Neuroscientist: Supplement That Makes Your TESTICLES Grow | Andrew Huberman
Summary
TLDRThis script delves into the intricacies of testosterone's role in human performance and behavior, emphasizing the importance of natural methods to boost levels. It discusses the impact of substances like Tongkat Ali and Fadogia agrestis on testosterone, which can elevate levels by 100-400 points without the need for testosterone replacement therapy (TRT). The conversation also touches on the interplay between testosterone and prolactin, highlighting how these hormones influence sexual desire, aggression, and body composition. Furthermore, it explores testosterone's mental effects, such as reducing anxiety and promoting a positive response to effort and challenge.
Takeaways
- 💪 The fundamental layer for optimal performance in sleep, learning, and sports is behavior, followed by nutrition, supplementation, prescription drugs, and off-label substances.
- 🏋️♂️ Testosterone plays a significant role in sports performance, and while anabolic steroids are often discussed, there are legal supplements that can naturally increase testosterone levels.
- 🌿 Tongkat Ali, a natural supplement, can raise free testosterone and overall testosterone levels by about 100 to 200 points when taken at a dosage of 400 milligrams per day.
- 💧 The typical dose for testosterone replacement therapy is 200 milligrams, administered once every week to two weeks, which is equivalent to one cc of cypionate.
- 🚫 Many men in their 20s and 30s may not need testosterone replacement therapy (TRT) and can maintain healthy testosterone levels through proper behaviors and nutrition.
- 🔄 Prolactin, a hormone associated with milk let-down in women, can also affect men, potentially increasing body fat and reducing sexual desire and aggression.
- 🌱 Fedogia agrestis, a Nigerian shrub, mimics luteinizing hormone and can stimulate the testes to produce more testosterone when combined with Tongkat Ali.
- 📈 The combination of herbal supplements like Tongkat Ali and Fedogia agrestis can lead to a significant boost in free testosterone, with some individuals experiencing an increase of 300 to 400 points.
- 🧠 Testosterone has mental effects, particularly reducing anxiety by binding to androgen receptors in the amygdala, the brain's fear and anxiety center.
- 🏃♂️ Testosterone encourages engagement in effort and challenge by making the body feel good, which is a natural drive similar to other basic human needs.
Q & A
What are the fundamental layers that affect human performance and behavior?
-The fundamental layers affecting human performance and behavior include sleep, learning, sports performance, nutrition, supplementation, prescription drugs, and off-label substances.
How does anabolics impact brain development and body function?
-Anabolics, such as testosterone and its derivatives, impact brain development and body function by influencing fear, aggression, and mental state.
What is Tongkat Ali and how does it affect testosterone levels?
-Tongkat Ali is a substance that can raise free testosterone and overall testosterone levels by about 100 to 200 points when taken at a dose of about 400 milligrams per day.
What is the typical dose for testosterone replacement therapy?
-The typical dose for testosterone replacement therapy is 200 milligrams, given once every week to two weeks.
How does the size of a syringe relate to the dosage of testosterone?
-The size of a syringe correlates to the dosage of testosterone, with a full syringe of one cc containing 200 milligrams of testosterone cypionate.
What is the role of prolactin in sexual desire and aggression?
-Prolactin is a molecule involved in milk let-down in lactating women but also plays a role in sexual desire and aggression in men, as it can shut down sexual desire.
How does the presence of a pregnant woman affect a man's prolactin levels?
-The presence of a pregnant woman, possibly through pheromones or odors, can increase a man's prolactin levels, leading to weight gain and preparation for co-parenting.
What is the Nigerian shrub Fedogia agrestis and how does it mimic luteinizing hormone?
-Fedogia agrestis is a Nigerian shrub that mimics luteinizing hormone, which stimulates the testes to produce more testosterone.
What is the typical increase in testosterone levels when using Fedogia agrestis?
-The typical increase in testosterone levels when using Fedogia agrestis, taken at about 600 milligrams, is a three to four hundred point increase.
How does testosterone affect the brain and effort?
-Testosterone makes effort feel good by interacting with the amygdala, the fear and anxiety center in the brain, thus reducing fear and promoting engagement in challenges.
What are the effects of testosterone on the body and its recovery?
-Testosterone increases protein synthesis, leading to muscle growth, recovery, and a lean physique, as it is crucial during puberty for growth and development.
