Clinical trials eye repurposed drugs to help Parkinson's patients
Summary
TLDRDr. Darren Moore from the Van Andel Institute discusses Parkinson's Disease, a progressive neurodegenerative disorder affecting millions globally. He highlights the absence of a cure but mentions several promising treatments, including repurposed drugs from conditions like diabetes. Dr. Moore also notes advancements in early diagnosis and the potential for new technologies, such as biomarkers, to improve detection and treatment responses. Additionally, he discusses the increasing prevalence of Parkinson's, possibly due to industrialization, while emphasizing the ongoing research and clinical trials aimed at slowing disease progression.
Takeaways
- 🧠 Parkinson's disease affects between 8-10 million people worldwide.
- 🩺 There is currently no cure for Parkinson's disease, but many treatments exist to manage symptoms.
- 💊 New therapies, including repurposed drugs like those used for diabetes, are being explored to treat Parkinson's.
- 🌐 A diabetes medication is currently in phase 3 clinical trials and may protect the brain from Parkinson's.
- 🧪 A recent phase 2 clinical trial in France showed promising results for slowing down Parkinson's progression.
- 🔬 Research is also looking into multi-use drugs that may have effects on Parkinson's disease.
- 📊 Diagnosing Parkinson's has improved, allowing for earlier detection in the pre-symptomatic stage.
- 📈 The prevalence of Parkinson's seems to be rising due to industrialization and environmental factors.
- 🧬 New technologies like spinal taps are being developed to better diagnose and predict responses to treatment.
- 🚀 Exciting advances in Parkinson's research hold promise for improved treatment in the future.
Q & A
What is Parkinson's disease?
-Parkinson's disease is a progressive neurodegenerative disorder that affects between 8 to 10 million people worldwide.
What is World Parkinson's Day?
-World Parkinson's Day is a day that provides an opportunity to stand in solidarity with people affected by Parkinson's disease.
Who is Dr. Darren Moore?
-Dr. Darren Moore is the Chair of Van Andel Institute's Department of Neurodegenerative Science, and he was interviewed to discuss developments in Parkinson's disease treatments.
Is there currently a cure for Parkinson's disease?
-No, there is no cure for Parkinson's disease at the moment, but there are several treatments that address its symptoms, and new treatments are being developed.
What are some of the promising treatments for Parkinson's disease mentioned in the interview?
-Some promising treatments include repurposing drugs used for other diseases, like a drug used to treat Type 2 diabetes, which is in phase 3 clinical trials for Parkinson's disease.
What is the significance of phase 2 and phase 3 trials in the development of Parkinson's treatments?
-Phase 2 and phase 3 clinical trials are crucial stages in drug development. Phase 2 trials focus on the drug’s effectiveness, while phase 3 trials are larger and confirm the drug's safety and efficacy before potential approval.
Why are drugs for other diseases being repurposed for Parkinson's disease?
-Some drugs for other diseases, like diabetes, may also have protective effects on the brain, making them potential treatments for Parkinson's disease.
Are more people being diagnosed with Parkinson's disease today compared to the past?
-Yes, more people are being diagnosed with Parkinson's, partly due to better diagnostic methods and increased awareness, but there also seems to be an increased burden due to factors like industrialization.
What are some early symptoms of Parkinson's disease?
-Early symptoms of Parkinson's disease, often referred to as the 'prodromal phase,' include loss of smell, constipation, and psychiatric symptoms that can precede the more recognizable motor symptoms.
How might new technology improve the diagnosis of Parkinson's disease?
-New technologies, such as advanced biomarkers like spinal taps, are helping researchers better diagnose Parkinson's disease and predict how patients might respond to treatments.
Outlines
🌍 Parkinson's Disease Overview and Global Impact
Parkinson's disease is a progressive neurodegenerative disorder affecting 8-10 million people worldwide. World Parkinson's Day is an opportunity to raise awareness and stand in solidarity with those impacted by the condition. The segment introduces Dr. Darren Moore, Chair of Van Andel Institute's Department of Neurodegenerative Science, who shares insights on the latest developments in Parkinson's research.
