What You Need To Know About Biotin | The Gillett Health Podcast #69

Summary

Dieses Podcast-Skript beleuchtet Biotin, eine B-Vitamin, das in der Haar-, Haut- und Nagel-Gesundheit eine Rolle spielt. Obwohl Biotin-Supplemente für die meisten Menschen nicht notwendig sind, kann die Situation für bestimmte Personen, wie den Gast James O'Hara, essentiell sein. Er diskutiert seine genetische Mutation, die eine Biotin-Supplementierung erfordert, und wie es seine Bluttestresultate beeinflusst hat. Die Diskussion umfasst auch die Rolle von Biotin in der Metabolismusregulation, die Bedeutung von Nahrungsmitteln und die Risiken von Biotin-Überschuss. Das Gespräch betont die Bedeutung präziser medizinischer Tests und die individuellen Bedürfnisse bei der Ernährung.

Takeaways

• 💊 Biotin ist ein Vitamin B7, das in der Nahrung vorkommt und für die Gesundheit von Haaren, Nägel und Haut wichtig ist.
• 🚫 Die Biotin-Supplementation ist für die meisten Menschen nicht notwendig und bringt keine signifikanten Vorteile.
• 🧬 James O'Hara hat eine partielle Biotinidase-Mutation, die für ihn die Biotin-Supplementation notwendig macht.
• 🧪 Biotinidase-Mangel kann zu Problemen wie Fettsäure-Synthese-Störungen, Haarausfall und Entwicklungsproblemen führen.
• 🍽️ Biotin kann durch eine ausgewogene Ernährung mit tierischen Produkten wie Leber, Eier, Lachs und Fleisch zugeführt werden.
• 🥑 Pflanzliche Biotin-Quellen sind Avocados, Süßkartoffeln, Nüsse und Samen.
• 🚫 Konsum von Eiweiß von Eiweiß (insbesondere pasteurisierte Flüssigkeit) kann zu einem Biotin-Mangel führen.
• 🧬 Genetische Tests können Aufschluss über mögliche Biotinidase-Mutationen geben und sind für eine präzise Diagnose wichtig.
• 🔬 Biotin kann bestimmte Laborwerte beeinflussen, darum ist es wichtig, bei der Interpretation von Testergebnissen den Biotin-Status zu berücksichtigen.
• 📈 Die Biotin-Industtrie ist ein Milliardenmarkt, aber die Notwendigkeit einer Supplementation sollte individuell betrachtet werden.
• 👨‍⚕️ Die Entscheidung, mit Biotin zu supponieren, sollte von Fachleuten getroffen werden, um die individuellen Bedürfnisse und Gesundheitszustand zu berücksichtigen.

Q & A

Was ist Biotin und warum ist es für die Haar-, Haut- und Nagelgesundheit wichtig?

Biotin ist ein B-Vitamin, auch bekannt als Vitamin B7, das für die Gesundheit von Haaren, Haut und Nägeln wichtig ist. Es spielt eine Rolle bei der Fettsäuresynthese und bei der Gluconeogenese und kann mit Haarausfall in Verbindung gebracht werden.

Welche Rolle spielt die Biotinidase-Enzymaktivität im menschlichen Körper?

Die Biotinidase-Enzymaktivität hilft bei der Umwandlung von Biotin in seine aktivierte Form, die für verschiedene生化 Prozesse im Körper notwendig ist, einschließlich der Fettsäuresynthese und der Gluconeogenese.

Ein Biotinmangel kann zu Symptomen wie Haarausfall (Alopezie), Hautproblemen und geschwächter Nervenfunktion führen. Es ist jedoch selten und oft mit bestimmten Enzymmangelzuständen verbunden.

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Welche Nahrungsmittel sind gute Quellen für Biotin?

Gute Biotingehaltsstoffe sind tierische Produkte wie Leber, Eier, Lachs, Schweinefleisch, sowie pflanzliche Optionen wie Avocados, Süßkartoffeln, Nüsse und Samen.

