Why Your Coffee Habit Might Be Better Than You Think - Dr Bryan Saunders

Dr Karan Explores Podcast
5 Jul 202451:23

Summary

TLDRIn this informative podcast, Dr. Brian Saunders, a caffeine expert, dispels myths surrounding coffee consumption and its effects on health and sleep. He discusses the benefits of caffeine for exercise performance, the impact of timing on its effects, and the role of adenosine receptors. Saunders also addresses the placebo effect of coffee rituals and the potential for tolerance due to habitual consumption. The episode provides insights into optimal caffeine dosage for performance enhancement and the importance of considering individual responses to caffeine.

Takeaways

  • ☕ Caffeine is a potent stimulant that can enhance exercise performance, improve muscle strength, power, and endurance, and is considered one of the most effective supplements for this purpose.
  • 🛌 Contrary to some beliefs, there is no strong scientific evidence that drinking coffee or caffeine early in the morning negatively impacts sleep due to cortisol levels.
  • 🤔 The idea of timing caffeine intake based on cortisol levels to avoid an 'afternoon crash' is not supported by evidence; individual responses to caffeine vary.
  • 🔍 Caffeine works by blocking adenosine receptors in the brain, which would normally promote sleepiness and suppress arousal, leading to increased alertness and wakefulness.
  • 💊 Caffeine's effects can be felt even at lower doses, but the optimal dose for exercise performance enhancement is between three to six milligrams per kilogram of body mass.
  • 🏋️‍♂️ For those using caffeine to boost workout performance, consuming it about an hour before exercise can be beneficial, though the exact timing may vary based on individual response.
  • 🚫 High caffeine intake can lead to negative side effects such as increased heart rate, blood pressure, anxiety, and digestive issues, and can potentially be lethal in extremely high doses.
  • 🌱 The source and preparation of coffee can significantly affect caffeine content, with variables like coffee bean type, growing location, and brewing method impacting the amount of caffeine in a cup.
  • 🧬 Genetic variations in how individuals metabolize caffeine do not strongly correlate with perceived effects on mood or arousal, suggesting other factors are at play.
  • 🔄 While habitual caffeine consumers may develop tolerance, meaning they need more caffeine to achieve the same effect, the performance benefits of caffeine for exercise do not appear to be significantly reduced.
  • 📉 Caffeine can have a negative impact on sleep quality, regardless of an individual's perception of its effects, and avoiding caffeine close to bedtime (approximately 9 hours before for regular coffee or 13 hours for high doses) can help mitigate this.

Q & A

  • Is it true that you shouldn't drink coffee first thing in the morning due to cortisol levels?

    -There is no strong scientific evidence to support the idea that drinking coffee first thing in the morning is detrimental due to cortisol levels. Caffeine works by blocking adenosine receptors, and the timing of coffee consumption may not significantly impact its effectiveness.

  • Can caffeine negatively impact sleep regardless of an individual's perception?

    -Yes, caffeine can have a negative impact on sleep by blocking adenosine receptors, which play a role in the sleep-wake cycle. Studies suggest that individuals may underestimate the negative effects of caffeine on their sleep, even if they feel they sleep well after consuming caffeine.

  • What role does caffeine play in enhancing exercise performance?

    -Caffeine is considered a very effective supplement for enhancing exercise performance. It can improve muscle strength, power, and endurance, allowing individuals to lift heavier loads and perform more repetitions.

  • Is there a specific time to stop drinking coffee to avoid sleep disruption?

    -Research suggests that to minimize caffeine's effects on sleep, it's best to avoid consuming coffee about nine hours prior to sleep for regular doses and 13 hours prior for larger doses, such as those found in pre-workout supplements.

  • Can coffee or caffeine consumption be beneficial for health outcomes?

    -Data generally suggests that moderate caffeine consumption can be beneficial for various health outcomes, including potential benefits for gut health, cardiovascular health, and liver protection due to antioxidants present in coffee.

  • What is the potential impact of caffeine on adenosine receptors and how might this relate to tolerance?

    -Caffeine, being structurally similar to adenosine, can bind to adenosine receptors and block their inhibitory effects. Over time, with regular caffeine consumption, the body may increase the number of adenosine receptors as a compensatory mechanism, which could lead to tolerance and reduced stimulatory effects of caffeine.

  • Is there a significant placebo effect associated with drinking coffee?

    -Yes, there is evidence of a significant placebo effect with coffee consumption. The expectation of receiving caffeine and the ritual of drinking coffee can contribute to increased arousal and alertness, even beyond the direct physiological effects of caffeine.

  • Can the benefits of caffeine for exercise performance be negated by habitual consumption?

    -Some studies suggest that habitual caffeine consumption may reduce the performance-enhancing effects of caffeine, while others show no significant difference. The exact impact may depend on the dose of caffeine provided before exercise and individual differences.

  • What is the recommended dosage of caffeine for enhancing exercise performance?

    -The literature suggests a dosage of three to six milligrams per kilogram of body mass for enhancing exercise performance. For a 70-kilogram individual, this equates to about 210 to 420 milligrams of caffeine.

  • Can the timing of caffeine ingestion before a workout impact its effectiveness?

    -While there is no definitive data suggesting an optimal timing for peak performance, caffeine typically takes about 30 to 60 minutes to enter the bloodstream and start taking effect. For short workouts, ingesting caffeine about an hour before may be beneficial.

  • What are some potential side effects of consuming caffeine beyond the recommended safe dose?

    -Exceeding the safe dose of caffeine can lead to increased blood pressure, heart rate, anxiety, sweating, palpitations, and gastrointestinal issues such as diarrhea or stomach upsets. Extremely high doses can be toxic and, in rare cases, fatal.

Outlines

00:00

🚫 Caffeine Misconceptions Debunked

This paragraph addresses common misconceptions about caffeine, such as the belief that it should not be consumed first thing in the morning due to cortisol levels. It introduces Dr. Brian Saunders, a caffeine expert, who discusses the benefits of caffeine for health and exercise performance. The paragraph emphasizes that while there is a lot of misinformation about caffeine, scientific research generally supports its positive effects, especially when consumed in reasonable amounts.

05:00

🕒 Clarifying Caffeine Timing Myths

The paragraph delves into the myth about the ideal time to consume caffeine, specifically the idea that drinking coffee first thing in the morning is less effective due to cortisol levels. Dr. Saunders explains the role of adenosine and how caffeine works as an antagonist to it, leading to increased arousal and wakefulness. The paragraph concludes that there is no strong evidence to support the idea that caffeine consumption should be timed with cortisol peaks to avoid an afternoon crash.

10:01

🔍 The Science of Caffeine Tolerance

This section explores why some people may feel sleepy or tired after consuming caffeine, possibly due to genetic differences in liver enzymes that metabolize caffeine. It discusses the possibility of upregulation of adenosine receptors in the brain with habitual caffeine consumption, leading to a reduced response to caffeine over time. The paragraph highlights the need for more research to understand individual reactions to caffeine fully.

15:03

☕️ Coffee's Cognitive and Ritualistic Benefits

The paragraph examines the potential placebo effect of coffee and the ritualistic aspects of drinking it, suggesting that these factors might contribute to the perceived alertness and energy boost. It discusses a study that compared the effects of caffeine in water versus coffee on brain activity, indicating that coffee might have a broader impact on cognitive functions, possibly due to the sensory experience and anticipation associated with its consumption.

20:05

💪 Caffeine's Impact on Exercise Performance

This section highlights caffeine's role as an effective supplement for enhancing various types of exercise performance, from short-duration sprints to long-endurance activities. It explains the mechanisms by which caffeine improves performance, such as increasing adrenaline and noradrenaline, blood flow, and glucose availability to muscles, as well as reducing the perception of effort during exercise.