💊 Current Treatments and Emerging Therapies
Dr. Moore discusses that while there is no cure for Parkinson's disease, various treatments exist to manage symptoms. He highlights exciting developments in repurposing drugs from other diseases, like diabetes, which may protect the brain. He mentions several promising therapies in clinical trials, including a drug in phase 3 trials that could potentially slow the progression of Parkinson's.
📈 Rising Diagnosis Rates of Parkinson's Disease
Dr. Moore explains that more people are being diagnosed with Parkinson's disease, likely due to improved diagnostic tools and awareness. He notes that some early symptoms, like constipation and psychiatric changes, often precede the more typical motor symptoms. Additionally, he suggests that societal factors, like industrialization, could be contributing to a general increase in Parkinson's cases, with around one million Americans currently affected.
🔬 Advancements in Technology for Parkinson's Diagnosis
New technologies, such as advanced diagnostic tests like spinal taps, are improving the ability to detect Parkinson's disease and predict how patients will respond to treatments. Dr. Moore emphasizes the potential of these technologies to revolutionize early diagnosis and treatment, ultimately leading to better outcomes for patients.
Mindmap
Keywords
💡Parkinson's Disease
💡Neurodegenerative
💡Treatment
💡Repurposing Drugs
💡Clinical Trials
💡Phase 3 Trial
💡Symptoms
💡Diagnosis
💡Biomarkers
💡Solidarity
Highlights
Parkinson's disease is a progressive neurodegenerative disorder affecting 8-10 million people worldwide.
World Parkinson's Day provides an opportunity to stand in solidarity with those affected by the condition.
Dr. Darren Moore, Chair of Van Andel Institute's Department of Neurodegenerative Science, discusses the current research on Parkinson's.
While there is no cure for Parkinson's, there are multiple treatments in development aimed at alleviating symptoms.
Repurposing drugs originally designed for other diseases, such as diabetes, could offer protective effects for Parkinson's patients.
International clinical trials, like the one in the UK, are exploring potential new therapies for Parkinson's.
One drug for type 2 diabetes is in Phase 3 clinical trials and may show promise for Parkinson's treatment later this year.
A Phase 2 trial in France found a drug that may slow decline in Parkinson's patients.
Repurposing FDA-approved drugs for other conditions, like diabetes, could offer new treatments for Parkinson's.
The increasing prevalence of Parkinson's may be due to better diagnostic methods and an aging population.
Early symptoms such as constipation and psychiatric issues can predate full Parkinson's diagnosis.
The industrialization of society might be contributing to the rising burden of Parkinson's disease globally.
Approximately 1 million Americans currently suffer from Parkinson's.
New technologies like spinal taps may help diagnose Parkinson's and predict how patients will respond to treatments.
Ongoing progress in Parkinson's research is yielding promising developments in diagnostics and treatment strategies.
Transcripts
>> PARKINSON'S DISEASE IS A
PROGRESSIVE NEURODEGENERATIVE
DISORDER THAT AFFECTS BETWEEN
8 10 MILLION PEOPLE WORLDWIDE.
IS WORLD PARKINSON'S DAY. A
DAY THAT PROVIDES AN
OPPORTUNITY TO STAND IN
SOLIDARITY WITH PEOPLE
AFFECTED BY THIS CONDITION.
AND JOINING ME RIGHT NOW TO
TALK MORE ABOUT IT. IS DOCTOR
DARREN MORE CHAIR OF VAN ANDEL
INSTITUTE'S DEPARTMENT OF
NEURODEGENERATIVE SCIENCE.
THANKS FOR JOINING US TODAY.
DOCTOR MOORE. THANKS FOR
HAVING ME. WHILE THERE IS
CURRENTLY NO CURE FOR
PARKINSON'S DISEASE, BUT THERE
ARE SEVERAL TREATMENTS THAT
TREATMENT ON THE HORIZON.
WHERE DO WE STAND WITH THIS.
>> YEAH. AS A A FEW THINGS IN
THE PIPELINE. SO WE THAT'S NO
JOKE TALKING TODAY. BUT WE
MANY THERAPIES THAT TREAT THE
SYMPTOMS VERY FOR MANY YEARS.
