Ashwagandha - Anti-inflammatory Mechanism
Summary
TLDRIn this informative talk, the host delves into the ancient herb Ashwagandha, used for centuries in Indian and African medicine, particularly for stress relief and adaptogenic behavior. Despite mixed feelings due to a lack of robust studies, the host explores its anti-inflammatory properties, noting its potential benefits for neurological symptoms and overall inflammation reduction. The discussion highlights Ashwagandha's modulation of the nuclear Factor Kappa B pathway, which plays a crucial role in cell survival and inflammation. The host also touches on potential side effects and drug interactions, emphasizing the need for caution and consultation with healthcare professionals. The talk is complemented with engaging cartoons and a special announcement about Dr. Bean's upcoming courses and pricing changes.
Takeaways
- 🌿 Ashwagandha is an Indian and African herb with a history of use going back 3000 years.
- 🧬 Despite limited strong human studies, ashwagandha has been used extensively in India and is part of Ayurvedic medicine.
- 🤔 The speaker has mixed feelings about ashwagandha due to a lack of robust evidence but acknowledges its traditional use.
- 📈 Ashwagandha is primarily used for stress relief and adaptogenic behavior, helping the body adapt to various stressors.
- ⚠️ There are potential side effects and contraindications with ashwagandha, especially for pregnant women and those with certain health conditions.
- 🤰 Ashwagandha may not be safe for pregnant women and its safety for nursing mothers is unknown.
- 💊 It can interact with various drugs, including those for diabetes, hypertension, and immune system suppression.
- 💤 Ashwagandha might cause drowsiness and should be used cautiously with sedative hypnotic drugs.
- 🔍 The script discusses the anti-inflammatory effects of ashwagandha and its mechanism of action on the nuclear Factor Kappa B pathway.
- 🐠 The talk humorously includes a Finding Nemo reference to explain the process of ubiquitination in the context of the nuclear Factor Kappa B pathway.
Q & A
What is the primary use of ashwagandha?
-The primary use of ashwagandha is for stress relief and adaptogenic behavior, meaning it helps a person adapt to stressors such as age, disease, or other stresses without getting overwhelmed.
What are the mixed feelings the speaker has about ashwagandha?
-The speaker has mixed feelings about ashwagandha because, despite its long history of use, they do not see strong studies supporting its efficacy, mostly finding in vitro studies or mouse models rather than robust clinical trials.
What is the significance of ashwagandha being part of ayurvedic medicine?
-Ashwagandha is significant in ayurvedic medicine because it has been used for approximately 3000 years, indicating a long-standing cultural tradition of its use for various health benefits.
What are some of the side effects and contraindications of ashwagandha mentioned in the script?
-Some side effects and contraindications of ashwagandha include its potential unsafety for pregnant women due to the risk of miscarriage, unknown effects on nursing mothers, possible irritation of the digestive tract, drug interactions with neurological and immune systems, lowering blood sugar levels, lowering blood pressure, and possible interference with immune-suppressing drugs.
What is the recommended dosage for ashwagandha?
-The recommended dosage for ashwagandha is 1000 milligrams per day, with long-term usage beyond 12 weeks having less supporting evidence.
What is the role of the nuclear Factor Kappa B (NF-κB) pathway in inflammation?
-The nuclear Factor Kappa B (NF-κB) pathway plays a crucial role in inflammation as it is activated by stressors, such as pathogens or cellular stress, leading to the production of inflammatory mediators. Ashwagandha is believed to modulate this pathway, thereby reducing inflammation.
How does ashwagandha interact with the NF-κB pathway?
-Ashwagandha is thought to modulate the NF-κB pathway by suppressing it, which in turn reduces the production of inflammatory mediators and leads to a decrease in inflammation.
What are some of the potential benefits of ashwagandha for long COVID patients as mentioned in the script?
-For long COVID patients, ashwagandha may provide benefits such as relaxation and improvement in neurological symptoms, potentially due to its anti-inflammatory effects on the brain.
What is the significance of the term 'Ganda' in ashwagandha?
