Brain Performance for Life | Dr. Amir Hadanny, 2024 Longevity Summit | Aviv Clinics

Summary

تحدث الدكتور أمير هاداني عن إمكانية إصلاح وتجديد الدماغ وأنسجة الشيخوخة بواسطة بروتوكول علاج الأكسجين الفائق للهيبرباريك. يشرح البروتوكول الأربعة المكونات الرئيسية: الطاقة، المحفزات، الخلايا الجذعية، وتكوين الأوعية الدموية الجديدة، مما يساعد في إصلاح الأنسجة المصابة. يوضح الدراسات أن هذا البروتوكول يؤدي أيضًا إلى تحسين الوظائف الحيوية وتقليل الخلايا الشيخوخية، مما يغير مسار عملية الشيخوخة بشكل إيجابي.

Takeaways

• 🧠 **الدماغ والجسد:** يمكن التجديد والإصلاح إذا اتبعت البروتوكول الصحيح، وهذه الفكرة تنطبق على الدماغ والأنسجة القديمة بشكل عام.
• 💡 **الهدف الأساسي:** زيادة فترة الصحة الجسدية (healthspan) أكثر من زيادة العمر (lifespan)، مع التركيز على الجودة في الحياة.
• 🧬 **التطور البيئي:** لم يكن التطور يخطط لنا أن نعيش لفترة طويلة، ولكن الطب الحديثة قد حل العديد من المشاكل الحيوية.
• 📉 **الخلايا الجذعية:** ت減少随着年龄的增长，它们对于修复 وتجديد الأعضاء الحيوية ضرورية.
• 🔄 **الخلايا القديمة:** تصبح غير مفيدة مع التقدم في العمر وترتبط بأمراض مثل السرطان والذهن الناقص.
• 🩸 **الاستحال:** يشير إلى تراكم الفقرات الدهنية وت閉塞 الarterioles الصغيرة، مما يؤدي إلى تلف العضو.
• 🚫 **القدرة على التجديد:** الاعتقاد القديم هو أن الدماغ لا يمكن أن يعاد توليده، ولكن الدراسات الأخيرة تشير إلى خلاف ذلك.
• 💊 **الأدوية والأدوية:** يُحاول من خلال الأدوية والعلاجات المختلفة تقليل الخلايا القديمة واستهداف المسارات البيولوجية.
• 🛑 **الأكسجين:** يعتبر الأكسجين العامل الحد الأقصى لنشاط الدماغ، ويمكن زيادة تركيزه في دماغنا من خلال الغرفة ال ハイبر屿ーبآرك.
• 🔁 **التأثير الناقص:** يُشير إلى مفهوم التأثير الناقص، حيث يمكن تحقيق تأثيرات الأكسجين الأدنى من خلال تقلبات الأكسجين في الغرفة ال ハイبر屿ーبآرك.
• 🌱 **الخلايا الجذعية:** يمكن استدعاء الخلايا الجذعية وجعلها تعمل في ال修復 والتجديد، ويوجد نوعين منها: الخلايا الهايموتوجينية والخلايا الجذعية الميسENCHymal.
• 🌿 **الأنجينوجينيس:** هي إنشاء الblood vessels الجديدة، التي تعتبر ضرورية لإعادة تغذية الأنسجة التالفة.
• 🧪 **التجارب السريرية:** تمت دراسات لتقييم تأثير البروتوكول على الدماغ والأعضاء الأخرى، وأظهرت تحسينًا في الدورة الدموية والوظائف الجسدية.
• 📈 **العمر الخلوي:** تم تحسين طول التلوموريس، وهو ما يُشير إلى تحسين عملية الشيخوخة.

Q & A

ما هي الوظيفة الوظيفية لد. أمير هاداني في شركته؟

د. أمير هاداني هو رئيس الطبيين ورئيس البحث في شركة أفيف العلمية، وهو أيضًا طبيب في مراكز أفيف في القرية.

ماذا يشير د. هاداني إلى أنه أهم من العمر؟

يشير د. هاداني إلى أن الصحة والعمر الصحي (healthspan) أكثر أهمية من العمر في المعنى التقليدي (lifespan)، حيث يركز على تحسين نوعية الحياة وتجنب الاضطرابات والأمراض المزمنة.

