Can we eat to starve cancer? - William Li

Summary

The script discusses the medical revolution of angiogenesis, a process that controls blood vessel growth, which is crucial in both healing and disease, particularly cancer. It explains how blood vessels adapt to different body environments and how their regulation can prevent or promote diseases. The speaker highlights anti-angiogenic therapy as a novel approach to cancer treatment by starving tumors of blood supply. Additionally, the script explores the potential of diet in preventing angiogenesis-related diseases, suggesting that certain foods may inhibit blood vessel growth to cancers and obesity, offering a natural, preventative strategy.

Takeaways

• 🌟 Angiogenesis is a medical revolution that has the potential to help conquer diseases like cancer by focusing on the body's process of growing blood vessels.
• 🔍 The human body contains about 60,000 miles of blood vessels, including 19 billion capillaries, which are essential for various functions like detoxification, gas exchange, and muscle contraction.
• 🌱 Blood vessels adapt to their environment, performing different roles in different organs, and are mostly established before birth, with only a few exceptions like wound healing and pregnancy.
• 🛡️ The body regulates blood vessel growth through a balance of stimulators and inhibitors, which can be disrupted in diseases, leading to conditions like insufficient or excessive angiogenesis.
• 🏥 Angiogenesis is a hallmark of cancer, where tumors grow by forming new blood vessels to supply them with oxygen and nutrients, a process that can be targeted with anti-angiogenic therapy.
• 💊 Anti-angiogenic therapy is a novel approach to cancer treatment that differs from chemotherapy by selectively targeting the blood vessels that feed tumors.
• 🐕 This therapy has been successfully applied not only in humans but also in animals, extending survival and improving quality of life in pets with cancer.
• 🍅 Diet can play a significant role in preventing angiogenesis and, by extension, cancer, with certain foods and beverages containing natural inhibitors of angiogenesis.
• 📊 There is scientific evidence that certain dietary habits, such as consuming cooked tomatoes, can reduce the risk of developing cancer by inhibiting angiogenesis.
• 🍽️ The concept of dietary cancer prevention could have broad implications for public health, consumer education, and even the insurance industry, potentially making cancer prevention more accessible.

Q & A

What is angiogenesis and why is it significant in medical science?

Angiogenesis is the process by which the human body grows new blood vessels. It is significant in medical science because it plays a crucial role in wound healing, the menstrual cycle, and pregnancy. Moreover, it is a key factor in the progression of diseases such as cancer, where it can lead to the growth of tumors by providing them with oxygen and nutrients.

How does the body regulate the growth of blood vessels?

The body regulates the growth of blood vessels through a system of checks and balances involving stimulators and inhibitors of angiogenesis. When needed, stimulators like angiogenic factors are released to promote the growth of new blood vessels. Conversely, inhibitors are used to prune back excess vessels to maintain a baseline level.

What role does angiogenesis play in the development of cancer?

Angiogenesis is a hallmark of cancer. Tumors cannot grow larger than a certain size without a blood supply. Once angiogenesis occurs, it allows tumors to grow exponentially by providing them with the necessary oxygen and nutrients. It also enables cancer cells to spread to other parts of the body through the bloodstream as metastases.

How does anti-angiogenic therapy work in the treatment of cancer?

Anti-angiogenic therapy works by cutting off the blood supply to tumors. This treatment selectively targets the blood vessels that feed cancers, starving them of oxygen and nutrients. Since tumor blood vessels are abnormal and poorly constructed, they are highly vulnerable to treatments that target them.

What are some examples of anti-angiogenic drugs used in cancer treatment?

Examples of anti-angiogenic drugs mentioned include Avastin, which is FDA approved, and an experimental drug for glioblastoma. These drugs have shown to reduce blood flow to tumors, thereby inhibiting their growth.

Can anti-angiogenic therapy be applied to animals as well as humans?

Yes, anti-angiogenic therapy has been successfully applied to animals. The script mentions a 99-year-old boxer dog named Milo who was treated with a cocktail of anti-angiogenic drugs and a cream, which extended his survival time significantly.

