Ep:385 REPLACE STATINS WITH THIS FDA-APPROVED PLAQUE STABILIZER

Summary

Dr. Rob Cvis discusses the underutilized drug colchicine as a powerful anti-inflammatory for cardiovascular disease, which the FDA has approved to be more effective than statins in reducing risk. He emphasizes its benefits for secondary prevention, particularly in patients with high CRP levels, and suggests it as a safer and cost-effective alternative to statins, potentially in combination with low-dose aspirin, for reducing inflammation and vascular events.

Takeaways

• 👨‍⚕️ Dr. Rob is discussing the underutilization of colchicine compared to statins for cardiovascular disease, despite its proven effectiveness.
• 💊 Colchicine, known for treating gout, has been FDA-approved for its higher risk reduction in cardiovascular disease compared to statins.
• 🧬 Colchicine's history dates back to 1500 BC, originally used for joint inflammation and is derived from a plant.
• 🔍 The drug works as a powerful anti-inflammatory, which is crucial in addressing the root cause of cardiovascular issues rather than just the symptoms.
• 💡 Dr. David Nebert, an electrophysiology cardiologist, highlighted the benefits of colchicine for secondary prevention in patients with existing cardiovascular disease.
• 📉 High-sensitivity C-reactive protein (hsCRP) levels are a significant indicator of inflammation and cardiovascular risk, where colchicine can be beneficial.
• 💲 The low cost and less aggressive marketing of colchicine may contribute to its lesser-known status compared to statins.
• 🛑 For patients with a history of heart attack, stroke, or significant plaque burden, colchicine should be considered as a serious medication option.
• 🚫 The script suggests that colchicine might be a replacement for statins rather than used in conjunction due to its anti-inflammatory properties.
• 📚 A study published in the Journal of the American College of Cardiology emphasizes the predictive power of hsCRP over LDL cholesterol for cardiovascular events.
• 📉 FDA approval in June 2023 recognized colchicine's role in reducing the risk of major adverse cardiovascular events, including in patients with atrial fibrillation.

Q & A

Who is Dr. Rob Cvis and what is his area of expertise?

Dr. Rob Cvis is a specialist in lipidology and cardiology, often referred to as the 'carb addiction Doc'. He focuses on the effects of carbohydrates on health and the role of various treatments in managing cardiovascular diseases.

What is the main point of the video regarding the use of Statins by cardiologists?

The video suggests that cardiologists often insist on prescribing Statins for cardiovascular disease, despite the availability of other drugs like colchicine that may be more effective at reducing the risk of cardiovascular events.

What is colchicine and how is it typically used?

Colchicine is a drug that has been used for centuries and is typically prescribed for conditions like gout and inflammation. It is derived from a plant and was known as early as 1500 BC.

Why does Dr. Cvis believe colchicine is more effective than Statins for certain cardiovascular conditions?

Dr. Cvis believes colchicine is more effective because it is a powerful anti-inflammatory that significantly reduces vascular inflammation, which is a primary factor in cardiovascular diseases. The FDA has approved colchicine for reducing coronary artery disease risk at a level greater than Statins.

What is the role of inflammation in cardiovascular disease as discussed in the video?

Inflammation is presented as a key factor in cardiovascular disease. It is suggested that by reducing inflammation, particularly in the blood vessels, the risk of cardiovascular events can be significantly lowered.

How does colchicine work in relation to atherosclerotic cardiovascular disease?

Colchicine works by reducing the activation of white blood cells, decreasing their aggressive function, and reducing their adhesion to plaques, which are a major component of atherosclerosis.

What is the significance of C-reactive protein (CRP) in the context of the video?

CRP is highlighted as a marker of inflammation that is more predictive of cardiovascular death than LDL cholesterol. Elevated CRP levels are an indication for considering colchicine as a treatment option.

What is the FDA's stance on the use of colchicine for cardiovascular disease?