ماذا يشير د. هاداني إلى أن التطور لم يخطط لنا أن نعيش لفترة طويلة؟

يشير د. هاداني إلى أن التطور لم يخطط لنا أن نعيش لفترة طويلة لأن الهدف الأساسي هو التكاثر والبقاء، ولم يكن التطور يتوقع أن نتجاوز مراحل التطور ويدخلنا في فاز ال الشيخوخة.

ما هي الوظيفة الرئيسية لخلايا الخلايا النووية في جسمنا؟

خلايا الخلايا النووية مهمة لإصلاح وتجديد الأعضاء في جسمنا، حيث تحتاج إلى التوازن بين التدمير والبناء العضوي.

ماذا يشير د. هاداني إلى أن الخلايا القديمة (senescent cells) تسبب؟

الخلايا القديمة تصبح غير مفيدة مع مرور الزمن وتتعلق في دمنا، وتشير إلى أن هذه الخلايا قد تصبح سامة وترتبط بأمراض مثل السرطان والذهن الناقص والأمراض القلبية.

ما هو الأثر السلبي على الدورة البيولوجية للخلايا القديمة؟

الخلايا القديمة تصبح غير مثمرة وتتعلق في دمنا، مما يؤدي إلى تجمعها وتشتت أثرها على الوظائف الحيوية، مما قد يؤدي إلى الإصابة بالسرطان أو الأمراض العصبية والقلبية.

ما هي الأهمية الأساسية لعملية الأكسجين في تطوير الخلايا النووية وإنشاء الوعق الجدari؟

الأكسجين هو العامل الحد الأقصى لنشاط المخ، وهو ما يحتاج إليه للعمل العالي وإصلاح الجرحى والأوجاع، ويتم زيادة تركيزه في المخ من خلال الغرفة الأكسجينة الفائقة.

ما هو الدور ال_TRIGGER_ في عملية التجديد العضوي؟

ال_TRIGGER_ يشير إلى HIF-1 alpha أو العامل النابضي لل hypoxia، والذي ينتج عندما تشعر الخلية بالتوتر ويؤدي إلى بدء سلسلة من العمليات التجديدية.

كيف يمكن لبرنامج أفيف الطبية أن يساعد في تحسين الصحة والعمر الصحي؟

يتضمن برنامج أفيف الطبية خمسة أركان أساسية: التدريب الجسدي، التدريب الذهني، التوجيه التغذائي، العلاج بالأكسجين الفائق، وتقييمات شاملة قبل وبعد العلاج لضمان النتائج الإيجابية.

ماذا يشير الدراسة إلى أن التأثير السلبي على الخلايا القديمة يمكن أن يساعد في تحسين التقدم في الشيخوخة؟

الدراسة تشير إلى أن تقليل عدد الخلايا القديمة الناجمة يمكن أن يساعد في تحسين التقدم في الشيخوخة، حيث تشير إلى أن البرنامج أفيف الطبية يساعد في تقليل عدد الخلايا القديمة.

ما هي النتيجة الإيجابية لبرنامج أفيف الطبية على مستوى الخلايا النووية والوعق الجدari؟

البرنامج أفيف الطبية يساعد في تعزيز الخلايا النووية وإنشاء الوعق الجدari، مما يؤدي إلى تحسين供應 الأكسجين والتدوير العضوي، وبالتالي تحسين الصحة والعمر الصحي.

Outlines

00:00

👨‍⚕️ Dr. Amir Hadanny's Introduction and Healthspan Focus

Dr. Amir Hadanny, a chief medical officer and head of research at Aviv Scientific, is introduced. He emphasizes the importance of healthspan over lifespan, focusing on the quality of life and the absence of disabilities and chronic diseases. He discusses the role of modern medicine in extending life but also the challenges of aging, including the transition from a protective phase to frailty. Dr. Hadanny highlights the significance of stem cells in maintaining health and the emergence of senescent cells as a factor in aging.

05:02

🧠 Brain Health and the Role of Oxygen

The script delves into the importance of oxygen for brain function, comparing the brain's energy needs to the dangers of texting while driving. It discusses the use of a hyperbaric oxygen chamber to increase oxygen levels in the brain, drawing an analogy to a Coca-Cola can to explain the process. The benefits of high oxygen levels for cognitive tasks and the potential for brain repair are explored.