-The term 'Ganda' in ashwagandha refers to the fragrance of the plant's root, which is due to the presence of flavonoids. This fragrance is associated with stress reduction, similar to the effects of being in a forest or jungle.
What are some of the active components in ashwagandha?
-Some of the active components in ashwagandha include withanolides, alkaloids like somniferin and somnin, and flavonoids, which contribute to its various health benefits.
What is the connection between ashwagandha and the character 'Nemo' from the script?
-The connection between ashwagandha and 'Nemo' is a play on words related to the NF-κB pathway. In the pathway, a protein called Nemo gets ubiquitinated and destroyed, which is part of the process that ashwagandha may modulate to reduce inflammation.
Outlines
🌿 Introduction to Ashwagandha and its Traditional Usage
The speaker begins by introducing the topic of the video, which is the discussion of ashwagandha, an herb used in Indian and African medicine for approximately 3000 years. Despite the long history of use, the speaker expresses mixed feelings due to a lack of strong modern scientific studies supporting its efficacy. The primary uses of ashwagandha are highlighted as stress relief and adaptogenic behavior, helping individuals adapt to various forms of stress. The speaker also mentions their family's background in traditional medicine, specifically ayurvedic medicine, and their personal connection to the herb. Additionally, the speaker promotes an upcoming change in pricing for their courses and provides some references and side effects of ashwagandha, such as its potential risks during pregnancy and its impact on the digestive system.
💊 Ashwagandha's Interactions and Effects on the Body
This paragraph delves into the effects of ashwagandha on the immune system, noting that it can boost immunity and potentially lower blood sugar levels, which could interfere with certain medications. The speaker also addresses the herb's impact on blood pressure and its contraindications with immune-suppressing drugs. Furthermore, ashwagandha's potential to cause drowsiness and its effects on thyroid hormone levels are discussed. The speaker emphasizes the importance of consulting with healthcare professionals before using ashwagandha, especially for long-term use beyond the studied 12 weeks.
🌲 Exploring Ashwagandha's Stress-Relief and Immune-Boosting Properties
The speaker explores the stress-relief and immune-boosting properties of ashwagandha, referencing a study that compared the stress levels and immune responses of people in forests versus a city environment like Tokyo. The study findings suggest that natural environments rich in phytochemicals and fragrances, such as forests, can reduce stress hormones and enhance immune function. This is likened to the effects of ashwagandha, which contains flavonoids that may contribute to its stress-reducing and immune-boosting capabilities. The speaker also lists various areas where ashwagandha has been studied, including its potential neurological, sedative, adaptogenic, sleep-inducing, anti-inflammatory, antimicrobial, cardioprotective, anti-diabetic, and reproductive benefits.
🧬 The Anti-Inflammatory Mechanism of Ashwagandha
Here, the speaker focuses on the anti-inflammatory effects of ashwagandha, particularly its impact on the nuclear Factor Kappa B (NF-κB) pathway, which is associated with cell survival and stress responses. The NF-κB pathway can be activated by external stressors, such as pathogens or toxins, or internal stressors, like changes in cell shape or pH levels. The speaker simplifies the complex cellular mechanisms involved in this pathway, explaining how ashwagandha may modulate it to reduce inflammation. The discussion also touches on the concept of gliosis, the overproduction of brain tissue cells in response to inflammation, and how ashwagandha might help in reducing brain inflammation.
🐠 The Cellular Pathway and the Role of 'Nemo' in Inflammation
In this section, the speaker continues the discussion on the NF-κB pathway, focusing on the activation and regulation of proteins within the cell. The narrative takes a creative turn by incorporating the story of 'Finding Nemo,' using it as an analogy to explain the process of protein ubiquitination and destruction. The speaker describes how certain proteins, once activated, can lead to the production of inflammatory mediators. Ashwagandha's role in modulating this process is highlighted, suggesting that it can suppress the inflammatory response by affecting the activation of NF-κB. The speaker also mentions a study that provides evidence for ashwagandha's anti-inflammatory effects.
