The 5 Essential Supplements Everyone Should Be Taking - Dr Layne Norton

Chris Williamson
26 Jul 202412:18

Summary

TLDRIn this insightful discussion, the top-tier supplements for overall health and performance are explored. Creatine monohydrate and caffeine lead the list, backed by extensive research for their benefits in enhancing strength, cognitive performance, and even mood. Whey protein earns its place for improving body composition, while rhodiola, ashwagandha, and beta-alanine are highlighted for their potential in reducing fatigue and boosting work capacity. The conversation delves into optimal dosages, timing, and the importance of understanding mechanisms behind supplement efficacy.

Takeaways

  • 💪 Creatine monohydrate is highly recommended for its benefits, including increased lean mass, strength, performance, and potential cognitive benefits. It's a well-researched, safe, and low-cost supplement.
  • ☕ Caffeine is a powerful nootropic and performance enhancer. It boosts cognitive and exercise performance, but it can negatively impact sleep, so it's best consumed earlier in the day.
  • 😴 Caffeine tolerance can be reset in about a week by going cold turkey, though withdrawal symptoms like headaches and fatigue are common during this period.
  • 🥤 Whey protein is a versatile, bioavailable protein source that improves body composition. Whey isolate is recommended for those with lactose sensitivity, while whey concentrate is cheaper but contains more carbs, fats, and lactose.
  • 🔬 Rhodiola rosea is beneficial for reducing fatigue and improving cognitive function, with optimal dosages ranging from 150 to 450 mg.
  • 🏋️ Ashwagandha has been shown to increase strength, lean mass, reduce cortisol, and modestly elevate testosterone. Typical dosages range from 300 to 600 mg.
  • 🌿 Beta-alanine and citrulline malate are useful for improving fatigue resistance and performance, though more research is needed.
  • 🤔 Despite some concerns about mechanisms, ashwagandha is believed to provide benefits beyond what is explained by its impact on cortisol and testosterone.
  • 📊 The speaker emphasizes that thousands of studies back creatine's benefits, highlighting its safety and efficacy over decades of research.
  • 🧠 Caffeine's analgesic effects are noted, and the potential for healthy user bias in studies correlating caffeine use with better recovery and sleep is discussed.

Q & A

  • What is the speaker's top recommended supplement and why?

    -The speaker's top recommended supplement is creatine monohydrate. It is recommended because it increases lean mass, improves strength, enhances performance, and may have cognitive benefits. It's also safe, low-cost, and backed by thousands of studies over decades.

  • What are the potential side effects of creatine, and how does the speaker address them?

    -The potential side effect mentioned is hair loss, based on a 2009 study that showed creatine supplementation increased DHT levels. However, the speaker dismisses this as not proven, as the study did not show a viable mechanism, and the results have not been replicated.

  • How does caffeine benefit cognitive and physical performance?

    -Caffeine is described as the original nootropic and performance enhancer. It increases cognitive performance and exercise performance, making it useful for both mental and physical activities.

  • What are the potential downsides of caffeine consumption?

    -The main downside of caffeine consumption is its negative impact on sleep. It is recommended to take caffeine earlier in the day to avoid disrupting sleep.

  • What is the suggested dosage of caffeine for different purposes?

    -For anti-fatigue benefits, as little as 50-100 milligrams may suffice. For performance benefits, around 200-300 milligrams is suggested, and for acute strength benefits, 300-600 milligrams may be effective.

  • How does the speaker describe the relationship between caffeine and dependency?

    -The speaker acknowledges that caffeine dependency can develop, with withdrawal symptoms such as headaches and fatigue. They recommend tapering off caffeine gradually to minimize discomfort.

  • Why does the speaker include whey protein in their recommended supplements?

    -Whey protein is included because it is a tasty, relatively cheap, and highly bioavailable form of protein that has been shown to improve body composition.

  • What are the differences between whey protein concentrate and isolate?

    -Whey protein concentrate is cheaper, contains more carbs and fats, and may not be well-tolerated by those sensitive to lactose. Whey protein isolate is more expensive, better tolerated by people with lactose sensitivity, and generally mixes better.

  • What are some other supplements mentioned by the speaker that they feel are beneficial?

    -The speaker mentions several other beneficial supplements including Rhodiola Rosea, beta-alanine, citrulline malate, ginseng, and ashwagandha. These are considered lower-tier but still show promise in improving performance and reducing fatigue.