10:03

🩺 The Hyperoxic-Hypoxic Paradox and Regeneration Triggers

The concept of the hyperoxic-hypoxic paradox is introduced, where high oxygen levels induce a stress response similar to low oxygen conditions, triggering regeneration. The role of HIF-1 alpha as a regeneration trigger is explained, and the effectiveness of repeated hyperbaric oxygen therapy sessions in inducing this factor is discussed. The importance of stem cells in tissue repair and the potential to recruit these cells through specific protocols are also covered.

15:03

🧬 Stem Cells, Angiogenesis, and Brain Repair

The paragraph discusses the types of stem cells, including hematopoietic and mesenchymal stem cells, and their roles in blood cell creation and organ regeneration. The necessity of angiogenesis, or the creation of new blood vessels, for tissue repair is highlighted. The concept of repairing injured areas in a nourishing environment, rather than a barren one, is used to illustrate the importance of blood supply. The potential of a specific protocol to induce angiogenesis is mentioned, with supporting evidence from MRI scans showing increased blood flow.

20:04

🧓 Aging Brain Treatment and Cognitive Decline Reversal

The script describes a trial called the 'reverse aging trial,' which targeted healthy individuals over the age of 65 to improve cognitive function. The results showed an increase in memory, attention, and information processing speed. The study also demonstrated the potential to improve blood flow and cognitive function in cases of mild cognitive impairment. The systemic effects of the treatment are discussed, including improvements in cardiopulmonary function, kidney health, and male genitalia.

25:06

🌿 Telomeres, Senescent Cells, and the Aviv Medical Program

The final paragraph discusses the impact of the treatment on telomere length, showing an elongation of over 25%. It also covers the reduction in senescent cells and the improvement in skin elasticity. The Aviv Medical Program is introduced, which combines hyperbaric oxygen therapy with physical training, cognitive training, and nutrition coaching. The program's structure, including initial assessments, a three-month treatment period, and follow-up evaluations, is outlined.

Keywords

💡Hyperbaric oxygen therapy

Hyperbaric oxygen therapy (HBOT) is a medical treatment that involves breathing 100% oxygen in a pressurized room or chamber. It's used to treat a variety of conditions by increasing the amount of oxygen in the blood, which helps to promote healing and can improve the effectiveness of the immune system. In the video, Dr. Hadanny discusses the use of HBOT for neuro rehab and aging, emphasizing its role in increasing oxygen levels in the brain to support cognitive function and repair.

💡Healthspan

Healthspan refers to the period of a person's life during which they are generally healthy and free from chronic illnesses or disabilities. It is distinguished from lifespan, which is the total number of years a person lives. The video emphasizes the importance of healthspan over lifespan, focusing on the quality of life and the ability to live without significant health issues.

💡Senescent cells

Senescent cells are aged cells that have ceased to divide and function properly, often becoming nonproductive or even toxic. They are associated with various age-related diseases, including cancer and Alzheimer's. In the context of the video, senescent cells are highlighted as a target for therapies aiming to reduce their negative impact on health and aging.

💡Atherosclerosis

Atherosclerosis is a condition where plaque builds up inside the arteries, which can lead to serious cardiovascular diseases like heart attacks and strokes. The video discusses how atherosclerosis affects not just large arteries but also small ones, known as arterioles, which can cause widespread, subtle damage to organs over time.

💡Cognitive decline

Cognitive decline refers to a decrease in cognitive abilities such as memory, attention, and information processing speed. It is often associated with aging and can be a sign of neurodegenerative diseases. The video explores the potential for reversing cognitive decline through specific therapies that target the aging brain.

💡Angiogenesis

Angiogenesis is the process through which new blood vessels form from pre-existing vessels. It is essential for healing and tissue regeneration. In the video, Dr. Hadanny explains how inducing angiogenesis is a critical component of the therapy he discusses, as it helps supply blood and nutrients to areas of the body that need repair.