The FDA has approved the use of low-dose colchicine to reduce the risk of major adverse cardiovascular events, including heart attack, stroke, and cardiovascular death in patients with established atherosclerotic disease.

Why does Dr. Cvis suggest that colchicine could be a better alternative to Statins for some patients?

Dr. Cvis suggests that colchicine could be a better alternative due to its anti-inflammatory properties, its effectiveness in reducing cardiovascular risk, and its lower cost compared to Statins.

What is the recommended dosage of colchicine according to Dr. David Nebert, as mentioned in the video?

Dr. David Nebert recommends a low dose of 0.5 mg of colchicine for patients with elevated CRP levels and a history of cardiovascular disease, as part of a secondary prevention strategy.

How does Dr. Cvis view the combination of low-dose aspirin and colchicine for certain patients?

Dr. Cvis sees the combination of low-dose aspirin and colchicine as a potentially healthier and more effective alternative to Statins, especially for patients with a history of cardiovascular events and ongoing inflammation.

Outlines

00:00

🤔 The Overlooked Superiority of Colchicine Over Statins

Dr. Rob Cvis discusses the puzzling preference of cardiologists for prescribing statins despite evidence suggesting that colchicine is more effective in reducing cardiovascular disease. He points out that colchicine, known for its use in treating gout, has been FDA-approved for its high risk reduction in atherosclerotic cardiovascular disease, a fact often overlooked. Dr. David Nebert, an electrophysiology cardiologist, is credited for bringing this to light. The video emphasizes the need to consider colchicine for its anti-inflammatory properties, especially in patients with a history of heart attack, stroke, or elevated C-reactive protein (CRP) levels, indicating inflammation.

05:02

🛡️ Colchicine as a Powerful Anti-Inflammatory for Secondary Prevention

This paragraph delves into the anti-inflammatory benefits of colchicine, highlighting its effectiveness in reducing vascular inflammation, which is superior to that of statins. Dr. Cvis suggests that colchicine should be considered for secondary prevention in patients with significant plaque burden or a history of cardiovascular events. The paragraph also touches on colchicine's role in reducing amyloid protein synthesis, associated with conditions like Alzheimer's disease, and its potential in managing atrial fibrillation by decreasing inflammation in heart cells. The importance of using the right dosage of colchicine to avoid toxicity is stressed, along with its historical use since 1500 BC for joint inflammation.

10:03

🧬 Colchicine's Mechanism of Action and Its Impact on Inflammation

The speaker explains the mechanism by which colchicine operates, focusing on its ability to reduce the activation and adhesion of white blood cells to plaque, a process fundamental to the development of atherosclerosis. Aspirin is mentioned as a complement to colchicine, with the dual therapy potentially offering significant benefits in managing cardiovascular disease by addressing both clot formation and inflammation. The paragraph also discusses the correlation between high uric acid levels, a risk factor for gout and kidney stones, and cardiovascular disease, suggesting that colchicine's benefits extend to these conditions as well.

15:03

💊 Dosage Considerations and the Role of Colchicine in Patient Management

Dr. Cvis shares insights on the dosing of colchicine, advocating for a low-dose approach to minimize toxicity risks while maximizing anti-inflammatory benefits. He discusses the cost-effectiveness of colchicine compared to statins and emphasizes the importance of patient knowledge in making informed decisions about their treatment. The video also presents a case study of a patient with a high calcium score and stroke history, suggesting that colchicine could have been a beneficial addition to the patient's regimen. Dr. David Nebert's dosing strategy for patients with elevated CRP is introduced, recommending an initial dose of 0.5 mg to 0.6 mg of colchicine.