What is the potential of using diet to prevent angiogenesis and thus cancer?

There is potential in using diet to prevent angiogenesis and cancer. The script discusses the presence of naturally occurring inhibitors of angiogenesis in many foods, which could boost the body's defense system against cancer by inhibiting the growth of blood vessels that feed tumors.

What are some foods that have been found to have anti-angiogenic properties?

Foods with anti-angiogenic properties mentioned in the script include red grapes (rich in Resveratrol), strawberries, soybeans, and various types of tea. These foods have been shown to inhibit angiogenesis in laboratory tests.

How does the concept of angiogenesis relate to obesity?

The concept of angiogenesis relates to obesity because fat tissue growth is highly dependent on blood vessel growth. The script suggests that inhibiting angiogenesis could potentially be used to control or reduce fat tissue by cutting off its blood supply.

What are the broader implications of understanding and controlling angiogenesis?

Understanding and controlling angiogenesis has broad implications for consumer education, food services, public health, and the insurance industry. It could lead to new preventative measures and treatments for diseases like cancer and obesity, and potentially influence dietary guidelines and health policies.

Outlines

00:00

🩺 Medical Revolution: Angiogenesis and Its Impact on Health

The speaker introduces the concept of angiogenesis, a medical revolution that has the potential to significantly impact the treatment of diseases like cancer. Angiogenesis refers to the body's process of growing new blood vessels, which is crucial for various bodily functions. The human body contains an extensive network of blood vessels, with the smallest being capillaries that play a vital role in health and disease. The speaker explains that while blood vessels typically do not grow in adults, there are specific circumstances such as wound healing and pregnancy where they do. The body maintains a balance of blood vessels through a system of stimulators and inhibitors. However, diseases can arise when this balance is disrupted, leading to either insufficient or excessive angiogenesis. The speaker emphasizes the importance of understanding angiogenesis in combating diseases that are characterized by abnormal blood vessel growth.

05:01

🛡️ Cancer and Angiogenesis: The Role of Blood Vessels in Tumor Growth

The speaker delves into the relationship between cancer and angiogenesis, highlighting that every type of cancer is characterized by angiogenesis. Cancers begin as small cell clusters without a blood supply, limiting their growth. However, as they evolve, they can trigger angiogenesis, allowing them to grow and spread. The speaker discusses anti-angiogenic therapy, a novel approach to cancer treatment that targets the blood vessels feeding the tumors, starving them of oxygen and nutrients. This method is distinct from traditional chemotherapy and has shown promising results in various types of cancer, including in animals like dogs. The speaker shares examples of how anti-angiogenic drugs have been used to extend the lives of pets with cancer, demonstrating the potential of this therapy in treating a wide range of cancers.

10:03

🍇 Preventing Cancer Through Diet: The Power of Anti-Angiogenic Foods

The speaker explores the possibility of preventing angiogenesis and, by extension, cancer through diet. They discuss the impact of diet on cancer development, noting that diet can account for 30 to 35% of environmentally caused cancers. Instead of focusing on what to remove from the diet, the speaker suggests adding foods that are naturally anti-angiogenic to boost the body's defense against cancer. They present a test system that measures the anti-angiogenic properties of various foods and beverages, demonstrating that many common foods, such as red grapes, strawberries, and certain teas, have potent anti-angiogenic effects. The speaker proposes the idea of a rating system for foods based on their ability to prevent angiogenesis, which could help consumers make informed dietary choices to reduce their cancer risk.

15:05

🍅 Tomatoes and Cancer Prevention: The Impact of Lycopene on Angiogenesis

The speaker presents a study that shows a correlation between the consumption of cooked tomatoes and a reduced risk of prostate cancer. They explain that tomatoes are a rich source of lycopene, which has anti-angiogenic properties that can inhibit the growth of blood vessels feeding cancer cells. The study's findings suggest that not only does lycopene consumption lower the risk of developing prostate cancer, but it also reduces the angiogenesis in those who do develop the disease. The speaker emphasizes the potential of dietary interventions in cancer prevention and the importance of further research into the role of a healthy diet in managing angiogenesis-related diseases.

