The IDEAL RATIO Between Testosterone & DHT-Derivatives? Vigorous Q&A

Summary

The video script discusses the ideal ratio of testosterone to non-aromatizing compounds like Primobolan or Masteron to minimize the need for an aromatase inhibitor (AI). The speaker suggests starting with a one-to-one ratio, which is easy to follow and accounts for different esters of testosterone and the two esters of Masteron and the single ester of Primobolan. The script delves into the mechanisms of different AIs, including the suicide inhibitor Aromasin and reverse-binding inhibitors like Arimidex or Letrozole. It emphasizes the importance of blood work to adjust the ratio based on individual serum estrogen levels. The video also mentions oral DHT derivatives and their potential effects on aromatization. The speaker provides a starting point for the one-to-one ratio based on the Avogadro's constant but stresses that personal blood work is crucial for determining the optimal ratio. The video concludes with a recommendation for regular blood work and the use of Diindolylmethane (DIME) to help metabolize estradiol and reduce the estrogenic burden.

Takeaways

• 📊 A one-to-one ratio of testosterone to a non-aromatizing compound like Primobolan or Masteron is suggested as a starting point to potentially avoid the need for an aromatase inhibitor (AI).
• 🧬 Testosterone comes in various esters, whereas Primobolan has two and Masteron has one, making the one-to-one ratio easy to follow regardless of the ester.
• 🔍 Dihydrotestosterone (DHT) derivatives like Boldenone, Dihydrobaldone, and some of their metabolites act as reverse-binding aromatase inhibitors, similar to Arimidex or Letrozole.
• ⚖️ Aromasin is a steroidal, suicide inhibitor that irreversibly binds to the aromatase enzyme, rendering it inactive and preventing the conversion of testosterone into estrogen.
• 📉 The one-to-one ratio is based on the logic that for each molecule of testosterone that can convert into estradiol, an equal molecule of a DHT derivative is needed to block this conversion.
• 💊 Oral DHT derivatives may not work as effectively as injectable ones in inhibiting aromatization, though they can still provide some effect.
• 🧪 Blood work is crucial to determine if the chosen ratio is effective for an individual, and adjustments may be needed based on serum estrogen levels.
• 📉 Body fat levels can influence the amount of aromatase enzymes and thus the potential for aromatization, which should be considered when determining dosages.
• 🔄 If blood work indicates high estrogen levels, the dosage of the steroid inhibiting conversion may need to be increased, or the ratio of testosterone to the inhibiting steroid may need to be altered.
• 🧮 For a more precise calculation, the Avocados constant can be used to determine the exact milligrams of testosterone and the non-aromatizing compound needed for a one-to-one molecular ratio.
• 💡 Dinomethione (DMN) can be used to help metabolize estradiol into estrogen and reduce the overall estrogenic burden from exogenous testosterone.

Q & A

What is the suggested starting ratio of testosterone to a non-aromatizing compound to minimize the need for an aromatase inhibitor?

The suggested starting ratio is one-to-one, meaning for every milligram of testosterone, you would use an equal milligram of a non-aromatizing compound like Primobolan or Masteron.

Why is blood work important when using a one-to-one ratio of testosterone to a non-aromatizing compound?

Blood work is crucial to determine if the chosen ratio is effective for an individual, as it can reveal serum estradiol levels and the need for further adjustments to the hormone balance.

How do dihydrotestosterone (DHT) derivatives act as aromatase inhibitors?

DHT derivatives like Boldrone, Dihydrobaldinone, and their metabolites act as reversely binding aromatase inhibitors, temporarily inhibiting the aromatization of aromatizable compounds.

What is a suicide inhibitor and how does Aromasin work as one?

A suicide inhibitor is a compound that becomes permanently inactivated after reacting with its target enzyme. Aromasin works as a steroidal suicide inhibitor by getting stuck in the aromatase enzyme, rendering it inactive and preventing the conversion of testosterone into estradiol.