20:05

📚 FDA Approval and the Future of Colchicine in Cardiovascular Disease Management

The final paragraph summarizes the FDA's approval of low-dose colchicine for reducing the risk of cardiovascular events in patients with established atherosclerotic disease or multiple risk factors. It contrasts the traditional focus on lipids and LDL cholesterol with the emerging understanding of inflammation as a key driver of cardiovascular disease. The paragraph cites a study from the Journal of the American College of Cardiology that positions high-sensitivity CRP as a stronger predictor of cardiovascular death than LDL cholesterol. It concludes with a strong personal endorsement from Dr. Cvis for considering colchicine as a replacement for statins in appropriate cases.

👋 Closing Remarks and Call to Support

In the closing paragraph, Dr. Cvis invites viewers to support the channel financially if they have found the information valuable, suggesting a contribution to the PayPal account mentioned. This paragraph serves as a sign-off, indicating the end of the video content.

Keywords

💡Statin

Statins are a class of drugs commonly prescribed to lower cholesterol levels, particularly LDL cholesterol, in order to reduce the risk of cardiovascular diseases. In the video, Dr. Rob CVIS discusses the common practice of cardiologists recommending statins as a first line of treatment without considering other potentially more effective options.

💡Colchicine

Colchicine is a medication derived from a plant and has been used since ancient times for treating gout and reducing inflammation. The video emphasizes that colchicine has been shown to be more effective in reducing cardiovascular risk than statins, but it is less commonly known or prescribed for this purpose.

💡Cardiologist

A cardiologist is a medical professional specializing in the diagnosis and treatment of heart conditions. The video script mentions that cardiologists often insist on prescribing statins, despite the existence of alternative treatments with potentially greater benefits, such as colchicine.

💡Inflammation

Inflammation is part of the body's immune response to harmful stimuli but can also contribute to the development of chronic diseases. In the video, Dr. Rob CVIS argues that inflammation is a key factor in cardiovascular disease and that colchicine is a powerful anti-inflammatory that can be more effective than statins in managing this aspect of the disease.

💡Atherosclerotic cardiovascular disease

Atherosclerotic cardiovascular disease refers to conditions caused by the buildup of plaque in the arteries, which can restrict blood flow and lead to heart attacks or strokes. The video highlights that colchicine has been approved by the FDA for reducing the risk of this type of disease more effectively than statins.

💡CRP (C-reactive protein)

C-reactive protein is a blood test marker used to measure inflammation levels in the body. The video script discusses the significance of CRP levels in determining the presence of inflammation and the potential benefits of using colchicine in patients with elevated CRP levels.

💡Secondary prevention

Secondary prevention refers to measures taken to prevent a second occurrence of a disease, especially after a first event like a heart attack or stroke. The video suggests that colchicine should be considered for secondary prevention in patients with established cardiovascular disease.

💡Uric acid

Uric acid is a waste product that can lead to gout and kidney stones when present in high levels. The video mentions that colchicine is commonly used to treat conditions related to elevated uric acid, such as gout, and that high uric acid levels are also associated with cardiovascular disease.

💡Aspirin

Aspirin is a medication often used for its anti-inflammatory and antiplatelet effects, which can help prevent blood clots. The video proposes a combination of low-dose aspirin and colchicine as a potentially more effective approach than statins for certain patients with cardiovascular disease.

💡Atrial fibrillation

Atrial fibrillation is a type of irregular heartbeat that can lead to blood clots, stroke, or heart failure. The video script indicates that colchicine may help reduce inflammation associated with atrial fibrillation and potentially decrease the risk of this condition.

💡Alzheimer's disease

Alzheimer's disease is a progressive neurological disorder that causes memory loss and cognitive decline. The video discusses the role of inflammation in Alzheimer's and suggests that colchicine, by reducing inflammation, may have a beneficial effect on the disease, unlike some drugs that directly target amyloid protein.

Highlights

Dr. Rob explains the common insistence on prescribing Statins by cardiologists despite their awareness of more effective alternatives for cardiovascular disease reduction.

Introduction of Colchicine, a drug known for its use in Gout but also recognized by the FDA for its higher risk reduction in cardiovascular disease compared to Statins.