25:05

⏰ Optimal Timing for Caffeine Ingestion

The paragraph discusses the timing of caffeine ingestion in relation to workout schedules. It suggests that while there is no definitive peak time for caffeine to enhance performance, it generally takes 30 to 60 minutes for caffeine to enter the bloodstream and start taking effect. The paragraph advises consuming caffeine an hour before a workout for short sessions and considering the half-life of caffeine for longer workouts.

30:08

⚠️ Warning Signs of Caffeine Overconsumption

This section warns of the potential side effects of excessive caffeine consumption, such as increased heart rate, blood pressure, anxiety, and gastrointestinal issues. It emphasizes the importance of adhering to safe caffeine limits to avoid negative health impacts and suggests that individuals be aware of the total caffeine intake from various sources, including energy drinks and pre-workout supplements.

35:08

🛑 Paradoxical Effects of Caffeine Intake

The paragraph investigates the paradoxical effect of caffeine, where some individuals feel more tired after consumption. It discusses the role of genetics in caffeine metabolism and the potential for upregulation of adenosine receptors with habitual use, which could diminish the stimulating effects of caffeine over time.

40:11

🔄 Resetting Caffeine Tolerance

This section explores the concept of caffeine tolerance and the potential benefits of a caffeine fasting period to reset the body's sensitivity to caffeine. It presents conflicting research findings on the impact of habitual caffeine consumption on the effectiveness of caffeine for exercise performance, suggesting that a higher dose before exercise might be necessary for those with higher daily caffeine intake.

45:12

🌙 Caffeine's Effect on Sleep Quality

The paragraph discusses caffeine's impact on sleep, noting that it can negatively affect sleep quality regardless of an individual's perception. It references a meta-analysis suggesting that avoiding caffeine intake approximately nine to 13 hours before sleep can minimize its effects on sleep, emphasizing the importance of being mindful of caffeine consumption, especially in the afternoon.

50:15

☕️ The Coffee Nap: Fact or Fiction?

This section examines the concept of the 'coffee nap,' where individuals consume coffee and then nap before the caffeine fully takes effect. The paragraph suggests that while this practice seems logical, there is a lack of scientific evidence to support its effectiveness, and personal experiences may vary.

🌱 Factors Affecting Coffee's Caffeine Content

The paragraph explores the factors that influence the caffeine content in coffee, such as the type of beans, their source, and the brewing process. It highlights the variability in caffeine levels between different coffee preparations and the difficulty in standardizing caffeine content, even in commercial coffee shops and pre-packaged coffee pods.

🌍 Global Impact of Coffee Consumption

The final paragraph emphasizes the widespread consumption of coffee as the second most consumed drink worldwide after water. It acknowledges the lack of awareness among consumers about the complex effects of caffeine on the body and the importance of understanding these effects for everyday health and well-being.

Mindmap

Keywords

💡Caffeine

Caffeine is a natural stimulant that is commonly found in coffee, tea, and other beverages. It works by blocking adenosine receptors in the brain, which helps to increase alertness and reduce the feeling of sleepiness. In the video, caffeine is discussed as a significant component of coffee that can enhance exercise performance and has various health benefits. The script mentions that caffeine can improve muscle strength, power, and endurance, and also discusses its potential negative effects on sleep.

💡Adenosine

Adenosine is a compound in the body that rises throughout the day and plays a crucial role in the sleep-wake cycle. It is an inhibitory neurotransmitter that promotes sleepiness and suppresses arousal. Caffeine mimics the structure of adenosine and binds to its receptors, thereby blocking its effects and increasing wakefulness. The script discusses adenosine in the context of why caffeine can be effective in the morning and whether it should be consumed immediately upon waking or later.

💡Exercise Performance

Exercise performance refers to the efficiency and effectiveness of an individual's physical activity, such as running, cycling, or weightlifting. The script highlights that caffeine is a potent supplement for enhancing exercise performance across various activities. It mentions that caffeine can improve muscle strength, power, and endurance, making it beneficial for both short and long-duration exercises.

💡Cortisol

Cortisol is a hormone that plays a role in the body's response to stress and is naturally elevated in the morning. The script discusses the idea that caffeine might interfere with the natural peak of cortisol, suggesting that waiting to consume caffeine until after this peak could be beneficial. However, the speaker notes that there is no strong evidence to support this theory.

💡Caffeine Tolerance

Caffeine tolerance refers to the reduced response to caffeine over time due to regular consumption. The script mentions that habitual caffeine users might experience a decrease in the stimulatory effects of caffeine, potentially due to an upregulation of adenosine receptors in the brain. This concept is relevant to discussions about the effectiveness of caffeine for exercise performance and the need for higher doses in chronic users.

💡Caffeine Metabolism

Caffeine metabolism is the process by which the body breaks down and eliminates caffeine. The script suggests that there may be genetic variations in how quickly individuals metabolize caffeine, which could affect how they respond to caffeine. However, it also notes that the link between caffeine metabolism and exercise performance is not strongly established.

💡Caffeine Dosage

Caffeine dosage refers to the amount of caffeine consumed, typically measured in milligrams. The script discusses optimal dosages for enhancing exercise performance, suggesting that 3 to 6 milligrams per kilogram of body mass can be effective. It also warns against exceeding safe limits, which can lead to negative side effects such as increased heart rate and anxiety.

💡Caffeine Half-Life

The half-life of caffeine is the time it takes for the concentration of caffeine in the body to decrease by half. The script mentions that caffeine has a relatively long half-life, which means its effects can last for several hours after consumption. This is relevant to discussions about the timing of caffeine intake before exercise and its potential impact on sleep.

💡Caffeine Side Effects

Caffeine side effects include a range of physiological and psychological responses that can occur with excessive caffeine consumption. The script highlights potential side effects such as increased heart rate, anxiety, and sleep disturbances. It emphasizes the importance of consuming caffeine within safe limits to avoid these negative impacts.

💡Coffee Brewing

Coffee brewing refers to the process of making coffee by extracting flavors and caffeine from coffee beans using various methods such as drip, percolator, or espresso machines. The script discusses how different brewing methods can affect the caffeine content in the final drink, which can be significant for those using coffee for its caffeine content and potential health benefits.

💡Health Outcomes

Health outcomes refer to the effects of a particular intervention or exposure on an individual's health. The script suggests that moderate coffee and caffeine consumption can have beneficial health outcomes, such as improved cardiovascular health, liver protection, and antioxidant effects. It contrasts these benefits with the potential negative effects of excessive caffeine intake.

Highlights

Caffeine is a highly effective supplement for enhancing exercise performance.

Coffee and tea are the most consumed beverages worldwide, after water.

There is a lot of misinformation about caffeine's impact on health; the data generally suggests positive health outcomes from moderate coffee consumption.

Caffeine works by blocking adenosine receptors, increasing arousal and wakefulness.

The timing of caffeine consumption in the morning may not affect its effectiveness as much as believed.

Caffeine may cause an increase in circulating adenosine levels, potentially leading to a post-caffeine crash.

Habitual caffeine consumers may develop tolerance, requiring more caffeine to achieve the same effects.

Caffeine can improve mood and reduce the perception of effort during exercise.

The ideal dose of caffeine for performance enhancement is between three to six milligrams per kilogram of body mass.

Caffeine's effects can last for several hours, even after six hours post-ingestion.

High doses of caffeine can lead to negative side effects such as increased heart rate, anxiety, and digestive issues.

Caffeine metabolism can vary between individuals, but it doesn't strongly correlate with perceived effects.

