Does Primobolan Act As An AI? Estradiol Blood Work Before And After

Summary

In this video, Derek from Placementrates.com discusses the impact of adding 200 milligrams of Primobolan to a testosterone regimen on estrogen levels. He uses the example of 'Vigorous Steve' to illustrate how Primobolan, a DHT derivative, can act as a natural anti-estrogen by competing with testosterone for binding at the aromatase enzyme. This competition may reduce the need for aromatase inhibitors (AIs) and affect the design of hormone protocols, providing insights into optimizing health and performance.

Takeaways

• 😀 The video discusses the effects of Primobolan (primo) on estrogen metabolism, using a case study from 'Vigorous Steve'.
• 🔍 'Vigorous Steve' followed a TRT protocol with 250mg of testosterone per week and used DHEA and Pregnenolone to backfill steroidogenesis pathways.
• 📉 When 'Vigorous Steve' added 200mg of Primobolan to his regimen, his estradiol levels dropped from 73 to 38.4 pg/mL, despite the same dose of testosterone.
• 🤔 The drop in estrogen levels suggests that Primobolan has anti-estrogenic properties, similar to Masteron, which inhibits estrogen-induced RNA transcription at the receptor site.
• 💡 The script suggests that Primobolan and other DHT derivatives may compete with testosterone for binding to the aromatase enzyme, thus affecting estrogen production.
• 🚫 It's important to consider the inherent anti-estrogenic effects of anabolic steroids when designing a protocol to avoid unnecessary use of AIs (Aromatase Inhibitors).
• 💡 The use of DHT derivatives might negate the need for AIs or allow for higher doses of aromatase substrates without inducing estrogenic side effects.
• 📚 The video emphasizes the importance of understanding how hormones interact in the body to design optimal protocols for performance enhancement and health.
• 🔄 The script highlights that Primobolan's interaction with aromatase is more complex than previously thought, involving competitive binding rather than no interaction at all.
• 📈 The case study indicates that Primobolan has a built-in anti-estrogenic component, which is worth considering when using it for performance enhancement.
• 👍 The video encourages viewers to subscribe, follow the blog at placementrates.com, and engage on social media for more in-depth discussions on hormone interactions.

Q & A

What is the main topic discussed in the video script?

The main topic discussed in the video script is the interaction of Primobolan (a type of anabolic steroid) with aromatase and its effects on estrogen metabolism.

Who is the person mentioned as sending their blood work results for discussion?

The person mentioned is 'Vigorous Steve', who is known on YouTube and has sent his blood work results to Derek from placementrates.com.

What is the significance of the blood work results shared in the script?

The blood work results are significant as they demonstrate a decrease in estrogen levels when Primobolan was added to the user's protocol, providing insights into the anti-estrogenic effects of Primobolan.

What is the role of DHEA and Pregnenolone in the context of the script?

DHEA and Pregnenolone are used to backfill steroidogenesis pathways that may be deficient due to the use of exogenous hormones, helping to maintain hormonal balance.

What was the initial estrogen level before adding Primobolan?

The initial estrogen level, specifically estradiol, was 73 picograms per milliliter before adding Primobolan.

What was the change in estrogen level after adding 200 milligrams of Primobolan?

After adding 200 milligrams of Primobolan, the estrogen level dropped to 38.4 picograms per milliliter.

What are DIM and Calcium D-Glucarate, and why were they added to the protocol?

DIM (Diindolylmethane) and Calcium D-Glucarate are supplements that were added to the protocol to control estrogen levels as a natural, over-the-counter means of handling estrogen metabolism.

How does Primobolan affect estrogen metabolism according to the script?

Primobolan appears to have an anti-estrogenic effect, possibly by competitively binding to the aromatase enzyme, thus reducing the conversion of testosterone into estradiol.

What is the takeaway message regarding the use of Primobolan in hormone protocols?

The takeaway is to consider the anti-estrogenic component of Primobolan and other DHT derivatives when designing hormone protocols, as they may reduce the need for additional anti-estrogenic drugs.

What does the script suggest about the interaction of DHT derivatives with aromatase?

The script suggests that DHT derivatives, such as Primobolan, may have a competitive action for binding with the aromatase enzyme, affecting estrogen metabolism at the enzyme level itself.

Why is it important to understand the interaction of hormones in the body as discussed in the script?

Understanding the interaction of hormones in the body is important for designing optimal protocols that are conducive to one's goals and health, and for maximizing progress while minimizing potential side effects.