Was ist ein inborn Error of Metabolism (IEM) und wie kann Biotin hier eine Rolle spielen?

Ein inborn Error of Metabolism ist eine Störung, bei der der Körper bestimmte chemische Prozesse nicht richtig durchführen kann. Biotin kann bei bestimmten IEMs, wie der Biotinidase-Mangel, eine wichtige Rolle spielen, indem es die Enzymaktivität unterstützt.

Welche Tests können helfen, einen Biotinidase-Mangel zu diagnostizieren?

Genetischer Test und die Bestimmung der Biotinidase-Aktivität im Blut können helfen, einen Biotinidase-Mangel zu diagnostizieren.

Was ist die empfohlene tagesmäßige Zufuhr von Biotin?

Die empfohlene tagesmäßige Zufuhr (RDA) von Biotin liegt bei etwa 30 Mikrogramm.

Welche Laborwerte können durch Biotin-Supplementierung beeinflusst werden?

Biotin kann Laborwerte wie TSH, freie T4 und T3, Kortisol, Estradial, Prolaktin und Vitamin D beeinflussen, da es mit verschiedenen Immunoassays reagieren kann.

Wie kann man Biotin-Wirkungen auf Labortests umgehen?

Indem man die Biotin-Supplementierung für einige Tage pausiert und dann die betroffenen Laborwerte erneut bestimmt, kann man die Auswirkungen von Biotin auf die Tests besser einschätzen.

Was ist die Beziehung zwischen Biotin und Carnitin?

Biotinmangel kann zu einer verminderten Carnitin-Synthese führen, da Biotin an die Prozesse beteiligt ist, die für die Carnitin-Produktion notwendig sind, was die Energieumwandlung im Körper beeinflusst.

Welche Rolle spielt das Genotype-Phenotype-Korrelationsverhältnis bei der Beurteilung von Biotinidase-Mangelzuständen?

Das Genotype-Phenotype-Korrelationsverhältnis ist wichtig, um zu bestimmen, wie die genetischen Mutationen sich in der realen Enzymaktivität im Blut manifestieren und wie sie die Behandlungsentscheidungen beeinflussen.

Was ist die Prognose für Menschen mit Biotinidase-Mangel, wenn sie korrekt behandelt werden?

Menschen mit Biotinidase-Mangel, die korrekt behandelt werden, haben in der Regel keine kognitiven oder Entwicklungsprobleme und können ein normales Leben führen.

Outlines

00:00

🧬 Biotin und die Bedeutung für die Genetik

Dieses Absatz beschäftigt sich mit Biotin als Bestandteil einer Milliarden-Industrie für Nahrungsergänzungen, die hauptsächlich wegen ihrer angeblichen Vorteile für Haut, Haare und Nägel konsumiert wird. Der Podcast diskutiert jedoch, dass Biotin-Supplementation für die meisten Menschen nicht notwendig ist. Ein besonderer Fall ist James O'Hara, der aufgrund einer genetischen Mutation eine Biotin-Supplementierung benötigt. Die Diskussion umfasst die Rolle von Biotin bei der Fettsäure-Synthese, Glukoneogenese und Haarwuchs, sowie die Bedeutung der Biotinidase-Enzymaktivität, die bei einem Mangel zu Problemen führen kann. Zudem wird auf die Notwendigkeit von evidenzbasierter genetischer Testung hingewiesen, um eine Biotinidase-Mutation zu diagnostizieren.

05:00

🥩 Biotin-Quellen und deren Bedeutung

In diesem Absatz werden die natürlichen Biotin-Quellen in der Ernährung erörtert, wie tierische Produkte wie Leber, Eier, Lachs und Schweinefleisch sowie pflanzliche Optionen wie Avocado, Süßkartoffeln, Nüsse und Samen. Es wird auch auf die potenzielle Vitamin-A-Intoxikation hingewiesen, die durch den Konsum von übermäßigem Rindfleisch auftreten kann. Die Diskussion umfasst auch die RDA für Biotin und die Idee, dass Biotin-Supplementation für die meisten Menschen keine klinisch signifikante Veränderung bringen wird, jedoch für bestimmte Fälle wie Mutationen in der Biotinidase-Gen verlässlich sein kann.