💡HIF-1 alpha

HIF-1 alpha, or hypoxia-inducible factor 1 alpha, is a protein that is stabilized under low oxygen conditions and plays a role in the body's response to hypoxia. It is involved in various cellular processes, including metabolism, cell proliferation, and apoptosis. In the video, it is mentioned as a trigger for cell regeneration, which can be induced by the hyperoxic-hypoxic paradox described by Dr. Hadanny.

💡Stem cells

Stem cells are undifferentiated cells that have the potential to develop into many different types of cells in the body. They serve as a repair system for the body and have the unique ability to divide and self-replicate indefinitely. The video discusses the importance of stem cells in tissue repair and how the therapy can recruit and activate stem cells to repair tissues.

💡Neuro rehabilitation

Neuro rehabilitation, or neuro rehab, is a medical treatment aimed at helping patients recover and improve their functioning after a neurological disorder or injury. The video script discusses Dr. Hadanny's research on using a unique HBOT protocol for neuro rehab, which is designed to improve cognitive function and repair the brain after injury.

💡Telomeres

Telomeres are the protective caps at the ends of chromosomes that shorten as cells divide and age. They are often used as a biomarker of aging, as their length is associated with cell lifespan and overall health. In the video, Dr. Hadanny mentions that their therapy has shown to elongate telomeres, suggesting a reversal of some aspects of cellular aging.

💡Aging process

The aging process refers to the gradual physiological and psychological changes that occur as a living organism grows older. The video discusses how the therapy developed by Dr. Hadanny and his team can improve the aging process by targeting senescent cells, enhancing cognitive function, and promoting tissue repair throughout the body.

Highlights

Dr. Amir Hadanny, a chief medical officer and head of research at Aviv Scientific, emphasizes the importance of healthspan over lifespan for a good quality of life.

Dr. Hadanny discusses the concept of protective aging and the transition to frailty, highlighting the role of evolution in our lifespan.

Stem cells decrease in number and function as we age, impacting our body's ability to repair and maintain organs.

Senescent cells, once useful for development and repair, become toxic and are linked to various diseases like cancer and Alzheimer's as we age.

Atherosclerosis, the hardening of arteries, is shown to primarily affect small vessels, leading to cumulative damage and organ dysfunction.

German study findings reveal the occlusion of small arterioles in the brain of 75-year-old men, even without symptoms, indicating ongoing micro damage.

Contrary to past beliefs, the brain can regenerate, as shown by research from the Weitzman Institute, challenging the notion of irreversible brain damage.

Dr. Hadanny outlines the 'recipe' for brain repair, which includes energy, a trigger, stem cells, and angiogenesis.

Hyperbaric oxygen therapy is introduced as a method to increase oxygen levels in the brain, aiding in cognitive tasks and repair processes.

The hyperoxic-hypoxic paradox is explained, where high oxygen levels induce a stress response leading to the production of HIF-1 alpha, a trigger for regeneration.

Repeated exposure to a specific hyperbaric oxygen protocol can recruit stem cells to repair tissues.

Angiogenesis, the creation of new blood vessels, is crucial for repairing damaged tissues by supplying them with blood.

The Aviv Medical Program, incorporating hyperbaric oxygen therapy and other components, has shown to reverse cognitive decline in aging.

The program has demonstrated improvements in blood flow to the brain, correlating with better cognitive function.

Systemic effects of the regeneration protocol are observed, with improvements in cardiopulmonary function and aerobic performance.

The program has shown the potential to repair not just the brain but other aging tissues, such as the heart and kidneys.

A decrease in senescent cells, a biomarker of aging, is observed in participants following the program.

Telomere length, which shortens with age, has been elongated by more than 25% in participants, indicating a reversal of cellular aging.

The Aviv Medical Program includes comprehensive assessments and a three-month treatment plan, with follow-ups to ensure long-term benefits.

Transcripts

So next we have Dr.

Amir Hadanny. Dr.

Hadanny is a chief medical officer and head of research at Aviv Scientific.

He's also, lucky enough, a physician at Aviv Clinics here in the Villages.

He's a Harvard research fellow in the Brain Modulation lab,

and he's published more than 60 scientific studies on, the use of a unique

hyperbaric oxygen therapy protocol for neuro rehab and aging.

Welcome, Dr. Hadanny. (applause)

You are here

because you understand this concept.

You've already heard about it at least twice.

And both Dr.

Eric Verdin and Dr.

