiline is hydrogenated polyisobutene and a plant extract from 'Nmra henae aspho eloides root', which is said to stimulate adipocyte differentiation and increase fat cell volume. The company's claims are based on an industry study, not peer-reviewed research, and Dr. Andrea emphasizes that the information presented is her opinion based on available data.
🔬 Volufiline's Scientific Basis and Clinical Study
The script delves into the scientific research behind Volufiline, discussing in vitro studies that show the ingredient's potential to stimulate pre-adipocytes to differentiate into fat cells and increase fat uptake. A clinical study is mentioned, where the ingredient was applied to one breast of women to measure its effect on breast size using a technique called FOITS. The study reported a mean increase of 2.2 percent in breast size, with a more significant increase observed in a subgroup of 'best responders'. However, Dr. Andrea expresses skepticism about the ingredient's ability to penetrate the skin and affect fat cells, as well as concerns about potential side effects such as the development of lipomas.
🤔 Skepticism and Safety Concerns Surrounding Volufiline
Dr. Andrea raises questions about the methodology of the clinical study, questioning whether the technique used was appropriate for measuring changes in breast volume. She also discusses concerns about the safety and specificity of a topical application that claims to stimulate fat cell differentiation. The potential for uneven distribution and absorption if the ingredient is mixed with other skincare products is also highlighted. Dr. Andrea advises against applying the raw material directly to the skin and expresses doubt about the ingredient's effectiveness and safety.
💬 Final Thoughts on Volufiline and Recommendations
In conclusion, Dr. Andrea expresses her overall skepticism about Volufiline, stating that it sounds too good to be true and suggesting that it likely is. She reiterates the need for more peer-reviewed research to confirm the safety and efficacy of the ingredient. While acknowledging that the ingredient may improve skin hydration, she advises viewers to be cautious about such claims. The video ends with a reminder of the importance of sunscreen and an invitation for viewers to share their experiences with products containing Volufiline in the comments section.
Mindmap
Keywords
💡Volume Fill-in
💡Dermatologist
💡Hydrogenated Polyisobutene
💡Adipose Cells
💡Saponins
💡In Vitro Studies
💡In Vivo Studies
💡FOITS
💡Lipomas
💡Hyaluronic Acid
💡Cosmetic Ingredient
Highlights
Introduction to the topic of 'Volume Fill-In', a trademark ingredient from Soderma, claimed to naturally fill the bust and buttocks.
Volume Fill-In is an alternative to filler, often used under the eyes to combat signs of aging.
The main ingredient, Hydrogenated Polyisobutene and NMRHA Asphodeloides Root Extract, is said to stimulate adipocytes, or fat cells, for a natural filling effect.
The company claims a non-hormonal treatment to enhance fat cell differentiation and survival.
The information provided is based on an industry study, not a peer-reviewed paper.
The root extract contains saponins, specifically sarsapogenin, believed to influence fat cell gene expression without hormonal effects.
In vitro studies showed the compound stimulated pre-adipocytes to differentiate into fat cells and increased fat uptake.
Clinical studies involved using FOITS technology to measure the effects on breast size.
The study showed an average 2.2 percent increase in breast size with Volume Fill-In.
A subset of participants saw an 8.4 percent increase in breast size, indicating potential variability in results.
Doubts about the ingredient's ability to penetrate the skin and affect fat cells at a deeper level.
Concerns about the potential for developing lipomas if the ingredient works as claimed.
The study's methodology is questioned, particularly the use of FOITS for measuring breast size.
The possibility that the observed effects could be due to skin hydration and surface smoothing rather than actual fat cell changes.
The ingredient's presence in other products without claims of volumizing effects.
Recommendation against applying the raw material directly to the skin due to potential irritation.
A call for more research and peer-reviewed studies to validate the safety and effectiveness of the ingredient.
The final opinion on the ingredient's efficacy and a warning about the potential risks of using it as claimed.