Why might the one-to-one ratio not work as effectively with oral DHT derivatives?

The one-to-one ratio might not be as effective with oral DHT derivatives because their relative binding affinities for the aromatase enzyme have not been established, and they may not provide the same aromatase inhibiting effects as injectable compounds.

What is the significance of the Avocados constant in calculating the ideal one-to-one ratio of molecules?

The Avocados constant allows for the calculation of the exact milligrams of testosterone and a non-aromatizing compound needed to achieve an equal number of molecules, providing a precise one-to-one ratio as a starting point.

What is the role of sex hormone-binding globulin (SHBG) in the context of the one-to-one ratio?

SHBG binds to sex hormones, affecting their availability. Although the relative binding affinities for SHBG are known, the exact impact on the one-to-one ratio and its adjustments based on blood work is not explicitly detailed in the script.

How often should one check their blood work after starting a hormone protocol?

It is recommended to check blood work about a month into the protocol to assess the serum estradiol levels and make any necessary adjustments to the hormone ratios.

What are some factors that can influence the need for an aromatase inhibitor?

Factors such as body fat levels, diet, and the amount of adipose tissue can influence the expression of aromatase enzymes and, consequently, the need for an aromatase inhibitor.

What is the alternative approach if blood work indicates that the one-to-one ratio is not effective?

If blood work indicates that the one-to-one ratio is not effective, one can adjust the ratio of testosterone to the non-aromatizing compound, or consider using a different approach such as daily micro administrations of testosterone without an aromatase inhibitor.

What is the role of Diindolylmethane (DIM) in managing estrogen levels?

DIM can help with the metabolism of estradiol into estrogen, thereby reducing the overall estrogenic burden of the exogenous testosterone being used.

How can one get a discount on health panels that include estradiol testing?

One can get a 10 percent discount on health panels from merrickhealth.com by using the vigorous discount codes provided in the video description.

Outlines

00:00

💪 Optimal Testosterone to Aromatase Inhibitor Ratio

The first paragraph discusses the ideal ratio of testosterone to non-aromatizing compounds like Primobolin or Masteron to minimize the need for an aromatase inhibitor. It emphasizes a one-to-one ratio as a starting point, explaining that this simplifies the process without needing to consider ester weights or individual esters. The speaker also touches on the role of dihydrotestosterone derivatives as reversely binding aromatase inhibitors, comparing them to other known inhibitors like Arimidex or Letrozole. The paragraph concludes with the recommendation to perform blood work after a month to assess serum estradiol levels and adjust the ratio if necessary.

05:02

🧪 Customizing Steroid Ratios Based on Blood Work

The second paragraph expands on the initial one-to-one ratio discussion by considering individual body differences, such as body fat levels and aromatase enzyme expression. It suggests that blood work is essential to determine if the starting ratio is effective for the individual and to make any necessary adjustments. The speaker provides a method using Avocados Constant to calculate the milligrams of testosterone needed to match with a DHT derivative, aiming for a molecule-for-molecule ratio. The paragraph concludes with advice on adjusting the ratio based on blood work results and mentions the use of Diindolylmethane (DINOMEthane) to help metabolize estradiol and reduce the overall estrogenic burden.

Keywords

💡Testosterone

Testosterone is a hormone that plays a key role in the development of male reproductive tissues and secondary sex characteristics. In the context of the video, it is discussed as a hormone that can be aromatized into estradiol, and the balance of testosterone with other compounds is crucial to avoid the need for aromatase inhibitors.

💡Primabolin

Primabolin, also known as Mesterolone, is a non-aromatizing anabolic steroid. It is mentioned in the video as a compound that can be used in conjunction with testosterone to potentially reduce the need for an aromatase inhibitor by providing a one-to-one ratio, which is a simplified approach to balancing hormones.

