Palha de Milho: Poder Analgésico dessa folha

Summary

This study from Nigeria investigates the analgesic and anti-inflammatory properties of corn husk extract, specifically from the green husk that envelops the corn cob. Administered in various doses, the extract was tested on animals using pain and inflammation models, such as hot plate tests, formalin-induced pain, and cotton pellet-induced inflammation. The results demonstrated that the extract significantly reduced pain and inflammation, outperforming the standard drug, indomethacin, particularly at a dose of 200 mg. This suggests that corn husk could be a powerful natural alternative for treating pain and inflammation.

Takeaways

• 😀 A study conducted in Nigeria investigated the analgesic and anti-inflammatory effects of corn husk extract.
• 😀 The corn husk extract was administered in doses of 25, 50, 100, and 200 mg via oral intake.
• 😀 The extract was tested using a hot plate model, where animals were exposed to a heated metal plate to measure pain tolerance.
• 😀 A longer time before the animal jumps from the heated plate indicates less pain, and a quicker jump indicates more pain.
• 😀 The study also used formalin to induce pain in the animal's paw, where the animal's response was measured by how much it licked the injured paw.
• 😀 The carrageenan test was used to induce inflammation in the animal's paw to measure the extract's anti-inflammatory effects.
• 😀 The cotton pellet test involved injecting a cotton pellet under the skin to induce inflammation and measure the extract's effects.
• 😀 Indomethacin was used as a comparative standard drug in the study to evaluate the effects of corn husk extract.
• 😀 The corn husk extract significantly reduced pain and inflammation compared to the control group, which received no treatment.
• 😀 At a dosage of 200 mg, the corn husk extract produced a greater effect in all tests compared to indomethacin, showing it was more effective in treating pain and inflammation.

Q & A

What is the main focus of the research mentioned in the transcript?

The research focuses on investigating the analgesic (pain-relieving) and anti-inflammatory activities of corn husk extract from the outer layers of the corn cob.

How was the corn husk extract administered in the study?

The corn husk extract was administered orally in doses of 25, 50, 100, and 200 mg.

What model was used to assess the effects of the corn husk extract?

The research used the hot plate model, where animals were placed on a heated metal plate to measure their pain response based on how long they could endure the heat before reacting.

What does the hot plate test measure in this experiment?

The hot plate test measures how long an animal can tolerate a heated surface before jumping, indicating how much pain the animal is feeling. The longer the animal withstands the heat, the less pain it is experiencing.

What is the significance of the formalin-induced paw test in this study?

The formalin test induces pain in the animal's paw using formalin injections, and researchers measure the animal's response, particularly the licking of the paw, which indicates the level of pain the animal is experiencing.

How is the carrageenan test used to assess inflammation?

In the carrageenan test, a substance that causes swelling is injected into the animal’s paw, and the degree of inflammation is measured to evaluate the anti-inflammatory effect of the corn husk extract.

What is the cotton pellet test used for in this study?

The cotton pellet test involves injecting a cotton pellet under the skin of the animal to observe inflammation over time, allowing researchers to assess the anti-inflammatory properties of the corn husk extract.

What was the comparison drug used in the study, and why?

Indomethacin, a well-known anti-inflammatory drug, was used as the comparison drug to evaluate the effectiveness of the corn husk extract.

What were the findings of the study regarding the corn husk extract compared to the control group?

The study found that the corn husk extract significantly reduced pain and inflammation compared to the control group, which did not receive any treatment.

How did the 200 mg dose of corn husk extract compare to indomethacin in the tests?

The 200 mg dose of the corn husk extract produced better results than indomethacin in all the pain and inflammation tests conducted.