10:00

🚫 Biotin-Supplementation und mögliche Nebenwirkungen

Dieser Absatz behandelt die Frage, warum Biotin-Supplementation nicht immer ratsam ist und welche Rolle die Biotinidase-Enzymaktivität dabei spielt. Es wird auf die potenziellen Nebenwirkungen von Biotin-Supplementation hingewiesen, wie Übelkeit und Magenbeschwerden. Es wird auch diskutiert, dass Biotinidase-Mangel selten vorkommt, aber bei Neugeborenen und Säuglingen lebenslangige Supplementierung notwendig sein kann, um eine normale Entwicklung von Hören, Sehkraft und dem Nervensystem zu gewährleisten.

15:00

🧪 Laborwerte und Biotin-Supplementation

In diesem Absatz werden die Auswirkungen von Biotin-Supplementation auf Laborwerte diskutiert, insbesondere auf Hormone wie TSH, freies T4, freies T3, Cortisol, Estradial, Prolaktin und Vitamin D. Es wird erwähnt, dass Biotin die Ergebnisse bestimmter Labortests stören kann, und es wird auf die Notwendigkeit verwiesen, die klinische Symptomatik mit den Laborergebnissen abzugleichen. Es wird auch auf die Bedeutung der Biotinidase-Aktivität als Goldstandard für die Entscheidung über die Behandlung hingewiesen.

20:02

📉 Biotin-Industrie und individuelle Medizin

Der letzte Absatz fasst die Diskussion über Biotin zusammen und betont die Bedeutung individueller Medizin und präziser Tests. Es wird darauf hingewiesen, dass Biotin-Supplementation für die meisten Menschen überschätzt ist und dass es in der Regel besser ist, aus einer ausgewogenen Ernährung zu profitieren. Der Podcast endet mit einem Aufruf an die Zuhörer, ihre Erfahrungen mit inborn errors of metabolism zu teilen und betont die Hoffnung, dass die Informationen hilfreich sind.

Keywords

💡Biotin

Biotin ist eine B-Vitamin, auch bekannt als Vitamin B7, das für die Gesundheit von Haut, Haaren und Nägeln wichtig ist. Im Video wird diskutiert, dass die meisten Menschen Biotin-Supplemente nicht benötigen, aber für bestimmte Personen, wie den Gast James O'Hara, kann die Biotin-Supplementation essentiell sein. Im Kontext des Skripts wird Biotin als Teil der Diskussion über die Bedeutung von Vitaminen für die Haarwuchs und die Rolle von Biotin bei der Fettsäure-Synthese und Gluko新生.

💡Biotinidase

Biotinidase ist ein Enzym, das bei der Umwandlung von Biotinoiden in Biotin involviert ist. Eine Mangel an diesem Enzym kann zu einer Biotin-Mangelzustände führen, was im Video als Teil der Diskussion über die Bedeutung von Biotin für die Gesundheit erwähnt wird, insbesondere in Bezug auf die Erfahrungen von James O'Hara mit einer partiellen Biotinidase-Mutation.

💡Supplementation

Supplementation bezieht sich auf die Einnahme von Nahrungsergänzungsmitteln, um die Ernährung zu ergänzen oder bestimmte Nährstoffe aufzustocken. Im Video wird die Biotin-Supplementation als mögliche Option für die Verbesserung von Haarwuchs und Haut gesundheit diskutiert, aber auch die Notwendigkeit einer differenzierten Betrachtung hinsichtlich individueller Bedürfnisse und Genetik.