Some people may feel sleepier after caffeine due to habitual consumption and reduced physiological response.

Caffeine can have long-term health benefits, including potential protection for the liver and cardiovascular system.

The ritual of coffee drinking, including its sensory experience, may contribute to cognitive and performance benefits beyond caffeine alone.

There is significant variation in caffeine content between different coffee preparation methods and even between pods from the same brand.

Caffeine's impact on sleep is significant, regardless of an individual's perception of its effects.

Avoiding caffeine intake approximately nine hours before sleep can help minimize its negative effects on sleep.

The concept of a 'coffee nap' may have some merit, but more scientific research is needed to confirm its effectiveness.

Transcripts

play00:00

this is everything you need to know

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about caffeine is it really true you

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shouldn't drink coffee first thing in

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the morning is there an ideal time to

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stop drinking coffee I think everybody

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knows that kind of person who takes has

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a cup of coffee before bed and

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supposedly sleeps great caffeine's

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having a negative impact on your sleep

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regardless of whether or not you think

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it is or not and is your coffee habit

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hurting your health in the long term if

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you enjoy coffee just go and enjoy

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coffee and the data in general suggests

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that actually caffeine or coffee CA

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consumption overall is very beneficial

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for a number of different Health

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outcomes Dr Brian Saunders is a caffeine

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expert armed with the latest research

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and Science and his lab specializes in

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caffeine's role in enhancing exercise

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performance caffeine is a pretty

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effective supplement if not the most

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effective supplement for enhancing

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exercise performance that's out there

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you can improve muscle strength muscle

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power muscle endurance so you can lift

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heavier loads and you can do more

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repetitions of that there's a lot of

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coffee fear and misinformation out there

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so today we're clearing that up is there

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evidence for this not really any that I

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know of I'm Dr Curran an NHS surgeon and

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this podcast we cut through the BS of

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Modern Health advice and tackle the

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biggest issues in science health and

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Medicine both coffee and tea are

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estimated to be the most consumed drinks

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worldwide second only to water but

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caffeine consumption is massively

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polarizing some some people celebrate

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its health benefits others demonize it

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and blame it for all sorts of poor

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health outcomes so if you're someone

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that feels guilty about your morning

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coffee habit or you're stressing about

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what time to drink your morning cuper

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you're hearing that you should have

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periods without caffeine or you're

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wondering whether you need to stop

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completely this one's for you Dr Brian

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Saunders from the University of sa Paulo

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is here to tell us the truth behind the

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online claims and what the scientific

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research actually says I've heard a lot

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a couple of years back about this whole

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thing about if you're consuming caffeine

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or coffee or any beverage which contains

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caffeine you shouldn't have it first

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thing in the morning because you're not

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getting you know the full bang for your

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buck because your cortisol is already

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elevated and caffeine is going to

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elevate your cortisol even more and

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actually it's better if you take it an

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hour and a half after you wake up when

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it can boost you even more when your

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cortisol slightly dips which sort of

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mechanistically I thought it made sense

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but recently there's more research which

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came out suggesting that not even a

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thing it doesn't really matter when you

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take your coffee or that potentially

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caffeine acts on your desing system

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which it does and another reason why you

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shouldn't consume in the morning is

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there any truth behind morning timing of

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caffeine at all yeah it's uh it's it's

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become quite big hasn't it this one uh a

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lot of people sort of in my day-to-day

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have come up to me and asked about this

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and you see a lot of promotion about

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online as you kind of briefly mentioned

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I think sort of the one thing to to take

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a step back is thinking about you know

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how does caffeine actually work so as

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you mentioned caffeine Works has a

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structure similar to adenosine in our

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body um and adenosine Rises um

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throughout the day and has an

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important uh role in the sleep wake

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cycle So within our brain it actually is

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quite inhibitory so it kind of promotes

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sleepiness suppresses arousal so if we

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block adenosine from doing that role we

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then can increase arousal increase

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wakefulness and alertness so essentially

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that's uh what what caffeine can do in

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the body so when it comes down to should

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I drink caffeine should I drink my

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coffee which contains caffeine first

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thing in the morning I've heard a few

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slightly different versions of why we

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supposedly should avoid this which you

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touched upon so essentially when we wake

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our circulating adenosine levels should

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be the lowest that they will be that day

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because during sleep adenosine uh is

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gradually cleared from from the brain

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but you know if we have a poor night's

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sleep we don't get enough sleep these

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levels might be higher than um desirable

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and so to block this most people will

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then take caffeine you know thinking

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okay that this will properly start my

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day properly wake my day but the

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argument I've seen then is that this

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adenosine that's in your body then still

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kind of hangs around and several hours

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later when the caffeine levels in our

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system start to drop then the adenosine

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that's hung around essentially can go

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back to doing its job and we get um an

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afternoon crash again kind of supposedly

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and so the theory is apparently to avoid

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this we should wait for our cortisol

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levels to Peak naturally so that

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cortisol can have some role in this

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clearance of that residual adeny

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caffeine stimulates cortisol levels and

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apparently the morning increase in

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cortisol levels due to caffeine

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ingestion is sort of

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undesirable because then apparently it

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doesn't allow cortisol to do its job so

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that's why people say wait 90 minutes to

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120 minutes before consuming caffeine it

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means that cortisol Peaks naturally can

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do its job clearing out adenosine and

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you feel naturally alert and then

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afterwards you can kind of bump that up

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with caffeine so I guess the question

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like going back to the actual question

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you asked is sort of is there evidence

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for

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this not really any that I know

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um I can't find any evidence even to

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kind of suggest that cortisol plays a

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role in adenosine clearance so I don't

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know why increasing this morning Peak

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would interfere with cortisol performing

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that role if it did that role anyway you

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know it might be relevant adenosine

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levels are low immediat as when we

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immediately wake up so maybe caffeine

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will have its least impact at that

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moment but I would say there's certainly

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no dat to to suggest that caffeine

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interferes with this cortisol Peak and

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how adenosine is processed and that this

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all causes an an an afternoon crash so

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the the evidence is weak or not even

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there in my opinion so when you

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suggested that caffeine has a similar

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structure to adenosine and therefore can

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bind to the adenosine receptors is

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caffeine bound to the adenosine

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receptors preferentially than adenosine

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or are they both got the same Affinity

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towards those receptor so my main

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question here is can caffeine work

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better to really get rid of that

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sleepiness in the morning when adenosine

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is still being cleared from the system

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after that night's sleep as for the

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specific Affinity I'm uh I'm not

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entirely sure something to to check into

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but what we do see um in in studies that

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actually measure the amount of adenosine

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or circulating adenosine is that when we

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provide an individual with caffeine that

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adenosine in the circulation then Rises

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which suggests that it potentially even

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removes that adenosine that's bound to

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the receptor so it certainly um seems to

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get in the way it is an an antagonist of

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those receptors and potentially even um

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displaces adenosine that is already um

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connected so is that a possible

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mechanism as to why people experience

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such a profound crash and tiredness

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after ingesting a lot of caffeine when

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this caffeine bumps away the bound

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adenosine to its receptors and

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eventually once the caffeine wears off

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you suddenly get a flurry of all of that

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free adenosine now rebinding to their

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receptors and suddenly causing a massive

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surge in tiredness or Lethy yeah it's

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it's it's certainly a potential um you

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know some people have suggested that it

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increases the sensitivity of these

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receptors to the adenosine then that

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then connect once um the caffeine sort

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of uh is metabolized essentially but

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again I I I think it's it's far more of

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a personal thing um rather than this is

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exactly what happens I don't think that

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the scientific evidence is particularly

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strong to suggest that um there's a

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bigger crash because of this um but

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certainly some people do seem to

