Taking Vitamin D3? This Might Save Your Life
Summary
TLDRThis video script delves into the complex relationship between vitamin D3, calcium, and vitamin K2 in the body. It refutes the claim that high D3 levels cause hypercalcemia, emphasizing the crucial role of K2 in directing calcium to bones and preventing arterial calcification. The speaker discusses the biochemical processes involving osteocalcin and Matrix GLA protein, and the importance of choosing the right form of K2 supplements, advocating for a balanced diet and proper supplementation to maintain heart and bone health.
Takeaways
- 💊 Vitamin D3 and calcium supplementation can have conflicting effects on health, with some studies showing increased bone density and others indicating a risk of heart and artery problems.
- 🩸 The script challenges the common belief that high levels of Vitamin D3 (hypervitaminosis D) necessarily lead to high blood calcium levels (hypercalcemia), suggesting that this is a misconception.
- 🧬 Vitamin D3 and K2 are crucial for calcium metabolism, with D3 enhancing calcium absorption and K2 being necessary for the proper functioning of certain proteins involved in calcium regulation.
- 🦴 Osteocalcin and Matrix GLA protein (MGP) are proteins that require Vitamin D3 and K2 to bind calcium effectively, with osteocalcin aiding in bone mineralization and MGP preventing arterial calcification.
- 🔬 The process of carboxylation, facilitated by K2, is vital for the high affinity binding of calcium by osteocalcin and MGP, which is essential for bone health and arterial protection.
- 🌱 Different forms of Vitamin K2 (menaquinones) exist, such as MK4 and MK7, with MK7 having a longer half-life and being more effective for long-term regulation of calcium deposition.
- 🥩 Dietary sources of K2 are mainly animal-based, including organ meats, cheese, and eggs, highlighting the importance of a balanced diet for optimal health.
- 💡 The speaker emphasizes the importance of understanding the biochemical pathways and mechanisms involved in calcium regulation to safely create supplement regimes.
- 📚 The script criticizes the lack of education on Vitamin D3 and K2 among some health professionals and advocates for more detailed knowledge in this area.
- 💡 The recommendation for Vitamin D3 and K2 supplementation is provided, suggesting one Super K supplement for every 10,000 units of D3, based on the speaker's clinical experience.
- 🚫 The speaker warns against taking advice from those who do not understand the complexities of Vitamin D3 and K2, including the importance of the cis and trans forms of K2.
Q & A
What is the main concern raised about vitamin D3 supplementation in the video script?
-The main concern is that some studies suggest vitamin D3 supplementation can lead to too much calcium in the blood, increasing the risk of hardening of the arteries, like in atherosclerotic heart disease.
What is the role of vitamin D3 in calcium metabolism according to the script?
-Vitamin D3, specifically its active form calcitriol, enhances calcium absorption from the gut by increasing the expression of calcium-binding proteins in the intestine, helps maintain calcium levels in the blood, and potentially mobilizes calcium from bones when necessary.
What are osteocalcin and Matrix GLA protein (MGP), and how do they relate to vitamin D3 and K2?
-Osteocalcin and MGP are proteins that depend on vitamin D3 for their production and on K2 for their proper functioning. Osteocalcin is involved in bone mineralization, while MGP prevents calcium deposition in arteries, thus maintaining vascular health.
Why is K2 important for the function of osteocalcin and MGP?
-K2 is a co-factor for the enzyme gamma-glutamyl carboxylase, which is responsible for the carboxylation of osteocalcin and MGP. This process confers a high affinity for calcium ions, allowing these proteins to effectively bind calcium and perform their roles in bone health and vascular protection.
What is the significance of the different forms of vitamin K2 (menaquinones) mentioned in the script?
-Different forms of K2, such as MK4 and MK7, have varying half-lives and roles in the body. MK4 is found in specific tissues and regulates gene expression involved in bone metabolism, while MK7 has a longer half-life and is effective in long-term regulation of calcium deposition in bones and preventing arterial calcification.
What is the video's stance on the advice given by a world-famous biohacker regarding the use of K2 supplements?
-The video strongly disagrees with the advice, stating that the biohacker lacks understanding and suggesting that most of the time, the advice given is not well-informed.