Outlines
💪 Testosterone and Its Impact on Behavior and Performance
The paragraph discusses the importance of testosterone in various aspects of life, including sleep, learning, and sports performance. It introduces the concept of supplementation and prescription drugs, highlighting the difference between anabolic steroids and natural supplements. The speaker mentions their past work on androgens and their effects on brain development and body function. Two natural supplements, Tongkat Ali and Fadogia agrestis, are introduced as ways to increase testosterone levels without the need for testosterone replacement therapy (TRT). The paragraph also touches on the role of prolactin, a hormone that can affect sexual desire and aggression, and its relationship with testosterone. The speaker suggests that many issues attributed to low testosterone are actually related to prolactin imbalances.
🐐 Testosterone's Role in Overcoming Fear and the Mating Drive
This paragraph delves into the psychological effects of testosterone, particularly its role in reducing fear and anxiety. It uses the example of male animals, such as Rams, to illustrate how testosterone surges can lead to aggressive behavior in the context of mating. The speaker explains that testosterone helps males overcome the fear of pain and punishment, which is crucial for engaging in battles for mating rights. The paragraph also discusses how testosterone can make effort and challenge feel rewarding, which is linked to the hypothalamus and the body's natural drives. The speaker notes that while testosterone depletion can lead to depression, a surge in testosterone can provide relief and reduce anxiety, provided it is within a healthy range.
Mindmap
Keywords
💡Testosterone
💡Supplementation
💡Tongkat Ali
💡Fadogia Agrestis
💡Prolactin
💡TRT (Testosterone Replacement Therapy)
💡Anabolics
💡Estrogen
💡Amygdala
💡Protein Synthesis
💡Hypothalamus
Highlights
Behaviors are fundamental for sleep, learning, and sports performance.
Nutrition, supplementation, prescription drugs, and off-label substances are discussed in the context of sports performance.
Hormones in sports often refer to anabolics and banned substances, but there are legal ways to augment testosterone.
Tonga Ali, a natural substance, can increase testosterone levels by 100 to 200 points when taken at 400 milligrams per day.
Testosterone replacement therapy typically involves a dose of 200 milligrams every week to two weeks.
Many men in their 20s and 30s may not need testosterone replacement therapy and can maintain healthy levels through proper behaviors and nutrition.
Prolactin, a hormone involved in milk let-down, can affect sexual desire and aggression, and is linked to 'dad bod' in men during their partner's pregnancy.
Fedogia agrestis, a Nigerian shrub, mimics luteinizing hormone and can boost testosterone levels.
Combining Tonga Ali and Fedogia agrestis can lead to a significant increase in free testosterone.
Fedogia agrestis can cause a noticeable increase in testosterone, with one case raising levels from the low twos to the 700 range.
Testosterone is known for its effects on voice, facial hair, muscle growth, and recovery, due to increased protein synthesis.
Testosterone makes effort feel good by interacting with the amygdala, the fear and anxiety center in the brain.
In animals and humans, testosterone surges are linked to the willingness to engage in battle or challenge.
Testosterone depletion can lead to feelings of depression, while a surge can provide relief and reduce anxiety.