💡Organic Acid Test

Ein Organic Acid Test ist eine diagnostische Methode, die verwendet wird, um Metaboliten im Urin zu messen, was bei der Identifizierung von Stoffwechselstörungen hilfreich sein kann. Im Video wird erwähnt, dass Biotin in einem solchen Test für Neugeborene gemessen werden kann, um mögliche Inborn Errors of Metabolism zu erkennen.

💡Genetic Mutation

Eine genetische Mutation bezieht sich auf eine Veränderung in der DNA-Sequenz, die zu einer Abweichung von der normalen Genstruktur führen kann. Im Video wird die Rolle einer partiellen Biotinidase-Mutation bei James O'Hara diskutiert und wie sie möglicherweise seine Biotin-Bedürfnisse beeinflusst.

💡RDA (Recommended Dietary Allowance)

Die empfohlene Nährstoffaufnahme (RDA) ist der Wert, der von den zuständigen Behörden als ausreichend angesehen wird, um die Nährstoffbedürfnisse der meisten Menschen zu decken. Im Video wird die RDA für Biotin erwähnt, um den Kontext für die Diskussion über Biotin-Supplementation zu setzen.

💡Nuance

Nuance bezeichnet die Feinheiten oder Subtilitäten einer Angelegenheit. Im Video wird darauf hingewiesen, dass die Diskussion über Biotin-Supplementation Nuance erfordert, um die individuellen Unterschiede in den Bedürfnissen und Reaktionen auf Biotin zu berücksichtigen.

💡Alopecia

Alopecia ist eine Bezeichnung für eine Reihe von Haarausfallbedingungen. Im Video wird erwähnt, dass Biotin eine Verbindung zu Haarwuchs hat und dass ein Mangel an Biotin zu Haarausfall führen kann.

💡Genetic Testing

Genetischer Test ist eine Methode, die verwendet wird, um genetische Mutationen oder Veränderungen zu identifizieren. Im Video wird erzählt, wie James O'Hara durch einen evidenzbasierten genetischen Test seine Biotinidase-Mutation entdeckte.

💡Inborn Errors of Metabolism

Inborn Errors of Metabolism (IEM) sind genetisch bedingte Stoffwechselstörungen, die zu einer Vielzahl von Gesundheitsproblemen führen können. Im Video wird auf die Bedeutung von Biotin und Biotinidase für das Verständnis bestimmter IEM hingewiesen.

💡Evidenzbasierte Medizin

Evidenzbasierte Medizin bezieht sich auf die Praxis, medizinische Entscheidungen auf der Grundlage von wissenschaftlichen Beweisen zu treffen. Im Video wird betont, wie wichtig es ist, evidenzbasierte genetischen Tests zu verwenden, um die Genmutationen und -bedingungen korrekt zu identifizieren und zu behandeln.

Highlights

Biotin is a B vitamin with a $4 billion industry for supplementation, often taken for skin, hair, and nails.

For most people, biotin supplementation is not worth it, but for some individuals like James O'Hara, it is essential.

Biotin, or vitamin B7, plays a role in fatty acid synthesis, gluconeogenesis, and is associated with alopecia.

James O'Hara has a partial biotinidase genetic mutation, which may affect his enzyme activity.

Biotin supplementation can affect blood test results, which James plans to monitor.

Genetic testing revealed James's mutation, prompting him to start biotin supplementation.

Egg whites can inhibit biotin absorption, potentially leading to deficiency.

Biotinidase deficiency is considered one of the less concerning metabolic diseases.

Homozygous mutations for biotinidase deficiency require lifelong supplementation for normal development.

Biotin supplementation is not always necessary but can be beneficial for carriers of certain mutations.

High biotin supplementation can interfere with lab tests, skewing results.

Biotin's impact on lab tests may not always correlate with clinical symptoms.

Biotin supplementation is overrated for hair growth and skin quality compared to other treatments like collagen.

Individualized medicine and precision testing are key takeaways from James's biotin journey.