📉 Summarizing Ashwagandha's Anti-Inflammatory Mechanism
The speaker summarizes the anti-inflammatory mechanism of ashwagandha, emphasizing its ability to reduce the production of inflammatory proteins by modulating the NF-κB pathway. The summary includes a brief overview of the various inflammatory mediators that ashwagandha may help regulate, such as interleukin-12, interleukin-6, interleukin-8, tumor necrosis factor alpha, interleukin-1 beta, and nitric oxide. The speaker concludes by reminding viewers of the upcoming price change for their courses and encourages viewers to like, subscribe, and share the video for support.
Mindmap
Keywords
💡Ashwagandha
💡Inflammation
💡Adaptogenic
💡Nuclear Factor Kappa B (NF-kB)
💡Stress relief
💡Phytochemicals
💡Flavonoids
💡In vitro studies
💡Mouse models
💡Drug interactions
💡Ubiquitination
Highlights
Ashwagandha is an Indian and African herb used for about 3000 years.
It is primarily used for stress relief and adaptogenic behavior.
Mixed feelings due to lack of strong studies, mostly in vitro or mouse models.
The presenter's family has a history of practicing Ayurvedic medicine.
Ashwagandha is being discussed due to audience request.
The presenter will focus on the anti-inflammatory aspect of ashwagandha.
Ashwagandha might be unsafe for pregnant women due to miscarriage risk.
It can irritate the digestive tract in some individuals.
Ashwagandha affects the neurological and immune systems.
It might lower blood sugar levels, impacting its use with anti-hyperglycemics.
It can also lower blood pressure, affecting its use with anti-hypertensives.
Ashwagandha may interfere with immune-suppressing drugs.
It might cause drowsiness or sleepiness due to its calming effect on the brain.
Ashwagandha may increase thyroid hormone levels.
The recommended dosage for ashwagandha is 1000 milligrams.
Ashwagandha has been studied for various effects including neural protection, sedative effect, and anti-inflammatory properties.
The active components of ashwagandha include retinoids, alkaloids, and flavonoids.
Ashwagandha affects the nuclear Factor Kappa B pathway, which is involved in cell survival and inflammation.
Ashwagandha modulates the nuclear Factor Kappa B pathway to reduce inflammation.
The study discussed shows modulation of various inflammatory mediators by ashwagandha.
The course page at DrBean.com is launching with finalized descriptions and prices.
The price for Dr Bean's courses will increase from $67 to $97 on Monday.
The presenter shares cartoons to illustrate the discussion on ashwagandha.
Transcripts
welcome to one more show in the talk
today we'll talk about horses and Nemo
you know the Finding Nemo the fish and
other such things and in this process
we'll discuss ashwagandha
this is a uh an Indian
an African herb that has been used for
about 3000 years
after reading the literature I have
mixed feelings about it I have not used
it for myself however this topic was
very much requested so let's look at
this topic it is actually fascinating to
look at this Urban how it works I'm only
going to take one part or one kind of a
section today and that is the
inflammation although its primary use is
for stress relief and for adaptogenic
Behavior meaning it allows a person not
to stress out because of something that
is bothering them for example let's say
stress of age stress of disease or other
stresses it helps them adapt
why I said I have mixed feelings is that
I do not see
strong studies for this
so from a studious point of view from an
Evidence point of view I see mostly in
vitro studies or Mouse models however be
aware that it has been used in India
India is a very large population it has
been used there for 3000 years my own
family
of course we are from Pakistan but our
ancestors were in Combined Indian
continent and my maternal side practiced
local medicine
ayurvedic medicine for 400 years and
these kind of herbs are of course part
of that process of practicing so let's
start
I have drawn some very cool cartoons for
you today as well so I hope you like
them
so first of all they say Dr bean.com in
the description of this video there is a
um link to get access to Dr bean.com we
have finally reached a point that our
courses page has become ready now all
descriptions are correct and all prices
are final Monday we will launch this so
this one this page will be uh changed on
Monday to move the price from 67 to 97
and then a week later that will be
retired as well and we will only be
offering the courses
so with this if you wanted to take
advantage of that you can this gives you
access to everything once we go towards
the courses you continue to be
grandfathered in the system so with this
here are some of the references and as I
have always done with the herbs
I try to put the side effects first so
that you are aware of what are the
contraindications because many of the