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subjectively feel this yeah is there any

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for example there's some phenomenon when

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some people become habituated to

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drinking a certain amount of coffee and

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progressively they need to increase the

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amount of coffee they drink to get the

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same effect what drives that is is there

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something which the body physiologically

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upregulates the amount of adenosine

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receptors to compensate for this

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caffeine blocking adenosine what what's

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going on that Mak someone tolerant

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towards caffeine a lot of people

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subjectively do feel that that you know

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the the more they drink caffeine the

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less they get that sort of um buzz from

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it and certainly in our lab when when we

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get people who are caffeine naive into

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the lab you know you can we we try to do

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double blind studies where we don't know

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and they don't know what they're taking

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but sometimes you know it's caffeine

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that they've taken that day because the

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the the buzz the change in their um

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Dynamic is is is clear to see but it

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does seem to be um less when an IND

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idual consumes caffeine whether it be

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via coffee or teas um chronically so

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it's difficult to say exactly what

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happens in humans because we don't have

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that data but when we look at uh Mouse

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models which is a far easier model to

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look at especially when considering we

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want to look at what happens in the

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brain and and and we can literally take

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the brain out and and look what's going

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on what we see is that in mice with

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regular caffeine

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consumption uh their brain brains

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actually increase the number of

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adenosine receptors as a kind of

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compensatory mechanism so that could

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diminish that kind of stimulatory effect

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over time because essentially the same

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amount of caffeine won't bind or you

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know won't bind to as many receptors

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they'll be more receptors free for the

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adenosine to bind and then again that

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adenosine to have its kind of depressive

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inhibitory

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effects I think a big caveat again would

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be number one this is in mice uh number

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two this is with caffeine doses kind of

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100 times that we use in humans or you

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know usually consuming a coffee or a tea

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Etc so we don't really know if the same

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is happening in humans but you know you

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can extrapolate a little and suggest

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that this this is maybe the mechanism

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that's happening so in terms of people

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drinking any sort of caffeine in the

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morning or ingesting any sort of

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caffeine in the morning is there a

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significant Placo effect at play more

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than just the caffeine having these

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physiological effects which obviously it

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does but is there also a huge uh role

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for the placebo effect in making people

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feel more alert and more energized I

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think short answer yes uh I love this

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kind of placebo stuff and and and our

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lab has some on

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studies uh looking at this topic maybe a

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bit more specific to um the caffeine and

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looking its influence on cognition and

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performance and the mechanisms behind it

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but I think um a lot of it overlaps so

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there's there's more and more data

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coming out suggesting that there's a

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huge potential placebo effect of that

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morning coffee and that might be linked

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to um kind of the expectation of getting

play11:56

that caffeine and that caffeine hit but

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also so sort of that whole ritual behind

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drinking your coffee your tea your your

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drink of choice when we look at maybe

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the expectation behind caffeine when

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somebody believes that they're getting

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caffeine but maybe they're actually just

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getting a placebo we already see

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increased arousal increased

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expectation um there's in terms of sort

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of my main area of of work we can see

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that it can improve exercise performance

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that's simply the expectation of or

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believing that I've received caffeine

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I'm going to get caffeine you can

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already see changes in mood changes in

play12:38

exercise performance but there was a

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recent really interesting study um that

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looked at taking caffeine as simply sort

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of a a supplement so I believe diluted

play12:49

in water versus caffeine in a coffee and

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so what they did they used some sort of

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complex measurement technique

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of the brain called resting state

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functional MRI so a highly complex

play13:05

analysis of brain activity but in this

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study so they made several measures of

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brain activity before and shortly after

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either consuming just caffeine so as a

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kind of supplement or an actual coffee

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and so they found that both caffeine and

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coffee did cause some changes in brain

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activity that were related to kind of um

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a greater preparing ESS to switch from

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resting to to working processes so it

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suggests that the caffeine maybe made

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people more ready for action um but some

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changes in brain activity were only seen

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when coffee was consumed and that like

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there was increased sort of connectivity

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in areas with um implicated in visual

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processing uh higher level cognitive

play13:54

functions such as working memory goal

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directed Behavior so it seems coffee

play14:00

produced a far more wide ranging effect

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on cognitive activity which suggests

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that actually the ritual of having a

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coffee May trigger kind of brain areas

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that's not only sort of due to the um

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effects of caffeine but maybe due to you

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know the stimulatory effects the the

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sensory experience of having that coffee

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maybe the smell the taste and

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anticipation so really really

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interesting data from uh from this study

play14:29

do you think the added benefits of

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consuming caffeine in the form of coffee

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in addition to those ritualistic habits

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and that conditioned Behavior it's also

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maybe could be due to all the you know

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the fermented beans the coffee beans the

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antioxidants the polyphenols and the

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sort of Prebiotic fibers from that

play14:51

adding to all of those cognitive and

play14:52

physical benefits yeah I I think um and

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that's potentially a limitation of this

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study to extrapolate that it's entirely

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Placebo effects here you know I guess

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what they probably needed was uh

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decaffeinated coffee as another control

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to be able to potentially eliminate

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other compounds within coffee that maybe

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generated these effects you know even if

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it is these other compounds and maybe

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not sort of only um Placebo effects that

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are generating these these um changes in

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brain activity you know it still does

play15:30

suggest that yeah maybe having that cup

play15:32

of coffee is more beneficial than

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somebody who prefers just to take a

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caffeine pill in the morning to to get

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their Buzz yeah so if someone were using

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some source of caffeine for boosting

play15:45

their exercise

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performance what benefits can someone

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Achieve Beyond just increase alertness

play15:53

and focus when they're consuming

play15:55

caffeine to boost their exercise

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performance whether they're a marathon

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runner or just lifting weights in the

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gym or cycling somewhere what can they

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expect well in general I think they can

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expect to probably improve their

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exercise performance yeah um the general

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consensus is certainly that caffeine um

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is a pretty effective supplement

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probably one of the if not the most

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effective kind of uh supplement for

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enhancing exercise performance that's

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out there and that's you know you

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mentioned there across a wide range of

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exercise types that's that's the really

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kind of fantastic and interesting thing

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with caffeine you know you see from the

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shortest duration activities you know

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kind of um those explosive

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high-intensity Sprints that maybe lasts

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up to one minute you know 100 meter

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running 200 meter running 50 m swimming

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a a cycling Sprint at the end of a race

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there's evidence that caffeine can

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improve performance if you sort of

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prolong that exercise duration a bit

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more um you know a middle duration

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Activity 4 kilometer cycling that might

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last anywhere from 4 to 8 minutes if you

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know depending on Elite to a

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recreational 2,000 meter rowing sort of

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six to nine minutes um maybe longer

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endurance activities 10 kilm 16 40 kilm

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cycling time trial performance cross

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country swimming skiing sorry Marathon

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running as you said there's data to show

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that caffeine can improve this kind of

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activity um you've got resistance

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exercise so you know when you when you

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get in the gym and you're performing

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contractions of of isolated or multiple

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muscle groups um there's evidence to

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show that you can improve uh muscle

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strength muscle power muscle endurance

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so you can lift heavier loads and you

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can do more repetitions of that and then

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even kind of team sports which is a

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whole mix of you know agility repeated

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Sprints and changes of direction there's