Colchicine's history dating back to 1500 BC and its traditional use for joint inflammation.

The anti-inflammatory properties of Colchicine and its effectiveness in reducing vascular inflammation more than Statins.

The FDA's approval of Colchicine for reducing coronary artery vascular risk at a level greater than Statins.

The economic factors influencing the prescription of Statins over Colchicine, despite the latter's proven benefits.

Colchicine's mechanism of action in reducing inflammation and its dosage considerations to avoid toxicity.

The role of Colchicine in reducing Amalo protein synthesis, associated with Alzheimer's disease.

Colchicine's potential in reducing atrial fibrillation by decreasing inflammation in pulmonary veins.

The synergistic effect of combining low-dose aspirin with Colchicine for secondary prevention of cardiovascular events.

The importance of considering inflammation as the primary cause of cardiovascular disease rather than focusing solely on lipids and LDL cholesterol.

The benefits of Colchicine in reducing the risk of a second cardiovascular event, particularly in patients with a history of heart attack or stroke.

The paper from the Journal of the American College of Cardiology highlighting the predictive power of inflammation over LDL in cardiovascular mortality.

Dr. Rob's opinion on using Colchicine as a replacement for Statins in certain patient populations.

The FDA's approval in June 2023 for the use of low-dose Colchicine to reduce the risk of myocardial infarction, stroke, and cardiovascular death.

The potential of Colchicine to be a cost-effective and safer alternative to Statins for patients with established cardiovascular disease.

The strategy of adjusting Colchicine dosage based on CRP levels and the importance of patient compliance.

