Membuat Sediaan Padat Tablet, Kapsul, Serbuk dengan Cara Granulasi - Farmasi

Summary

In this video, the instructor, Sri Mulyani, guides viewers through the process of preparing solid dosage forms including tablets, capsules, and powder using a dry granulation method. The script details the composition and calculations for the ingredients such as mefenamic acid, PVP, amprotab, and magnesium stearate, along with steps to mix, granulate, and prepare the final product. Emphasizing practical application, the tutorial provides insights into pharmaceutical formulation, ensuring the audience learns key techniques for effective medication preparation.

Takeaways

• 😀 The video introduces the preparation of solid dosage forms such as tablets, capsules, and powders using dry granulation technique.
• 😀 The pharmaceutical composition of each tablet is calculated to weigh 750 mg, with ingredients like mefenamic acid as the active ingredient, and polyvinylpyrrolidone (PVP) as a binder.
• 😀 Mefenamic acid is used in the formulation for its analgesic and antipyretic properties, with a required amount of 30 grams for 60 tablets.
• 😀 PVP is used as a binder, and its proportion is calculated at 10% of the tablet's weight, amounting to 4.5 grams for 60 tablets.
• 😀 Amprotab (or amylum) is included as a disintegrant, with 4.5 grams required for 60 tablets.
• 😀 Lactose is used as a filler, calculated based on the remaining weight after accounting for other ingredients, totaling 6 grams for 60 tablets.
• 😀 Magnesium stearate and talcum are included as lubricants at specific percentages, amounting to 0.48 grams and 0.98 grams respectively for 60 tablets.
• 😀 The production process involves mixing the internal ingredients and half of the external ingredients until homogeneous.
• 😀 The mixture is then processed using a machine to prepare it for granulation, followed by crushing into a granular form using a mortar and pestle.
• 😀 The final step involves sieving the granules and blending the remaining external ingredients to ensure homogeneity before the powder is ready for encapsulation into capsules and tablets.

Q & A

What is the main focus of the video?

The main focus of the video is demonstrating how to prepare solid dosage forms such as tablets, capsules, and powders through dry granulation, specifically in the context of pharmaceutical preparation.

What is the active ingredient used in the formulation for the tablet?

The active ingredient used in the tablet formulation is mefenamic acid, which is utilized for its analgesic and antipyretic properties.

How is the amount of mefenamic acid in the tablet calculated?

The amount of mefenamic acid is calculated as 500 mg per tablet, and for a batch of 60 tablets, this amounts to 30,000 mg or 30 grams.

What role does polyvinylpyrrolidone (PVP) play in the formulation?

Polyvinylpyrrolidone (PVP) acts as a binder in the tablet formulation, and 10% of the total weight per tablet is calculated, resulting in 70 mg per tablet, or 4.5 grams for 60 tablets.

What is the function of amprotab (amilum) in the tablet formulation?

Amprotab (amilum) serves as a disintegrant, helping the tablet break down after ingestion. It is used at 10% of the total weight, which results in 75 mg per tablet, or 4.5 grams for 60 tablets.

How is the amount of lactose (lactosum) determined for the tablet?

Lactose is used to make up the remaining weight of the tablet after accounting for mefenamic acid, PVP, and amprotab. The amount of lactose is 100 mg per tablet, which totals 6 grams for 60 tablets.

What is the purpose of magnesium stearate in the tablet formulation?

Magnesium stearate is used as a lubricant or glidant to improve the flow of the powder during the tablet-making process. It is calculated as 1/90th of the tablet weight, resulting in 8.5 mg per tablet or 0.48 grams for 60 tablets.

What other lubricant is used in the formulation alongside magnesium stearate?

Talcum powder is also used as a lubricant or glidant, calculated at 2/96ths of the tablet weight, which results in 16.3 mg per tablet or 0.98 grams for 60 tablets.

What is the process for preparing the tablet granules?

The preparation process involves mixing all the inner ingredients and half of the outer phase ingredients until homogeneous, followed by the use of a machine to mix the ingredients further. The mixture is then crushed into granules and sieved.

How is the final tablet batch completed after granulation?

The remaining outer phase ingredients are mixed with the granules until fully homogeneous, and the mixture is then ready to be encapsulated into tablets, capsules, or powder forms for packaging.