Biotin's role in metabolism and its supplementation effects are nuanced and vary between individuals.

The biotin industry is a $3.6 billion market as of 2023, with projected growth.

James's personal experience with biotin supplementation provides insights into its potential necessity for certain genetic profiles.

The podcast emphasizes the importance of understanding one's genetic makeup and how it may affect nutrient needs.

Transcripts

today's podcast is over biotin a B

vitamin that is A4 billion industry when

it comes to supplementation a lot of

people take it for skin hair and nails

or just hair and I guess I could save

you a lot of time if you're not

interested in the Nuance biotin

supplementation for most people is

definitely not worth it so perhaps you

can skip the video but biotin

supplementation for my good friend James

O'Hara is essential so maybe you're

interested to listen in and hear why

welcome back to the gillet health

podcast where we give you tools to

develop a balanced approach for health

I'm Dr klege Jette and I'm James O'Hara

nurse practitioner and today we're

talking about biotin uh specifically I

guess more about biotin inborn eras of

metabolism so actually something you

might be able to pick up on a organic

acid test oh interesting if you're a

newborn if you're ordering organic acid

test on newborns which is actually a

great test as opposed to adults um Bio

10 of those tests when you're young but

not when you're

old clever play on words there um so

biotin seems to me at least like a

fairly boring B vitamin compared to some

of the other more popular B vitamins

talk about thomine depletion and alcohol

that's pretty interesting that's pretty

exciting uh biotin is called vitamin B7

and it has some sort of non-specific

roles but things do go wrong whenever

you have a severe deficiency in the

biotinidase enzyme so it helps with

synthesis of fatty acids we know there's

some interplay between free fatty acid

levels biotin levels and

carnitin um biotin true biotin

deficiency is rare but it also helps

with gluconeogenesis and there's associ

with alopecia um given that it's

involved in both neural development and

hair growth yeah so fortunately I just

have a partial biotinidase genetic

mutation uh and to be clear I don't know

yet how this correlates with my actual

enzyme activity in the blood so I'll be

getting that test sometime in the future

um but for now I'm empirically

supplementing with uh a mega do of biot

in I I suppose in context of the RDA um

and later we'll go through how that's

affected my blood test results but um so

did you do an oats test for that or how

did you find out you have a deficiency

you just asked your

GP yeah I uh got some evidence-based

genetic testing so I'm not a huge fan

and I wouldn't trust the results with

certainty from something like uh any

consumer company that's not you know

running things through a certified lab

like alumina um and and depending on how

many times they're reading these so it

was an invate test um that I think does

use alumina but they are a clinical

grade test so this is when you are

specifically trying to verify in Born

erors of metabolism or your umis for

genetic hereditary cancers those sorts

of things multiple endocrine neoplasia

yeah you don't want to have a

proprietary unvalidated polygenic risk

score um you want to use something that

is you know viable verifiable and not

necessarily just trying to give you a

diagnosis or create a pathology where

there's not one yeah that's a good

summary um so I guess you got the uh you

know evidence-based testing you got the

results and then you saw it said

something about mutation and you freaked

out and then um called the self-service

lab portal that you ordered this on I

sent 15 emails each about two minutes

apart uh didn't hear anything back so I

frantically called and then texted into

the clinic number um Google reviews

Reddit yeah left a bunch of reviews and

then um saw biotin a and Biotin and

figured I should probably take that

stuff that's the chart can Fair enoughbe

we can put that up with a bunch of

squiggly lines yeah the reason why we're

laughing when you just kind of think

this is funny is that there's a lot of

these what we call self-service lab

companies you can go online um you know

technically a healthcare provider still

orders it I think um but even for tests

that are genetic tests or um you know uh

tests that in general you would want to

do some shared decision- making before

ordering you can just order these and

then yeah what happens if there's a test

that is potentially leading to something

that's clinically actionable like a

cancer antigen just by itself no context

no patient history like a CA