Transcripts

hi folks this is Dr Rob cvis and I am

the carb addiction Doc and is the final

in the series of lipidology Cardiology

Statin type uh drugs and Statin thinking

um one of this is the final video and

one of the things that perplexes me

always is when you see a cardiologist

before you even walk in the door you

might be a delivery person but they're

talking to you about you need to be on a

Statin and there's nothing that can

dissuade them from that narrative and

yet there are several things that they

know about that they absolutely know

about it's in their literature FDA

approved where the drugs are far more

effective at reducing cardiovascular

disease than statens and yet they will

insist on a stattin and most of them

have never ever mentioned this word so

there's a drug out there called culture

scene some of you may know it if you've

got Gout you've probably heard of

culture scene but most of you there's

nobody that's watching these videos that

doesn't know the word Staten and I bet

you very very few of you know the word

culture scene so uh the FDA a few years

ago proved culture

scene as a very powerful

drug with a much higher risk reduction

than

stattin for cardiovascular disease for

atherosclerotic cardiovascular disease

and um you've seen this guy on this

channel I've got a a friend and a

patient by the name of Dr David nebert

who is a electrophysiology cardiologist

he's a cardiologist and he brought this

to my attention I knew about and I use

culture scene for my Gout patients I use

it for inflammation but I haven't looked

at the association of culture scene and

risk reduction for cardiovascular

disease and yes the you want to reduce

the inflammatory response you want to

reduce the cause of the inflammation but

early on as you responding to that this

inflammation why not let's consider and

let's talk about culture scene and what

it does and what the risks and benefits

are so in patients on a standard

American diet in patients with a

significant you've had a CAC score now

you've got pla in your you know you've

got pla in your blood vessels or you've

had a heart attack you've had a stroke

you've had an event and we

call the intervention secondary

prevention so you've had an event now

we've got to reduce

the risk of a second intervention uh of

a second event and the FDA as I said has

approved C culture scene to reduce

coronary artery vascular risk CBD

risk at a level that is far greater than

Statin so if you have positive

cardiovascular disease and measurable

inflammation and this blood work that we

do high fertin or a highly selective CRP

C reactive protein above two now ideally

I want that below three which is an

anti-inflammatory thing but if youve got

ongoing

inflammation and we can measure that

with white cell count we can measure it

with um uh fertin CRP is the one that

the cardiologists use and I think it's a

valid valid number if that's elevated

and you have plaque culture scene should

be a seriously considered medication for

a while to reduce that

inflammation and we're talking about

something that is secret why because

culture scene doesn't cost very much

money doesn't make a lot of money for

the insurance companies it is ranked as

the

184th most commonly prescribed drug

stattin being right up there is number

one or two I think that one through cuz

money money and I know I'm not that jist

conspiracy theorist but that is a direct

correlation especially if you

consider a significantly increased risk

production versus stens so what is

culture scene culture scene actually

comes from a plant and we've known about

it since 1500

ad okay sorry uh 1500 BC I'm sorry BC

before

Christ okay 1500 years before Christ uh

folks ate this for joint inflammation

it's one of the crocus plants they used

to consume it for joint

inflammation so what culture scene does

is culture scene is a powerful

anti-inflammatory we go into the

mechanism and the most common use of

culture scene right now is for gout for

elevated uric acid so if you have an

attack of gout affects your fingers

affects your toes big toes is the most

common one or if you have kidney stones

a lot of doctors like myself will use a

short 2 or 3 Day course of of culture

scine to reduce the inflammation from

gut but uric acid uh which is a product

of fructose consumption a carbohydrate

um also results in a risk of gout and a

risk of kidney stones sodium Uric urate

Stones um and alopurinol is one of the

drugs that dumbs that down so alopurinol

is this is the preventive why do we use

culture scine that often as prevention

although I do because its drug range its

dosage range has to be very tight it can

have devastating effects when it's

overdosed so please the more is better

population out there the more is better

a little bit work going to take more

please do not do that if you're going to

consider culture scene because more can

be very toxic at a high level range but

if you're in the 0.5 to point6 range and

I'm going to at the end of this I'm

going to use Dr neighbor it's dosing uh

pattern uh to talk about it but what

culturein does is it prevents

inflammation of the joints and so

culture scine is a very powerful

anti-inflammatory primarily associated

with goat use uh with gout goat with

gout use however

vascular inflammation and a reduction in

vascular inflammation is its primary

effect so culture scene significantly

reduces the vascular inflammatory

response far better than Statin and it

it should be a go-to

drug for secondary prevention that is

the most important consideration so if

you've got a significant plaque burden

if you've had an event to stroke or a