Keywords

💡Angiogenesis

Angiogenesis refers to the process through which the body forms new blood vessels. In the context of the video, it is highlighted as a critical biological process that can be both beneficial and detrimental to health. The video explains how angiogenesis is essential for wound healing and the formation of the placenta during pregnancy, but when out of balance, it can lead to diseases such as cancer, blindness, and arthritis. The concept is central to the video's theme, emphasizing the potential of controlling angiogenesis to treat or prevent diseases.

💡Capillaries

Capillaries are the smallest blood vessels in the human body, crucial for the exchange of oxygen, nutrients, and waste products between blood and tissues. The video mentions that there are 19 billion capillaries in the human body, emphasizing their vital role in maintaining health. They are depicted as 'vessels of life' and are also implicated in diseases when angiogenesis is dysregulated, as seen in cancer development.

💡Angiogenic factors

Angiogenic factors are proteins that stimulate the growth of new blood vessels. The video describes them as 'natural fertilizer' that can tip the balance in favor of blood vessel growth. They are essential for normal physiological processes but can also contribute to disease progression, particularly in cancer, where they can promote tumor growth and metastasis.

💡Anti-angiogenic therapy

Anti-angiogenic therapy is a treatment approach that aims to inhibit the growth of new blood vessels, particularly to tumors, by targeting angiogenic factors. The video discusses this therapy as a novel method for cancer treatment, distinct from traditional chemotherapy, as it focuses on cutting off the blood supply to cancer cells, thereby starving them. Examples given include the use of drugs like Avastin, which has shown to reduce blood flow to tumors.

💡Cancer

Cancer is a group of diseases characterized by the uncontrolled growth and spread of abnormal cells. The video emphasizes cancer as a condition where angiogenesis is out of balance, with tumors relying on new blood vessels for growth and metastasis. It also discusses the potential of preventing angiogenesis as a strategy to keep cancers from becoming dangerous, highlighting the importance of early intervention.

💡Metastasis

Metastasis is the process by which cancer cells spread from their original site to other parts of the body through the bloodstream or lymphatic system. The video explains how angiogenesis facilitates metastasis by allowing cancer cells to enter the circulation and form new tumors in distant organs, which is a critical factor in cancer progression from a treatable to a life-threatening condition.

💡Diet and cancer

The video suggests that diet plays a significant role in cancer development, with certain foods containing natural inhibitors of angiogenesis that could help prevent cancer. It discusses the potential of using dietary changes as a preventative measure against angiogenesis-related diseases, positioning food as a tool for health promotion and disease prevention.

💡Resveratrol

Resveratrol is a naturally occurring compound found in red grapes and red wine, highlighted in the video for its anti-angiogenic properties. It is presented as an example of a dietary factor that can inhibit abnormal blood vessel growth, suggesting that consuming foods rich in resveratrol could contribute to cancer prevention.

💡Obesity

Obesity is mentioned in the video as another condition influenced by angiogenesis, as adipose tissue growth is dependent on blood vessel development. The video suggests that anti-angiogenic strategies could be used not only for cancer but also for obesity management, indicating the broad implications of angiogenesis research for public health.

💡Food synergy

Food synergy refers to the concept that combining certain foods can have a greater health benefit than consuming them individually. The video provides an example where a blend of two less potent teas becomes more effective in inhibiting angiogenesis than either tea alone, illustrating the potential of dietary combinations in enhancing the body's natural defenses against diseases.

Highlights

Angiogenesis is a medical revolution that could help conquer diseases like cancer.

The human body contains 60,000 miles of blood vessels, including 19 billion capillaries.

Blood vessels adapt to their environment, playing crucial roles in various organs.

Adults typically don't grow new blood vessels except in special circumstances like wound healing.

The body regulates blood vessel growth through a system of stimulators and inhibitors of angiogenesis.