💡Masteron

Masteron, or Drostanolone Propionate, is another non-aromatizing anabolic steroid. The video discusses its use in a one-to-one ratio with testosterone to potentially minimize the need for aromatase inhibitors, similar to the approach with Primabolin.

💡Aromatase Inhibitor (AI)

An aromatase inhibitor is a class of drugs that help to reduce the amount of estrogen in the body by inhibiting the aromatase enzyme, which converts testosterone to estradiol. The video explores the possibility of reducing or eliminating the need for AIs by balancing testosterone with non-aromatizing compounds.

💡Dihydrotestosterone (DHT)

Dihydrotestosterone is a male sex hormone that is an androgen and is more potent even than testosterone. In the video, DHT derivatives are discussed as they can act as reversely binding aromatase inhibitors, which is relevant to the discussion on balancing hormones without the need for AIs.

💡Aromasin

Aromasin, or Exemestane, is a steroidal aromatase inactivator that is different from other aromatase inhibitors because it irreversibly binds to the aromatase enzyme, rendering it inactive. This is contrasted with the reversible binding of other inhibitors in the video.

💡Blood Work

Blood work refers to the process of analyzing a person's blood samples to assess their health. In the video, it is emphasized that individuals should perform blood work to monitor their serum estradiol levels and adjust their hormone ratios accordingly, which is crucial for personalized hormone therapy.

💡Estrodiol

Estrodiol, or estradiol, is the primary female sex hormone. The video discusses the importance of managing estradiol levels when using testosterone and non-aromatizing compounds to avoid the need for aromatase inhibitors.

💡Avocados Constant

The Avocados Constant is a term used in the video to refer to a calculation method that determines the milligrams of testosterone needed to match the molecular amount of a non-aromatizing compound like Masteron or Primobolan, aiming for a one-to-one ratio.

💡Serum Estrogen Levels

Serum estrogen levels refer to the concentration of estrogen in the blood. The video emphasizes the importance of monitoring these levels through blood work to ensure that the chosen ratio of testosterone to non-aromatizing compounds is effective in managing estrogen levels without the need for aromatase inhibitors.

💡Dinomethane

Dinomethane is mentioned in the video as a supplement that can help with the metabolism of estrodial into estrogen, thereby reducing the overall estrogenic burden of exogenous testosterone. It is presented as an alternative or supplementary approach to managing estrogen levels.

Highlights

A one-to-one ratio of testosterone to a non-aromatizing compound like Primobolan or Masteron can potentially lower or eliminate the need for an aromatase inhibitor.

The simplicity of a one-to-one ratio makes it easy to follow without needing to calculate ester weights or consider individual esters.

Dihydrotestosterone (DHT) derivatives act as reversely binding aromatase inhibitors, similar to Arimidex or Letrozole.

Aromasin is a steroidal, suicide inhibitor that inactivates the aromatase enzyme, preventing the conversion of testosterone into estradiol.

The one-to-one ratio is based on the logic that for each molecule of testosterone that can convert into estradiol, an equal molecule of a DHT derivative is needed to block this conversion.

Oral DHT derivatives may not work as effectively as injectable ones in inhibiting aromatization, with Proviron being a known inhibitor of testosterone conversion to estradiol.

Binding affinities for aromatase enzymes and sex hormone-binding globulin are not well established, necessitating the reliance on blood work for individual dosing.

A one-to-one ratio of testosterone to a steroidal, non-suicidal aromatase inhibitor is a good starting point, but blood work is essential for adjusting dosages.

Monitoring serum estradiol levels before, during, and after a cycle can help determine if further adjustments are needed.

Body fat levels can influence the amount of aromatase enzymes and the potential for aromatization, which should be considered when determining dosage ratios.

The one-to-one ratio is a starting point, and individuals may need to adjust the ratio of testosterone to the inhibiting steroid based on blood work results.

Avocados constant can be used to calculate the milligrams of testosterone needed to match a specific amount of a steroidal, reversely binding aromatase inhibitor, regardless of esters.