125 or a PSA and if you if you have your

average 70 to 80y old male get a PSA on

like whatever these self-service lab

portals then yeah they are uh very

likely to be greater than four so anyway

that's a little bit of a tangent um back

into the biotin um why supplement aren't

you supposed to get these things through

the diet we're always emphasizing um you

know you can get everything in the diet

that you can via supplementation it's

just harder yeah and I think the RDA is

around 30 micrograms which is a very low

amount relative to what you know your

hair skin and nail supplements contain

um so great sources are animal products

so like beef liver um eggs salmon pork

Meats in general and then some

plant-based options would be things like

avocado sweet potato nuts and seeds um I

it would have been fun to do a little

bit of math maybe someone can do this

for us in the comments section see like

how much beef liver would I have to take

in to get 10,000 micrograms of biotin a

whole a whole bottle of gorilla mined

Argentinian beef liver freeze dried yeah

and I assume I would get a vitamin A

toxicity before I would get enough

biotin intake for you that is

possible that's interesting I guess uh

what do you take 40 micrograms 50

micrograms yeah 10,000 micrograms or 10

million nanograms of biotin per day that

that sounds uh highly anabolic for your

hair I guess yeah maybe this is why I'm

losing my hair all along it's just

biotin deficiency

uh probably not just Biotin do you think

you'd have this much hair if you were

born

female probably had

more probably so wouldn't you so you

think the gender difference is playing a

role there probably so although it could

be advantageous from like a social media

perspective to sell biotin

supplementation to everyone by correctly

saying that it is helping with your hair

growth because for 99 plus per of people

it's not going to make any clinically

significant difference for but for you

it likely is it'll be interesting to

watch I think I'm about H probably about

a month in at this point I haven't

noticed things directly one way or the

other and of course there's a lot of

variables there but um we'll do an

update podcast sometime down the road to

take over those things do you think

divulging this personal health

information affects your sexual

Marketplace value for potential suitors

I'm glad I don't have to worry about

that uh he's married by the way not to

me yeah my wife and I actually have the

same um HF gene

mutation so unfortunately it's not the

main Gene pair but I've talked about

this on the the podcast before if we're

unable to manage postpartum Hemorrhage

in the future any potential female

offspring of yours will be highly

adapted yeah if we uh if Society

collapses and we have to revert to our

prepping podcast strategy yeah we did

that one a while back is there like a

prepper only dating service you have to

have an HF mutation

I mean Iron is a more valuable commodity

that can't just be made into supplements

M um wow we went way off B so we talked

about things to eat now things not to

eat if you want to get enough biotin um

egg whites and this is something that I

I've actually done in the past the uh

like pasteurized liquid egg whites the

super easy way to get more protein in I

think with cooking you do denature the

protein there so I mean that it's cooked

thoroughly yes but I have actually drank

these liquid egg whites I remember

seeing the more plates more dates video

on this way back probably five six years

ago um yeah and I have also drank liquid

egg whites and this is probably why a

lot of bodybuilders are bald right U

more plates more dates made you bald by

suggesting to drink liquid egg whites

actually he gets credit for I he he

actually talked about a potential biotin

insufficiency or defy if you very

regularly do this um yeah probably not

why all bodybuilders are bald other

factors that play there but yeah it's a

thing like don't do this in general or

check your bio and levels if you do and

probably don't do this at all if you

have a known mutation yeah um speaking

of mutations if you had to have a

metabolic disease how does this how does

this rate like I guess on a scale of 1

to

10 um 10 being the most concerning one

being the least concerning where would

this rate so you said tin being the most

concerning the most concerning yeah like

uh p dis yeah this is a a one out of 10

I highly recommend it um and I found

this paper titled biotinidase deficiency

if you have an inherited metabolic

disease this is the one to have and

again metabolic disease I don't think

that I'm on the disease Spectrum but

there could be a sort of subclinical

deficiency there yep um and we'll go

