Pharmaceutics Making solution (BTEC Pharmaceutical Science)

Summary

The video explains the process of preparing liquid solutions for both internal and external use, focusing on the proper handling of ingredients, solubility, and measurements. It highlights the importance of accurate dosing, using syringes and spoons for internal solutions, and the role of double-strength chloroform water as a preservative in certain formulations. Additionally, it covers the preparation steps, including the proper order of adding solutes, the tools required, and the importance of stirring and measuring to ensure consistency and accuracy in creating the final solution.

Takeaways

• 😀 Solutions are liquid mixtures with one or more soluble ingredients dissolved in a vehicle, typically water.
• 😀 Common internal solutions include those used for measuring accurate doses, typically with a 5 ml spoon.
• 😀 External solutions like mouthwashes, gargles, antiseptics, and lotions also follow similar preparation principles.
• 😀 Double-strength chloroform water is a common preservative in oral liquid dosage forms.
• 😀 Double-strength chloroform water is prepared by mixing 90 ml of water with 5 ml of concentrated chloroform water.
• 😀 Incorrect preparation of double-strength chloroform water can cause chloroform to separate, as it exceeds its solubility limit.
• 😀 Always add the solute to the solvent, not the other way around, to avoid precipitation of ingredients.
• 😀 When preparing a solution, it's important to pre-measure liquid ingredients using the smallest possible measuring instruments.
• 😀 Glass beakers are typically used for preparing solutions as they allow easy stirring and dissolution.
• 😀 Double-strength chloroform water must be used when preparing solutions that require it, and solutes should be added in order of their solubility.
• 😀 Solutions should be transferred to a suitable measuring container, rinsed with the solvent, and stirred well before transferring to the final dispensing bottle.

Q & A

What is a solution in the context of the transcript?

A solution is a liquid containing one or more soluble ingredients dissolved in a vehicle, usually water.

What is the typical vehicle used for internal solutions?

Water is typically used as the vehicle for internal solutions.

What is the purpose of a spoon in liquid dosage forms?

Spoons are designed to accurately measure a 5 milliliter dose of the solution.

Why is a syringe used for doses less than 5 milliliters?

A syringe is used when the dose is less than 5 milliliters to ensure precise measurement.

What is double-strength chloroform water and how is it prepared?

Double-strength chloroform water is a solution made with chloroform and water, often used as a preservative in oral liquid dosage forms. It is prepared by adding 5 milliliters of concentrated chloroform water to 90 milliliters of water and stirring to make up to 100 milliliters.

What happens if double-strength chloroform water is incorrectly prepared?

If prepared incorrectly, with the chloroform added first and then topped with potable water, the chloroform will precipitate out of the solution and settle at the bottom.

Why is it important to check the solubility of solid ingredients when preparing a solution?

Checking the solubility of solid ingredients ensures that they will dissolve properly in the vehicle, preventing issues with incomplete dissolution or precipitation.

What is the recommended order of adding solutes to a solution?

Solutes should be added in order of solubility, with the least soluble ingredient being added first.

Why should glass beakers be used when preparing solutions?

Glass beakers are suitable for preparing solutions because they allow easy stirring, which is essential for dissolving solutes effectively.

What should be done after transferring the solution to a conical measure?

After transferring the solution to the conical measure, the beaker should be rinsed with more vehicle, and the rinsing should be added to the solution in the measure.