What Is The Right Dose Of Finasteride For You?
Summary
TLDRفي هذه الحلقة من برنامج 'hair loss show'، نناقش自定义剂量(Customized dosing)للعلاج 'finasteride' المخصص لعلاج الهزال الرأسي. يشرح الأطباء رو素ل نوسدن و فيكام جاش كيف يعمل الدواء على منع تحويل هرمون التستوستيرون إلى ديهيدرو تستوستيرون (DHT) التي تسبب الهياكل الرأسية تصغر. يشددا على أن الهدف هو تقليل DHT إلى عتبة معينة، وليس القضاء عليها بالكامل لتجنب الآثار الجانبية. ويناقشا الطريقة البيولوجية للأدوية وأهمية العثور على الDosage المناسب لكل شخص بشكل منفرد، مما يتطلب معرفة واسعة وتوجيهات متخصصة.
Takeaways
- 🚀 ال絮叨 حول 'Finasteride' في حل الفقدان الشعري، والتركيز على الDosage المخصص.
- 🧬 في الفقدان الشعري الذكري، هناك سبب جيني، ويتم تحويل الهرمون التستوستيرون إلى 'ديهيدروكسورتون' (DHT) من خلال فpository الخمسة.
- 🛡️ 'Finasteride' يمنع تحويل الهرمون إلى DHT من خلال كسر عمل فpository الخمسة.
- ⚖️ يجب أن نخفض مستويات DHT لأسفل عتبة معينة، لكن ليس إلى صفر، حيث أن DHT يفعل العديد من الأشياء الجيد، لكن يمكن أن يسبب تصغير الشعر فوق تلك العتبة.
- 🔍 لا يوجد عتبة معينة تناسب الجميع، فكل شخص يحتاج إلى دوز مختلفة من 'Finasteride'.
- 💊 يمكن أن تبدأ الأدوية بmilligram ثلاث مرات في الأسبوع، لكن هذا ليس دائمًا ينطبق على الجميع.
- 📈 بعد بدء العلاج، يمكن أن يتطلب الأمر 6 أشهر لرؤية التأثير النهائي على الفقدان الشعري.
- 🔄 إذا لم يظهر أي أعراض جانبية ولم يستمر الفقدان الشعري، فقد تكون الDosage الحالي مناسبًا.
- ➕ إذا استمر الفقدان الشعري، فقد يكون الDosage الحالي غير كافي للحد من DHT، مما يتطلب زيادة الDosage.
- 🤔 يمكن أن يتطلب تقييم الDosage من قبل شخص ماهر في مجال الفقدان الشعري للتأكد من أن الDosage مناسبًا.
- 🌐 الخصية الجينية هي العامل الرئيسي الذي يميز بين الأفراد في الاستجابة على العلاج.
Q & A
ما هي الهدف من ال絮叨 في حلقة الفيديو هذه؟
-ال絮叨 في حلقة الفيديو هذه هي مناقشة ال絮叨 المخصصة لعلاج ال絮叨، وتحديد الDosage المناسب لعلاج الهزال الرأسي.
ما هي ال絮叨؟
-ال絮叨 هي دواء يستخدم لعلاج الهزال الرأسي ويمنع تقليل حجم الشعر من خلال كسر تحول هورمون الذ酮 إلى نسخة أخرى من هذا الهرمون يدعى الذ酮 الثانوي.
لماذا لا نريد أن نخفض مستويات الذكون الثانوي إلى صفر؟
-لأن الذكون الثانوي له أفعال إيجابية في الجسم، ولكن يمكن أن يسبب تصغير الشعر إذا وصلت مستوياته إلى عتبة معينة.
ما هي الهدف النهائي من إستخدام ال絮叨؟
-الهدف هو تقليل مستويات الذكون الثانوي إلى عتبة معينة توقف تصغير الشعر، ولكن ليس التقليل على الإطلاق لأن ذلك قد يسبب أعراض جانبية.
لماذا يعتبر تخصيص ال絮叨 'علمًا غير مثالي'؟
-لأن ال絮叨 يتطلب معرفة الDosage المناسب لكل شخص على حدة، مما يتطلب تجربة وتقييم شخصي لشخص.