articles that talk about some herbs they
do not usually put the side effects
having said that I I know that you are
aware that side effects for every
medicine
are studied in Pharmacology every
medicine has side effects that doesn't
mean that medicine is not used usually
the dosage that is used for a drug and
the frequency of the use
provides us the best
effect with least side effects the
dosage for this is 1000 milligram
and let me show you some of the side
effects and contraindication and then we
look at the anti-inflammatory mechanism
there are many people who use it on
daily basis I have seen many long covet
patients using it and feeling better and
then there are some for whom it does not
work very well so ashwagandha here this
is Merc Manuel is a small evergreen
shrub that grows in India Middle East
and Africa the botanical name is this I
want to go to the
the side effects so ashwagandha is
probably unsafe for pregnant women
because it might increase the risk of
miscarriage whether nursing mothers
should take it or not we do not know
because there are no studies for nursing
mothers and it can irritate digestive
tract in some people
the drug interactions remember that it
is it affects on the neurological system
it affects on the immune system it
actually boosts so when you talk about
boosting the immune system this is a
drug that actually boosts it it makes
the innate arm
a little more active and more strong if
we can use that as a as a flexible
medical term
so uh ashwagandha might lower blood
sugar levels
and thus make it unsafe to use with
anti-hyperglycemics
then it it can lower blood pressure as
well so be careful to use it with
anti-hypertensives then it seems to
change the immune system's activity and
it might interfere with those immune
system drugs that are suppressing the
immune system so drug is let's say we
are taking drugs to suppress immune
system and then we take ashwagandha it
can reduce their activity by boosting
the immune system
and those cool beans who've been here
with me for a long time they know that I
do not like to use the word boosting
because boosting actually means moving
the immune system
above and beyond its normal expected
behavior however this drug actually does
boost the immune system
and because of that drugs like
cyclosporines or microfenolate
Etc prednisolans it does not work very
well with them or should not be taken it
can shave off some of that effect
ashwagandha might take might make people
drowsy or sleepy because it does have an
effect on the brain and calming effect
one part of that side effect could be
sleepiness
some combining sedative hypnotic drugs
used to help with the Sleep ashwagandha
might take make people too sleepy in
them
ashwagana may increase thyroid hormone
levels so doctors carefully monitor the
thyroid functions so Merc manual says no
recommendation they don't think it is
useful but that is Merck Manual take
that with a grain of salt
this is WebMD and what is important here
is the dosing so if you see here WebMD
says ashwagandha has most often been
used by adults in doses up to thousand
milligram daily for up to 12 weeks speak
with a healthcare doctor so more than 12
weeks or three months usage there are
not much studies
once again people have been using it for
a long time
there are all of these links are present
in the description of this video
this is the study this is 2023 in
pharmaceutics and this study was uh 6
February 2023 is when it was received
and now it is accepted in 20 March 2023
and published on 24 March so it's a very
recent write-up this study is what I'm
gonna take one part at a time and
discuss if you would like more
discussions about ashwagandha if there
isn't much interest then I would leave
it after this discussion
so today I'm gonna talk about
anti-inflammatory but there are other
effects here as well
with this I have some other
links in the description as well that
would help you see or read various
components of actual panda with this
I'm gonna now go to
this
sometimes I forgot to re forget to reset
it so these are gifts for Humanity and
they're continuing
this is what we're talking about
ashwagandha it is an it is called Indian
ginseng ginseng it is called Indian
winter cherry it is not actually the
winter cherry it is just called Indian
winter cherry it is called vitinia
sluggered or withinia somnifera
the root is the actual
um
component that is used for medical
purposes or medicinal purposes ashwa so
I do not know how to pronounce it very
well I'm not from India so I do not know
exactly how to pronounce it ashwa means
horse and this is my depiction of force
whatever it means I know that the nose
is a little crooked but anyways that is
horse and Ganda means fragrance so its
root has at fragrance of the plants
because of flavonoids in them and so it
is horse and fragrance remember this
that wherever we have flavonides and
