I Analyzed EVERY NMN Human Study (Including MIB-626). The Facts (‼️2024‼️)

Summary

This video script delves into the efficacy of NMN, an anti-aging supplement, through a comprehensive review of 16 clinical trials. It highlights the lack of significant impacts on health metrics such as blood sugar, cholesterol, and blood pressure, despite increasing NAD levels. The script also discusses the potential benefits on exercise performance and sleep quality in older adults, while expressing skepticism about NMN's geroprotective claims due to mixed and inconclusive results.

Takeaways

• 🧪 NMN (Nicotinamide Mononucleotide) is a popular anti-aging supplement with various human clinical trials investigating its effects.
• 🔍 The speaker is not affiliated with any supplement or pharmaceutical company, ensuring unbiased review.
• 🏥 Initial safety studies on NMN showed it raised NMN metabolites without affecting heart rate or blood pressure, indicating short-term safety.
• 📈 A peculiar finding was a 51% increase in bilirubin levels in some subjects, though still within normal range, and not consistent across studies.
• 🚫 No negative side effects were reported in a larger safety study involving 31 participants given 1,250 mg of beta-NMN daily for 4 weeks.
• 💊 Beta-NMN did not lower cholesterol, LDL, or triglyceride levels, despite the dosage, suggesting no impact on these health markers.
• 🚶‍♂️ A 2-month study with 66 participants found no side effects from the Uthever brand of NMN, but it also did not improve walking distance or well-being significantly.
• 🩸 A clinical trial with diabetic patients showed a 25% increase in muscle insulin sensitivity with NMN but no significant improvement in blood sugar levels.
• 💉 A study involving NMN infusions (not supplements) in healthy individuals showed a temporary drop in triglyceride levels, suggesting different mechanisms of action.
• 🏃‍♀️ Among amateur runners, NMN supplementation improved ventilatory threshold but not VO2 Max, muscle strength, or endurance.
• 👴 In older adults, chronic NMN supplementation showed mixed results with some reporting improved sleep and daytime function, but no significant impact on cognitive tests or physical performance.

Q & A

What is Nicotinamide mononucleotide (NMN) and why is it popular?

Nicotinamide mononucleotide, known as NMN, is an anti-aging supplement that has gained popularity due to its potential to increase levels of NAD+ in the body, which is associated with various health benefits and slowing the aging process.

What was the outcome of the first safety study on NMN involving 10 healthy men?

The first safety study found that NMN raised metabolites of NMN without affecting heart rate or blood pressure. However, it reported a 51% increase in bilirubin, which remained within the normal range, and this increase was not observed in other studies.

What was the dosage and duration of the safety study involving 31 healthy individuals?

In the safety study with 31 healthy individuals, they were given 1,250 mg of beta-NMN or a placebo daily for 4 weeks.

What were the effects of the Uthever brand of NMN on the NAD to NADH ratio in a 2-month study?

The Uthever brand of NMN increased the NAD to NADH ratio by about 40% in the 2-month study involving 66 healthy men and women.

Did NMN show any significant improvements in blood sugar levels in the clinical trial involving 35 overweight women with elevated blood sugar levels?

No, the clinical trial showed that while NMN increased insulin sensitivity by about 25%, there were no significant improvements in blood sugar levels.

What was the result of the 3-month study involving 11 healthy men and women taking 250 mg of NMN daily?

The study found that NMN raised plasma NMN levels but failed to lower blood sugar, hemoglobin A1c, cholesterol, LDL cholesterol, or triglyceride levels. Interestingly, it reported a doubling of triglyceride levels after one month, which returned to higher than normal levels by the end of the study.

What was the focus of the cardiovascular disease study involving 34 men and women in their late 40s?

The study aimed to determine if NMN could improve the health and functioning of blood vessels, but it found no significant differences in arterial stiffness between the placebo and supplement groups.

What were the findings of the study on NMN and exercise performance in amateur runners?

The study found that NMN supplementation improved the ventilatory threshold, indicating that runners could exercise harder before feeling difficulty. However, it did not improve VO2 Max, oxygen saturation, muscle strength, muscle endurance, or flexibility.

What was the observation regarding telomere length in the small study involving 8 individuals taking NMN for 3 months?

The study reported a significant increase in the length of telomeres in white blood cells after 3 months of NMN supplementation, suggesting a potential impact on aging at the cellular level.

What was the outcome of the study involving 80 middle-aged men taking different dosages of beta-NMN for 2 months?

The study showed that 600 mg of beta-NMN was more effective at raising NAD levels than 300 mg, but 900 mg did not outperform 600 mg. Participants reported improved quality of life, with those on 600 and 900 mg doses noticing benefits within 30 days.

What is the general consensus on the side effects of NMN based on the clinical trials presented in the script?

The general consensus from the clinical trials is that NMN does not report any significant negative side effects.

What is the author's overall stance on NMN as a geroprotective supplement after reviewing the clinical trials?

The author remains skeptical of the claims for NMN as a geroprotective supplement based on the results of the clinical trials presented.