  • What concerns does the speaker have about ashwagandha despite its positive effects?

    -The speaker is concerned about the lack of a clear mechanism behind ashwagandha's benefits, particularly in increasing strength, lean mass, and reducing cortisol. They express caution whenever outcomes are observed without a known mechanism.

Outlines

00:00

💊 Essential Supplements Everyone Should Consider

This paragraph discusses the 'Mount Rushmore' of supplements, with a focus on creatine monohydrate. Creatine is highlighted as a safe and extensively studied supplement, known for increasing lean mass, strength, and cognitive performance. The speaker debunks the myth that creatine causes hair loss, explaining that the claim is based on a single, unreplicated study. They emphasize that creatine's benefits are well-supported by thousands of studies worldwide. Caffeine is also introduced as another key supplement, praised for enhancing cognitive and exercise performance, though it's noted that it can negatively affect sleep if consumed later in the day.

05:03

☕ Caffeine: Benefits, Dosage, and Dependency

The focus shifts to caffeine, discussing its benefits, optimal dosage, and the potential for dependency. Caffeine is acknowledged for its performance-enhancing effects, especially at higher doses, though it can lead to withdrawal symptoms when consumption is reduced. The speaker shares personal experiences of tapering caffeine intake before competitions, noting its slight analgesic effects. The paragraph also touches on the ability to reset caffeine tolerance within a week, though this process can cause discomfort.

10:05

🧬 Whey Protein and Other Tier Two Supplements

This paragraph explores whey protein as another foundational supplement, noting its affordability, taste, and effectiveness in improving body composition. Different forms of whey, such as isolate and concentrate, are compared, with recommendations based on lactose tolerance. The discussion then moves to 'Tier Two' supplements like Rhodiola Rosea, beta-alanine, citrulline malate, and ashwagandha, which show promising benefits but require more research. Dosage recommendations for these supplements are also provided, along with a brief commentary on the mechanisms behind their effects.

Mindmap

Keywords

💡Creatine Monohydrate

Creatine monohydrate is a popular supplement known for enhancing muscle mass, strength, and exercise performance. In the video, it is highlighted as a 'Mount Rushmore' supplement due to its widespread benefits, including improved cognitive function and potential effects on depression. The discussion emphasizes its safety, with thousands of studies supporting its use, and debunks myths such as its alleged link to hair loss.

💡Caffeine

Caffeine is a stimulant widely recognized for its ability to boost cognitive and physical performance. It is described as the 'original nootropic' and a crucial supplement for enhancing focus and exercise outcomes. The video discusses the optimal timing and dosage for caffeine intake, noting its impact on sleep and potential for dependency. Despite these downsides, caffeine is credited with significant benefits, including its role in reducing fatigue and improving strength during workouts.

💡Whey Protein

Whey protein is a high-quality, bioavailable protein supplement that is widely used to improve body composition by supporting muscle growth and recovery. The video includes it in the top tier of essential supplements, praising its affordability, taste, and effectiveness. Different forms of whey protein, such as isolate and concentrate, are discussed, with considerations for lactose intolerance and specific benefits related to antioxidant status.

💡Supplement Tiers

The concept of 'supplement tiers' refers to the categorization of supplements based on their effectiveness, safety, and research backing. In the video, the speaker organizes supplements into tiers, with the 'Mount Rushmore' tier including the most reliable and well-researched options like creatine, caffeine, and whey protein. The second tier includes supplements with potential benefits but less extensive research, such as beta-alanine, citrulline malate, and ashwagandha.

💡Beta-Alanine

Beta-alanine is a supplement that is known for its role in improving exercise performance by delaying muscle fatigue. It is mentioned in the video as part of the second tier of supplements, with particular reference to its popularity in the fitness community, partly due to endorsements by athletes. The supplement is noted for its ability to enhance endurance during high-intensity workouts.

💡Ashwagandha

Ashwagandha is an adaptogenic herb used to manage stress and improve strength, lean mass, and overall well-being. The video discusses its inclusion in the second tier of supplements, noting its ability to reduce cortisol levels and modestly elevate testosterone. Although it has shown promising results in increasing lean mass and strength, the exact mechanisms remain unclear, prompting a cautious but optimistic view.

