PRAKTIKUM PEMBUATAN TABLET ASAM MEFENAMAT - METODE GRANULASI KERING

Summary

This video provides a step-by-step guide on the dry granulation process for tablet manufacturing. It details the tools and ingredients used, such as Magnesium Stearate, Amprotab, and Asam Mefenamat. The process involves mixing internal and external ingredients, followed by granulation, sieving, and tablet pressing. The goal is to create uniform, high-quality tablets without the use of binders or solvents. The video emphasizes the importance of thorough mixing and proper granulation techniques to ensure consistency and optimal tablet quality.

Takeaways

• 😀 The tablet production process discussed is dry granulation, a method that avoids the use of binders and solvents.
• 😀 Basic tools for the process include a mortar and pestle, a hatrick press, and a granulator machine.
• 😀 The formulation for the Mefenamic Acid tablet consists of both active and excipient ingredients, including magnesium stearate, parfum, amprotab, and lactose.
• 😀 The dry granulation process begins with mixing the inner phase ingredients to achieve a homogeneous blend.
• 😀 The outer phase ingredients, including lubricants like magnesium stearate, are added to the inner phase in steps to ensure uniformity.
• 😀 After the mixing, the compound is pressed in the tablet press to form large granules, which are further processed.
• 😀 The granules are then coarsely milled and sieved using a number 20 sieve to refine the granule size.
• 😀 The granulation process is aimed at achieving a more consistent and high-quality granule compared to earlier methods.
• 😀 The use of the tablet press ensures that the granules are formed into tablets after the sieving process.
• 😀 The final step involves checking the granules and tablets for uniformity and ensuring they meet the required specifications.

Q & A

What is the main process described in the script?

The main process described in the script is the dry granulation method for tablet production.

What are the key tools used in the dry granulation process?

The key tools used in the dry granulation process are a mortar and pestle, a hatrick tablet press, and a sieving tool.

What is the role of magnesium stearate in the formulation?

Magnesium stearate serves as a lubricant in the tablet formulation, helping to reduce friction during the compression process.

What is the purpose of adding PVP (Polyvinylpyrrolidone) in the tablet formulation?

PVP is used as a binder in the tablet formulation to help the ingredients adhere together, even though no solvent is involved in dry granulation.

What is the purpose of the dry granulation process?

The purpose of the dry granulation process is to produce tablets without the use of binders or solvents, focusing on mechanical pressure to form granules.

What is the significance of homogenizing the mixture during the process?

Homogenizing the mixture ensures that the ingredients are evenly distributed, which is critical for ensuring consistent tablet quality.

How is the dry granulation mixture processed after the ingredients are combined?

After combining the ingredients, the mixture is placed in a tablet press, compacted, and then sieved to obtain coarse granules.

What is the purpose of sieving the granules through a number 20 sieve?

Sieving the granules through a number 20 sieve helps to separate the finer particles from the coarser ones, ensuring uniformity in the granule size.

What happens after the granules are sieved?

After sieving, the granules are compressed again using the tablet press to form the final tablets.

What is the final result of the dry granulation process described in the script?

The final result of the process is the formation of tablets that are compact, consistent, and ready for use, after completing the pressing and sieving steps.