SO THAT'S WHY WE IN TERMS OF
MEDICATION. NEW APPROACH
REPURPOSING DRUGS ALL OF THE
DISEASES SUCH AS DIABETES THAT
MAY HAVE SOME INDICATION THAT
THEY MAY ALSO PROTECT THE
BRAIN A WALKING TALKING WE
HEAR OF WANT TO HAD SOMETHING
CALLED THE INTERNATIONAL IN
CLINICAL TRIALS, SHIFT ALONE
WAS KILLED OFFICES IN THE UK.
WHEN WE REPORT THIS FDA
APPROVED DRUGS THAT MAY HAVE,
YOU KNOW, OTHER DISEASES THAT
MAY HAVE A EFFECTS IN
PAKISTAN. SO WHY IS AS THAT A
ACTUALLY TREAT TYPE 2
DIABETES. THAT THIS IS NOW IN
PHASE 3 CLINICAL TRIALS AND
SHOULD READ OUT LATER THIS
YEAR. WE JUST FINISHED A PHASE
2 TRIAL OF SPONSORING A FACE
TO CHARLES A NEXT. SENATE TIDE
WHICH WILL IS THAT IS THAT A
DRUG SEEMS TO HAVE. BENEFICIAL
EFFECTS ON SLOWING DECLINE IN
IN PARKINSON'S PATIENTS IN
TRIAL IN FRANCE RECENTLY
NATIONAL PHASE 2 TRIAL
EXCITING TIMES FEELS OUT OF
PHASE. 3 TRIAL OF A MEDICINE
COOLDOWN. RUSSELL. STRANGE
CALL NUMBER. FOR SOME REASON
SEEMS HAVE EFFECTS ON THE
BRAIN. AND SO THESE ARE KIND
OF REPURPOSING OFFENSE. WE ALL
COME TO GETTING A MULTI-USE
ABOUT OFFICERS CAUSE IT. AND
SO THAT'S LEADING TO NEW
CLINICAL. ALSO, YOU DON'T MOVE
AROUND THE POCKET CERTAINLY
SOUNDS PROMISING INTERESTING
CONNECTION THERE WITH THOSE
DRUGS AND POSSIBLY HELPING THE
SYMPTOMS. SO TAKING A LOOK AT
THESE LAST FEW YEARS OR MORE
PEOPLE GETTING DIAGNOSED WITH
PARKINSON'S ARE.
>> DO MORE PEOPLE SUFFER FROM
IT THAN IN THE PAST. OR WHAT
ARE WE SEEING WITH THE
NUMBERS.
>> I THINK WE'RE GETTING
BETTER AT DIAGNOSING WHO HAS
PARKINSON'S. AND AND, YOU ALSO
DETECTED BEFORE LONG,
REPUBLICANS. WHAT WE CALL A
PRO TRUMP WILL FACE A DISEASE
SO WE CAN WINTER FUN. THINGS
LIKE STINK. THIS EVIDENCE IS
IN CONSTIPATION PSYCHIATRIC
SYMPTOMS THAT. FREE PROCEED TO
SYMPTOMS. BUT THERE ALSO SEEMS
TO BE AN INCREASED BURDEN IN
GENERAL IN SOCIETY OF OF THE
DUE TO A INDUSTRIALIZATION. WE
DON'T QUITE KNOW. THERE'S A
LOT STUDIES OUT IT DOES SEEM
TO BE RISING IN PROBLEMS.
ROUGHLY EFFECTS ABOUT
1 MILLION AMERICANS AT THIS
POINT IN TIME. YEAH.
>> DO YOU THINK NEW TECHNOLOGY
COULD BETTER HELP DETERMINE
WHAT CAUSES THIS CONDITION IN
THE FUTURE.
>> YEAH, I THINK GUYS
DEFINITELY THAT'S BEEN REALLY
NICE DEVELOPMENTS RECENTLY
ENOUGH. I'M OFTEN DEVELOP THIS
WOULD BE LIKE A STEPHEN HESTER
AURORA, A SPINAL TAP THIS. I'M
TOLD BY SEE THAT CAN ALLOW YOU
PARKINSON'S AND HOW YOU MIGHT
RESPOND TO MEDICATION
CERTAINLY FASCINATING AND IT'S
GOOD TO KNOW. THE PROGRESS IS
BEING MADE ON THIS DOCTOR
DARREN MOORE.
>> TARA VAN ANDEL INSTITUTE'S
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