💡Adaptogens

Adaptogens are natural substances that help the body adapt to stress and restore balance. In the video, both rhodiola and ashwagandha are cited as examples of adaptogens, praised for their ability to improve fatigue resistance and cognitive function. These supplements are said to 'put you back to center,' making them valuable for maintaining mental and physical performance under stress.

💡Citrulline Malate

Citrulline malate is a supplement known for its ability to enhance exercise performance by reducing fatigue and potentially stimulating mTOR, a key pathway for muscle growth. In the video, it is discussed within the context of the second tier of supplements, with an emphasis on its performance-enhancing effects during workouts and its possible anabolic properties.

💡Supplement Mechanisms

Supplement mechanisms refer to the biological processes through which supplements exert their effects on the body. The video touches on the importance of understanding these mechanisms, especially for supplements like ashwagandha, where the outcomes (e.g., increased lean mass) are evident, but the exact biological processes are not fully understood. This highlights the need for further research to elucidate how certain supplements achieve their benefits.

💡Healthy User Bias

Healthy user bias is a type of bias where individuals who engage in healthy behaviors, like using supplements or wearables, might also engage in other health-promoting activities, skewing the perceived effectiveness of the supplements. The video suggests that the positive sleep and recovery data associated with caffeine use from wearable device users might be influenced by this bias, as these individuals are likely also exercising more and maintaining healthier lifestyles.

Highlights

Creatine monohydrate is considered a must-have supplement due to its extensive research supporting benefits like increased lean mass, improved strength, enhanced performance, and cognitive benefits.

Despite concerns, creatine is safe, with a large body of evidence debunking myths about hair loss, which originated from a single unreplicated study in 2009.

Creatine also shows potential in treating depression, with effects comparable to SSRIs, making it a low-cost, high-yield supplement with diverse benefits.

Caffeine is praised for its cognitive and exercise performance-enhancing effects, although it can negatively impact sleep if consumed later in the day.

Interesting data from WHOOP suggests caffeine consumption is linked to better recovery and sleep quality, though this may be influenced by confounding factors like healthier lifestyles among users.

Caffeine dosage varies depending on the desired effect: 50-100 mg for anti-fatigue, 200-300 mg for performance benefits, and 300-600 mg for acute strength gains.

Caffeine withdrawal can cause symptoms like headaches and fatigue, but tolerance can be reset within a week by going cold turkey.

Whey protein is another essential supplement, valued for its taste, affordability, and ability to improve body composition. Whey isolate is recommended for those with lactose sensitivity.

Whey protein concentrate contains beneficial components that positively influence glutathione and antioxidant status, though it may cause digestive issues for some.

Beta-alanine, citrulline malate, and ashwagandha are mentioned as beneficial supplements with good research backing, but more long-term studies are needed.

Ashwagandha is noted for increasing strength, lean mass, reducing cortisol, and modestly boosting testosterone, but the exact mechanism remains unclear.

Rhodiola Rosea is recommended for its adaptogenic properties, enhancing fatigue resistance and cognitive performance, with effective dosages ranging from 50 to 450 mg.

Citrulline malate is highlighted for its potential to improve fatigue resistance and may have a small anabolic effect by stimulating mTOR.

The speaker expresses interest in further understanding the mechanisms behind supplements like ashwagandha, especially when significant benefits are observed without clear explanations.

Creatine, caffeine, and whey protein are emphasized as foundational supplements with substantial evidence supporting their efficacy, while other supplements like ashwagandha and Rhodiola Rosea are considered beneficial but require more research.

Transcripts

play00:00

what are supplements that everybody

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should have in their stack on average do

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you think what are the supplements that

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really work okay so I kind of like

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Branch these into like tiers right so my

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Mount Rushmore of supplements would be

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uh creatin monohydrate would be number

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one um dosage frequency five grams a day

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there may be evidence that like 10 or

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even maybe a little bit more has

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cognitive benefits Tim Farris been

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talking about that yeah so it's very

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safe I mean there are people who have

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been hand ringing about creatin for a

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long time and the the worst thing that

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you can say about it is people say Well

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it causes hair loss no there was a

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single study in 2009 that showed creatin

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supplementation increased DHT that is

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not the same thing as showing hair loss

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DHT is a marker and that is a mechanism

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now that's never been replicated and

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they didn't show a viable mechanism by

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which it does it because the

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the the their testosterone levels didn't

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change which is the precursor and then

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the in the the the product after DHT

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didn't change so either creatin is

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having some direct effect on this enzyme

