The IDEAL RATIO Between Testosterone & DHT-Derivatives? Vigorous Q&A
Summary
TLDRThe video script discusses the ideal ratio of testosterone to non-aromatizing compounds like Primobolan or Masteron to minimize the need for an aromatase inhibitor (AI). The speaker suggests starting with a one-to-one ratio, which is easy to follow and accounts for different esters of testosterone and the two esters of Masteron and the single ester of Primobolan. The script delves into the mechanisms of different AIs, including the suicide inhibitor Aromasin and reverse-binding inhibitors like Arimidex or Letrozole. It emphasizes the importance of blood work to adjust the ratio based on individual serum estrogen levels. The video also mentions oral DHT derivatives and their potential effects on aromatization. The speaker provides a starting point for the one-to-one ratio based on the Avogadro's constant but stresses that personal blood work is crucial for determining the optimal ratio. The video concludes with a recommendation for regular blood work and the use of Diindolylmethane (DIME) to help metabolize estradiol and reduce the estrogenic burden.
Takeaways
- 📊 A one-to-one ratio of testosterone to a non-aromatizing compound like Primobolan or Masteron is suggested as a starting point to potentially avoid the need for an aromatase inhibitor (AI).
- 🧬 Testosterone comes in various esters, whereas Primobolan has two and Masteron has one, making the one-to-one ratio easy to follow regardless of the ester.
- 🔍 Dihydrotestosterone (DHT) derivatives like Boldenone, Dihydrobaldone, and some of their metabolites act as reverse-binding aromatase inhibitors, similar to Arimidex or Letrozole.
- ⚖️ Aromasin is a steroidal, suicide inhibitor that irreversibly binds to the aromatase enzyme, rendering it inactive and preventing the conversion of testosterone into estrogen.
- 📉 The one-to-one ratio is based on the logic that for each molecule of testosterone that can convert into estradiol, an equal molecule of a DHT derivative is needed to block this conversion.
- 💊 Oral DHT derivatives may not work as effectively as injectable ones in inhibiting aromatization, though they can still provide some effect.
- 🧪 Blood work is crucial to determine if the chosen ratio is effective for an individual, and adjustments may be needed based on serum estrogen levels.
- 📉 Body fat levels can influence the amount of aromatase enzymes and thus the potential for aromatization, which should be considered when determining dosages.
- 🔄 If blood work indicates high estrogen levels, the dosage of the steroid inhibiting conversion may need to be increased, or the ratio of testosterone to the inhibiting steroid may need to be altered.
- 🧮 For a more precise calculation, the Avocados constant can be used to determine the exact milligrams of testosterone and the non-aromatizing compound needed for a one-to-one molecular ratio.
- 💡 Dinomethione (DMN) can be used to help metabolize estradiol into estrogen and reduce the overall estrogenic burden from exogenous testosterone.
Q & A
What is the suggested starting ratio of testosterone to a non-aromatizing compound to minimize the need for an aromatase inhibitor?
-The suggested starting ratio is one-to-one, meaning for every milligram of testosterone, you would use an equal milligram of a non-aromatizing compound like Primobolan or Masteron.
Why is blood work important when using a one-to-one ratio of testosterone to a non-aromatizing compound?
-Blood work is crucial to determine if the chosen ratio is effective for an individual, as it can reveal serum estradiol levels and the need for further adjustments to the hormone balance.
How do dihydrotestosterone (DHT) derivatives act as aromatase inhibitors?
-DHT derivatives like Boldrone, Dihydrobaldinone, and their metabolites act as reversely binding aromatase inhibitors, temporarily inhibiting the aromatization of aromatizable compounds.
What is a suicide inhibitor and how does Aromasin work as one?
-A suicide inhibitor is a compound that becomes permanently inactivated after reacting with its target enzyme. Aromasin works as a steroidal suicide inhibitor by getting stuck in the aromatase enzyme, rendering it inactive and preventing the conversion of testosterone into estradiol.
Why might the one-to-one ratio not work as effectively with oral DHT derivatives?
-The one-to-one ratio might not be as effective with oral DHT derivatives because their relative binding affinities for the aromatase enzyme have not been established, and they may not provide the same aromatase inhibiting effects as injectable compounds.