Regular blood work is crucial to determine if the chosen ratio is effective or needs adjustment, and to monitor overall health.

Dinomethane can be used to help metabolize estradiol into estrogen, reducing the overall estrogenic burden from exogenous testosterone.

For those who prefer a more conservative approach, daily micro administrations of testosterone through subcutaneous injections may reduce the need for an aromatase inhibitor.

The speaker provides resources for checking serum estrodiol levels and offers discount codes for health panels, emphasizing the importance of health monitoring.

The importance of individualized approaches to hormone therapy is emphasized, with the need for regular blood work and possible adjustments to dosages based on personal health markers.

Transcripts

so you can get that ideal one-to-one

ratio molecule for molecule as a

starting point

but you know that you still need to do

your blood work

figure steve here with the vigorous q a

for all of your

bodybuilding related questions today's

question is from awesome austin fit

what is a good ratio for testosterone

base and a non-aromatizing compound like

primabolin or mastrone to have a lower

or no need for an aromatized inhibitor

similar way to put it how much

testosterone and how much maestro or

primo not to use an ai well i've said it

many times before on this youtube

channel all you need is a one-to-one

ratio

of course this is a very simple answer

and not what you expect of me so let me

dive into it a little bit more

scrutinously and before we do please

like the video leave a comment for the

algorithm and consider subscribing if

you haven't already hit the notification

bell button while you're at it so you

can get notified whenever a new video

drops

i always set a one-to-one ratio because

it's easy it's easy to follow you don't

have to calculate the ester weight you

don't have to think about which

individual esters because testosterone

comes in many different esters and

maestro has two different esters and

primo has only one ester so if i say for

example 250 milligrams testosterone plus

250 milligrams primo or 250 milligrams

masteron the ester is kind of irrelevant

and you'll still get

proper aromatized inhibiting effects

keep in mind that dihydrotestosterone

derivatives baldrone

dihydrobaldinone and some of their

metabolites act as a reversely binding

aromatized inhibitor in a similar

fashion that arimidex or letrozole

femera

act as a reversely binding aromatized

inhibitor you have aromasin which is

steroidal it is a suicide inhibitor

aromasin due to its chemical composition

gets stuck in the aromatized enzyme

rendering it inactive so this aromatized

enzyme is no longer able to convert

testosterone into estradiol or the

animal into methyl estradiol for that

matter and you would need further

aromatized enzyme expression in adipose

tissue to restore the amount of

aromatized enzymes which you just

murdered

with eczema stain or aromacin keep that

in mind all of the other aromatized

inhibitors are reversely binding that

means they go into the aromatized enzyme

stay there for minutes or longer i'm not

exactly sure how long they stay within

because it also depends on which

compounds enters the aromatase enzyme

and temporarily inhibits aromatization

of aromatizable compounds after which

due to entropy

the dihydrotestosterone derivative or

the baldness or the dihydropoldenon or

the aramidex or the letrozole

exit

the aromatized enzyme after which

testosterone the anabol anything else

that's aromatizable can enter the

aromatase enzyme again and convert into

its respective metabolites so the reason

why i came up with the one-to-one ratio

is because when you look at it logically

the amount of testosterone which is able

to convert into estradiol through the

aromatized enzymes needs to be blocked

with an equal amount of a

dihydrotestosterone derivative boldenon

or dihydrobaldenone preventing the use

of an aromatized inhibitor and this is

how i came up with the one-to-one ratio

for each single testosterone molecule

you would need one molecule of a

reversely binding aromatize inhibitor

which would temporarily block the

conversion of testosterone in the

estradiol by taking its place

in the aromatized enzyme now of course

that sounds very very simple and it's

very very easy to follow so let's say

you take 500 milligrams of test any

ester you would add on top 500

milligrams of any ester or masterone any

ester or baldenon or dihydroboltanon any

ester

now i feel that it doesn't really work

as well with oral dht derivatives even

though you may still get some aromatized

inhibiting effects most notably proviron