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or this is a data artifact that has not

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been

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replicated I tend to lean towards the

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ladder um so creatin monohydrate

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increases lean mass improves strength

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improves performance performance

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improves cognitive performance it has

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been shown to have a similar effect on

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depression as

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ssris I'm not saying for people to do

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use cre come off your SSR and switch it

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out for cre I'm just saying that this

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seems to have some really ubiquitous

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benefits so and even like some of the

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more disease States we starting to see

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some benefits for creating

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supplementation so I'm not saying

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everybody should be on it but it is a

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lowcost high yield supplement that is

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very safe and we're not talking about a

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couple studies we are talking about

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thousands of studies done over decades

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in Labs all over the world I am very

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confident um now caffeine caffeine is

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the original neut Tropic it is the

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original performance enhancer um and if

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you look at the benefits of caffeine

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increases cognitive performance

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increases exercise performance um

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downsides negatively impacts sleep so if

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you're going to take it do it earli in

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the day preferably unless you've got a

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podcast yeah uh you know what one of the

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wildest Things is uh whoop release a uh

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aggregated set of their data at the end

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of each year and on whoop you can track

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behaviors and it will correlate those

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behaviors with outcomes that you get HIV

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resting heart rate sleep sleep quality

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duration blah blah blah one of the best

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predictors of good recovery and sleep

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was caffeine

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interesting yeah so that and that's

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likees tens of thousands of people

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that's interesting so this could be a

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case where you know there's confounding

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variables of perhaps people who are

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taking in more caffeine are exercising

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harder and that's helping them get

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better sleep right that's interesting so

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there's obviously like I mean we know

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based on the mechanistic human

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randomized control trials that caffeine

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negatively impacts sleep I wonder what

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about is there a potential that you've

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got kind of like a healthy user bias

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here with people that doing whoop know

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that You' got a 9 hour half life for

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caffeine so maybe they're pumping a

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couple in a morning and then by the time

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that they get to an evening time that

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adenosine is yeah I mean I I think um

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what's probably the most likely outcome

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is some sort of healthy user bias with

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people who are using wearables also

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taking a lot of caffeine probably more

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likely to exercise and have other

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healthy lifestyle behaviors but why

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would all of the people that are using

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whoop are using whoop like it's

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interesting it's something I I try and

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reach out to the guys and get a little

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bit more data I could send that to you

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all right so creatine caffeine for

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caffeine uh couple of questions first

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off there's no real like Optimal dosage

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but what do you think about when it

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comes to dosage what do you think about

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when it comes to timing and what do you

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think about when it comes to dependency

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so obviously earlier in the day is going

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to be better for Sleep based on what we

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know um as far as dosage I mean you get

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some anti- fatigue benefits like 50 100

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milligrams you get get start to get the

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performance benefits once you get up

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around 2 300 milligrams of caffeine like

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for

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exercise strength benefits like acute

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strength benefits are more like 3 to 600

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milligrams of caffeine Christ so I mean

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I'm I'm a a pretty big fan of caffeine

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and before the meat on Saturday I'll

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probably have about a nice 5 600

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milligram shot right at the beginning

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and I'll probably have a 200 milligram

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boost which I'm lifting in prime time at

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600 p.m. so I probably won't be sleeping

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real great that night but that's okay

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just one night um so yeah for the for

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the more like standout kind of

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performance

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benefits um you know you got to get a

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little bit higher dosage dependency yeah

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I mean you can definitely get I mean

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there are absolutely caffeine withdrawal

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symptoms I go through them whenever I

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start tapering off for a meat because

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I'll usually taper down to I used to

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completely cut it cold turkey and I just

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found that that was intolerable so I go

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down to about 100 milligrams a day uh

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because actually the other thing people

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don't realize in I found I'm like when I

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cut out caffeine completely I started

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like feeling like aches and pains and

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stuff it's actually a slight uh

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analgesic it has a slight analgesic

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effect and I started getting all these

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like like feeling why am I like having

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like back pain that I haven't had before

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the other things and when I just went

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down to kind like 100 milligrams a day

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to kind of like just maintain um I

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noticed that that stuff went away all

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right

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caffeine um one other thing to add you

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you can completely reset your caffeine

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tolerance in about a week if you go cold

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turkey but you're going to feel pretty

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miserable for a couple days it's it's I

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mean I thought it I thought it was a