What is the significance of the Avocados constant in calculating the ideal one-to-one ratio of molecules?
-The Avocados constant allows for the calculation of the exact milligrams of testosterone and a non-aromatizing compound needed to achieve an equal number of molecules, providing a precise one-to-one ratio as a starting point.
What is the role of sex hormone-binding globulin (SHBG) in the context of the one-to-one ratio?
-SHBG binds to sex hormones, affecting their availability. Although the relative binding affinities for SHBG are known, the exact impact on the one-to-one ratio and its adjustments based on blood work is not explicitly detailed in the script.
How often should one check their blood work after starting a hormone protocol?
-It is recommended to check blood work about a month into the protocol to assess the serum estradiol levels and make any necessary adjustments to the hormone ratios.
What are some factors that can influence the need for an aromatase inhibitor?
-Factors such as body fat levels, diet, and the amount of adipose tissue can influence the expression of aromatase enzymes and, consequently, the need for an aromatase inhibitor.
What is the alternative approach if blood work indicates that the one-to-one ratio is not effective?
-If blood work indicates that the one-to-one ratio is not effective, one can adjust the ratio of testosterone to the non-aromatizing compound, or consider using a different approach such as daily micro administrations of testosterone without an aromatase inhibitor.
What is the role of Diindolylmethane (DIM) in managing estrogen levels?
-DIM can help with the metabolism of estradiol into estrogen, thereby reducing the overall estrogenic burden of the exogenous testosterone being used.
How can one get a discount on health panels that include estradiol testing?
-One can get a 10 percent discount on health panels from merrickhealth.com by using the vigorous discount codes provided in the video description.
Outlines
💪 Optimal Testosterone to Aromatase Inhibitor Ratio
The first paragraph discusses the ideal ratio of testosterone to non-aromatizing compounds like Primobolin or Masteron to minimize the need for an aromatase inhibitor. It emphasizes a one-to-one ratio as a starting point, explaining that this simplifies the process without needing to consider ester weights or individual esters. The speaker also touches on the role of dihydrotestosterone derivatives as reversely binding aromatase inhibitors, comparing them to other known inhibitors like Arimidex or Letrozole. The paragraph concludes with the recommendation to perform blood work after a month to assess serum estradiol levels and adjust the ratio if necessary.
🧪 Customizing Steroid Ratios Based on Blood Work
The second paragraph expands on the initial one-to-one ratio discussion by considering individual body differences, such as body fat levels and aromatase enzyme expression. It suggests that blood work is essential to determine if the starting ratio is effective for the individual and to make any necessary adjustments. The speaker provides a method using Avocados Constant to calculate the milligrams of testosterone needed to match with a DHT derivative, aiming for a molecule-for-molecule ratio. The paragraph concludes with advice on adjusting the ratio based on blood work results and mentions the use of Diindolylmethane (DINOMEthane) to help metabolize estradiol and reduce the overall estrogenic burden.
Mindmap
Keywords
💡Testosterone
💡Primabolin
💡Masteron
💡Aromatase Inhibitor (AI)
💡Dihydrotestosterone (DHT)
💡Aromasin
💡Blood Work
💡Estrodiol
💡Avocados Constant
💡Serum Estrogen Levels
💡Dinomethane
Highlights
A one-to-one ratio of testosterone to a non-aromatizing compound like Primobolan or Masteron can potentially lower or eliminate the need for an aromatase inhibitor.
The simplicity of a one-to-one ratio makes it easy to follow without needing to calculate ester weights or consider individual esters.
Dihydrotestosterone (DHT) derivatives act as reversely binding aromatase inhibitors, similar to Arimidex or Letrozole.
Aromasin is a steroidal, suicide inhibitor that inactivates the aromatase enzyme, preventing the conversion of testosterone into estradiol.
The one-to-one ratio is based on the logic that for each molecule of testosterone that can convert into estradiol, an equal molecule of a DHT derivative is needed to block this conversion.
Oral DHT derivatives may not work as effectively as injectable ones in inhibiting aromatization, with Proviron being a known inhibitor of testosterone conversion to estradiol.
Binding affinities for aromatase enzymes and sex hormone-binding globulin are not well established, necessitating the reliance on blood work for individual dosing.
