Praktikum - Uji Disolusi

Summary

The video provides a detailed guide on conducting dissolution testing for amoxicillin tablets. It covers the preparation of the testing apparatus, including filling the chamber with 900 mL of aquades and setting the temperature to 37°C. The speaker explains the steps to adjust the stirring speed to 75 RPM and set a testing duration of 30 minutes, as per Indonesian pharmacopoeia. Following the setup, the amoxicillin tablet is placed in the chamber, and samples are taken at five-minute intervals. The video concludes with a thank-you note, emphasizing the importance of accurate dissolution testing.

Takeaways

• 🔬 The equipment setup includes a dissolution tester containing aquades up to a marked limit.
• 💧 The chamber holds 900 mL of aquadest as the dissolution medium for testing children's tablets.
• ⚙️ The apparatus features a paddle type for controlling temperature, speed, and testing time.
• 🌡️ The testing temperature is generally set at 37°C.
• 🔄 A standard testing speed of 75 RPM is used during the dissolution process.
• ⏲️ The dissolution test for amoxicillin tablets lasts for 30 minutes, as per Indonesian pharmacopoeia guidelines.
• 💊 Amoxicillin tablets are placed into the chamber without touching the bottom and sealed properly.
• 🧪 A 2.5 mm filter membrane is prepared and placed in the setup for the testing procedure.
• 📏 During the test, samples are taken at specific intervals: 5, 10, 15, 20, and 25 minutes.
• 🙌 The overall practical session demonstrates the dissolution testing of amoxicillin tablets.

Q & A

What is the main purpose of the apparatus mentioned in the transcript?

The apparatus is designed for conducting dissolution tests on amoxicillin tablets.

What medium is used for the dissolution test?

Aquadest (distilled water) is used as the dissolution medium, with a volume of 900 mL in the chamber.

What is the standard temperature used during the dissolution test?

The standard temperature for the dissolution test is set at 37°C.

What is the typical stirring speed used during the test?

The typical stirring speed used in the dissolution test is 75 rpm.

How long does the dissolution test for amoxicillin tablets last?

The dissolution test lasts for 30 minutes, as per the Indonesian Pharmacopoeia guidelines.

What should be done with the amoxicillin tablet before starting the test?

The amoxicillin tablet should be placed in the chamber containing the dissolution medium without touching the bottom.

What type of membrane filter is prepared for the dissolution test?

A filter membrane with a diameter of 2.5 mm is prepared and placed on the filter paper.

What is the procedure for taking samples during the dissolution test?

Samples of 5 mL are taken at specific time intervals: 5, 10, 15, 20, and 25 minutes.

How is the sample prepared for analysis after being taken?

The sample is transferred into a 10 mL volumetric flask and diluted with aquadest to the 10 mL mark.

What is the significance of the dissolution test for amoxicillin?

The dissolution test is crucial for determining the release profile of the amoxicillin tablet, ensuring its effectiveness and compliance with pharmacopoeial standards.