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so much evidence to show that caffeine

play18:08

can also improve various aspects of

play18:11

performance during this kind of activity

play18:13

so if you look at the entirety of the

play18:16

data you know there's probably 300 400

play18:19

uh studies out there in general the

play18:23

average shows a pretty pretty decent

play18:26

performance enhancing potential of Cafe

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you know I think some people might think

play18:31

that they you know a recreational Runner

play18:34

I'll take some caffeine and now all of a

play18:35

sudden I might be S of chasing down

play18:37

Usain Bolt during that 100 meter it's

play18:41

not a miracle worker you know the

play18:43

effects that we see in these studies are

play18:45

generally kind of small to moderate okay

play18:48

it doesn't mean it doesn't matter um

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especially if you're a competitive

play18:52

athlete but I think um it's certainly a

play18:56

caveat that I always like to mention to

play18:57

people yeah the these are small to

play19:00

moderate performance improvements it's

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not a miracle worker yeah I guess it's

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going to optimize you as much as your

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threshold allows given your current

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physical limitation so if you're already

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an ultr level athlete it's going to give

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you the extra 1 two% if you're you know

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a casual Runner it will give you an

play19:20

extra 1 to two% but won't make you a

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professional uh and really what I wanted

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to query was how exactly does it exert

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these benefits what's the mechanism

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underpinning these exercising boosting

play19:31

abilities of caffeine is it increase

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blood flow is it enhance recovery

play19:37

increased uh you know glucose usage by

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muscles what's going on it's effects on

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mood and on um uh arousal

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motivation is part of its influence for

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sure so as as we've already mentioned by

play19:56

uh interfering with adenosine receptors

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it can enhance mood and all these um

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factors but then essentially um what we

play20:04

see is an increase in in a in a lot of

play20:08

um hormones that can lead to direct

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benefits on the muscle so um we see an

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increased in increas in uh adrenaline

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noradrenaline you know that kind of

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fight or flight

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response um that kind of leads leads to

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hyperarousal and you see an increase in

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circulating glucose cardiac output blood

play20:30

flow to the working muscles as you

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mentioned um so that's definitely sort

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of one method by which it works there's

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also a large literature that we see that

play20:40

um caffeine can decrease the perception

play20:43

of effort during exercise so it feels

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easy easier so that same say pace might

play20:50

feel easier or you could kind of flip

play20:52

that and you could run faster for the

play20:57

same kind of perception of effort and

play20:59

that's likely also due to the fact that

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there's adenosine receptors present in

play21:05

um nerve endings that are involved in

play21:07

pain signal transduction wow so if you

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antagonize these receptors you could

play21:12

potentially reduce the signal of pain

play21:15

reducing that perception of pain and

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effort during exercise which I think is

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an important stimulus to how hard and

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how how much effort an individual um is

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putting in and then there's also some

play21:28

some suggestion um that there are Direct

play21:32

effects on muscle that it can increase

play21:34

kind of the the sensitivity of the

play21:36

muscle to calcium release which is

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really important for muscle contraction

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there's a bit of debate about how much

play21:41

caffeine is necessary for that but it

play21:44

seems quite sort of all all-encompassing

play21:47

of a variety of potential mechanisms

play21:50

which is probably why caffeine Works

play21:53

kind of across the board for so many

play21:55

different exercise types so if someone

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was an average caffeine consumer what

play22:01

sort of dose of caffeine would provide

play22:04

these increased benefits the literature

play22:07

suggests caffeine relative to your body

play22:10

mass so um most research out there has

play22:15

probably used um doses between three and

play22:19

six milligrams per kilogram of body mass

play22:22

now I always like to highlight to people

play22:25

it's milligrams and not grams you know

play22:28

there's there's there's been some

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horrendous mistakes made um so for say

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70 kilo individual that's about 210

play22:38

milligrams of caffeine wow and that that

play22:40

already seems to be um performance

play22:43

enhancing it is a lot it is a lot it's

play22:46

you know depending on the source of

play22:48

coffee or where you get it from it's

play22:50

it's two to three espressos essentially

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wow so you know given that the kind of I

play22:56

guess safe limit in a day for a human is

play22:59

roughly around 400 Mig maybe so you know

play23:03

getting 200 Mig upwards is good going

play23:06

for you know exercise boosting potential

play23:09

for caffeine oh yeah oh yeah and and

play23:12

again if if you look at those

play23:14

recommendations they are quite wide if

play23:15

you think about it for like from

play23:18

doubling from 3 to six milligram so I

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would always recommend as maybe a

play23:22

starting point go for that lower end and

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kind of see if it works for you see how

play23:28

you react see if you know if you're

play23:30

actually measuring your performance if

play23:32

it's boosted your performance lower than

play23:35

3 milligrams per kilo of body mass has

play23:38

been shown to be effective so you could

play23:40

even go towards the lower end um maybe

play23:45

less of an effect um but certainly to go

play23:48

above 6 milligrams per kilo you then

play23:52

entering potentially trickier water

play23:55

potentially some side effects and the

play23:59

general data doesn't suggest that it's

play24:01

more beneficial and actually might not

play24:03

be um beneficial so i' kind of stick to

play24:06

the lower end of of those ranges I just

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provided is there an ideal time to

play24:12

ingest caffeine so it peaks in your

play24:14

bloodstream before the workout say 30

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minutes 60 Minutes 90 minutes before you

play24:18

work out to consume a certain dosage

play24:21

there's no good data to suggest we need

play24:23

to reach our Peak or that Peak caffeine

play24:26

in the blood equals Peak performance um

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but obviously you know it does take

play24:32

about you know depending on the

play24:34

ingestion type maybe sort of 30 to 60

play24:37

Minutes for it to really enter the

play24:39

bloodstream and start taking effect so

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yeah if if you're you know going for a

play24:45

short workout I I would say you know

play24:47

maybe an hour before your workout um

play24:50

ingest caffeine if you're going to be if

play24:53

you're doing longer workouts I mean the

play24:56

wash out the halflife of caffeine the

play24:58

time it takes to be metabolized and

play25:00

excreted is long so if you're if you're

play25:03

taking say that 3 milligrams per

play25:05

kilogram dose in 5 hours you're still

play25:08

going to have about half of what that

play25:10

peak in your blood was so in general I

play25:14

think timing isn't too much of an issue

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but again if your workout is short you