Transcripts
well hey guys get excited we are
covering another highly requested topic
in today's video and that is value
fill-in voluphiline
volufeline however you want to say it if
you are new here welcome my name is
andrea i am a board certified
dermatologist i post skincare content
here on youtube that sounds of interest
to you consider subscribing or following
me over on instagram or tiktok as i post
there a lot as well now what exactly is
volume fill-in this is a trademark
ingredient from the company soderma and
it claims to fill the bust and buttocks
naturally people pursue this ingredient
as an alternative to filler a lot of
people are motivated to use it under
their eyes you'll recall from my video
on how our face changes with age that
with age we get hollows under the eyes
as the fat is redistributed and we have
bony resorption that also can make our
eyes look smaller so people are
motivated to do all sorts of things by
all sorts of products to put around
their eyes to make them look more
youthful more open
reduce under eye puffiness etc
that's why eye creams are so popular
even though you don't need one anyways i
digress this ingredient the company
claims can enhance the decollete fill it
in what exactly is this ingredient is it
you know it's the trademark volume
filling but what exactly is that
hydrogenated poly isobutene
and nmra henae aspho eloides root
extract that is a mouthful it is a plant
extract that this company claims
stimulates adipocytes which are the fat
cells to differentiate just thus having
a natural filling effect they claim that
this plant derived molecule is a
non-hormonal treatment to
enhance fat cell differentiation and
survival but also filling of those fat
cells and they claim that that is how it
can work to enhance your bust line or
act as a filling ingredient now
everything that they claim is based on
their
industry study not a peer-reviewed
published paper but you can find their
industry study online if you want to
read it i will link it down below that
is where the information in this video
is coming from the information in
today's video as a reminder or as a
point of emphasis is merely my opinion
based on what is available in terms of
information from this company but this
is not anything that is standard of care
it is a cosmetic ingredient so remember
that when you're watching this this is
based on my opinion so that root extract
it's got compounds in it called saponins
specifically one such saponin
sarsapogenin
quite abundant in many plants but it's a
phytosterol they claim or allege that it
has no hormonal effects meaning it won't
impact your testosterone levels your
estrogen levels progesterone levels or
any glucocorticoid hormones the compound
is dissolved in oil
now i think my understanding is they
identified this compound perhaps out of
a screen looking for compounds that
might influence
fat cell
gene expression differentiation i'm not
exactly sure honestly how they
discovered this particular compound but
they have done some studies on this
compound both in vitro which for the
record in vitro typically means looking
at cells in a dish whereas in vivo which
they also did means in actual either
animal models or an actual people all
right so they're in vitro studies they
took human
pre-adipocytes those are cells that want
to be fat cells but aren't quite fat
cells yet they incubated them in this
compound and they then did something
called gene expression profiling and
they identified that genes that are
expressed in adipocyte differentiation
meaning that pre-adipocyte becoming who
it wants to be a fat cell
those genes were turned on in the
presence of this compound and the
control cells that were not incubated in
the presence of this compound didn't do
that not only did this particular
compound stimulate those pre-adipocytes
to differentiate into a full-blown fat
cell and it also helped in stimulating
uptake of fat so these in vitro studies
kind of suggest that this compound can
help pre-adipocytes turn into fat cells
and stay that way for a period of time
at least and also take up fat and have
fat vesicles and why the heck would we
want that or breast augmentation which
is what really this trademark ingredient
originally was kind of
marketed or touted as that that would
help just kind of naturally fill in the
breasts to enhance
i guess fat cell differentiation in the
breast tissue so they then took this
compound into actual clinical an actual
clinical study in actual people women
and what they did was they used
something called foits which stands for
fast optical in vivo topometry of human
skin this is basically a method used in
the industry to
kind of look in a 3d fashion at the
optical properties of skin it's kind of
a way to measure wrinkle depth my
understanding i'm not an expert in this
technique but that is what i can glean
from reading about it different papers
online foits they had women put the
volume fill in compound on one breast
and not on the other women's breast size
fluctuates with the menstrual cycle
so basically each woman served as her
own internal control by comparing it to
the opposite breast now they originally
enrolled 32 subjects only 30 actually
ended up completing the study only 28
cases were evaluable at the end time
point i'm not sure why they excluded the