What is the recommended ratio of vitamin D3 to K2 supplementation according to the script?
-The script suggests that for every 10,000 units of D3, one should take one Super K supplement, which is a form of K2.
Why does the speaker believe that many doctors and researchers are poorly educated regarding vitamin D3 and K2?
-The speaker believes that many in the medical field are not aware of the importance of K2 activity and the roles of osteocalcin and Matrix GLA protein in calcium regulation, leading to conflicting study results and misguided supplement advice.
What are some dietary sources of K2 mentioned in the script?
-Dietary sources of K2 mentioned include animal tissues such as organ meats, chicken, beef, grass-fed pork, cheese, eggs, and duck.
What is the speaker's view on plant-based diets in relation to K2 intake?
-The speaker suggests that a plant-based diet may not be sufficient for obtaining K2, as it is primarily found in animal tissues, and implies that a carnivorous diet is more aligned with human nutritional needs for this vitamin.
What advice does the speaker give regarding the selection of K2 supplements?
-The speaker advises to choose a K2 supplement that clearly states it contains the trans form of MK7, as this is the natural form found in our diet. The speaker recommends Super K by Life Extension as it specifies that all the MK7 is in the trans form.
Outlines
🧪 Vitamin D3 and Calcium Controversy
The script begins by addressing the conflicting studies on the effects of Vitamin D3 and calcium intake on health. It discusses the potential for high Vitamin D3 intake to increase calcium levels in the blood, possibly leading to atherosclerosis, while calcium supplementation could either improve bone density or increase the risk of heart and artery problems. The speaker challenges the conventional wisdom on Vitamin D3 supplementation, arguing that the medical establishment's understanding is flawed. The video promises to delve into the complex relationship between Vitamin D3, calcium, and the role of Vitamin K2 in calcium metabolism, aiming to clarify the mechanisms and counteract misinformation.
🔬 The Role of Vitamin D3 and K2 in Calcium Metabolism
This paragraph delves into the biochemical processes involving Vitamin D3 and Vitamin K2, explaining their crucial roles in calcium absorption and distribution within the body. Vitamin D3 is described as enhancing calcium absorption from the gut and maintaining blood calcium levels, while also influencing the production of proteins that depend on Vitamin K2 for proper function. The paragraph introduces two key proteins, osteocalcin and Matrix GLA protein (MGP), which are essential for bone mineralization and preventing arterial calcification, respectively. The importance of Vitamin K2 in the carboxylation process, which allows these proteins to bind calcium effectively, is emphasized, highlighting the interconnectedness of these vitamins in maintaining cardiovascular and bone health.
🛡️ Preventing Arterial Calcification with Matrix GLA Protein
The focus shifts to Matrix GLA protein (MGP) and its function in preventing arterial calcification. MGP is portrayed as a guardian of arterial health by binding calcium and preventing its deposition in the arteries, thereby maintaining their flexibility and preventing the hardening associated with cardiovascular disease. The paragraph explains the molecular mechanisms by which MGP inhibits the growth of calcium phosphate crystals in the vascular system and impedes the transformation of smooth muscle cells into osteoblast-like cells, which are responsible for arterial calcification. The importance of adequate levels of active, carboxylated MGP for cardiovascular health is underscored, and the potential risks of low MGP levels are linked to cardiovascular disease.
🥩 Sources of Vitamin K2 and Supplementation Advice
The final paragraph discusses dietary sources of Vitamin K2, primarily found in animal tissues, and addresses the need for supplementation when dietary intake is insufficient. The speaker argues against plant-based diets in the context of obtaining essential nutrients like Vitamin K2. For those who require supplementation, the paragraph provides guidance on choosing the right form of Vitamin K2, specifically highlighting the importance of the trans form of MK7 found in nature. The speaker recommends a K2 supplement called Super K by Life Extension for its purity and quality, and offers a general guideline for supplementation based on the intake of Vitamin D3. The paragraph concludes with a cautionary note on the importance of personalized health management and the limitations of providing specific supplementation advice without individual assessment.