Nir Barzilai, you'll probably hear it a lot.

But you notice there's a big difference between lifespan,

which is the years we're counting and we're celebrating birthdays

since the day we were born.

But that's not the important part.

The important is health.

Then, is the amount of time you spend

with good quality of living, the amount of time

you don't have disabilities, chronic diseases and what we call frailty,

simply what some of us will just call not living.

You're here in The Villages, all of you,

because you know this and you chose this to spend

your time in the best quality of life.

And that's our goal.

Our goal is to increase or locate

healthspan, not lifespan. I think Dr.

Verdin made this point that living to 100 without healthspan is not worth it.

And when we think about

evolution, why is that?

Why we're not supposed to live that long?

So evolution didn't plan for us to get that far, right?

As mammals we were brought here, like any other mammal,

to reproduce and get the heck out.

That's true.

That's true.

That's what we were made for.

But modern medicine has solved so many problems.

Think about it.

Antibiotics, then heart attacks, now strokes all the things

and cancers for most, and all the things that have shortened

our life to 30 to 40 to 50 to 60.

Think about 100 years ago.

So we were not supposed to get to where we are, but we are

because of modern medicine.

And when we get past the path,

the stage that evolution is planned for us and we reach that

aging phase, there are two phases here.

The one we call protective aging,

that we live with good healthspan,

but there is a threshold

that might come

where we switch to the frailty,

to the part that we don't have

good, healthy living.

There are many hallmarks that Dr.

Barzilai mentioned some of it, so I'll mention a few of them

to let you understand why it would cause this? Why does it happen?

One of them, of the hallmarks is stem cells decreasing.

You can see on the graph that we reach a plateau somewhere

in the reproductive years because again, that's

what evolution planned for us to live through those years.

And then as we age, that number

and function of stem cells decrease.

STEM cells are important to repair.

We're at constant building and destroying any organs of our body,

and we need stem cells to balance destruction of our organs.

So the moment we reach that threshold that we talked about earlier,

that's where we switch to frailty and lack of healthspan.

Another process, the other

hallmark is something we call senescent cells.

Apparently we have different cells in our body

that are important for development

to creating different organs, to creating repair of organs.

Some of them actually been found to be protected from different cancers.

But apparently, as we age, as time

passes on again, switching off the phase,

we were supposed to live at, those cells become non useful.

They don't have a purpose anymore and they stay in our bloodstream.

We call them senescent cells and apparently

they become toxic from being productive.

They're actually becoming nonproductive.

Call them senescent cells or dormant cells or zombie cells,

and they're actually associated with cancer,

with Alzheimer's, with cardiovascular disease.

So a lot of companies are trying different medications, like you heard,

of course, analytics to try to decrease senescent cells to target this pathway.

Another process

that you all know about is atherosclerosis,

that accumulation of plaques, cholesterol plaques

with a lot of other things going on there that clogging your arteries.

If you have a big artery

being clogged up in your heart, you have a heart attack.

If you have a big artery clogged in your in your brain,

you have a stroke.

But what about the small arteries?

Apparently, the biggest issue with atherosclerosis

is the small vessels, not the large ones that cause heart attack or stroke.

We have small arteries we called arterioles

that are being occluded all the time,

all the time in any organs, including our brain,

are being included every day.

We suffer those tiny damages, tiny damage that accumulate,

and that's what eventually can lead to the dysfunction of that organ.

Here's a good

example of what's going on in our brain.

So this is a German study that followed.

Let's see if the video working. Yep.

So this German group followed 75 years old

men that went into an MRI scanner

week after week without any symptoms.

They were 75 and they went into MRI week after week.

And what you will notice is those tiny little blips.

Here's a couple on week four,

here's another week six weeks, seven.

You see all those tiny blips?

That's exactly what I was talking about.

Small arterioles, small arteries are being occluded

and we have a tiny damage,

a tiny damage in our brain.

But that happens everywhere in our body.

That's the dysfunction that our organs suffer as we age.

What can we do about it?

So when I studied medicine,

they told us it can’t be done for the brain.

You cannot regenerate it.

It doesn't have the capability to regenerate.

Whatever is gone is gone.

Live with it.

And this was not long ago.

This was 20, 22 years ago.

