Praktikum Farmasi Fisik: Percobaan Uji Disolusi (2) - dibuat sebelum pandemi Covid-19

Summary

This script describes the process of conducting a dissolution test for pharmaceutical tablets. It covers the steps involved in setting up the dissolution testing apparatus, adjusting temperature and speed settings, and adding the tablets to dissolution vessels. The procedure includes regular sampling at 15-minute intervals to monitor the solubility of the tablets. The video also emphasizes the importance of performing multiple repetitions and replacing the dissolution medium when necessary. The process ends after 45 minutes, followed by stopping the apparatus, resetting the temperature, and turning off the device.

Takeaways

• 😀 Ensure the dissolution testing equipment is turned on before starting.
• 😀 Set the test temperature to 37°C, the body temperature.
• 😀 Lower the paddle into the dissolution vessel and attach it to the pedal.
• 😀 Use the paddle for tablet samples and the basket for capsule samples.
• 😀 Fill each vessel with the appropriate medium and immerse the paddle.
• 😀 Use a thermometer to ensure the dissolution medium is at the correct temperature.
• 😀 Set the dissolution tester speed to 50 RPM and duration to 45 minutes.
• 😀 Start the dissolution test and add the tablets to the vessels simultaneously.
• 😀 Collect dissolution samples every 15 minutes to monitor solubility.
• 😀 Replace the medium with fresh solution after each sample collection to maintain accuracy.

Q & A

What is the first step in setting up the dissolution test apparatus?

The first step is to turn on the dissolution test apparatus to prepare it for use.

What is the required temperature for the dissolution test medium?

The temperature should be set to 37°C, which is the normal body temperature.

Why is the paddle lowered into the dissolution vessel?

The paddle is lowered into the dissolution vessel to mix the medium and allow proper testing of the tablet's dissolution process.

How is the dissolution test apparatus set for speed and duration?

The speed is set to 50 RPM, and the duration is set for 45 minutes.

What should be done with the dissolution vessel caps?

The caps of the dissolution vessels should be closed after inserting the paddle to maintain the test conditions.

How often should the medium be sampled during the test?

The medium should be sampled every 15 minutes to monitor the dissolution process of the tablet.

Why is it necessary to replace the medium after each sample is taken?

The medium needs to be replaced after each sample to maintain consistent conditions for the remaining dissolution process.

What is the purpose of taking samples at different time points?

The purpose of taking samples at different time points is to determine how much of the tablet has dissolved at each specific time interval.

What should be done after the dissolution test reaches the 45-minute mark?

Once the 45-minute test duration is complete, the dissolution apparatus will stop automatically, and the temperature should be lowered to 0°C.

What action should be taken once the test is complete?

After the test is complete, the results should not be printed, and the apparatus should be turned off.