others they don't reveal why they looked
specifically at women ages 18 to 35. the
women could not be pregnant or
breastfeeding because obviously that
would influence breast size no
underlying hormonal issues and their
body weight had to have been stable for
at least three months prior to enrolling
in the study so they applied a five
percent cream gel of the volume in to
one breast twice a day or 56 days total
they were evaluated at 28 days and then
again at 56 days there was a somewhat
increase in size at 28 days as time went
on however that increase in size became
more noticeable so at the end of the
study there was a mean of 2.2 percent
increase in breast size with voluphillin
they pulled aside eight women who they
considered the best responders at 28
days there was a 6.6 increase in breast
size and at the end of the study they
got you know the best sort of results
this is a this little cohort of eight
women at the end of the study they had
eight point four percent increase in
breast size with the volume fill in but
again the average increase in breast
size across all was only 2.2 so that's
all well and good so should you go
putting this all over your face is it
going to fill in your face um i'm
skeptical of course that this is doing
anything to stimulate adipocyte
differentiation i mean just think about
it you're applying it to the surface of
the skin how is that compound actually
going to
penetrate all the way into the skin
across the dermis the deeper layers of
the skin into the subcutaneous that's
where the fat is to influence fat cell
differentiation i know it sounds
attractive to want to replace lost
volume in the face i get that question
all the time how can i restore volume
from fat loss in the face that happens
with age and it's really
attractive to try and do that with
something as simple as a cream gel that
you put on your skin but i mean think
about it would you really want to do
that in such a non-specific way to just
suddenly be stimulating fat cell
differentiation that could have some
negative consequences i mean how do you
how does the if this works the way that
they claim it does if it actually gets
into the skin and does this like they
like allegedly it does i mean how is it
controlled you know a concern i would
have if this did work the way they claim
it does is that you would end up
possibly at risk for developing little
fatty tumors that are actually pretty
common they're called lipomas they're
not dangerous but they bother patients
it can be cosmetically disfiguring
patients seek having them removed
they're easy to remove actually well
depending on the location they're pretty
easy to remove some of them can be
painful those are called angio lipomas
um sometimes people get a lipoma like
right here on the forehead so just
putting this on and you know thinking
that it's selectively going to cause
increase in fat cell mass exactly where
you want it and no more no less i find
that very very
doubtful suspicious questionable
i really just don't think that this does
what it claims it does now people will
say well how do you know if you never
tried it
i mean even if i tried it and i saw some
improvement i would still have this
reservation so that really doesn't
change anything while it's great they
have a study showing an increase in
breast size there's really a complete
dearth of
studies on this ingredient that are peer
reviewed to really say how safe this is
to be doing to the skin overall in the
study at least it appears like this
ingredient is well tolerated there
aren't really any you know i mean
they're not telling us about any adverse
effects although not everybody completed
the study and they don't tell us why so
i do question was that because of some
sort of side effect that they aren't
disclosing that being said you know
whenever there's a study people drop out
for their own personal reasons but you
can imagine that if people who were in
the study and not seeing any results
they may be more likely to get bored and
drop out prematurely so that's another
thing to factor in which we're not being
told as to why they they dropped out at
least that i could find in their report
but i don't think it actually penetrates
into effect change in fat cell mass
differentiation or what have you and
even if it did that seems questionable
in terms of safety the other issue that
i have with the way that they did this
study is again i'm not an expert on this
technique but my understanding is that
foits the fast optical in vivo topometry
of human skin study my understanding is
it's meant to assess in a 3d fashion the
skin not the sub cutis
basically
from what i glean in terms of how the
study is technique is used it's to study
wrinkle depth
which honestly putting something
moisturizing on the skin
will smooth out the skin surface and i'm
questioning are they really measuring an
increase in breast size here or are they
merely measuring a reduction
in
surface irregularity a skin smoothing
effect merely from applying an emollient
to one side versus the other i really
question why they elected this
particular technique as opposed to
something to image the breast tissue
itself like mammography or ultrasound i
mean you know something of that nature
to more objectively i guess quantify the
breast tissue as opposed to my
understanding this technique is really