Mindmap
Keywords
💡Vitamin D3
💡Calcium
💡Hypercalcemia
💡Atherosclerosis
💡Vitamin K2
💡Osteocalcin
💡Matrix GLA Protein (MGP)
💡Carboxylation
💡Menaquinones
💡Supplementation
💡Personal Health Management
Highlights
Vitamin D3 supplementation can lead to hypercalcemia, which increases the risk of arterial hardening, yet some people with high D3 levels have normal calcium levels.
Vitamin D3 enhances calcium absorption in the gut by increasing calcium-binding proteins, which regulate calcium levels in the body.
K2 is essential for activating proteins like osteocalcin and Matrix GLA protein, which are crucial for proper calcium regulation and preventing calcification in arteries.
Osteocalcin, produced by osteoblasts, helps integrate calcium into the bone matrix, promoting bone mineralization and strength.
Matrix GLA protein prevents calcium from being deposited in arteries, helping to maintain arterial flexibility and prevent calcification.
There are different forms of K2, such as MK4 and MK7, which play distinct roles in calcium regulation, with MK7 being more systemic due to its longer half-life.
Supplementing with K2 is crucial when taking high doses of D3 to ensure calcium is directed to the right places and to prevent arterial calcification.
High D3 levels without corresponding K2 can lead to improper calcium regulation, increasing the risk of cardiovascular issues.
The presence of carboxylated proteins is essential for binding calcium and preventing its deposition in soft tissues.
MK4 is specific to certain organs, while MK7 is more effective for long-term calcium regulation across the entire body.
The wrong form of K2 in supplements (CIS vs. trans) can render the supplement ineffective, emphasizing the importance of choosing the right product.
Matrix GLA protein’s interaction with BMP2 is crucial for preventing vascular calcification by keeping smooth muscle cells in a non-calcified state.
Understanding the interaction between D3 and K2 is vital for creating safe supplementation regimes that prevent arterial calcification and promote bone health.
Many doctors and studies overlook the importance of K2 when evaluating the effects of D3, leading to conflicting results regarding calcium's impact on bones and arteries.
Supplementing with D3 and K2 should be based on individual health assessments, as improper dosing can lead to severe health issues.
Transcripts
some studies give people vitamin D3 and
it gives them too much calcium in their
blood increasing the risk of hardening
of the arteries like in atherosclerotic
heart disease some studies give calcium
and it could increase bone density while
someone else finds that it can increase
the risk of heart and or artery
problems how can that be how can D3
cause too much calcium in the blood as
an essential nutrient and studies show
that a higher calcium intake can lead to
both both arteries worsening and Bones
improving in different studies at the
same time if you take vitamin D3 you
need to pay attention to this video
because it can seriously help you make
sure that your heart and arteries aren't
at risk I'm going to go into quite a bit
of detail that I don't think any doctor
in the world has ever put out uh let
alone on YouTube that I know of anyway
and it's it's not going to be quick but
if someone you know takes D3 or yourself
sending them this video could help save
their heart and I know that's a bold
claim but if you watch all of it I think
you'll agree with me by the end see a
short while ago I was speaking at the
Royal College of physicians in London
there was someone there called Trevor
stain who started a skare company called
s he stood up at the front and he said
D3 supplementation is extremely
dangerous because it causes
hypercalcemia h honestly I was so Keen
to go up to the front and disagree but
luckily you know I withheld myself out
of respect and I I stayed where I was
but that statement is extremely
misleading and is a complete abomination
of statistical
inferencing you see he represents what
practically every doctor on the planet
says however regular viewers of this
channel know my blood tests are public
and specifically they show that I have a
dangerously high level of D3 now why
have I been told it's dangerously High
because it apparently causes
hypocalcemia but if that's the case how
is my calcium level perfectly normal if
the medical establishment is correct how
am I living proof that D3 doesn't cause
hypercalcemia I'll tell you how because
the daily recommended intakes the
medical guidelines and commonly accepted
nutritional advice is a complete load of
rubbish and if you think I'm some sort
of cons iracy theorist explained to me
how I have toxic D3 levels and no
hypercalcemia then and I'm not the only
one I'll get on screen here a scientific
paper of two case reports where two
people were taking an exceptionally high
dose of D3 every day now one had
hypervitaminosis with
hypercalcemia and the other was
absolutely fine how's it possible that
only one had a problem if D3 causes
hypercalcemia