Some schools still teach it.

Maybe. I hope not.

This is a work from the Weitzman Institute by Michael Schwartz,

showing that it is possible

that an injury to the brain

is exactly like an injury to

any other part of our body.

We can fix it.

It can be regenerated, it can be repaired.

And the concept of repairing a wound or an injury in

the brain is exactly the same as an injury anywhere else.

The name of the cells may be different because we name them differently,

but the concepts are exactly the same.

So now is the time for you to

take out your notes and write the recipe of how to repair the brain.

That's what you need.

It's exactly like making a cake.

Number one, energy, and we're going to review

each one of them exactly which fridge you're going to take it from.

Number one energy, mostly oxygen.

Number two is a trigger.

Talk about three, stem cells, and four is the creation of new blood vessels

or what we called angiogenesis.

Let's talk about the first one.

Energy.

Apparently, oxygen

is the limiting factor for our brain activity.

How do we know this?

The best example is

you guys texting and driving.

Please don't.

Right? The moment you try to text and drive. Bam!

Something happens. Whoa. What happened? Why?

Because we don't enough energy to multitask.

That's what happens.

And then as we get older, it gets harder and harder.

The exception is women, right?

They can multitask, they can do everything.

They can text and drive.

I allow it.

So but that's the best example

that you really need a lot of oxygen

in order to do high performance of your brain.

Obviously, when you want to repair a wound, when you want to repair

an injury, you need even higher than the basic oxygen.

We're always utilizing.

So how can we increase

how can we increase oxygen?

Right. We're breathing normal oxygen,

normal air that 21% oxygen, that's the best we can do.

Right.

What we found out, we can increase oxygen to the brain.

Something we call a hyperbaric oxygen chamber.

It looks like this.

The picture on the right,

it's a metal

hallway, a metal chamber

that you walk in, you sit down,

the door is closed, and then we compress it with air

to a high pressure

and then we breathe 100% oxygen under that pressure.

Why do we need both oxygen and pressure?

Because

due to physics law,

we are able to dissolve much

more oxygen to our blood at high pressure.

The best way to understand is a Coca-Cola can.

And no, I'm not getting funded by Coca-Cola.

Think about that.

The Coca-Cola can has carbon dioxide

pressurized into the liquid.

The moment you open the cap, that's CO2 coming up.

So when you walk into a hyperbaric chamber, you are a Coca-Cola can.

This is not a Pepsi.

So that's the first component of oxygen.

And we wanted to check it out.

So a couple of years ago, we took several

a student from college

and we put them in the hyperbaric chamber and we gave them dual task

like text and driving.

So on one hand they were answering some questionnaires and on the other hand

they had to do some motor task putting beads into a different cup

and they had to do it together.

What we found out, if the chamber is not working, they're not breathing oxygen.

They do it in a certain rate pretty poorly.

If we turn it on and they're breathing high pressurized oxygen,

they do much better.

They are able to text and drive.

So that's the first component.

The second component, a trigger.

We need to tell the brain

to start healing itself, to regenerate them.

In 1995, they found out this trigger called

HIF-1 alpha or hypoxia induced factor,

one alpha.

And this is the factor that's being produced

when a cell feels stress,

the moment the cell feels stress,

it produces this factor and a lot of regenerating cascades occur.

We won't go into all the cascades. There,

but those are the cascade that create

regeneration.

Dr. Verdin talked about caloric restriction,

caloric restriction, create stress in order to induce regeneration.

This is exactly the same concept.

When the cell feels stress, it produces.

HIF-1 alpha

we found out that if we do

repeat it exposures i.e.

going every day to a hyperbaric chamber they have today,

we are able to induce

HIF-1 alpha and at 60 times we're actually picking

the level of HIF-1 alpha.

But wait a minute, how am I able to get HIF-1 alpha

with high oxygen when it's supposed to be induced with low oxygen?

Right. Hypoxia is low oxygen.

The reason is a concept

we introduced called the hyperoxic-hypoxic paradox.

Getting hypoxia, with actually high oxygen.

What we're doing in the chamber, we're doing a specific protocol

that you breathe pressurized oxygen on

and then off on and off for a certain period of time.

What it does, it causes oxygen fluctuations.

