PSPA Blok IV - 06 Uji Disolusi

Summary

This video script covers the Amoxicillin tablet dissolution test practicum, explaining the key steps and competencies required. It includes procedures for data collection, identifying problems, solving issues, and recording results. The dissolution test is conducted using distilled water as the medium, with precise temperature and speed settings. The script also emphasizes professional behavior in the laboratory, ensuring cleanliness and proper handling of materials. Finally, the dissolution profile is recorded, comparing tablet performance against pharmacopoeia standards to determine if the tablets meet the required dissolution criteria.

Takeaways

• 😀 The Amoxicillin tablet dissolution test is a crucial practicum for pharmaceutical preparation.
• 😀 The competencies assessed in this practicum include data collection, problem determination, problem solving, recording, and reporting, as well as professional behavior.
• 😀 Amoxicillin tablet dissolution testing requires 900 ml of distilled water as the dissolution medium.
• 😀 The test uses a Type 2 dissolution apparatus and a chromatography system with a mobile phase of pH 5.0 and acetonitrile.
• 😀 Tablets must dissolve at least 70% within 30 minutes to meet the required standards.
• 😀 Problem determination involves identifying the correct dissolution testing tools, including the Type 2 apparatus.
• 😀 The dissolution test procedure includes preparing the apparatus, setting the correct temperature (usually 37°C), speed (75 RPM), and test time (30 minutes).
• 😀 The Amoxicillin tablets are placed in the dissolution chamber, ensuring they do not touch the bottom of the chamber.
• 😀 Samples are taken at regular intervals (5, 10, 15, 20, 25, and 30 minutes) and analyzed for dissolution concentration.
• 😀 The results are evaluated by comparing the dissolution profiles to the required standards: tablet A may not meet the requirements, but tablet B should meet them based on the dissolution curve analysis.

Q & A

What is the primary focus of the Amoxicillin tablet dissolution test practicum?

The primary focus is to assess various competencies such as data and information collection, problem determination, problem-solving, recording and reporting, and professional behavior in the context of testing the dissolution of Amoxicillin tablets.

What are the key competencies assessed in this practicum?

The key competencies are: data and information collection, problem determination, problem-solving, recording and reporting, and demonstrating professional behavior and nature.

What is the required dissolution medium for the Amoxicillin tablet dissolution test?

The dissolution medium required is 900 mL of distilled water, as specified in the Indonesian Pharmacopoeia 4th edition.

Which type of tool is used for the Amoxicillin tablet dissolution test?

The test uses a Type 2 dissolution tester, which is commonly used for tablet dissolution testing.

What is the temperature setting for the Amoxicillin tablet dissolution test?

The temperature for the dissolution test is set at 37°C, which is the standard temperature for this type of testing.

What is the speed setting for the dissolution test?

The speed of the dissolution test is set at 75 RPM (rotations per minute), which is commonly used for testing tablet dissolution.

How long should the Amoxicillin tablet dissolution test run?

The dissolution test is conducted for 30 minutes, as per the guidelines in the Indonesian Pharmacopoeia monograph.

How are samples collected during the dissolution test?

Samples are collected at various time intervals: 5, 10, 15, 20, and 25 minutes. A 5 mL aliquot of the dissolution medium is taken at each time point.

What is the required dissolution percentage for a tablet to pass the test?

A tablet must dissolve more than 70% of its content within 30 minutes to pass the test. Tablets that dissolve less than 70% do not meet the required standards.

What is the role of the professional behavior competency in this practicum?

The professional behavior competency ensures that candidates maintain a clean and organized workspace, avoid scribbling on worksheets, and handle equipment and materials with care and precision.