Compounding sublingual rapid dissolve tablets

Summary

This video walks viewers through the step-by-step process of creating sublingual sildenafil tablets. It covers everything from blending the active ingredient and flavor agents, to pressing and baking the tablets for rapid dissolution under the tongue. The process emphasizes the importance of uniform tablet size and the benefits of sublingual administration, which bypasses the liver for faster action. Once the tablets are formed, they are carefully removed from molds and packaged for easy use. The video offers insights into the precision required for making these effective tablets, highlighting both the technical equipment and manual handling involved.

Takeaways

• 😀 The process begins with blending the active ingredient (sildenafil) with flavor agents to ensure uniformity.
• 😀 A sieve is used to make sure all the ingredients are the same size, which is critical for tablet consistency.
• 😀 An Arditi vehicle is used to activate flavoring agents and help mix the ingredients thoroughly.
• 😀 The mixed ingredients are compacted into a mold, with pressure applied to form uniform tablet shapes.
• 😀 Baking is done at 230°F (110°C) for 30 minutes, ensuring the mixture solidifies into a rapid-dissolve form.
• 😀 The rapid-dissolve tablets are specifically designed to dissolve under the tongue for faster absorption, bypassing the liver.
• 😀 The final product is a lower dose due to the quick absorption method, which doesn’t require processing by the liver.
• 😀 Packaging is done carefully to avoid damaging the tablets, with each one placed into a separate sleeve to keep them intact.
• 😀 The packaging is labeled with instructions for use, emphasizing the sublingual application and dosage equivalence to oral tablets.
• 😀 The completed sublingual tablets are designed for quick, effective treatment, with precise dosing and easy usage instructions.

Q & A

What is the purpose of making sublingual sildenafil tablets?

The purpose of making sublingual sildenafil tablets is to create a dosage form that dissolves quickly under the tongue, allowing for faster absorption of the active ingredient and bypassing the liver, leading to a quicker onset of action.

What is the role of the Arditi vehicle in the process?

The Arditi vehicle is a specialized substance used to blend the active ingredients and flavoring agents effectively, ensuring uniformity in the mixture before forming the tablets.

Why is it important for the ingredients to be sieved?

Sieving the ingredients is crucial to ensure that all the particles are the same size. This uniformity is important for the successful formation of consistent sublingual tablets.

What is the function of the inverse seen machine in the process?

The inverse seen machine is used to mix the ingredients efficiently by rotating and flipping the mixture back and forth. This helps achieve a thorough blending of the active ingredient and flavoring agents.

How do the tablets achieve rapid dissolution under the tongue?

The tablets are designed using a specialized base that dissolves quickly when placed under the tongue, allowing the drug to be absorbed directly into the bloodstream without passing through the digestive system.

What temperature and time are required to bake the tablets in the oven?

The tablets need to be baked at 230°F for 30 minutes using a convection oven, which ensures that the rapid-dissolve base solidifies and the tablets are formed correctly.

What is the significance of sublingual tablets bypassing the liver?

By bypassing the liver, sublingual tablets avoid first-pass metabolism, meaning the active ingredient is not broken down by the liver before it reaches the bloodstream, allowing for a more effective and faster onset of action with a lower dose.

How is the tablet shape and size maintained during the formation process?

The tablet shape and size are maintained by pressing the powder into molds and tamping it down firmly. This process ensures that the tablets are compact and uniform in size, making them suitable for consistent dosing.

What precautions must be taken when handling the tablets after they are baked?

After baking, the tablets must be handled gently to avoid breaking or crumbling. They should be allowed to cool for a few minutes before being removed from the molds to prevent damage.

How are the finished sublingual tablets packaged for use?

The finished tablets are carefully removed from the molds and packaged into individual sleeves. Each sleeve holds a specific number of tablets and is labeled with the dosage information, ensuring proper use and easy access for the consumer.