Apa itu Interaksi Obat? | mengenal interaksi obat

Summary

In this video, the speaker discusses drug interactions, emphasizing their importance for pharmacy students and healthcare professionals. The video covers the mechanisms behind drug interactions, such as pharmacokinetics (absorption, distribution, metabolism, and excretion) and pharmacodynamics (effects on the body). It explains how drug interactions can either enhance or diminish the effects of medications, and provides guidance on managing potential interactions, especially for patients taking multiple medications. The speaker also highlights the importance of clear communication between doctors to prevent harmful drug interactions, while reassuring that not all interactions are dangerous.

Takeaways

• 😀 The speaker addresses the delay in posting content due to a busy schedule, balancing work at the hospital and studying pharmaceuticals.
• 😀 A new study module book for pharmacy students is available, focusing on fast learning for those preparing for the Indonesian Pharmacist Competency Exam. The book is 274 pages long, fully colored, and updated for the latest clinical pharmacy and pharmaceutical technology topics.
• 😀 The speaker emphasizes the importance of understanding drug interactions, including the combination of multiple medications, which can affect the efficacy of each drug.
• 😀 Drug interactions not only occur between medications but can also involve food, supplements, and even herbal medicines. These interactions are generally more harmful than beneficial.
• 😀 Interactions can occur through different mechanisms such as pharmacokinetics (absorption, distribution, metabolism, and excretion) and pharmacodynamics (how drugs work in the body).
• 😀 In the absorption phase, certain drugs can affect how other drugs are absorbed, such as when drugs coat the digestive tract, preventing others from being properly absorbed.
• 😀 The metabolism phase involves the body's process of converting drugs into forms that can be more easily eliminated, and some drugs can either speed up or slow down the metabolism of other drugs.
• 😀 In the distribution phase, medications are carried throughout the body by proteins like albumin, and interactions can occur if one drug affects how another drug binds to these proteins, potentially altering its effectiveness.
• 😀 The excretion phase involves the elimination of drugs from the body, typically through urine or bile. Some drugs can interfere with this process, either speeding it up or slowing it down, which can affect the drug’s duration and intensity.
• 😀 Interactions between drugs can result in antagonistic effects (opposing actions) or synergistic effects (enhanced actions), such as when two drugs both irritate the stomach, increasing the risk of gastrointestinal issues.
• 😀 To avoid harmful drug interactions, patients should inform their doctors about all medications they are taking, including those prescribed by different specialists, ensuring that potential interactions are considered when new drugs are prescribed.

Q & A

What is drug interaction?

Drug interaction occurs when two or more substances, such as medications, foods, supplements, or even herbal remedies, affect each other's actions in the body, either enhancing or reducing their effects.

What are the main types of drug interactions?

The main types of drug interactions are pharmacokinetic interactions (involving absorption, distribution, metabolism, and excretion) and pharmacodynamic interactions (how drugs work within the body).

How can pharmacokinetic interactions affect drug absorption?

Pharmacokinetic interactions can influence drug absorption by affecting how a drug is absorbed into the body, such as when one drug interferes with the absorption of another, often by altering the conditions in the digestive tract.

What is the role of metabolism in drug interactions?

In metabolism, the body processes drugs to make them easier to excrete. Some drugs can accelerate or slow down the metabolism of other drugs, which can either reduce their effectiveness or increase their side effects.

Can food or supplements cause drug interactions?

Yes, food, supplements, and even herbal remedies can cause drug interactions by either enhancing or reducing the effectiveness of medications.

What is an example of a pharmacodynamic drug interaction?

An example of a pharmacodynamic interaction is when an antihypertensive drug, which dilates blood vessels, is taken with a decongestant like ephedrine, which constricts blood vessels, resulting in opposing effects.

How can drug interactions affect the distribution phase of pharmacokinetics?

During the distribution phase, drugs are transported throughout the body, often by proteins like albumin. Drug interactions can alter the binding of drugs to these proteins, leading to increased free drug concentration and possibly enhancing their effects.

What is the significance of excretion in drug interactions?

Excretion refers to how drugs are eliminated from the body, primarily through the kidneys or bile. Drug interactions can either speed up or slow down the elimination of a drug, potentially affecting its duration and intensity of action.

Why is it important to inform doctors about all ongoing medications?

It is crucial to inform doctors about all medications you're taking, including those from other doctors, to avoid harmful drug interactions. This allows healthcare providers to adjust prescriptions accordingly to prevent adverse effects.

What are the different levels of drug interactions and their significance?

Drug interactions are classified into three levels: serious (high risk, often requiring avoidance), moderate (requires monitoring but may be used under supervision), and low (minimal risk, usually monitored). This classification helps guide medical decisions on whether and how to combine medications.