Diseases can result from an imbalance in angiogenesis, affecting over a billion people worldwide.

Angiogenesis is a hallmark of cancer, as tumors require new blood vessels to grow.

Microscopic cancers are common but usually harmless without a blood supply.

Cancer becomes dangerous when angiogenesis occurs, allowing it to grow and metastasize.

Anti-angiogenic therapy is a new approach to cancer treatment that targets the blood supply.

Anti-angiogenic drugs have shown promise in treating various types of cancer in humans and animals.

There has been a 70 to 100% improvement in survival for some cancers with anti-angiogenic therapies.

Diet may play a significant role in cancer prevention, with 30 to 35% of cancers linked to environmental factors.

Many foods contain natural inhibitors of angiogenesis that could help prevent cancer.

A rating system is being developed to score foods based on their anti-angiogenic properties.

Eating certain foods, like tomatoes, has been shown to reduce the risk of prostate cancer.

Anti-angiogenic approaches may also have applications in treating obesity.

The potential of angiogenesis research extends to consumer education, public health, and the insurance industry.

Transcripts

[Music]

[Music]

[Applause]

good

afternoon there's a medical Revolution

happening all around us and it's one

that's going to help us conquer some of

society's most dreaded conditions

including cancer and the revolution is

called

angiogenesis and it's based on the

process that our bodies use to grow

blood vessels so why should we care

about blood vessels well the human body

is literally packed with them 60,000

miles worth in a typical adult end to

end that would form a line that would

circle the Earth

twice the smallest blood vessels are

called capillaries we've got 19 billion

of them in our bodies and these are the

vessels of life and as I'll show you

they can also be the vessels of

death now the remarkable thing about

blood vessels is that they have this

ability to adapt to whatever environment

they're growing in for example in the

liver they form channels to detoxify the

blood in the lung they line air sacks

for gas exchange in muscle they cork

screw so that muscles can contract

without cutting off circulation and in

nerves they course along like power

lines keeping those nerves alive and we

get most of these blood vessels when

we're actually still in the womb and

what that means is that as adults blood

vessels don't normally grow except in a

few special

circumstances in women blood vessels

grow every month to build the lining of

the uterus during pregnancy they form

the placenta which connects mom and baby

and after injury blood vessels actually

have to grow under the scab in order to

heal a wound and this is actually what

it looks like hundreds of blood vessels

all growing towards the center of the

wound so the body has the ability to

regulate the amount of blood vessels

that are present at any given time and

it does this through an elaborate and

elegant system of checks and balances

stimulators and Inhibitors of

angiogenesis such that when we need a

brief burst of blood vessels the body

can do this by releasing stimulators

proteins called androgenic factors that

act as natural fertilizer and stimulate

New Blood vels to sprout and when those

excess vessels are no longer needed the

body prunes them back to Baseline using

naturally occurring Inhibitors of

angiogenesis now there are other

situations where we start beneath the

Baseline and we need to grow more blood

vessels just to get back to normal

levels for example after an injury and a

body can do that too but only to that

normal level that set point but what we

now know is that for a number of

diseases there are defects in the system

where the body can't prune back extra

blood vessels or can't grow enough new

ones in the right place at the right

time and in these situations Ang

androgenesis is out of balance and when

androgenesis is out of balance a myriad

of diseases result for example

insufficient androgenesis not enough

blood vessels leads to wounds that don't

heal heart attacks legs without

circulation death from stroke nerve

damage and on the other hand excessive

androgenesis too many blood vessels

drives disease and we see this in cancer

blindness arthritis obesity Alzheimer's

disease in total there are more than 70

major diseases affecting more than a

billion people worldwide that all look

on the surface to be different from one

another but all actually share abnormal

androgenesis as their common

denominator and this realization is

allowing us to reconceptualize the way

that we actually approach these diseases

by controlling

androgenesis now I'm going to focus on

cancer because androgenesis is a

Hallmark of cancer every type of cancer

so here we go this is a tumor dark gray

ominous Mass growing inside a brain and