heart attack culine should be a very

serious drug at the top of that list

until we get rid of the

inflammation maybe together with with an

aspirin and we have to shift our

thinking of cardiovascular disease away

from lipids and away from LDL and

cholesterol toward inflammation once you

consider inflammation as the cause of

this disease then culture seene Falls

very neatly into place and in my opinion

and I'm going to modify my management

the combination for certain patients

with high risk a combination of a lowd

dose aspirin as well as culture scine at

low dose is the healthiest combination

especially if you've had a stroke or

heart attack now one of the interesting

things is that ccine also reduces amalo

protein synthesis and for those of you

who don't know amalo amalo is a protein

replacement within organs when cells of

those organs die so we see amalo in the

pancreas and people with diabetes type 1

diabetes but the biggest biggest

biggest replacement tissue replacement

by amalloy

occurs in the brain and we call that

disease

Alzheimer's and so many experimental

companies are are are uh producing drugs

that block block protein synthesis that

block am that block amalo protein

synthesis and the FDA has even approved

some of these pathetically weak drugs

you've heard about them Alzheimer's

because they're going to make money but

they don't affect Alzheimer's because

Alzheimer's is an inflammatory

condition and the amalo is there to

replace the death of the brain cells and

what culine does is it's associate with

a reduction in amalo but it doesn't

directly reduce amalo it reduces the

inflammation so there are lower levels

of amalo

but what they do the farmer companies

they directly treat the amalo block the

production of amalo but that's not

fixing the inflammation cine

does cine is also so we've talked about

it as inflammation in the blood vessels

the plumbing to reduce aerosis but

culture scene also works very

effectively and attention diabetics type

two diabetics culture works very

effectively to reduce inflammation

in the cells of your pulm

veins the blood vessel cells that over

time will modify and become electrified

those cells in your pulmonary veins can

become

electrified and have an electrical

signal when they shouldn't have a signal

that interferes with the normal

signaling of the electrical system of

the heart and we call that atrial

fibrillation and ccine also reduces

inflammation in those cells and reduces

the the abnormal electrification of the

heart and has an anti- atrial

fibrillation

effect so the combination and and to how

where exactly does culine

work well cusine specifically reduces

activation of white blood cells of

lucites decreases their activation

decreases their aggressive function and

decreases their adhesion

to plaque and if you remember plaque

starts out with a fibrin clot adding

platelets aspirin blocks that and then

the activated platelets bring white

cells in and the white cells bring

macrofagos in and The macras Bu bring

pla in or lipids so if you use an

aspirin to block platelets and you use

culturein to reduce that effective the

the inflam inflammation and the

activation of those white cells and the

adherence of those white cells you are

doing two massive things to reduce clot

propagation while not interfering with

the clot itself because there are things

like eloquest that are factor 10A

Inhibitors that prevent the clot well if

I cut myself I want a clot and yes

ideally I want activated plates I want

activated white cells but if there's a

balance between reducing a cut from a

clot uh from uh the clotting from a cut

and reducing pla formation if I'm at

risk for pla formation

this is where that balance Works where I

can still clot off a or at least create

an early clot for a a cut which is a

onetime event but I'm not having this

ongoing massive anti-inflammatory

response excessive anti-inflammatory

response occurring in my blood vessels

that is going to kill me of a heart

attack or a stroke there's no right

answer it's not absolute but that is

what we do with people that already have

inflammatory disease so the baby aspirin

shouldn't be taken by someone who's got

no risk or low risk same with the

culture scene but if your uric acid is

high if you're a PL inflammatory and

you've got plaa you've had an event the

combination of ASP and culture scene is

highly recommended particularly as a

weapon against Statin so stop the Statin

and take those two

meds just be very aware of the dosing

and low dosing is the way to

go so culture scene interferes with

white cell adhesion white cell function

and it also reduces the inflamm romes

that put out all these pro-inflammatory

cyto kindes so it reduces the

inflammatory uh risk and so many people

with cardiovascular disease aeroic

cardiovascular disease have high uric

acid

levels high uric acid levels and we see

that even our in our Alam HRS so there's

that double

benefit so I become very very gung-ho on

on culture scene albeit my primary focus

is to reduce inflammation so I don't

need any of those drugs but if you

already have the disease and you don't

want to see

propagation this may be a better added

strategy definitely in my opinion the

baby aspirin and then under certain

circumstances the addition of culture SE

so example I had a patient couple of

weeks ago taking his baby aspirin but he

has a huge burden I think it was 36 or

3,700 um C score and also a burden of

pluck in all of his vessels in the cored

in the ver

uh and he had a small stroke on

aspirin disease everywhere and developed

a small clot in the Basler artery of his