play25:21

know if you're only going to do half an

play25:22

hour one hour maybe then make sure that

play25:23

you're taking the caffeine one hour

play25:25

before that but those effects are then

play25:27

going to last for for for a few hours

play25:29

and I think there's one study that shows

play25:31

even sort of six hours after ingestion

play25:34

caffeine is still having uh performance

play25:36

enhancing effects yeah so assuming

play25:39

someone blow past the 400 mgram ceiling

play25:43

that's safy consumed for a human in a

play25:45

24-hour period you know presumably you

play25:48

know you're going to have those really

play25:50

emphasized effects of caffeine that

play25:53

would have been okay at a physiological

play25:55

safe dose of increased blood pressure

play25:58

increased heart rate which is all

play26:00

exercise boosting but they start to

play26:03

become negative influencers and you may

play26:05

get anxiety increased sweating um

play26:09

palpitations maybe some GI side effects

play26:12

some you know diarrhea or you know tummy

play26:14

upsets what other quite dangerous side

play26:16

effects can you come if you're really

play26:18

pushing that you know safe 24-hour

play26:21

dosage I think you've you've kind of hit

play26:23

the nail on the head there those are

play26:25

those are all potential side effects

play26:28

when we we increase the the dose of

play26:32

caffeine um aside from

play26:34

Simply potentially toxic doses now again

play26:38

in general we we we we're not going to

play26:41

hit those toxic uh um doses with say a

play26:46

cup of coffee or or even like a one

play26:49

little capsule of caffeine but um

play26:52

sometimes there's there's there's

play26:54

caffeine and say pre-workout supplements

play26:56

that people um ingest and and they don't

play27:00

think about the amount of caffeine

play27:01

that's in there they're looking to

play27:02

increase I don't know the amount of

play27:04

carbohydrate or creatin and so they

play27:06

increase that dose accidentally

play27:08

increasing the amount of caffeine um

play27:11

which then could lead to really quite

play27:13

High toxic doses of of caffeine which at

play27:18

the really high end could could lead to

play27:20

death and unfortunately there are kind

play27:22

of case reports of this in the

play27:24

literature it is rare and it is um

play27:28

really a lot a lot of caffeine you know

play27:30

that you would have to ingest sort of in

play27:33

into the grams into the several you know

play27:35

10 to 20 kind of grams of of of caffeine

play27:38

but again even going above six

play27:40

milligrams per per kilo you can increase

play27:44

you know potential GI discomfort you can

play27:46

increase anxiety anxiety is a big one

play27:49

you know if if you're a person who

play27:52

already potentially suffers from anxiety

play27:55

is more prone to panic panic attacks you

play27:58

know increasing again we've said it kind

play28:00

of uh caffeine can increase uh

play28:03

adrenaline noradrenaline so that

play28:05

increases heart rate blood pressure

play28:08

symptoms that are similar to uh anxiety

play28:10

and so that can exacerbate that anxiety

play28:14

you're increasing cortisol the stress

play28:16

hormone so that can heighten feelings of

play28:19

stress and anxiety and so that could

play28:22

potentially negate any potential

play28:25

benefits um of taking that caffeine so

play28:29

we certainly have to look to limit um

play28:33

look to take the minimal beneficial dose

play28:36

in my opinion sometimes you know more is

play28:39

is generally not better go stick towards

play28:42

that lower end and and and see what

play28:44

happens I think a lot of people fail to

play28:47

appreciate that end of the day you know

play28:48

caffeine is a potent drug whether we

play28:51

like that word or not it is a drug and a

play28:53

lot of these leading energy drinks in

play28:55

the market a full can may contain upward

play28:58

of 150 160 milligram of caffeine and I

play29:02

know several people who chug through

play29:04

three or four of those a day so they're

play29:07

regularly consuming more than the safe

play29:09

dose and not even really thinking about

play29:12

it and then you wonder you know they're

play29:14

feeling stressed probably because of

play29:16

that you know heightened phal flight

play29:19

response and the cortisol and the

play29:20

adrenaline and all those effects of

play29:23

caffeine which is consistently going

play29:25

Beyond you know a safe metabolic dose

play29:28

people don't realize the like the true

play29:32

potential it's always that kind of with

play29:34

like with many things that kind of

play29:36

inverted you you know of course in in

play29:39

small little doses it can be great it

play29:43

can be fantastic I I I love my cup of

play29:46

coffee in the morning I love a cup of

play29:48

tea in the afternoon um I I I enjoy a

play29:51

bit of caffeine sometimes pre-workout

play29:54

but once you start to sort of overdo it

play29:57

hit the excess that's when it can become

play30:01

too much can become um

play30:04

deleterious and then it's it's no longer

play30:08

positive it's negative and it can cause

play30:10

all kinds of negative impacts really so

play30:13

the stereotypical view of caffeine is

play30:15

that you take it and you feel alert and

play30:18

you feel focused but paradoxically there

play30:20

are a lot of people who take caffeine or

play30:23

any sort of coffee or anything like that

play30:26

and they actually feel more tired and

play30:29

this always struck me as quite strange

play30:31

and I suspected maybe they are you know

play30:34

genetically faster metabolizers of

play30:37

caffeine and they just you know Chow

play30:39

through it their liver enzymes just Chow

play30:41

through the caffeine a lot quicker but

play30:44

apart from genetic variances in the

play30:47

liver enzymes metabolizing caffeine and

play30:49

reducing the halflife of it is there any

play30:51

other mechanism as to why some people

play30:54

might paradoxically feel sleepy or tired

play30:57

of after consuming caffeine well I think

play31:00

the caffeine metab metabolism stuff is

play31:02

quite interesting because although yes

play31:06

we have people who are faster

play31:09

metabolizers and slower

play31:11

metabolizers the extent to which this

play31:13

actually modifies kind of perception of

play31:17

of mood perception of arousal doesn't

play31:20

seem to link to that genetic makeup so

play31:25

um in collaboration with some colleagues

play31:27

uh at the University of Brazilia we

play31:28

actually looked at you know does an

play31:31

individual's genotype for caffeine

play31:34

metabolism um link to how they in

play31:38

general respond to caffeine a

play31:40

questionnaire based um assessment of you

play31:43

know how they whether they get the

play31:44

Jitters whether they feel anxious

play31:46

whether they feel um an upward liftting

play31:49

mood Etc and there doesn't actually seem

play31:53

to be that strong a link between um

play31:57

caffeine metabolism or or or and and

play32:00

genetics and how an IND an individual

play32:03

actually perceives or feels following

play32:07

ingestion and um just on a side note as

play32:10

well I think the data in terms of kind

play32:13

of caffeine metabolism and exercise

play32:15

performance following

play32:17

caffeine it's a tenuous Link at best at

play32:20

the minutes so I think we need certainly

play32:22

more more data on the topic but I

play32:25

wouldn't say that there's strong

play32:26

evidence to suggest that caffeine

play32:30

metabolism matters all that much I I

play32:32

think I might be proven wrong at the

play32:35

lower doses but I think sometimes when

play32:38

you know like I said a 3 milligram per

play32:40

kilo dose is already so much that we're

play32:42

probably already

play32:43

saturating um most things and so

play32:47

metabolism of caffeine doesn't actually

play32:49

make um that much of a difference as to

play32:53

what's going on when um somebody takes

play32:56

caffeine and actually um feels sleepier

play33:01

personally um I haven't sort of

play33:04

encountered too many of these

play33:05

individuals I've certainly encountered

play33:08

individuals who don't perceive an effect