كيف يمكننا معرفة الDosage المناسب لل絮叨 لكل شخص؟
-من خلال بدء بDosage أساسي ومراجعة الحالة بعد 6 أشهر وتعديل الDosage بناءً على النتائج والآثار الجانبية.
ماذا يفعل الطبيب إذا كان ال絮叨 لم يوقف الهزال الرأسي؟
-قد يزيد الطبيب من الDosage أو يضيف دواء ثانٍ للمساعدة في منع الهزال الرأسي.
ماذا يفعل الطبيب إذا كان ال絮叨 يسبب أعراض جانبية؟
-قد يخفض الطبيب الDosage أو يغير الطريقة التي يتناوله ال絮叨 للتخفيف من الآثار الجانبية.
ما هي الخطوات التي يتبعها الطبيب لتحديد الDosage المناسب لل絮叨؟
-يبدأ الطبيب بDosage أساسي ويتابع الحالة بعد 6 أشهر، ثم يقرر ما إذا كان يجب زيادة أو تقليل الDosage بناءً على النتائج.
هل يمكن أن يساعد ال絮叨 في تحسين حالة الهزال الرأسي؟
-نعم، يمكن لل絮叨 أن يساعد في تحسين حالة الهزال الرأسي إذا تم تخصيص الDosage بشكل صحيح وتقييم الحالة بانتظام.
هل يختلف ال絮叨 في التأثير من شخص لشخص؟
-نعم، يختلف ال絮叨 في التأثير من شخص لآخر ويعتمد ذلك على الجينوم الفريدي للشخص.
Outlines
🧑⚕️ Customizing Finasteride Dosing for Hair Loss Treatment
The first paragraph introduces the topic of the video, which is the customized dosing of Finasteride for hair loss treatment. The video features Dr. Russell Nudson and Dr. Vicam J Aash, who discuss hair loss issues and treatments. The paragraph emphasizes the importance of not reducing DHT levels to zero to avoid side effects, and the goal is to find the minimum effective dose for each individual. It explains that Finasteride works by blocking the conversion of testosterone to DHT, and that finding the right dosage is an art that varies from person to person. The paragraph also mentions the common starting point in the treatment process, which is taking 1 milligram of Finasteride three times a week, and the importance of reviewing the patient's response after six months to adjust the dosage accordingly.
🔬 Genetics and the Individualized Approach to Hair Loss Treatment
The second paragraph delves into the genetic factors that make each person's response to hair loss treatment unique. It stresses that the dosing of Finasteride cannot be a one-size-fits-all approach and must be tailored to the individual's genetic makeup, which cannot be measured or predicted. The paragraph highlights the need for professional guidance in customizing the treatment plan, ensuring that the dosage is both effective in stabilizing hair loss and safe by avoiding side effects. The video concludes by encouraging viewers to look forward to the next episode for further insights into hair loss treatment.
Mindmap
Keywords
💡Finasteride
💡DHT
💡Androgenic Alopecia
💡Customized Dosing
💡Threshold
💡Miniaturization
💡Pharmacology
💡Genetics
💡Side Effects
💡Hair Loss Progression
💡Medical Treatment
Highlights
The episode focuses on customized dosing of Finasteride for hair loss treatment.
Finasteride works by blocking the conversion of testosterone to dihydrotestosterone (DHT).
DHT is responsible for hair miniaturization above a certain threshold.
The goal is to lower DHT levels to a specific threshold without completely eliminating it to avoid side effects.
The optimal threshold for DHT reduction varies from person to person.
Customized dosing of Finasteride is not a one-size-fits-all approach.
Pharmacological insights suggest that daily Finasteride may be excessive and lead to side effects.
Starting dose is typically 1 milligram three times a week for most patients.
The effectiveness and side effects of the medication are reviewed after 6 months of use.
If hair loss continues, the dose may need to be adjusted by increasing Finasteride.
Side effects may indicate that DHT levels have been reduced too much, requiring a lower dose.
The decision on dosage adjustment is based on individual response and genetic factors.
Genetics play a significant role in determining the individual's response to Finasteride.
The process requires guidance from a professional who understands hair loss treatment.