flavonus there is going to be stress
reduction uh remember that study from
Japan where they sent out a few people
to Forest and another few people to
Tokyo and they gave the people going to
Tokyo they gave them money to party and
relax and the people who went to Forest
they were also
us to relax and have fun when they came
back
they thought that people who went to
Tokyo they would have better
relaxation and they would be in a better
shape compared to those who went to the
jungle and it turned out
that because of the Phantom sites
because of the phytochemicals and the
fragrance in the jungle or the forest
the people who went to the forest they
had lower stress hormones lower cortisol
levels lower norepinephrine epinephrine
levels and they had a higher volume or
concentration or count of natural killer
cells so their immune system was
performing better and their stress
hormones were performing
meaning going down on the other hand the
people who went to Tokyo they did not
have this change although they were also
relaxed and having fun so that means
that if you are near plants that
actually relaxes you more and that
boosts your immune system
so this is a plant as well with its
fragrance whenever you have a plant's
fragrance that means you are actually
inhaling the flavonals and flavonoids
flavonoids actually so that is
ashwagandha
so areas of study there are many areas
in which it has been studied nowadays
for neural protection sedative effect
adaptogenic effect as I said before
sleep
anti-inflammatory antimicrobial
cardioprotective anti-diabetic
and possible reproductive outcomes
and hormone modulations today I tried to
write it in my cursive handwriting and
you can see it is so difficult to read
even I cannot read my own Android and it
is yet a clean end in writing anyways
Active Components
so there are many phytochemicals that
are present it's a plant right so it is
going to have phytochemicals or plant
chemicals in it the important ones are
retinoids and alkaloids and there are
for example with anolites are
retinopharyn a retinolides a to Y with
henon and so on similarly there are
alkaloids as well we tendin somniferin
somnin Etc it has flavonoids II and
these are the kind of flavonides that
are present
so it has good chemicals that are
present in it now I'm gonna go through
anti-inflammatory effect
this is where we'll talk we have already
talked about horse I promised you that
we'll talk about horse I just hope that
CDC does not put a tweet out tomorrow
that you are not a horse so don't take
flavonus or ashwagandha but now I'm
going to talk about Nemo as well as
we're gonna see if we can find Nemo
so anti-inflammatory effect so what it
does is basically it affects the nuclear
Factor Kappa B pathway
so before I go and discuss one of the
pathway just one there are actually many
Pathways I'm only going to talk about
one to kind of make a point here
the nuclear Factor Kappa B pathway is
usually said to be the cell survival
pathway
the mechanisms that are orchestrated
inside a cell imagine for a second the
gears turning in the cell
they become active in this pathway
nuclear Factor Kappa B pathway
either because of stressors outside of
the cell
for example
presence of the pathogens presence of
bacteria presence of viruses presence of
toxins presence of foreign material that
the cell doesn't like those can activate
uh pathogen recognition receptors or PR
one important one is called tall like
receptor or tlr4 and that inside is
connected with nuclear Factor Kappa B
Gears of the system and that produces an
inflammatory response from the cell
just a survival Behavior similarly
within the cell as well and surrounding
the cell there may be an absence of the
foreign material but still
stressors on the cell for example
extraordinary stretch or skew of the
cell or the pH is different or the
oxygen levels are not correct so other
stresses of the cell can also cause
nuclear Factor Kappa B to become active
this is why we say that nuclear Factor
Kappa B system can become activated
as a canonical system or canonical
pathway which means the pathogen comes
in or foreign material comes in or some
some offending agent from outside is
introduced in our body and our body is
now going to respond with the survival
Instinct or survival mechanism and not
just the Instinct but also the molecules
and that will be the canonical nuclear
Factor Kappa B pathway the non-canonical
pathway is where the body and the cells
are activating this pathway nuclear
Factor Kappa B but for
internal stressors
so how does it work let's start from
here
and actually before my diagram I want to
show you
to if you go to this link
this is a diagram where the this part
here is the nuclear Factor copper B this
p50 and p65 are actually the ones and
you can see that there are many Pathways
that would activate it I am only going