play33:12

they they they take caffeine and uh they

play33:15

don't actually feel the effects and I

play33:16

would say that's probably more to do

play33:18

with them likely being a habitual

play33:21

consumer so what we do see um with

play33:25

habitual consumption is that those phys

play33:27

ological effects again likely or

play33:30

potentially due to an upregulation of

play33:33

the adenosine receptors in the brain um

play33:36

the physiological effects are reduced so

play33:40

um with with um kind of

play33:43

lowlevel lowish level habitual

play33:45

consumption maybe up to about 200

play33:47

milligrams per day we can see a a

play33:50

blunting in the cortisol response um

play33:53

whereas sort of really higher end um

play33:56

habitual consumption kind of maybe above

play33:58

that 400 milligrams per day um

play34:01

recommendation that may even abolish

play34:04

that cortisol response after caffeine

play34:06

ingestion similarly kind of adrenaline

play34:08

or adrenaline response can be blunted in

play34:11

in chronic caffeine users so in those

play34:14

individuals I think that would probably

play34:16

explain why they don't feel as much Buzz

play34:21

as um as other people so those people

play34:24

who are habitual caffeine consumer

play34:27

humors and maybe they've experienced

play34:30

some blunted physiological response

play34:33

objectively and maybe even subjectively

play34:36

to themselves they perceive that same

play34:38

dose of caffeine to have less of an

play34:40

effect is there any value in those

play34:43

people still consuming their same dose

play34:45

of caffeine to get any benefits will

play34:48

they get any benefits or should they

play34:50

undertake a period of I don't know

play34:52

caffeine fasting to almost reset their

play34:55

tolerance our lab has been studying this

play34:58

and so a few years ago we we we came out

play35:02

with some research where we we got

play35:04

people with different levels of Habitual

play35:06

caffeine consumption you know ranging

play35:08

from pretty caffeine naive all the way

play35:11

up to you know in excess of the 400

play35:13

milligrams per day and we showed that

play35:17

caffeine provided acutely before

play35:19

exercise improved their exercise

play35:21

performance regardless of there was no

play35:23

association you know there wasn't a

play35:25

blunting in those individuals with

play35:27

higher use there wasn't a greater effect

play35:30

in in those with um lower use so our

play35:33

data and and we have more data coming

play35:35

out um suggests that maybe your habitual

play35:39

caffeine intake doesn't matter that much

play35:42

in terms of EX benefits for exercise

play35:45

performance but you know science is

play35:48

science and you you can find so many

play35:50

studies showing the opposite and so

play35:52

pretty much at the same time as we we

play35:54

our study came out another study did

play35:57

suggest a blunting in the effect so this

play36:00

study was was controlled in a different

play36:03

way they they got caffeine naive

play36:05

individuals so with very low caffeine

play36:08

consumption they provided caffeine prior

play36:11

to exercise and showed it improved

play36:13

performance but then half the group went

play36:15

away and took caffeine every day for for

play36:17

a month so then when they came back they

play36:21

were now kind of Habitual or chronic

play36:24

caffeine users and then when they were

play36:26

tested again that caffeine prior to

play36:29

exercise was less efficient it didn't

play36:33

eliminate the performance benefits of

play36:35

caffeine but it was reduced and so you

play36:38

know that suggests that maybe caffeine

play36:41

um chronic caffeine consumption

play36:44

does uh inhibit a little bit um its

play36:48

effects the key difference is maybe in

play36:51

the dose provided before exercise so in

play36:54

the other group study they provided 3

play36:57

Mig per kilogram of body mass daily and

play37:01

then provided the same amount pre

play37:03

exercise whereas the amount we gave to

play37:05

our participants was on the whole

play37:08

greater than their daily dose um so it

play37:11

was 6 milligrams per kilo that we

play37:13

provided so maybe the key is if you're

play37:16

an individual who you know drinks say

play37:19

approximately three milligrams of of per

play37:22

kilo um of caffeine per day then maybe

play37:26

prior to exercise you need a a bit more

play37:27

than that to then truly get the benefits

play37:31

now that's a little bit extrapolating

play37:33

the data we're actually testing that

play37:35

right now in our lab so hopefully um

play37:37

that'll come out in the next few months

play37:40

but um you know I think I think there is

play37:43

some logic to it I guess if you look at

play37:46

the literature you'll see different

play37:48

numbers quoted for the halflife of

play37:51

caffeine and I guess that will also vary

play37:53

depending on the individual as well I

play37:54

guess maybe anything from 5 hours to 8

play37:56

hours or anything in between and

play38:00

although caffeine has various

play38:02

physiological benefits it also has that

play38:04

negative effect on sleep and its

play38:07

interaction being an antagonist of the

play38:09

adenosine system as well which helps us

play38:12

to sleep is there any way or sort of any

play38:17

way to clear caffeine faster if you'd

play38:21

consumed a large amount in the few hours

play38:24

leading up to your bedtime and you

play38:26

didn't want it to affect your sleep in

play38:28

the way that it mechanistically does so

play38:31

we've actually been looking trying to

play38:33

look into this to see if there is say a

play38:37

caffeine

play38:38

antagonist but from our

play38:41

searches um I don't believe there is one

play38:45

so the unfortunate thing for those who

play38:49

do want to take caffeine later in the

play38:51

day or have taken more than they want

play38:54

and are having trouble sleeping is that

play38:56

in general

play38:58

you're not you're just going to have to

play39:00

wait for for lady time to do its job but

play39:04

you know that I think the easiest way to

play39:06

avoid that is to just limit your

play39:09

afternoon intake of caffeine and kind of

play39:12

see what works with you I think an

play39:15

important point when it comes to sleep

play39:18

there's a really nice study showing

play39:21

differences in what we objectively

play39:25

perceive or how we objectively perceive

play39:27

caffeine to influence our sleep versus

play39:30

what it objectively does so in this

play39:33

study they provided caffeine sort of 63

play39:36

and immediately before bedtime versus

play39:39

not providing

play39:41

caffeine and when you ask somebody to

play39:44

objectively quantify sort of um how

play39:47

quickly they fell asleep how much they

play39:49

slept um uh Total Sleep Time generally

play39:55

they underestimate

play39:57

the effects or the negative effects that

play39:59

caffeine has had on their sleep so

play40:00

generally they underestimate or

play40:03

overestimate their Total Sleep time they

play40:05

overestimate the percentage time they're

play40:07

actually asleep so caffeine's having a

play40:11

negative impact on your sleep kind of

play40:13

regardless of whether or not you think

play40:14

it is or not you know I think everybody

play40:16

knows that kind of person who takes has

play40:18

a cup of coffee before bed and

play40:19

supposedly sleeps great I'm one of those

play40:23

but after reading this study I thought

play40:25

well this this actually suggests that

play40:27

despite my perception it might not be

play40:30

the the true case there was a

play40:32

metaanalysis that came out last year

play40:34

kind of pooling so many different

play40:36

studies that um suggests that if we want

play40:40

to limit caffeine's effects on our sleep

play40:44

we should look to avoid um consuming

play40:47

kind of coffee about nine hours from

play40:50

about nine hours prior to sleep and at

play40:54

bigger doses so those kind of preworkout

play40:56

doses is the data suggest that we want

play40:59

to limit that to 13 hours before bed so

play41:03

you know if you're going to bed at 10

play41:05

that's kind of limiting it to 9:00 a.m.