is known to inhibit the conversion of

testosterone into estradiol and winstrol

and anavar might potentiate that to a

very low extent again the relative

binding affinities for the aromatized

enzymes haven't been established neither

have the relative binding affinities for

the sexual body globulin we only know

the relative binding affinities for the

androgen receptor and the mineral

glucocorticoid receptors and the

glucocorticoid receptors in the estrogen

alpha and beta receptors right the

receptors are known about the enzymes

and the delivery mechanisms the albumin

and the shvg unfortunately unknown so we

have to go by blood work a one-to-one

ratio of testosterone and a steroidal

non-suicidal aromatized inhibitor is a

good place to start and then after a

month on that protocol keeping your

injection frequency in your dosing the

same

a month into it please go do your blood

work see where your serum estrodial

levels are at test your serum estrogen

levels before check them during your

cycle and see if you need further

adjustments maybe you have a lot of

aromatized enzyme expression or maybe

you don't have so much because your body

fat levels are generally lower or you've

been dieting for a while this entire

month you've dropped body fat reducing

the amount of adipose tissue that you

have and thus reducing the amount of

aromatized enzymes in the potential for

aromatization that you have

so you always need to stay on top of

your ratios between testosterone and the

other steroid which inhibits the

conversion

and if your bloodwork tells you your

estrogen is going too high maybe you

need to increase this steroid that it's

inhibiting the conversion or change your

ratio maybe you're happy using 500

milligrams in total per week and instead

of using 250 milligrams of tests and

let's say 250 milligrams of primo you

reduce the test to 200 milligrams and

increase the primo to 300 milligrams so

again this one-to-one ratio is just a

starting point ultimately it's your

blood work that determines which ratio

you need to follow you know what i'll do

for all of you nerdy guys out there that

are just as nerdy as i am

i'll use the avocados constant

to calculate how many milligrams of

testosterone you would need to match

a master on primobolan or balderone or

dihydrobaldenone

regardless of esters

how many milligrams of each you would

need to get the exact

same amount of molecules i've done

videos about this in the past it didn't

get so many views so hopefully we can

mix it into this one

based on the avocados constant you would

get a certain amount of molecules i

think it's 602.11

6 tillion or quintillion molecules i'll

have to do a quick refresher so i'll be

on the screen on one of these sides this

amount of milligrams for each

testosterone ester would yield the same

exact same amount of molecules for this

amount of milligrams of a steroidal

reversely binding aromatized inhibitor

so you can get that ideal one-to-one

ratio molecule for molecule as a

starting point

but you know that you still need to do

your blood work to determine if this

ratio is working for you

or not

and again if you can't pinpoint it down

go back to trt use 100 milligrams of

testosterone per week space that over

daily micro administrations

subcutaneously

in which case most likely you don't need

an aromatized inhibitor as well

and otherwise there's always dinomethane

100 milligrams in the morning and 100

milligrams in the evening to help with

the metabolism of estrodial into

estrogen and estrogen reducing the

overall estrogenic burden of the

exogenous testosterone that you're

getting

i think this answers your questions

pretty much hope it was helpful hope you

can decide which route to go with your

testosterone and your dht derivative or

other compounds which will inhibit the

conversion of testosterone into

estradiol you can find everything that

i'm associated with down below in the

description section have a look at some

of my sponsors and affiliates so you can

save yourself some money while shopping

online and if you want to check your

serum estrodiol levels head over to

merrickhealth.com vigorous for a budget

panel which includes estradiol and a

couple other markers so you can stay on

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follow me on instagram and tick tock at

vigor steve

front double bicep for the vigorous crew

no aromatize inhibitor is required

because i'm matching my testosterone to

promote the nitrolone hopefully in an

ideal ratio but then again i'll do blood

work every month to see if i need to

adjust this ratio further thank you guys

so much for watching

see you in the next video