to talk about these two Pathways and
still within this I'm only going to talk
about this one area this one I'm I'm
gonna remove or ignore tram I'm going to
ignore all of this as well but I want to
make sure that it is in front of you
that there are more ways to activate the
nuclear Factor Kappa B the point I'm
making is ashwagandha actually
modulates this pathway and suppresses it
so that the inflammatory state is
reduced when this state is taken up in
the brain then the brain's inflammatory
State responds by gliosis gliosis is
overproduction of the brain's tissue
cells which are going to respond with
inflammation and ashwagandha suppresses
that too because of that it can in
theory from a mechanism point of view
reduce brain's inflammation and also
reduce inflammation in the body
I think this is why it may have been
um for some long covet patients who've
been saying that hey when I take
ashwagandha that allows me to number one
be relaxed and number two my
neurological symptoms improve so maybe
these are the combinations so back here
imagine that in here this is all a cell
inside this is the cell membrane on the
membrane we have tall like receptor four
and we also have interleukin receptor
so the cells respond to interleukins
this is interleukin one receptor that
also activates the nuclear Factor Kappa
B and call like receptor four that would
uh that would Identify some pathogen in
the environment
now if we go in here the tall like
receptor 4 on the inside of the cell it
is connected to a couple of proteins
called
tirap and tram
I am gonna go this pathway as I said t i
r a p
when become active how when we have
something here let's say a pathogen a
gram negative bacterial
lipopolysaccharide some toxins on the
bacteria they are here it's all like
receptor four becomes active when it
becomes active it activates both of them
I'm only going to be here so let's say
tirap becomes active when that becomes
active it activates another protein
called my d88
my d88 so my d88
so today
your takeaway are going to be two basic
things one is ashwagandha can be used to
reduce inflammation in the brain and in
the tissues and second is the the
pathway that it uses is nuclear Factor
Kappa B pathway it suppresses that so
now there are just some fun characters
my d88 protein when that becomes
activated it causes another set of
proteins which are called irak4 and
irak5 one
it activates them or we use also the
term it recruits them it activates them
it brings them in action so it recruits
them with the irak
it is another protein attached to them
called traf 6.
this protein once it is activated what
it does is there is another complex of
three proteins
actually this complex of two proteins
called Tab 2 3 and take one tab take so
we are we are getting near a fish so you
open up a tab in your in your restaurant
and take one fish so tab two three and
take one when these become activated or
tack one not take when these become
activated what they do is there is
another protein called Nemo
when they will become these two guys
will become active they will activate
Nemo
now here is an interesting thing when
Nemo is activated
there is ubiquitination of Nemo what
does that mean Nemo will be destroyed
ubiquitination inside ourselves mean and
I've done a complete discussion about
ubiquitination and autophagy in terms of
intermittent fasting mechanisms
in the ubiquity Nation our cells can try
to destroy
proteins in two ways
it can destroy proteins as a regular
mechanism which you would see here for
example Nemo will be destroyed as a
normal function of the cell this is like
opening a door so the cell would not
open the door it would just destroy the
door but that doesn't mean there is a
disaster happening that simply means
that is a function it is trying to open
a door inside and it broke it and to
open it
then so this would be called autophagus
sorry ubiquitination
ubiquitination does not cause alarm in
the cell that proteins are breaking this
is a normal mechanism
the other one is that we have done
autophagy which can pick up the raw
material or the or the bad detangled
d-shaped denatured proteins and break
them down and that actually causes alert
as well so back here the Nemo protein
gets ubiquini ubiquitinated that means
it gets marked to be destroyed
so of course it then gets destroyed when
it gets destroyed then this stack won
this is such a funny story this stack
one then sneaks beyond the Nemo and goes
and connects with this pathway do you
see there are two proteins here let me
make them bigger
there are two proteins this is ikkb and
this is ikk Alpha and you see this
little DAC has snuck in and now it is
phosphorylating phosphorylating means
putting a phosphate many times when we
are activating a protein in our cells we
put a phosphate on them we give them
currency we give them money to become
active so here tack one has come in near