Transcripts
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look their behaviors are the fundamental
layer you have to do the right things
for anything for sleep for learning for
sports performance but then there's
nutrition supplementation prescription
drugs and then off-label stuff right and
so we always think of it when you hear
hormones in sports you always think just
the raw conversation about anabolics all
the banned stuff we can talk about that
stuff and how it works years ago I used
to work on androgens testosterone and
its derivatives and how it impacts brain
development and body function fear and
and also mental state but there's a
category of supplements that are very
interesting
that for most people who aren't
exploring testosterone augmentation for
sport work very well to increase
testosterone by about 100 to 200 points
not you know 300 you know not a tripling
or anything like that and the main ones
are two substances one is called Tonga
Ali oh yeah which is that stuff's real
yeah oh yeah so Tonga Ali about 400
milligrams per day has the effect of
raising free testosterone and overall
testosterone by about 100 to 200 points
so the typical dose of of uh
testosterone replacement therapy is 200
milligrams given once every week to two
weeks but when you look at a full
syringe what is that so for one cc one
mil right that's 200 milligrams
typically of cypionate which is sold one
cc a full cc is only two one cc is it
not going to be that much it's a yeah so
it depends if you have a little narrow
syringe okay right right but if you have
a syringe that goes up to ten what is
that that's 10 CC's that's that's 10 CC
yeah that's a thousand oh kilograms that
makes sense right so so it would be two
on that and that's 200 milligrams that's
right so well okay so as long as we're
going now you're saying like two full
syringes yeah I mean I actually think
that a lot of people who think they need
trt when I hear about guys in their 20s
and 30s it
look I'm in my mid-40s and I can tell
you that you can get and maintain very
healthy testosterone levels without trt
if you do the right things the behaviors
the nutrition all the other stuff a lot
of problems that are that are layered
onto estrogen are actually problems with
prolactin which is a molecule that's
involved in milk let down and lactating
women but it actually shuts down the
sexual desire and aggression you know
when this is interesting about prolactin
so this happens in brooding birds and it
happens in humans they've done this a
study published in the journal Nature
which is our kind of Apex Journal showed
that when the husbands of pregnant women
because of something maybe a pheromone
maybe some odor of the pregnant woman
actually increases the man's prolactin
when they're pregnant puts body weight
on the guy he starts laying down body
fat presumably to prepare the father for
the long sleepless nights ahead because
humans have always co-parented wow I'm
mostly co-parented we all know women do
far more but who's out there who get fat
don't feel bad yeah so that's going on
the dad bodice is due to an increase in
prolactin and testosterone and prolactin
are kind of working in opposite fashion
so it's a very interesting thing but the
way you describe it is correct now for
people that aren't getting prescribed
trt but want the increase in
testosterone they're these plant
compounds like Tonga Ali and another one
which is very interesting it's a
Nigerian shrub called fedogia agrestis
and it mimics luteinizing hormone which
is the hormone that comes out of the
hypothalamus that stimulates the testes
if you got those in your ovaries if
you've got those to make more
testosterone for estrogen and so those
two herbal supplements together can give
a significant boost in free inactive
testosterone so you said Tongan Ali can
give you 100 to 200. how about that what
does the other one give you fedojia is
usually taken at about 600 milligrams
um and that can the most dramatic effect
I've ever seen was somebody who had his
testosterone down in the low twos or I
think it was like low twos and it he got
it up to the 700 range which but that's
it but that that's an outlier right most
people are going to see about a three to
four hundred Point increase and that's
what the two of them synergistically the
doji will actually make the testes grow
it's a it's a noticeable difference
testosterone has the effects we're all
aware of like deepening The Voice facial
hair muscle growth recovery Etc mostly
because testosterone increases protein
synthesis you look at a young male in
puberty to protein synthesis machine
yeah they eat theyad and they just grow
and grow and grow and they're putting on
muscles and they're lean and you know so
most often they're lean but in any case
testosterone has some very interesting
effects on the brain the the major
mental effect of testosterone is it
makes effort feel good
oh that makes sense and the reason it
does it is that the amygdala this fear
Center in the brain this anxiety Center
in the brain has Androgen receptors it
has testosterone receptors and so
the way this works in animals and in
humans as well is that for most species
the males of that species never get a
chance to mate
right so if you think about I'll
probably pick an example where you'll
you'll know the exception because I know
you know a lot about natural animals and
animals that are hunted but if you think
about animals with antlers like Rams
there's been a lot of research believe
it or not on Rams it'd be fun I'd love
to work on you know Rams have enormous
balls
and they have to fight for the right to
mate yes and the fighting is a choice
right and the decision to walk away is a
choice usually they usually don't kill
each other although I know some of the
injuries can lead to death so
testosterone these surges in
testosterone that happen seasonally in
certain species like Rams or even these
little hamsters the males will rip each
other's testicles off in order to fight
for the right to mate so males of a
given species have to actually overcome
the fear of pain and Punishment and the
surge in testosterone is what causes the
shift to the willingness to engage in
battle and so when humans are taking low
doses or reasonable doses of
testosterone or they're increasing their
testosterone or they're going through
puberty
effort and leaning into pain and
challenge actually has the effect of
making the body feel soothed and good
it's a drive just like sex is a drive or
drinking water when you're thirsty is a
drive this stuff is all anchored deep
within the hypothalamus when people are
testosterone depleted they feel
depressed and when people have a surge
of testosterone they feel relief and
anxiety provided it's in the appropriate
range
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