what I'm going to teach you now should
have been taught in high school and at
the very least in medical school
obviously they weren't the video is for
my friend Nikki that was told by quite a
world famous biohacker in the world of
Health optimization to use a K2
supplement from Thorn which as you'll
see by the end of this video I think is
absolutely terrible now this biohacker
is a complete and has no idea what
he's talking about most of the time at
least calcium in the bones is perfectly
normal calcium in the arteries is
problematic in other words hypercalcemia
D3 causes activity in the Realms of
calcium regulation in the body the exact
mechanism when understood brings about
safety to each and every one of you that
supplements with it at home now ideally
you'd be getting D3 naturally but I
fully understand that that's not always
possible for some of you I certainly
trouble at times because I travel around
the world a lot and I never stop working
basically so let's take a closer look at
that
mechanism D3 and K2 play a crucial role
in calcium metabolism they work together
to ensure that calcium is efficiently
absorbed and directed to the appropriate
areas in the body such as bones and
teeth and away from soft tissues like
arteries where it can cause harm one of
the first things that D3 which is choc
calciferol does is enhance calcium
absorption it's converted into its
active form calat trial which is 125
dihydroxy vitamin D3 in the liver and
kidneys Now cal trial enhances the
absorption of calcium from the gut by
increasing the expression of calcium
binding proteins in the intestine in
other words D3 causes us to make
proteins that are used in binding
calcium around the body it can help us
to regulate this mineral this calcium
calci trial helps maintain calcium
levels in the blood by promoting calcium
reabsorption in the kidneys and
potentially mobilizing or unlocking
calcium from bones when necessary now
why would calcium need to be removed
from Bones surely that's a bad thing
well in certain circumstances like say a
sudden change in diet temporarily
sacrificing some calcium from the bones
for a short period of time and then
putting it back later can help tolerate
the sudden change of diet hopefully you
will never need to liberate calcium from
the bones but we have that ability if
needed as well as inducing the
production of calcium binding proteins
D3 also influences the expression of
other proteins that depend on
K2 so you got one set of proteins that
get made to meet up with calcium for
absorption and you got another set that
need to meet up with K2 in order to sort
that uh absorbed calcium because we've
got D3 present overarching the entire
regulation now the proteins which D3
makes that need to meet up with K2 are
really important to know and probably
very few if any of your doctors will
know anything about them osteocalcin and
Matrix GLA protein
MGP both of them need K2 to function
properly I'll explain what they are now
it's going to be quite detailed and you
may need to watch it several times but
it's wor worth it if it stops you or
someone you know getting blocked
arteries I'm going to give you a brief
intro to each of these two enzymes and
then later on I'll go into them in
detail so that you can argue against
anyone that tries to tell you they're
not important or that you you don't need
it alongside D3 or even to see whether
your doctor knows what they're talking
about so you can walk away if needed so
the first one is called
osteocalcin it's synthesized by Osteo
blasts which which are cells responsible
for forming bone matrix or bone
scaffolding called osteoid D3 binds
something called
vdr which is vitamin D receptor and this
causes the expression of the gene that
codes for osteocalcin osteocalcin
contains three GLA residues each capable
of binding a calcium ion now these
residues are located in the N terminal
region of the protein the left of the
protein if you like forming a really
high Affinity binding site for calcium
like a magnet the GL residues coordinate
with calcium ions through electrostatic
interactions because calcium ions are
positive and the
carboxilate keate the calcium ions and
that creates a stable complex That's
essential for the subsequent steps of
bone
mineralization the second one is Matrix
GLA protein it's a small protein made of
glutamic acid residues now once it gets
carboxilate again I'll go through what
that is in a second it turns into gas
carboxy glutamic acid residues and now
it can then bind calcium very well now
when these two link up with K2 there's a
process called carboxy as I just
mentioned K2 is a co-actor for an enzyme
called gam gluty carboxilate it's this
enzyme when it has its friend K2 around
that carboxilate the two previous
enzymes I've just mentioned carox is a
process by which a type of acid called a
carboxilic acid is produced by reacting
something with carbon dioxide the
reverse is called
decarbox where you remove a carbon ALC
group from a compound and release a
carbon
dioxide it's this