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placebo thing and then I did it and I

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was like why does my head hurt and why

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am I so freaking tired and then my ex

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was like you haven't had caffeine in two

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days duh I'm like oh yeah duh uh creatin

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caffeine whey protein uh whey protein

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tasty relatively cheap

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soluble um been shown to improve body

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composition numerous times it's not

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magic it's just a very tasty kind of

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ubiquitous form of protein that's highly

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bioavailable so I put it on my Mount

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Rush isolate concentrate concentrates

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perfectly fine in fact there may be some

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benefits to concentrate in that it has

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uh some of the um uh some of the

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components that positively influence

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glutathione and antioxidant status um

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but a lot of people don't tolerate a

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pure concentrate well

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um because there's lacto there's quite a

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bit of lactose in it and um some people

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have sensitivities to the lactalbumin in

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way uh a we isolate is going to

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basically eliminate the lactose so if

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you have any kind of lactose sensitivity

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most people tolerate whe isolate like um

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my company outwork nutrition the protein

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we sell is a whe isolate people like is

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is that because it's more anabolic than

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concentrate I'm like no we just want to

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make sure that almost anybody could use

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our protein uh it is more expensive

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typically mix is better too so there's

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just there's trade-offs uh weight

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concentrates cheaper but there's more

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carbs and fats and more

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lactose uh if you don't tolerate either

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of those well then a way hydrate will

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probably work for you which is basically

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pre-digested way so they've chopped up

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The lactal Bu tastes it does not taste

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very good and it's expensive but it it

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will work well for somebody who can't

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tolerate the lactalbumin in a way and

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then we go down to like my tier two

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which is stuff that I feel strongly is

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beneficial uh but I just want to see

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like more research done over a greater

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period of time and those would be things

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like uh rodol Rosa um uh things like

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beta alanine citrine malite um Jin sing

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actually has quite a bit of good

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research on it naming the ingredient

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profile of neonic here I'm just there we

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are yeah there it is that's what we're

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here for baby that's what we're here for

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uh uh B ashwaganda ashwaganda another

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one so B ranine everyone went crazy for

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that when Matt Fraser said on Rogan that

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that was maybe it was Rogan or something

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else he basically retired from Crossfit

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and said that I think he was taking like

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some obsurd amount of berer alanine and

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attributed a lot of his sort of

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increased work capacity acutely to that

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um was citrine malet in there was that

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one of the ones you just said yeah yeah

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why uh fatigue resistance it also seems

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to there's some studies suggesting it

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may simulate mour that may be a small

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anabolic effect we don't know if that's

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like independent of other things that

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stimulate him tour but it seems to incre

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improve performance uh and improve

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fatigue resistance just going through

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what we went through there the uh Rola

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the jinang the uh citrine berer alanine

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and the ashwaganda have you got dosages

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that you prefer for yourself with those

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yeah so Rola it seems like anywhere from

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like 150 milligram to 450 milligram and

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then after that it actually seems to be

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like a a kind of shap off end shape yeah

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um you know we

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um actually even as low as 50 milligrams

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there might be some benefits as well but

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if you want like the like there's some

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studies that show like uh actual

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decreased fatigue and actually decreased

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perception of fatigue as well as well as

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like uh cognition benefits and it seems

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to be like a very um we call an

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adaptogen ashwag is kind of like that as

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well so it kind of

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um puts you back to Center for lack of a

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better term

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um but yeah some good data on fatigue

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resistance for that uh

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ashwaganda oh man dosage why did it

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escaped my mind just now I think that's

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actually uh about 150 to 300 milligrams

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or sorry 300 to 600 milligrams for

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ashonda

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um that's uh in our recovery product and

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downside to that is doesn't mix super

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well um when you when you mix up our

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recovery product it tastes great but it

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kind of looks like uh Beach water a

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little bit um because of the the

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sediment but the

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ashwaganda it's interesting

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because I'm convinced pretty convinced

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because there's been quite a few studies

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now showing reliably it increases

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strength lean mass um and decreases

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cortisol and modestly elevates

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testosterone but the effects of on

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cortisol and testosterone would not be

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enough to show those lean mass benefits

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so my one hesitation is I kind of want

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to know what theck mechanism yeah what

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the mechanism is for that cuz whenever I

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see an outcome but we don't know the

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mechanism I kind of get the heebie

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jeebies yeah we'll get back to talking

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