just looking at the surface and i don't
know that you would actually be
detecting changes in breast volume with
this technique again i'm not an expert
but i do question if this really was the
best methodology to test for this type
of outcome and i suspect this probably
does have a hydrating effect for the top
of the skin and that can have a skin
plumping effect similar to any topical
humectant like hyaluronic acid or
peptides for example and it's a botanic
ingredients it may have
anti-inflammatory effects
antioxidant effects as well you could
speculate that maybe have a you know
help with moisture retention as well as
reducing oxidative stress that
contributes to discoloration and overall
that may give a more
skin brightening illuminating effect
but a lot of that could just be achieved
by using a basic moisturizer i've
noticed that this particular plant
extract not the trademark ingredient but
this particular uh plant extract the
nmrna
asphaloides uh extract root extract i've
noticed it's in other products
it's in for example i think revlon has
some lip glosses that contain this
ingredient i've seen it in a few other
just on a quick online search you will
find that particular root extract in
other products now they're not claiming
a filling effect a volumizing effect or
anything like that so
um i don't think that this trademark
combination is the only
only
only guy on the block but uh yeah i mean
it's interesting that they market it
this way but i guess what uh one other
thing that always gives me pause now on
you can go on amazon of course and you
can buy the raw material which i find
interesting you can buy a vial it looks
like of the volume filling ingredient
it's an oily it's in an oil on the
amazon site they tell you you know they
show this data that i've talked about
here
about the the breast size increase and
they tell you to just put a few drops in
your skin care product which i always
you know again i'm not a cosmetic
chemist but we're talking about an oily
substance here that you're going to put
into your skin care products how do we
know that it's going to
you know distribute evenly in that
product and then when you put it on the
skin that you're going to get even
uptake is it going to be patchy you can
imagine if you had a
again not a cosmetic chemist but i would
imagine that if you take an oily
substance like this if you have a more
water-based lotion that you're using is
it going to mix in i don't i honestly
don't know i'm not going to pretend to
to know about that kind of thing that
seems to me more of a compounding issue
but i do question like if you mix it in
with products is it actually going to be
evenly distributed on the skin and have
even penetration or are you going to get
clumping i really don't know much about
how this particular ingredient behaves
in in products so in the study they used
5
gel cream cream gel but if you just go
dropping this into your lotion
moisturizer serum what have you what's
the final percentage going to be i
certainly do not recommend applying the
raw material which is what it's sold as
directly to your skin that can be
incredibly irritating all right y'all
long story short what do i think of this
ingredient i think it sounds too good to
be true it likely is yes i know i've
never used it but honestly i would say
the same exact thing even if i used it
and all of a sudden you know came in
here with
like
my 16 year old eyeballs and you know
massive
filled lips or whatever which i doubt is
going to be what happens here be very
careful when it comes to claims like
this i i you know again this is my
opinion based on what the information
that they have presented this is my
opinion on the likelihood that this is
going to work the way that they say it
does um but i do think at the most you
will see an improvement in skin
hydration with this ingredient seems
plausible and i suspect that may
underlie some of the filling effects
that people are seeing
i would love to see more research with
this ingredient and then i would have
more confidence that it is not only safe
but effective in terms of doing what it
says it does but if it claims to
stimulate fat cell differentiation
we would want to do that in a controlled
fashion right i mean you could end up
with lipomas fatty tumors things that
you don't want so that's why i
questioned does this really work why are
we not seeing that type of outcome i
know rhodiola had a breast filling cream
breast plumping cream with this in it i
think they still have that actually so
that's one product that i'm aware of
that has this it's also in several asian
skin care products so let me know in the
comments have you used a product that
has this did you buy the raw stuff
online and try and mix it in with your
products did you see any magic filling
effect but that's what i can tell you
about this ingredient and my doubts as
to if it works the way that it's touted
to work again my opinion
but i hope you all enjoyed this video on
the end slate it's going to be my video
on how your face changes with age so
definitely check that one out if you
missed it but if you like this video
give it a thumbs up share with your
friends and as always don't forget
sunscreen and subscribe i'll talk to you
guys tomorrow bye
[Music]
you
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