under the microscope you can see

hundreds of these brown staining blood

vessels capillaries that are feeding

cancer cells bringing oxygen and

nutrients but cancers don't start out

like this and in fact cancers don't

start out with a blood supply they start

out as small microscopic nests of cells

that can only grow to one half a cubic

millimeter in size that's the tip of a

ballpoint pen then they can't get any

larger because they don't have a blood

supply so they don't have enough oxygen

or

nutrients and in fact we're probably

forming these microscopic cancers all

the time in our body autopsy studies uh

from people who died in car accidents

have shown that about 40% of women

between the ages of 40 and 50 actually

have microscopic cancers in their

breasts about 50% of men in their 50s

and 60s have microscopic prostate

Cancers and all virtually 100% of us by

the time we reach our 70s will have

microscopic cancers growing in our

thyroid yet without a blood supply most

of these cancers will never become

dangerous Dr Judah folman who was my

mentor and who is the Pioneer of the

androgenesis field once called this

cancer without

disease so the body's ability to balance

angiogenesis when it's working properly

prevents blood vessels from feeding

Cancers and this turns out to be one of

our most important defens mechanisms

against

cancer in fact if you actually block

androgenesis and prevent blood vessels

from ever reaching cancer cells tumors

simply can't grow up but once

angiogenesis occurs cancers can grow

exponentially and this is actually how a

cancer goes from being harmless to

deadly cancer cells mutate and they gain

the ability to release lots of those

angiogenic factors natural fertilizer

that tip the balance in favor of blood

vessels invading the cancer and once

those vessels invade the cancer it can

expand it can invade local tissues and

the same vessels that are feeding tumors

allow cancer cells to exit into the

circulation as

metastases and unfortunately this late

stage of cancer is the one at which it's

most likely to be diagnosed when

androgenesis is already turned on and

cancer cells are growing like

wild so if androgenesis is a Tipping

Point between a harmless Cancer and a

harmful one then one major part of the

angiogenesis revolution is a new

approach to treating cancer by cutting

off the blood

supply we call this anti-androgenic

therapy and it's completely different

from chemotherapy because it selectively

aims at the blood vessels that are

feeding the Cancers and we can do this

because tumor blood vessels are unlike

normal healthy vessels we see in other

places of the body they're abnormal

they're very poorly constructed and

because of that they're highly

vulnerable to treatments that Target

them in in fact when we give cancer

patients anti-angiogenic therapy here an

experimental drug for a Goma which is a

type of a brain tumor you can see that

there are dramatic changes that occur

when the tumor is being

starved here's a woman with a breast

cancer being treated with the

anti-androgenic drug called avastin

which is FDA approved and you can see

that the Halo of blood flow disappears

appears after

treatment now I've just shown you two

very different types of cancer that both

responded to antiandrogenic therapy so a

few years ago I asked myself can we take

this one step further and treat other

cancers even in other

species so here is a 99-year-old boxer

named Milo who had a very aggressive

tumor called a malignant neurofibroma

growing on his shoulder it invaded to

his lungs his veterinarian only gave him

three months to live so we created a

cocktail of anti-angiogenic drugs that

could be mixed into his dog food as well

as an anti-angiogenic cream that could

be applied on the surface of the tumor

and within a few weeks of treatment we

were able to slow down that Cancer's

growth such that we were ultimately able

to extend Milo's survival to six times

what the veterinarian had initially

predicted all with a very good quality

of life and we've subsequently treated

more than 600 dogs we have about a 60%

response rate and prove survival for

these pets that were about to be

euthanized so let me show you a couple

of even more interesting

examples this is a 20-year-old dolphin

living in Florida and she had these

lesions in her mouth that over the

course of three years developed into

invasive squa cell cancers so we created

an anti-androgenic paste we had it

painted on top of the cancer three times

a week and over the course of 7 months

the cancers completely disappeared and

the biopsies came back as

normal here's a cancer growing on a lip

of a quarter horse named Guinness it's a

very very deadly type of cancer called

an angro saroma had already spread to

his lymph nodes so we used the

anti-androgenic skin cream for the lip

and the oral cocktail so we could treat