So you have very high oxygen levels

and then normal, high and then normal. Never low.

But that difference, that delta between high and normal

causes the body and the brain to feel stress

and induce that trigger of regeneration, that HIF-1 alpha

hope that's clear.

So that's the second component.

The third one, stem cells.

We talked about this. we start to lose them

and those are the building blocks

of any organ in our body.

We found out that again, if we do repeated exposure in that specific,

we are able to recruit stem cells

and make them work and repair tissues.

One type is something called hematopoietic, meaning they're able

to create blood cells and blood vessels that we'll talk in a second.

The other one, mesenchymal stem cells,

those are the cells that are able to regenerate

brain or liver or heart.

They can differentiate to anything.

And again,

we're able to peek after 60 sessions.

The last component, the fourth component, angiogenesis

creation of new blood vessels.

Think about that.

You would to repair

a dead tissue and injured tissue.

Where would you like to plant a small

seed in the desert or in the flourishing meadows?

Right.

You have to supply the plant with water, or in our case,

the injured tissue with new blood vessels that will supply blood.

Otherwise it will not be successful.

Think about what we saw

from the German study, all those tiny blips.

Unfortunately, if I scan each one of you in the crowd

right now in the MRI, that's what I'll find.

Those tiny white spots that you saw that the German groups have shown you,

because we're creating them every day, every week.

Those tiny spots

are the injured areas.

So again,

do I want to repair them in the desert or in the meadow?

I have to create new blood vessels as the fourth

component.

So, again,

the hyperoxic-hypoxic paradox, we have shown that by doing

a specific protocol, I am able to create new blood vessels.

This was shown in animals

by exposing them to this protocol

and then taking biopsies

from their brain tissues, which

and then we try to do it in humans.

The problem is I had most of my participants

did not want me to take their brain out.

Come on, research, people.

So what we did,

we did MRI. MRI is a scanner

and we did a unique protocol that measures blood flow.

How much blood flow gets into each point, What you see on the left,

on the left side, on the top row, you can see the baseline scan.

And then on the middle left row, the second middle,

you see much more red regions.

What it means we get more blood flow to a lot of areas.

The only way you will get that picture or more blood flow constantly,

not just for an instant, is by creating

new blood vessels or angiogenesis.

So there you go.

The four components.

We got the recipe done energy trigger, stem cells and angiogenesis.

Now the questions,

where do we deploy it?

What's the perfect injury to use it?

So we started off

with stroke, which is a classic injury

of brain.

This is a 62 year old woman that suffered

a stroke on her left side of the brain 14 months before she came to us,

and she suffered from aphasia, or inability to speak

and right side weakness.

We analyzed it with our SPECT scan and we found out why

and we located the areas that were injured

and we are able to repair

those areas are the speech center and the motor cortex.

We put there through the program, enabling those four components

that I've discussed.

And then on

the right side, in the circles you can see

we improved those.

The green areas become yellow

not entirely, but most of them

meaning we repairing

injured tissue, utilizing those four components.

And that translated for that woman to start talking again

after 14 months from the stroke and starting to move her

right hand.

What about the aging brain?

Right.

So stroke is a very specific injury,

but we talked about

the micro strokes,

those white spots that we see on any

anyone's brain after the age of 60,

those micro strokes, those small vessels that are being occluded

and eventually cause a decline

in cognitive function, can we treat that?

So we set out and we did

a randomized controlled trial called it the reverse aging trial,

where we targeted

patients that were 65 years old.

I wouldn't even call them patients because they were healthy.

They did not have a stroke, they did not have a traumatic brain injury.

No other brain pathology.

They were just incredible people

over the age of 55

and they went through the program.

We induced those four components of regeneration,

and these are the results

we were able to increase through cognitive function

in memory, in attention, information processing speed.

So that functional decline

with aging has been reversed.

We were able to know

exactly which parts of the brain of the brain

we were able to fix to repair that tissue.

We were able to show we're improving blood flow

because we are creating new blood vessels in the brain.

And that correlated with better cognitive function.

We even did it in even more advanced cases of aging,

which is pathological aging, not healthy aging,

what we call mild cognitive impairment

when the in the pathology in the brain

is more advanced than just functional decline

here, we were able again

to increase blood flow by angiogenesis

and improve cognitive function.

