How this disease changes the shape of your cells - Amber M. Yates

TED-Ed
6 May 201904:41

Summary

TLDRSickle-cell disease is a genetic disorder that alters hemoglobin, causing red blood cells to become rigid and sickle-shaped. This mutation, initially a defense against malaria, leads to a range of debilitating symptoms due to poor blood flow and oxygen delivery. Treatments like hydroxyurea and bone marrow transplants offer hope, with new therapies on the horizon aiming to prevent sickling or reduce cell stickiness, potentially revolutionizing care for those affected.

Takeaways

  • 🌀 Sickle-cell disease is a genetic disorder affecting the shape and function of red blood cells.
  • đŸ©ž Red blood cells in individuals with sickle-cell disease contain mutated hemoglobin that causes them to become rigid and sickle-shaped after releasing oxygen.
  • đŸš« The sickle shape makes red blood cells harder and stickier, leading to blockages in blood vessels and a lack of oxygen to tissues.
  • đŸ€’ This blockage can cause a range of symptoms, including pain, infections, breathing difficulties, vision problems, and even strokes.
  • 🔄 The lifespan of sickle red blood cells is significantly shorter, averaging only 10-20 days compared to a normal 4 months, resulting in sickle-cell anemia.
  • 🌿 The sickle cell mutation originally evolved as a beneficial adaptation in regions where malaria is prevalent, providing some resistance to the disease.
  • 🧬 A child inheriting the mutation from one parent has enough abnormal hemoglobin to deter malaria parasites without severe sickling.
  • 🌐 Most people with sickle-cell disease have ancestry from countries where malaria is endemic, particularly in Africa.
  • 💊 Treatments for sickle-cell disease include hydroxyurea to reduce sickling and bone marrow transplants, although the latter is complex and not widely accessible.
  • đŸ› ïž New medications and DNA editing technologies offer promising advancements in treating sickle-cell disease by preventing sickling or reducing cell stickiness.
  • 🌟 As treatments improve, there is hope for enhancing the quality of life for patients in regions most affected by both malaria and sickle-cell disease.

Q & A

  • What is the primary function of red blood cells?

    -Red blood cells transport oxygen from the lungs to all the tissues in the body.

  • What is the role of hemoglobin in red blood cells?

    -Hemoglobin proteins in red blood cells are responsible for carrying oxygen molecules.

  • How do normal red blood cells maintain their flexibility?

    -Normal red blood cells have a pliable, doughnut-like shape and hemoglobin proteins float independently inside, allowing them to accommodate even the tiniest of blood vessels.

  • What is the effect of the genetic mutation in sickle-cell disease on hemoglobin?

    -In sickle-cell disease, a genetic mutation causes the hemoglobin to lock together into rigid rows after releasing oxygen, deforming the red blood cells into a sickle shape.

  • Why do sickled red blood cells have difficulty flowing through blood vessels?

    -Sickled red blood cells are harder and stickier, which prevents them from flowing smoothly through blood vessels and can lead to blockages.

  • What are the consequences of blocked blood vessels in sickle-cell disease?

    -Blocked blood vessels can prevent oxygen from reaching various cells, causing a range of symptoms including pain, infections, difficulty breathing, vision problems, and even strokes.

  • How does the lifespan of sickled red blood cells differ from that of healthy cells?

    -Sickled red blood cells have a much shorter lifespan, living only 10 to 20 days compared to a healthy cell's 4 months.

  • What is the condition resulting from the constant depletion of red blood cells in sickle-cell disease?

    -The constant depletion of red blood cells in sickle-cell disease results in a condition called sickle-cell anemia.

  • Why did the sickle cell mutation originally evolve as a beneficial adaptation?

    -The sickle cell mutation originally evolved as a beneficial adaptation because it provided resistance to malaria, a tropical disease historically prevalent in certain regions.

  • How does having the sickle cell mutation from only one parent affect an individual's resistance to malaria?

    -If a child inherits the mutation from only one parent, there will be enough abnormal hemoglobin to make life difficult for the malaria parasite, while most of their red blood cells retain their normal shape and function.

  • What are some of the current treatments for sickle-cell disease?

    -Current treatments for sickle-cell disease include medications like hydroxyurea to reduce sickling, bone marrow transplantations for a curative measure, and promising new medications that intervene in novel ways such as keeping oxygen bonded to hemoglobin or reducing the stickiness of sickled cells.

  • How does the ability to edit DNA potentially impact the treatment of sickle-cell disease?

    -The ability to edit DNA raises the possibility of enabling stem cells to produce normal hemoglobin, which could be a significant advancement in the treatment of sickle-cell disease.

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Étiquettes Connexes
Sickle CellGenetic MutationHemoglobinRed Blood CellsOxygen TransportHealth ConditionsMedical AdaptationMalaria ResistanceTreatment AdvancesDNA EditingPatient Care
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