A one-to-one ratio of testosterone to a steroidal, non-suicidal aromatase inhibitor is a good starting point, but blood work is essential for adjusting dosages.
Monitoring serum estradiol levels before, during, and after a cycle can help determine if further adjustments are needed.
Body fat levels can influence the amount of aromatase enzymes and the potential for aromatization, which should be considered when determining dosage ratios.
The one-to-one ratio is a starting point, and individuals may need to adjust the ratio of testosterone to the inhibiting steroid based on blood work results.
Avocados constant can be used to calculate the milligrams of testosterone needed to match a specific amount of a steroidal, reversely binding aromatase inhibitor, regardless of esters.
Regular blood work is crucial to determine if the chosen ratio is effective or needs adjustment, and to monitor overall health.
Dinomethane can be used to help metabolize estradiol into estrogen, reducing the overall estrogenic burden from exogenous testosterone.
For those who prefer a more conservative approach, daily micro administrations of testosterone through subcutaneous injections may reduce the need for an aromatase inhibitor.
The speaker provides resources for checking serum estrodiol levels and offers discount codes for health panels, emphasizing the importance of health monitoring.
The importance of individualized approaches to hormone therapy is emphasized, with the need for regular blood work and possible adjustments to dosages based on personal health markers.
Transcripts
so you can get that ideal one-to-one
ratio molecule for molecule as a
starting point
but you know that you still need to do
your blood work
figure steve here with the vigorous q a
for all of your
bodybuilding related questions today's
question is from awesome austin fit
what is a good ratio for testosterone
base and a non-aromatizing compound like
primabolin or mastrone to have a lower
or no need for an aromatized inhibitor
similar way to put it how much
testosterone and how much maestro or
primo not to use an ai well i've said it
many times before on this youtube
channel all you need is a one-to-one
ratio
of course this is a very simple answer
and not what you expect of me so let me
dive into it a little bit more
scrutinously and before we do please
like the video leave a comment for the
algorithm and consider subscribing if
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drops
i always set a one-to-one ratio because
it's easy it's easy to follow you don't
have to calculate the ester weight you
don't have to think about which
individual esters because testosterone
comes in many different esters and
maestro has two different esters and
primo has only one ester so if i say for
example 250 milligrams testosterone plus
250 milligrams primo or 250 milligrams
masteron the ester is kind of irrelevant
and you'll still get
proper aromatized inhibiting effects
keep in mind that dihydrotestosterone
derivatives baldrone
dihydrobaldinone and some of their
metabolites act as a reversely binding
aromatized inhibitor in a similar
fashion that arimidex or letrozole
femera
act as a reversely binding aromatized
inhibitor you have aromasin which is
steroidal it is a suicide inhibitor
aromasin due to its chemical composition
gets stuck in the aromatized enzyme
rendering it inactive so this aromatized
enzyme is no longer able to convert
testosterone into estradiol or the
animal into methyl estradiol for that
matter and you would need further
aromatized enzyme expression in adipose
tissue to restore the amount of
aromatized enzymes which you just
murdered
with eczema stain or aromacin keep that
in mind all of the other aromatized
inhibitors are reversely binding that
means they go into the aromatized enzyme
stay there for minutes or longer i'm not
exactly sure how long they stay within
because it also depends on which
compounds enters the aromatase enzyme
and temporarily inhibits aromatization
of aromatizable compounds after which
due to entropy
the dihydrotestosterone derivative or
the baldness or the dihydropoldenon or
the aramidex or the letrozole
exit
the aromatized enzyme after which
testosterone the anabol anything else
that's aromatizable can enter the
aromatase enzyme again and convert into
its respective metabolites so the reason
why i came up with the one-to-one ratio
is because when you look at it logically
the amount of testosterone which is able
to convert into estradiol through the
aromatized enzymes needs to be blocked
with an equal amount of a
dihydrotestosterone derivative boldenon
or dihydrobaldenone preventing the use
of an aromatized inhibitor and this is
how i came up with the one-to-one ratio
for each single testosterone molecule
you would need one molecule of a
reversely binding aromatize inhibitor
which would temporarily block the
conversion of testosterone in the
estradiol by taking its place
in the aromatized enzyme now of course
that sounds very very simple and it's
very very easy to follow so let's say