brain well

perhaps if he was on culture scene as

well as aspirin that may not have

happened now the good news is they got

to him early they removed that clot and

he's got very little residual effect of

that stroke but it could have been

catastrophic and if he wasn't on the

aspirin he probably would have

died or had death of his brain

but I'd like to put him or suggest to

him I never put anybody on suggest to

him that we add culture scene to the mix

now he's also doing a wonderful job of

reducing ongoing

inflammation reducing ongoing

inflammation through dietary changes

through Lifestyle Changes which is the

foundation but because he's got existing

disease because he had a

life-threatening event the risk or the

downside of culture scene any downside

which is really from toxicity is far

more worth accepting for the massive

benefit so that's the way my brain works

and I'm not going to he says no I'm fine

with that it's a decision we make but in

order to say yes or no you need the

knowledge and you need the science not

the emotive thinking I'm not going to

scare him I'm just going to say hey this

is something we've learned this is

something you can add to it now this

from David neighbor so this is a

cardiologist's use of this medic a and

in his population he sees a lot of

people that are not willing to go on a

on a low carbohydrate diet my population

are all at least trying and if you're

trying but struggling or if you say

screw it well screw it doesn't is not

going to fix the problem but what David

talks about is when he sees a CRP and we

test CRP on everybody above two and you

have pre-existing cardiovascular disease

he uses A5 MGR dose now for gout we use

a 6 Mig dose a day and that that cost

you about $20 a month through something

like good

RX about $32 at CVS for a 90day supply

so it's not expensive just like baby

aspin is not expensive statins are far

more expensive although they may be

covered by insurance

so um if you have if you meet the

criteria secondary prevention

significant plaque burden elevated CRP

then adding culture scene to your

aspirin and ask me about it if you're a

patient of mine maybe a very effective

safe non-toxic non-harmful way to go

because of the stattin profile of harm

and less

Effectiveness and under these

conditions you can even go to lower

dosing so as your CRP improves you can

go down to taking half a tablet 2.5 migr

every day or maybe even doing it Monday

Wednesday Friday because the benefits

occur at a very low dose

so that's David's strategy I found that

half a tablet on weekend strategy works

pretty well in people who struggle with

compliance or people who uh um do not

have a very high CRP but have a high

plaque

burden so I think the the

value of preventing clot in a safe way

where we know it's

effective it has value in people with

pre-existing disease but if you've got a

zero CC score like me don't even go down

that pathway but work really hard on

preventing inflammation not smoking not

having insulin

resistance and that's where the gp1s and

some of the diabetic medications may

have greater Advantage but you need to

know about culture scene you need to

know about its effect you need to ask

those questions and the final thing I'll

tell you this is the paper the paper

published in the journal uh the Journal

of the American College of Cardiology

says lowd dose culture seen for

secondary prevention of carony artery

disease and I'll give you the

summary inflammation assessed by means

of Highly sensitivity CRP

hscp is a more powerful determinant of

cardiovascular Death and All cause

mortality than low density lipoprotein

ldlc

so hscrp a mark of inflammation is more

predictive of cardiovascular death than

LDL which is what every cardiologist is

measuring all the time that's their

starting point and these are

cardiologists several therapies that

Target residual

inflammation residual inflammatory risk

significantly reduce vascular event

rates for coron artery disease patients

already taking

other medications including statins lowd

dose culture scene and I'm going to

paraphrase here may be a very healthy

very effective and this is coming from

me Robert cus not them because they use

it on top of a Statin a very very

healthy alternative to a Statin and the

low dose is .5 Mig Orly and this has

been shown to safely lower major adverse

cardiovascular Risk by 31% % amongst

those with stable atherosclerotic

disease and

23% secondary reduction if you've had a

heart attack so if you've had a heart

attack your risk of a second heart

attack is lowered by 23% basically one

quarter reduction on culture scene

without any other changes you then

change your diet and you massively

reduce

that these magnitudes are magnitudes of

benefit are

larger than those seen with lipid

lowering

agents lipid lowering and inflammatory

Inhibitors are not in Conflict but are

synergistic and I disagree with that I

disagree with that

statement that's where they and I

disagree culture scene is a replacement

for stattin not to be used with a

stattin in my opinion but in June of

2023 exactly a year ago the US Food and

Drug Administration the FDA approved the

use of lowdose culture scene to reduce

the risk of myocard fuction stroke Cal

rasul and cardiovascular death in

patients with established atic disease

or multiple risk factors for

cardiovascular disease

including atrial

fibrillation

H it's in the College of Cardiology they

don't talk about

it because it doesn't fit their

narrative that inflammation is the

problem not lipids

if I've made you think if I've given you

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