But think about this.

I've told you that we have the small vessel disease

happening in any organ,

so not just the brain,

so that for components of regeneration occurs everywhere, systematically.

If you do them with a protocol, with the right protocol,

that's why we're able to see systemic effects.

So when we measured the same individuals in the trial,

they improved their cardiopulmonary

aerobic performance by more than 15%.

There's a parameter called VO2 max or the maximal oxygen consumption

that we know is one of the best predictors for mortality.

In older age, we were able to improve

because again,

we generated tissue

where

we correlated it with the blood flow in the heart.

We didn't again, they didn't want a biopsy of the heart again, sorry.

So we did an MRI of the heart

and we were able to show that we were increasing the blood flow

through the heart because again, we're creating new small

blood vessels in, the heart for better perfusion.

That translates

to better aerobic function,

but not only the heart

rate MRI of the kidneys.

And we showed we were able to repair the kidneys.

And of course,

the male genitalia.

And I'm really hoping for the question, what about them?

What about the women?

We haven't analyzed that yet,

but for males,

what we saw, we are able to regenerate

blood vessels in the genitalia, which are the most important.

That's what's basically working there.

Right.

And think about it,

erectile

dysfunction is exactly in a lot of the cases is exactly that.

With aging, we have small blood vessels that are being occluded and.

Then it can go up.

So if you're creating new blood vessels,

you're improving function.

The other thing that we showed in the study,

remember those senescent cells,

those zombie cells that shouldn't be there

hanging out in our blood, we're able to show

that we were actually decreasing them so that senescent cells, one of the

biomarkers or the hallmarks of aging, we were able to decrease that number,

meaning by utilizing those four components of regeneration,

we're actually improving the aging process.

We're changing the trajectory of aging.

Another biomarker that we worked on is telomeres.

Telomeres are, you know, in

each cell we have DNA molecules

that are wrapped in something we called chromosomes.

And at the end of each chromosome,

we have a cap called a telomere.

And we know that it shortens with age.

Every year that passes, it shortens.

our participants have elongated their telomere length

by more than 25%.

We showed that the skin gets better.

The senescent cells are not just in the bloodstream.

They're also in the skin, they're in every organ.

Again, we're able to remove them.

Their numbers decrease significantly.

So again, those toxic zombie cells have decreased, because of this program,

the elastic fibers

in the skin got better.

So again, utilizing

four components of regeneration

repairs to shoot not just in the brain

systematically.

Once we completed this study,

we formed the Aviv and we formed the Aviv Medical Program.

And this is what we do.

We try to do neurodegeneration

and change the trajectory of aging, the core

of our program is that hyperbaric oxygen therapy protocol

that I've shared with you, that you wrote the components.

If you do it right with the right protocol, that's the of it.

But you've heard already from the best of the best.

What else do you need to do?

That's why we want better

than our trial.

So we incorporate all the other things that you must do

in addition to the core of the protocol.

We do physical training because we know that exercise is so important.

We do cognitive training

in order to stimulate our brain even further

to the right areas that we want to target regeneration.

We do nutrition coaching because again, you heard

that nutrition is so important.

So those five pillars that you all took notes from Dr.

Eric Verdin then are incorporated

in this because this is obvious.

You must do this.

We have to add them in.

The program incorporates all of it.

In addition

to the core that we talked about.

But any person that comes to the Aviv Medical Program start with assessments.

We do a

lot of evaluations, blood samples, cognitive functions,

physical function and scans, like you saw, MRI scans, SPECT scans.

And then we go through the treatment.

Usually the treatment is three months.

Why three months?

Because I showed you it's data driven.

We know that.

That's when we get the peak results

of our stem cells of our trigger.

At the end,

we repeat all of our evaluations

to make sure that we did

change.

Obviously, we have the subjective reports, but we also want to see

the objective reports of what we change systematically in the brain.

But we don't want only the short term.

We also follow up after six months

to make sure these results have sustained

long term.

To summarize

what I've tried to show you, that

brain repair and regeneration is possible

if you do it right,

if you do the right protocol, it is purposeful,

But not only the brain. Aging tissues.

If you utilize the right protocol

and those four components,

you're able to create neurodegeneration.

Thank you very much.