Customized dosing aims to find the lowest effective dose for each individual.
The treatment's success is measured by stabilization of hair loss rather than complete cessation.
The episode concludes with a reminder of the importance of professional guidance in hair loss treatment.
Transcripts
hi everyone and in this episode we're
going to talk again about finest ride
but specifically customized dosing of
finest
ride welcome to the hair loss show Dr
Russell nudson and Dr vicam J aash
discuss issues relating to hair loss and
the medical and surgical treatment of
hair loss in both men and
women hi everyone welcome back to the
hair loss show thanks again for watching
please remember to to like And subscribe
uh to the channel now one of the videos
that we've done in the past has been on
customized dosing of feride but I wanted
to go uh back over a few Concepts again
but sort of specifically discuss in a
little bit more detail why it is such an
imperfect science all right so uh let's
talk about finest ride real quick and
we've gone through this multiple times
but essentially if we look at uh male
patent hair loss or androgenic alope ia
uh there's a genetic cause but you got a
hormone testosterone that's get gets
converted into another form of that
hormone
dihydrotestosterone by the f f five
Alpha reductase enzyme and essentially
what finest does is it blocks that
enzyme if you block that enzyme you
block the conversion of that to that and
therefore lower that in the system all
right but the key here is what we want
to do is we want to lower it uh by to a
specific threshold we don't want to get
the DHT down to zero okay because that
does no one any good and in fact that's
what causes a lot of the problems or the
side effects associated with DHT so DHT
does a lot of good things but it can
above a certain threshold cause uh
miniaturization of the hair so when
we're looking at this mechanism what
we're trying to do with the finestro is
give the minimum amount that we can to
get it below a certain threshold and in
doing so stop that process of
miniaturization remember hair loss is a
progressive condition so it just gets
worse with each passing year so what
we're trying to do is just lower it uh
to a certain threshold what is that
threshold no one knows all right it's
different for you it's different for me
it's different for the next person and
that is part of the Artistry associated
with the you know with the science of
medication in uh in hair loss is
deciding what is the right dose for you
it's not a cookie cutter approach it's
not 1 milligram a day it's not 3 migs a
week uh it's you know there it varies
from person to person and it's about
finding what that lowest dose is for you
all right so if we look at the
pharmacology or how the medication Works
finestro we're talking about how it
works how it's metabolized generally
what we found through experien is that
you don't need need to take it on a
daily basis okay that's probably a
little bit too much and it drops the DHT
down a little bit too much and then
you're more likely not always you're
more likely to cause uh to result in
side effects in
individuals so uh as part of uh you know
my practice what I do is I generally
start uh a milligram three times a week
all right so Monday Wednesday Friday all
right so it's quite easy now is that
does that work for everyone no it works
for most people works for a lot of
people I found that that is probably the
sweet spot but from there we will then
decide on how you know how do we
progress from there what what is the
dose that we need to be on longterm and
so what we'll do is we'll start people
on the medication review them and it
takes about 6 months to see you know see
what steady state is at 6 months if they
say look I've been on this uh particular
regime and I've had no side effects and
my hair loss is stabilized well there
you go that's your dose carry on nothing
to change but if you got someone who's
got continued hair loss on that
particular regime well then you know
that you haven't reduced this by enough
all right so we need additional blockade
of of that and that may be through
either adding more finess ride all right
so increasing the dose either on a daily
Bas on that particular day or increasing
the frequency over the course of a week
um or adding a second agent in and
that's a different discussion all right
or or the other option is that you get
uh someone who's uh stabilized but is
also getting side effects then you know
well actually I've dropped that down uh
too much and so in that individual you
need to Peg back on the dose and see
where um where the symptoms lie how the
progression of hair loss is continuing
and and really that that particular that
difference between each and every
individual person what makes each every
individual person different and it's all
down to the genetics of the individual
and it's not something that we can
measure not something that we can uh
predict so basically the the the key
there is that yes you can customize the
dosing it's uh it's not a cookie cutter
approach and it needs to be assessed by
someone who knows what they what they're
looking for and be able to guide you
through uh that process so hope you find
that useful thanks again for watching
and we'll see you on the next episode
take
[Music]
care
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