play41:07

in the morning so wow not that people

play41:10

are necessarily going to do this but

play41:12

just people should be aware that it can

play41:14

interfere with your sleep and so you

play41:16

know the more you take the more you take

play41:18

in the afternoon the more it can

play41:20

negatively impact upon your sleep how

play41:23

much value can you place on these I

play41:25

guess these trending things on social

play41:27

media where people talk about having a

play41:29

coffee nap where they consume some

play41:32

coffee then have a nap almost before the

play41:35

coffee really hits their system and then

play41:37

as they wake up from their 45 60 Minute

play41:40

power nap the coffee then hits and

play41:43

they're now less groggy after their nap

play41:46

but they've also got the added benefit

play41:47

of the caffeine and the coffee peeking

play41:49

and they feel good is it any scientific

play41:52

underpinning as to Coffee naps if you

play41:55

can immediately fall asleep following

play41:57

that coffee um then and and have that

play42:01

you know generally your nap should kind

play42:03

of be I think around 20 minutes half an

play42:05

hour max then you would wake up at the

play42:09

moment that caffeine is kind of really

play42:11

starting to rise and and and having an

play42:14

effect I think it's one of those

play42:16

that mechanistically

play42:19

logistically it seems to make sense but

play42:24

until we actually test it in my opinion

play42:27

it's all just kind of hearsay and you

play42:31

know it's it it's all about like your

play42:34

first sort of uh question about you know

play42:36

should we take it immediately upon

play42:38

waking or 90 minutes to 120 Minutes

play42:41

there might sometimes be some rationale

play42:45

for doing this but until we actually

play42:48

measure it properly in the lab if some

play42:50

somebody goes out and does it then it's

play42:52

all just

play42:54

anecdotal but it doesn't mean to say

play42:56

that if it works for you then great then

play42:59

you know I I sometimes think that with

play43:02

science sometimes we are too quick to

play43:04

dismiss a person's personal

play43:07

feelings but you know it is important

play43:10

that we say oh here is the data on

play43:12

average this is the

play43:14

direction but of course there can be

play43:17

some deviations from that direction

play43:20

depending on

play43:21

individuals yeah I guess you know

play43:23

anecdotal data is still data and if you

play43:26

get a series of anecdotal data points it

play43:28

becomes a case Series so yeah guess it's

play43:31

not straightforward just to wipe that

play43:32

off and disregard it but what was

play43:35

interesting is that previously you

play43:36

mentioned that uh caffeine consumption

play43:40

can sensitize the adenine receptors to

play43:42

be you know more sensitive towards the

play43:44

effects of adenosine and potentially

play43:46

there may be some upper regulation of

play43:48

the adenosine receptors as well is there

play43:50

any long-term effect on the adenine

play43:53

receptors when you habitually consume

play43:55

caffeine in the very long term to the

play43:58

point where it actually could cause

play44:00

these longer term physiological changes

play44:02

again I don't think we we have that data

play44:05

I don't think we we we know what it does

play44:09

especially in humans because it's pretty

play44:13

difficult to take a brain biopsy so I I

play44:16

don't think anybody's going to be

play44:17

volunteering for that anytime soon again

play44:20

all you can do is look at um what kind

play44:24

of um long-term data suggests when we

play44:28

look at Snippets of you know people's

play44:31

long-term use so you know you can

play44:33

evaluate that via questionnaire and then

play44:35

look at their General Health and I think

play44:38

in general the data do suggest that

play44:42

caffeine or coffeine consumption overall

play44:45

is very beneficial for a number of

play44:47

different Health outcomes we look at oh

play44:50

there might be a m a reduction in

play44:52

exercise performance with habitual

play44:54

consumption so we we we should really

play44:56

sort of remove remove it from the diet

play44:58

to avoid this but it's such a minor

play45:01

thing when in the long term if you enjoy

play45:04

coffee just go and enjoy coffee and the

play45:06

data in general suggests that actually

play45:09

caffeine consumption and coffee intake

play45:12

in those you know reasonable doses again

play45:15

as you mentioned before 400 milligrams

play45:17

per day is kind of set as as as the

play45:20

upper limit or

play45:22

thereabouts then you're you're you're

play45:24

likely to gain long-term benefits and

play45:27

and you're not likely to get any um

play45:30

unfavorable um issues in my opinion yeah

play45:33

I think that some of the study I read

play45:35

suggested up to three cups of coffee a

play45:37

day could actually you know provide some

play45:39

significant benefits for gut health

play45:42

cardiovascular health even some liver

play45:44

protection and the antioxidant effect of

play45:47

um you know the chlorogenic acid and

play45:48

various things in uh coffee and coffee

play45:50

beans I mean Brazil and South America in

play45:53

general has some pretty great coffee is

play45:56

there any

play45:57

thing you'd recommend in terms of the

play45:59

preparation of coffee or the Brewing or

play46:01

the even types of beans and locations

play46:04

and how they're harvested that has any

play46:06

effect as to really maximizing the

play46:09

caffeine dosage and how great it is for

play46:12

absorption depending on where it's

play46:15

soured how it's soured and how it's made

play46:17

yes so obviously there are there are you

play46:19

know plenty of different kinds of or or

play46:22

or sources of um caffeine um obviously

play46:25

coffee beans is is one of the most

play46:29

well-known but then you know you've got

play46:31

cacao beans uh you've got Cola nuts from

play46:34

Africa tea leaves obviously um at a

play46:38

generally at a lower amount yba mate the

play46:41

Guan Berry here in in Brazil which I

play46:44

believe can actually kind of in general

play46:47

per um Bean contains more caffeine than

play46:50

a than a coffee bean so you know the

play46:54

different types of beans the different

play46:56

locations or where they're

play46:58

grown probably even one coffee bean to

play47:02

the next Coffee Bean right next to it

play47:05

the amount of caffeine in there will

play47:07

likely differ and then you know you've

play47:10

got to factor in um the processing you

play47:14

know Brazil I agree has some fantastic

play47:18

coffee but it also has some pretty

play47:20

abysmal coffee in my opinion I've been

play47:22

to um a really nice uh coffee Farm here

play47:26

where you know they fully explain the

play47:28

process and you know the most popular

play47:31

but most popular maybe because they're

play47:34

quite cheap brands or or or or coffees

play47:37

out there are generally the less good

play47:40

beans that have kind of been filtered

play47:42

away and also contain a bit of dirt and

play47:45

a bit of stuff that you wouldn't

play47:46

necessarily want in there and so they

play47:48

over roast them to make it a bit more

play47:52

flavorsome but you know you can kind of

play47:55

see it in the color it's kind of more

play47:56

black color whereas coffee shouldn't

play47:58

really be that really dark black color

play48:01

it should be a more light muddy Brown

play48:04

and so that will already change or or

play48:08

likely change the caffeine content how

play48:10

much we don't really know but we do know

play48:13

that you know processing preparation if

play48:16

you do have a drip coffee if you use a

play48:18

percolator if you have you know a

play48:20

pressure espresso this can all influence

play48:24

how much caffeine is actually in

play48:27

uh your coffee but even you know trying

play48:31

to standardize that will still lead to

play48:34

different caffeine content so there's

play48:37

some really nice studies showing that

play48:39

again the different preparation types

play48:40

lead to a different amount of caffeine

play48:43

using the same kind of pack of coffee um

play48:46

if you go to a coffee shop you might

play48:48

think oh that might be more standardized

play48:50

but no there's a there's really nice

play48:52

data showing that the same coffee from

play48:54

the same popular brand

play48:57

coffee shop um on consecutive days the

play49:01

actual caffeine content ranged kind of

play49:03

between 250 and 550 milligrams within

play49:07

that one coffee like obviously big big

play49:11

coffee espresso pods there's a really

play49:13

nice study from Ben des's group in um

play49:17

Australia where you know you might think

play49:19

that they'll probably be able to

play49:21

standardize better the amount of

play49:22

caffeine in each of these

play49:24

pods but no they actually vary quite

play49:27

wildly from one pod to the next and

play49:30

don't exactly match up with What's um

play49:32

actually written on the

play49:34

label it's something I always mention to

play49:36

people who want to use caffeine for

play49:39

exercise

play49:40

performance can you use caffeine in

play49:43

coffee to improve performance of course

play49:45

you can there's some nice studies that

play49:47

show that but you don't know exactly how

play49:50

much caffeine you're getting that's the

play49:52

issue so if you're somebody who only

play49:55

wants a little but on that one day you

play49:58

get a huge impact you know you get that

play50:00

550 milligrams that might not be

play50:03

beneficial to you or or or it might be

play50:05

that you get the wheat coffee today and

play50:07

there's less caffeine so if you want to

play50:09

know exactly how much caffeine you're

play50:11

getting then you know maybe a supplement

play50:15

um is is the better option for you for

play50:18

your for your workout I think I heard I

play50:20

hope this is correct but it's the second

play50:22

most consumed drink in the world after

play50:24

water and I think given that it's

play50:26

certainly very widely consumed by a lot

play50:29

of people you know millions billions of

play50:31

people around the world most people

play50:34

don't really appreciate the nuance and

play50:37

the level of complexity as to what's

play50:39

going on in their systems consuming this

play50:42

quite potent drug so thank you very much

play50:44

Brian for adding all of this nuance and

play50:46

science to the world of coffee which is

play50:48

you know incredibly important to

play50:50

people's everyday lives thanks again to

play50:52

Dr Brian Saunders next episode we meet

play50:55

exercise scientist Dr Mike isrel who

play50:58

tells us just how little you can work

play51:00

out and still reap the benefits the most

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effective way to lose weight and why

play51:05

supplementing with creatine isn't just

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for bodybuilders and much more subscribe

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so you don't miss it and the weekly Dr K

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Related Tags
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