Pembuatan Tablet Salut (Coated Tablet Process)

Summary

This video provides a step-by-step guide on sugar coating tablets using a sub-coating pan. It explains the purpose of sugar coating, including protecting the drug, masking unpleasant taste, enhancing tablet appearance, and potentially influencing drug release. The process involves preparing the pan, applying a sugar-based solution containing polyglutamic acid and purified water, and carefully drying the tablets with hot air while maintaining rotation. The coating is applied repeatedly until tablets are fully covered, followed by oven drying for one day. Viewers are guided through each stage with clear instructions to ensure even, high-quality coating and optimal tablet presentation.

Takeaways

• 😀 Sugar coatings on tablets are generally water-soluble, allowing them to dissolve quickly in gastrointestinal fluids.
• 😀 One purpose of sugar coating is to protect the drug inside the tablet from external factors.
• 😀 Sugar coatings can mask the unpleasant taste of certain drugs, making them easier for patients to take.
• 😀 The coating can improve the appearance, color, and texture of tablets.
• 😀 Sugar coatings may also influence the release profile of the drug from the tablet.
• 😀 Before using the sub-coating pan, it must be prepared clean and dry.
• 😀 The sub-coating pan should be turned on to rotate continuously during the coating process.
• 😀 The sub-coating solution is poured onto the rotating tablets and then dried using hot air from a hairdryer.
• 😀 The coating process is repeated in cycles until the tablets are fully covered.
• 😀 After coating, the tablets are dried in an oven for one day to complete the process.
• 😀 The sub-coating solution typically contains sugar, polyglutamic acid, and water.

Q & A

What is the primary purpose of the sugar coating on tablets?

The sugar coating protects the drug inside the tablet from external factors, masks unpleasant taste, and can influence the tablet's release properties.

How does sugar coating affect the taste of the tablet?

Sugar coating can mask the unsavory or bitter taste of the drug, making it more palatable for patients.

What materials are used to make the sub-coating solution?

The sub-coating solution is made of sugar, polyglutamic acid, and aqua DES.

Why is it important to keep the sub-coating pan clean and dry before use?

A clean and dry pan ensures that the coating adheres evenly to the tablet surface and prevents contamination.

What role does rotation play in the sub-coating process?

Rotating the pan helps distribute the coating solution evenly across the tablet surfaces.

How is excess solution removed from the tablets during coating?

Excess solution is drained using hot air, often from a hairdryer, while the pan continues to rotate.

How many times should the coating and draining process be repeated?

The process should be repeated until the solution of sub-coating runs out and the tablet surface is fully covered.

What is the final step after coating the tablets?

The final step is to dry the coated tablets in an oven to ensure the coating is stable and set.

Can sugar coating influence the release of the drug in the body?

Yes, the sugar coating can affect how the tablet dissolves and releases the drug once ingested.

Why might color and texture be added to tablets via sugar coating?

Color and texture improve the tablet's appearance, making it more visually appealing and easier to identify.

Is sugar coating water-soluble, and why is that important?

Yes, sugar coating is water-soluble, which allows it to dissolve quickly when it comes into contact with gastrointestinal fluids.

What is the purpose of using polyglutamic acid in the coating solution?

Polyglutamic acid helps the sugar coating adhere better to the tablet surface and may enhance the durability of the coating.