carox that allows osteocalcin and Matrix
GL protein to effectively bind calcium
to themselves this is because carox
confers a very high affinity for ca2+
ions calcium ions uncarboxylated
compounds lack this capability and so
they're less effective in bone
mineralization everything in biology is
is chemistry and physics so the way you
know someone knows what I'm talking
about is if they can go through it in
this scale of detail in the in the
chemical interaction size
scale so now we've seen how these
enzymes get activated by K2 it's
important to understand the different
types of K2 that can do this calcium
regulation and then I'll explain what
ostocalcium MGP actually do chemically
in detail because that's important to
know so there are multiple forms of K2
that exist they're known as menaquinones
and they come in quite a few different
sizes of their atomic structure to make
it easy they're actually given names
based on the size and and we get them
called things like MK4
MK5 blah blah blah so MK4 is the form
found in specific tissues like the brain
uh pancreas and arteries it's one of the
smaller ones and a smaller a mano
quinone is the shorter its halflife in
the body its lifespan in the body so MK4
has a short half life and it can
regulate gene expression involved in
bone metabolism as you now know mk7 is
another important one as you can tell
from Seven being bigger than four it's
uh a longer chain as a molecule because
it has a longer halflife too well it has
a longer half life because it's bigger
because of this it's effective in the
long longer term regulation of calcium
deposition in bones and preventing
calcification of arteries it works more
systemically around the whole body
unlike MK4 which is more organ specific
as I've said so I guess now that we
understand that D3 induces um the
production of osteocal a matrix GLA
protein and these two then depend on K2
to function properly what happens when
all of these boxes are ticked what's
actually happening inside your tissues
when you have the right combination of
of vitamins or or nutrients and Minerals
Well ocalin binds calcium and integrates
it into the bone matrix which promotes
the mineralization and strength of that
bone hydroxy appetite is the crystalline
form of calcium phosphate that
constitutes the inorganic component of
bone osteocalcin facilitates the
nucleation which is a formation of a of
a crystalline material from a solution
of hydroxyapetite crystals by binding
calcium ions and concentrating them in
specific regions of the osteoid or the
bone matrix this localized accumulation
of calcium creates a kind of favorable
environment for the formation of hydroxy
appetite which we also have in our teeth
hence why K2 is really important for
dental health too now once nucleation
occurs osteocalcin binds to these
growing hydroxy appetite crystals see
the protein structure allows it to
stabilize this crystal lattice and
promote the orderly deposition of
additional calcium and phosphate
ions so this process helps to increase
the size and density of these
hydroxyapetite crystals in the bone and
that's what enhances the mechanical
strength of that bone I know that's
complicated maybe for a lot of you even
actually to the Consultants that I've
taught that to for the first time um but
I advise you to watch it back several
times if you need to in order to
understand it noral Works in Contour
with other bone matrix proteins like um
Osteo
osteopontin uh bone cprotein
etc etc they also contribute to the
mineralization the regulation of calcium
deposition but if I go into those as
well this already long video is going to
be way too long for the average person
to not get a headache from so I can talk
about those in another video if if you
guys want now Matrix J protein on the
other hand prevents calcium from being
deposited in the arteries in order to
prevent vascular calcification and
improve artery health keeps it flexible
instead of rigid now it does this
because when it binds calcium it
prevents it from being deposited in the
arteries the calcium is trapped in a way
right when you hold a child's hand they
can't then go and run into the road
because you're holding them back um MGP
has a has a relatively complicated life
like osteocalcin which I'm going to
teach you
too it directly interacts with
hydroxyapetite which is again the
crystalline structure of calcium
phosphate and inhibits its nucleation
and growth but within the vascular
system now so the protein binds the
surface of young hydroxy appetite
crystals and prevents further growth and
propagation and this action is what
impedes the calcification process in the
initial or early stages now MGP does
this um by inhibiting the activ activity
of something called bmp2 which is a
signaling molecule that promotes oogenic
differentiation and calcification of
vascular smooth muscle cells so cells
that are making up Our arteries so by
binding to bmp2 MGP prevents it from
triggering Pathways that lead to the
transformation of these smooth muscle