through some of the interesting points

about that so

um obviously if it is a homozygous

mutation then these children uh and

babies will require lifelong

supplementation in order for normal

development of hearing Vision um the

neurological system to develop normally

um so this says prior to treatment

concentrations with or concentrations of

individuals with profound biotinidase

deficiency may be decreased or in the

low normal range isn't low normal still

normal

uh that's pretty debatable I would argue

any low normal value lab value warrants

an

explanation whether it is inaccurate

laboratory assay or whether it is poor

lifestyle or whether it is um genetic

mutation one way or another biotin

supplementation yeah or biotin

supplementation

um yeah so um the lower it is the

more it makes sense to supplement but

for I I suppose even for heterozygotes

or carriers um why not supplement if

like what's the downside of

supplementing slightly higher Amino

assay biomarkers of certain sorts yeah

and potentially adverse effects so I

personally for myself I can't tell any

difference in my day-to-day um taking 10

million nanograms of biotin versus

taking none U but some people people I

think this is when it's notorious for

causing some upset stomach or some

nausea um I do take them usually after

breakfast if I'm thinking about my

day-to-day routine so I don't know if

that makes a difference or not uh but in

any case I haven't had any adverse

effects as far as I know um we'll go

through some of the lab values in a bit

but this also notes that if someone is

being appropriately treated they're

always going to have elevated

concentrations in urine and in the serum

so that's not a reliable way to sort of

of track um like the disease state or if

the treatment is correcting the

deficiency um unless I think there's

something in there about like

non-compliance so uh I suppose now that

my doctor will be checking my bioin

levels to make sure that I'm compliant

with my

supplementation maybe not um what does

it mean by enzimatic activity it says

you should track entic activity um to

see kind of like where your phenotype is

because usually when you check like an

MTHFR you just see if you have you know

one or two mutations and you don't worry

about how much that is doing or do you

some people

do the the answer is yes you do and um

we'll link our MTHFR podcast below where

we also kind of talk about uh enzimatic

activity which we measure by proxy with

homocystine and methylmalonic acid

levels but I did think that it was

interesting that it mentioned that this

is kind of like the um the gold standard

for which to base uh treatment

Decisions by yeah because the genotype

doesn't always match the phenotype so

the phenotype is hey we've got this

enzyme measured in the blood what is its

activity level in comparison to what

we'd expect is it 10% of what we'd

expect is it 60% of what we'd expect so

I'll have that test done and then

determine whether I need to take a

Biotin supplement but in the meantime I

think it's reasonable with very little

downside and no perceivable side effects

to continue with

supplementation um there's a little bit

bit of information about carnitine which

I find kind of counterintuitive here but

there's a lot of biochemistry there so

probably a PhD in specifically like

biotin metabolism or carnitine

metabolism would be able to tell us more

but there may be some concern for

carnitine depletion in people who are

biotin deficient um whether that's by

malnutrition or by um having a mutation

in the

enzyme yeah or potentially less

synthesis free fatty acids or a less

processing of free fatty acids I think

inborn era of metabolism uh especially

with

um uh triglyceride level variation

carnitine and shunting fuel into the

cell and not just into the cell into the

mitochondria is kind of one of the first

empiric treatment mechanisms I think of

especially if there's High hyper

triglyceridemia but anyway that's a bit

of a rabbit Trail there

um I guess uh in other testing that

you've done so far um you know you're on

10,000 micrograms or 10 million

nanograms of biot and uh this is

probably just wildly skewing your Labs

everywhere you would think so based on

what you hear people blame on Biotin and

I'm sure the results vary from Lab to

lab but I have a number of labs I just

happened to recently get um through

vibrant America uh it was top-notch

experience got the results back pretty

quickly and I have a free T4 free T3 a

TSH a fertin a cortisol estradi and a

prolactin and a vitamin D all of which

uh there are claims that biotin can

interfere with these so examine.com

listed out all of these markers and it's

really interesting because you have my