from the inside as well as the outside

and over the course of six months he

experienced a complete

remission and here he is six years later

Guinness with his very the

owner now obviously antiandrogenic

therapy could be used for a wide range

of cancers and in fact the first

pioneering treatments for people as well

as dogs are already becoming available

there's 12 different drugs 11 different

cancer types but the real question is

how well do these work in practice so

here is actually the patient survival

data from eight different types of

cancer and the bars represent survival

time taken from the era in which there

was only chemotherapy or surgery or

radiation available but starting in

2004 when anti-androgenic therapies

first became available you can see that

there has been a 70 to 100% Improvement

in survival for people with kidney

cancer multiple Myoma colorectal cancer

and gastrointestinal stromal tumors

that's

impressive but for other tumors and

cancer types the improvements have only

been modest

so I started asking myself why haven't

we been able to do

better and the answer to me is obvious

we're treating cancer too late in the

game when it's already established and

often times it's already spread or

metastasized and as a doctor I know that

once a disease progresses to an advanced

stage achieving a cure can be difficult

if not

impossible so I went back to the biology

of Andrew Genesis and started thinking

could the answer to cancer be preventing

androgenesis beating cancer at its own

game so that cancers could never become

dangerous this could help healthy people

as well as people who have already

beaten cancer once or twice and want to

find a way to keep it from coming back

so to look for a way to prevent

androgenesis and cancer I went back to

look at Cancer's causes and what really

intrigued me was when I saw that diet

accounts for 30 to 35% of

environmentally caused

cancers now the obvious thing is to

think about what we could remove from

our diet what to strip out take away but

I actually took a completely opposite

approach and began asking what could we

be adding to our diet that's naturally

anti-angiogenic that could boost the

body's defense system and beat back

those blood vessels that are feeding

cancers in other words can we eat to

starve

cancer well the the answer is yes and

I'm going to show you how and our search

for this has taken us to the market the

farm and to the spice cabinet because

what we've discovered is that Mother

Nature has laced a large number of foods

and Beverages and herbs with naturally

occurring Inhibitors of anog

Genesis so here's a TI system we

developed uh at the center of a ring

from which hundreds of blood vessels are

growing out in a starburst fashion and

we can use this system to test dietary

factors at concentrations that are

attainable by eating

so let me show you what happens when we

put in an extract from red grapes the

active ingredients Resveratrol it's also

found in red wine this inhibits abnormal

androgenesis by

60% here's what happens when we add an

extract from

strawberries it potently inhibits

androgenesis an extract from

soybeans and here is a growing list of

our anti-androgenic foods and beverages

that we're interested in studying

and for each food type we believe that

there's different potencies within

different strains and varietals and we

want to measure this because well while

you're eating a strawberry or drinking

tea why not select the one that's most

potent for preventing cancer so here are

four different tees that we've tested

they're all common ones Chinese Jasmine

Japanese CA Earl Gray and a special

blend that we prepared and you can see

clearly that the teas vary in their

potency from less potent to more potent

but what's very cool is when we actually

combine the two less potent together the

combination the blend is more potent

than either one

alone this means there's food

Synergy here's some more data from our

testing now in the lab we can simulate

tumor angiogenesis represented here in a

black bar and using this system we can

test the potency of cancer drugs so the

shorter the bar less androgenesis that's

good and here are some common drugs that

have been associated with reducing the

risk of cancer in people statins

non-steroidal anti-inflammatory drugs

and a few others they inhibit

androgenesis too and here are the

dietary factors going head-to-head

against these drugs you can see they

clearly hold their own and in some cases

they're more potent than the actual

drugs soy parsley garlic grapes berries

I could go home and cook a tasty meal

using these

ingredients so imagine if we could

create the world's first rating system

in which we could score Foods according

to their anti-androgenic cancer

preventative properties and that's what

we're doing right

now now I've shown you a bunch of lab