cells into osteoblast like cells which
are responsible for depositing calcium
inside arterial walls now MGP plays a
crucial role in maintaining the state of
these smooth muscle cells preventing
their trans differentiation into other
types of cells that contribute to the
calcification process through its
inhibitory effects on bmp2 and other you
know calcification promoting factors MGP
helps keep vascular smooth muscle cells
in their contracted state which is
essential for normal vascular
function it also binds two extracellular
Matrix components bits outside the cell
in the vascular wall such as elastin and
collagen which are crucial sites for
calcium binding and deposition so
binding to the these ECM proteins it
also prevents calcium from anchoring to
The Matrix and forming calcified
deposits well they shouldn't be thereby
protecting the structural Integrity of
the blood vessel so adequate levels of
active carboxylated MGP uh Matrix G
protein are crucial for preventing
arterial calcification and maintaining
cardio Health low levels of carboxilate
MGP are associated with cardiovascular
disease so this is why some studies find
calcium supplementation gives artery
calcification and others find bone
density increases it's because the
researchers are so poorly educated that
they don't know about K2 activity and
ocalin and Matrix GL protein this is how
I have massively High D3 levels but my
calcium is absolutely fine because I
understand this pathway and understand
how to safely create supplement regimes
if needed if is the key word there by
the way the ideal diet shouldn't need
supplements on the whole So based on
that where do you find K2 which
supplements should I use if I need it
well men Quinones are found mainly in
animal tissues like organ Meats chicken
beef grass-fed pork cheese eggs duck I
think even geese so if you think humans
are designed to live plant-based then
you need to grow up frankly the fact
that this thing is essential and you get
it from animals should tell you
something and as you can probably guess
as a carnivore I'll be absolutely fine
but what if you do need a supplement
well first off that's a sign that
clearly your diet isn't sustaining you
and you need to change but if
supplements are needed for for whatever
reason then here's some
tips MK4 and 7 are the forms that you'll
find in in supplements the others like
MK 5 6 8 9 10 11 12 Etc you're not
really going to find those but here's
where people get scammed mk7 exists in
two forms CIS and trans I won't get into
isomerism chemistry with you because it
will confus the hell out of everyone but
just understand that there's two forms
CIS and trans the trans of form is the
type that's found in nature and in what
we eat this is why I don't need to worry
I'm always getting the right form on a
Carnival diet and there's no plant food
preventing the absorption because yes
plant food does prevent you absorbing
what's in the meat
uh now if a supplement says mk7 on the
back then some will be trans and some
will be assis if they don't say then
either they're too dumb to realize one
is more important than the other or
they've got a mixture and they don't
want to admit it that's why the best K2
supplement on the market in my view is
Super K by life extension before anyone
thinks it I have no affiliation with the
company at all and I have no affiliate
link either if you look on the back it
clearly states that all the mk7 is trans
and not CIS how much do you take well M
I suggest to my patients that for every
10,000 units of D3 they take one Super K
A Day so a patient of mine that is on
5,000 a day of of D3 they take one Super
K as well I can't give a recommendation
to you all because when I set the levels
for my patients I do it as part of uh
something called a a personal Health
Management Service where we get a lot of
tests like Bloods and body G done which
help me see what they need um they'll
come to me with things like obesity or
diabetes or polycystic overy syndrome or
epilepsy you know or something and they
say look I want you to make me better I
want you to make me healthy it's part of
a service I do um called personal health
disease longevity management and as part
of the Baseline measurements I'll see
the D3 level in the blood tests as well
as a load of other things so I can then
give a recommendation now if you ask me
in the comments how much D3 and K2 is
right for you honestly I'm I'm sorry but
it's literally impossible to say without
seeing you and examining you uh there is
data available from studies that look at
different doses of K2 and it's its
history and things like that um but this
video can't go on for hours and hours
unfortunately but hopefully this has
been educational um and uh hopefully it
has told you not to listen to the people
that give you supplement advice that
don't know these these things like sis
and trans and the different forms of
menaquinones
and uh hopefully I'll see you in the
next video see you soon
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