data point I given the prior data point

was from uh let's say

2022 I believe was one the last time I

went through vibrant is but you can see

how consistent these labs are so and you

can order all these on gillet health.com

if you click order Labs we'll promote

that um yeah but even if you're not a

clinic member but yeah we'll post these

up on the screen and you can see how

these have trended and in general they

just haven't except something kind of

happened to your fertin which I don't

know if that's due to biotin or not yeah

this is probably more due to some HCG

and also due to some PRP so some iron

loss in the blood there fertin was

around 50 so 56 yep so I'm not quite

fertin deficient I think they don't

consider deficiency until you're below

30 but when you get to be around 50 you

may have some concerns about your sort

of Maximum Exercise capacity those HF

Snips really aren't very clinically

penetrant or perhaps it's just the um

photomy of various sorts yeah Fittin up

to this point has not climbed too much

but my iron binding capacities when I'm

not taking HCG tend to be very low it

does look like your TSH went up

by um what is that 0.

2.3 so it did go up yeah so it was

probably like a 2.9 or something like

that previously and now it's at a

3.6 um so far my TSH appears to be

unaffected by the relatively large dose

of the biotin MH and then you actually

had sort of the opposite happen with the

freet T4 yep uh free T4 free T3

relatively stable maybe a touch

decreased so it's definitely not a case

I've seen case studies of um biotin

supplementation causing hyperthyroidism

and that is definitely not happening um

in your case yeah and one of the things

to note is if you're a clinician or if

you're a patient on this side you have

to think does this lab match up with my

clinical presentation or like how I'm

feeling or symptoms that I'm having so

even if my TSH was 200 I'm not going to

think anything based off of a single lab

value in the absence of symptoms that

would corroborate that so you know if

you do have biots and it's skewing

something you know educate the patient

hey pause your bio in for three days

three days isn't going to make or break

anything it's probably not even helping

your hair growth or hair loss so cut it

out for a few days we'll recheck things

and sometimes it could be the biotin

sometimes it could be a lab air because

they're very rare but unfortunately they

do happen from time to time there's a

lot of other biomarkers that can be

skewed by uh biotin supplementation but

I believe most if not all of these are

Amino assays to where it's kind of cross

detecting and then when it fluoresces or

whatnot the biotin makes it um seem

usually stronger so we'll list those in

the uh com in the description as well

yeah and I didn't have these drawn uh I

wasn't having any cardiac symptoms so

didn't have a CK or a trapon and if I

was having those drawn I would probably

be in a hospital not walking into a

vibrant laboratory yeah uh hope

hopefully it would be in a hospital can

manage my M outpatient right uh I don't

know about that so fortunately that U um

is not the case um so yeah I guess doing

a podcast on biotin like you know you're

taking biotin that's a great

representative we probably are selling

supplementation with a account code

because it is a $6.5

billion industry estimated by 2030 or

perhaps this will knock that estimated

value back a bit yeah I did call it a

boring B vitamin so maybe they're not

going to reach that 6.5 billion um in

any case you know now it is a 3.6

billion as of last year 2023 MH and I

think it's overrated in terms of hair

growth nail growth skin quality um

certainly there are cases where people

like oh I started doing this and I

noticed this result and I don't want to

say that it could never be helpful but

compared to something like just a high

quality collagen collagen protein or

just a high protein intake in general

it's probably not doing a whole lot yeah

uh that's a good summary so um another

notch in the belt for individualized

medicine and precision testing uh

hopefully that gives people

plenty of takeaways if the only takeaway

is most of them are probably not a great

candidate for biotin

supplementation yeah and to be clear I'm

not getting any organic acid testing to

look at how this biotin is affecting

things I'm going to follow these sort of

standard of care and looking at the

enzyme and and doing what makes sense

yeah um for any questions or comments or

if you want to share your uh inborn ER

of metabolism um comment below on

Instagram or YouTube or whatnot um and

uh thank you for your time thank you for

listening may God bless you with health

and happiness