you take 500 milligrams of test any
ester you would add on top 500
milligrams of any ester or masterone any
ester or baldenon or dihydroboltanon any
ester
now i feel that it doesn't really work
as well with oral dht derivatives even
though you may still get some aromatized
inhibiting effects most notably proviron
is known to inhibit the conversion of
testosterone into estradiol and winstrol
and anavar might potentiate that to a
very low extent again the relative
binding affinities for the aromatized
enzymes haven't been established neither
have the relative binding affinities for
the sexual body globulin we only know
the relative binding affinities for the
androgen receptor and the mineral
glucocorticoid receptors and the
glucocorticoid receptors in the estrogen
alpha and beta receptors right the
receptors are known about the enzymes
and the delivery mechanisms the albumin
and the shvg unfortunately unknown so we
have to go by blood work a one-to-one
ratio of testosterone and a steroidal
non-suicidal aromatized inhibitor is a
good place to start and then after a
month on that protocol keeping your
injection frequency in your dosing the
same
a month into it please go do your blood
work see where your serum estrodial
levels are at test your serum estrogen
levels before check them during your
cycle and see if you need further
adjustments maybe you have a lot of
aromatized enzyme expression or maybe
you don't have so much because your body
fat levels are generally lower or you've
been dieting for a while this entire
month you've dropped body fat reducing
the amount of adipose tissue that you
have and thus reducing the amount of
aromatized enzymes in the potential for
aromatization that you have
so you always need to stay on top of
your ratios between testosterone and the
other steroid which inhibits the
conversion
and if your bloodwork tells you your
estrogen is going too high maybe you
need to increase this steroid that it's
inhibiting the conversion or change your
ratio maybe you're happy using 500
milligrams in total per week and instead
of using 250 milligrams of tests and
let's say 250 milligrams of primo you
reduce the test to 200 milligrams and
increase the primo to 300 milligrams so
again this one-to-one ratio is just a
starting point ultimately it's your
blood work that determines which ratio
you need to follow you know what i'll do
for all of you nerdy guys out there that
are just as nerdy as i am
i'll use the avocados constant
to calculate how many milligrams of
testosterone you would need to match
a master on primobolan or balderone or
dihydrobaldenone
regardless of esters
how many milligrams of each you would
need to get the exact
same amount of molecules i've done
videos about this in the past it didn't
get so many views so hopefully we can
mix it into this one
based on the avocados constant you would
get a certain amount of molecules i
think it's 602.11
6 tillion or quintillion molecules i'll
have to do a quick refresher so i'll be
on the screen on one of these sides this
amount of milligrams for each
testosterone ester would yield the same
exact same amount of molecules for this
amount of milligrams of a steroidal
reversely binding aromatized inhibitor
so you can get that ideal one-to-one
ratio molecule for molecule as a
starting point
but you know that you still need to do
your blood work to determine if this
ratio is working for you
or not
and again if you can't pinpoint it down
go back to trt use 100 milligrams of
testosterone per week space that over
daily micro administrations
subcutaneously
in which case most likely you don't need
an aromatized inhibitor as well
and otherwise there's always dinomethane
100 milligrams in the morning and 100
milligrams in the evening to help with
the metabolism of estrodial into
estrogen and estrogen reducing the
overall estrogenic burden of the
exogenous testosterone that you're
getting
i think this answers your questions
pretty much hope it was helpful hope you
can decide which route to go with your
testosterone and your dht derivative or
other compounds which will inhibit the
conversion of testosterone into
estradiol you can find everything that
i'm associated with down below in the
description section have a look at some
of my sponsors and affiliates so you can
save yourself some money while shopping
online and if you want to check your
serum estrodiol levels head over to
merrickhealth.com vigorous for a budget
panel which includes estradiol and a
couple other markers so you can stay on
top of your health and get 10 percent
off using the vigorous discount codes
follow me on instagram and tick tock at
vigor steve
front double bicep for the vigorous crew
no aromatize inhibitor is required
because i'm matching my testosterone to
promote the nitrolone hopefully in an
ideal ratio but then again i'll do blood
work every month to see if i need to
adjust this ratio further thank you guys
so much for watching
see you in the next video
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