data and so the real question is what is

the evidence in people that eating

certain foods can reduce androgenesis in

cancer

well the best example I know is this

study of 79,000 Men followed over 20

years in which it was found that men who

consumed cooked Tomatoes two to three

times a week had up to a 50% reduction

in their risk of developing prostate

cancer now we know that tomatoes are a

good source of lycopene and lycopene is

anti-androgenic but what's even more

interesting from the study is that in

those men who did develop prostate

cancer those who ate more servings of

tomato sauce

actually had fewer blood vessels feeding

their cancer so this human study is a

prime example of how anti-androgenic

substances present in food and consumed

in Practical levels can impact on cancer

and we're now studying the role of a

healthy diet with Dean ornish at UCSF

and tus University on the role of this

healthy diet on markers of angiogenesis

that we can find in the

bloodstream now obviously uh what I've

shared with you has some Far ranging

implications even Beyond cancer research

because if we're right it could impact

on consumer education Food Services

Public Health and even the insurance

industry and in fact some insurance

companies are already beginning to think

along these lines check out this ad from

Blue Cross Blue Shield of

Minnesota and for many people around the

world dietary cancer prevention may be

the only practical solution because not

everybody can afford expensive endstage

Cancer Treatments but everybody could

benefit from a healthy diet based on

local sustainable anti-androgenic

crops now finally I've talked to you

about food and I've talked you about

cancer so there's just one more disease

that I have to tell you about and that's

obesity because turns out that adapost

tissue fat is highly angiogenesis

dependent and like a tumor fat grows

when blood vessels grow so the question

is can we shrink fat by cutting off its

blood

supply so the top curve shows the body

weight of a genetically obese mouse that

eats non-stop until it turns fat like

this furry tennis

ball and the bottom curve is the weight

of a normal Mouse if you take the obese

Mouse and give it an androgenesis

inhibitor it loses weight stop the

treatment gains the weight back restart

the treatment loses the weight again

stop the treatment gains the weight back

and in fact you can cycle the weight up

and down simply by inhibiting

androgenesis so this approach that we're

taking for cancer prevention May also

have an application for

obesity the really truly interesting

thing about this is that we can't take

these obese mice and make them lose more

weight than what the normal Mouse's

weight is supposed to be in other words

we can't create super model

mice and this speaks to the role of

Andre Genesis in regulating healthy set

points Alberton Georgie once said that

Discovery consists of seeing what

everybody has seen and thinking what

nobody has thought I hope I've convinced

you that for diseases like cancer

obesity and other conditions that there

may be a great power in attacking their

common denominator Andre Genesis and

that's what I think the world needs now

thank

you I haven't few questions for you so

um these drugs aren't exactly they're

not exactly in mainstream cancer

treatments right now for anyone out here

who has cancer what would you recommend

do you recommend pursuing these

treatments now for most cancer patients

so there are anti-androgenic treatments

that are FDA approved and U if you're a

cancer patient or working with Advocate

anyone you should ask and there are many

clinical trials um the angiogenesis

foundation has followed almost 300

companies and there's about 100 more uh

drugs every the pipeline so consider the

approved ones look for clinical trials

but then between what the doctor can do

for you we need to start asking what can

we do for ourselves and this is one of

the themes that I'm talking about is we

can Empower ourselves to do the things

that doctors can't do for us which is to

use knowledge and take action and if

Mother Nature has given us some Clues we

think that there might be some a new

future in the value of how we eat and

what we eat is really our chemotherapy

three times a day right and um along

those lines for people who might have

risk factors for a cancer would you

recommend pursuing any treatment sort of

prophylactically or simply pursuing the

right diet with lots of tomato sauce

well you know there's abundant

epidemiological evidence and I think an

Information Age it doesn't take long to

go to a credible Source like pmid the

National Library of Medicine to look for

epidemiological studies for cancer risk

reduction based on diet and based on

common medications and that's certainly

something that uh anybody can look into

okay well thank you so much