ikk Alpha and beta and it is now
phosphorylating ikk beta that
phosphorylation would activate this one
ikk beta which in turn will take a
phosphate and phosphorylate this little
guy so do you see that they are in turn
phosphorylating and activating each
other some of them are just going poof
they are disappearing like Nemo so if
this was a movie Finding Nemo you will
not find Nemo because Nemo would get
destroyed so here ikk beta when that
becomes active it would phosphorylate
this ik beta Alpha this guy this little
thing here where there is a protein
you can see probably that this little
protein is holding on to two baby
proteins
this is a very common pattern in our
cells where a protein protects the other
protein and prevents it from functioning
by hugging it and binding with it
so imagine that
in your home there is a refrigerator
you do not want the refrigerator to be
opened there is a delicious cake in
there yummy cake
so what you do is you go and hug the
refrigerator
so now the refrigerator is not
accessible to others because you are
hugging it or you are sequestering it
that is what's happening here this
little protein is called ik beta alpha
or ikk
it is
sequestering or binding with two more
proteins called p50 and p65 this whole
complex together is the nuclear Factor
Kappa B complex in this complex one
protein is The Binding protein to
protect these two active ones these two
little baby proteins are actually the
active ones
they are protected by this guy
and why do you think we are protecting
them very simple these two proteins
are the ones that would cause the cell
to produce inflammatory mediators
so if you let them be
free like little naughty children in the
cell they're gonna run in the nucleus
and ask the nucleus to make inflammatory
proteins
we don't want them to do that so what do
we do we bind them to this bigger mommy
protein
so now this complex
is present and when ikk beta here
becomes active it will attach a
phosphate to this proteins when this
protein gets the phosphate attached to
it that causes this protein to become
destroyed
or degraded by ubiquitination
when this gets so who got destroyed here
Nemo and ikk
when that gets destroyed guess what
proteins become free the p50 and p65
become free these are the actual active
nuclear Factor Kappa B transcripting
proteins why do we call them
transcripting proteins because they
would go in the nucleus they will bind
with the DNA and they would open up the
DNA for transcription or gene expression
so as soon as this mother protein got
destroyed or ubiquitinated these two
children protein became free they ran
into the nucleus
and they bound to their corresponding
genes
and once they got bound there we would
say Gene promotion they will promote the
gene now to become expressive so Gene
will open up and the messenger RNA will
be produced this messenger RNA will then
come out of the cell and will attach
with the ribosome with the Golgi
operators and it would so smooth and
rough endoplasmic reticulum would be the
one with the ribosome that would then
produce the actual proteins that are the
responsive proteins and various kind of
inflammatory proteins will be produced
now various Pathways produce some more
than the others for example the the tall
like receptor pathway produces these
ones more
compared to the other Pathways that
might produce these more
but in any event when the ashwagandha is
given and it is modulating the nuclear
Factor Kappa B pathway all of these can
be reduced what are these interleukin-12
inflammatory
interleukin-6 quite through inflammatory
actually interleukin-6 blockers are
given all the time for controlling the
inflammation interleuking eight tumor
necrosis Factor Alpha interleukin One
beta interleukin once sorry six and then
I wrote six here as well nitric oxide
stress
enzymes as well
that will produce the reactive oxygen
species reactive nitric oxide species
so these would all start going down the
result of that is that the inflammation
will go down and now just very quickly
this is the mechanism I just explained
one tiny part of this whole thing now if
I go back here to this study
in this study
I'm not going to read the whole
paragraph but this is the section
for
okay so I lost the section one second
here so this is the anti-inflammatory
section here all of these color
variations that I have are because they
have various in vitro or Mouse model
studies in which they said that this
study was done and that study showed the
modulation of these inflammatory
mediators that it just showed and I
showed you the pathway for how these get
modulated
so this is the discussion thank you very
much for listening in
um take advantage of this awesomely low
price for Dr Bean because on Monday we
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see you tomorrow
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