Why Your Coffee Habit Might Be Better Than You Think - Dr Bryan Saunders
Summary
TLDRIn this informative podcast, Dr. Brian Saunders, a caffeine expert, dispels myths surrounding coffee consumption and its effects on health and sleep. He discusses the benefits of caffeine for exercise performance, the impact of timing on its effects, and the role of adenosine receptors. Saunders also addresses the placebo effect of coffee rituals and the potential for tolerance due to habitual consumption. The episode provides insights into optimal caffeine dosage for performance enhancement and the importance of considering individual responses to caffeine.
Takeaways
- ☕ Caffeine is a potent stimulant that can enhance exercise performance, improve muscle strength, power, and endurance, and is considered one of the most effective supplements for this purpose.
- 🛌 Contrary to some beliefs, there is no strong scientific evidence that drinking coffee or caffeine early in the morning negatively impacts sleep due to cortisol levels.
- 🤔 The idea of timing caffeine intake based on cortisol levels to avoid an 'afternoon crash' is not supported by evidence; individual responses to caffeine vary.
- 🔍 Caffeine works by blocking adenosine receptors in the brain, which would normally promote sleepiness and suppress arousal, leading to increased alertness and wakefulness.
- 💊 Caffeine's effects can be felt even at lower doses, but the optimal dose for exercise performance enhancement is between three to six milligrams per kilogram of body mass.
- 🏋️♂️ For those using caffeine to boost workout performance, consuming it about an hour before exercise can be beneficial, though the exact timing may vary based on individual response.
- 🚫 High caffeine intake can lead to negative side effects such as increased heart rate, blood pressure, anxiety, and digestive issues, and can potentially be lethal in extremely high doses.
- 🌱 The source and preparation of coffee can significantly affect caffeine content, with variables like coffee bean type, growing location, and brewing method impacting the amount of caffeine in a cup.
- 🧬 Genetic variations in how individuals metabolize caffeine do not strongly correlate with perceived effects on mood or arousal, suggesting other factors are at play.
- 🔄 While habitual caffeine consumers may develop tolerance, meaning they need more caffeine to achieve the same effect, the performance benefits of caffeine for exercise do not appear to be significantly reduced.
- 📉 Caffeine can have a negative impact on sleep quality, regardless of an individual's perception of its effects, and avoiding caffeine close to bedtime (approximately 9 hours before for regular coffee or 13 hours for high doses) can help mitigate this.
Q & A
Is it true that you shouldn't drink coffee first thing in the morning due to cortisol levels?
-There is no strong scientific evidence to support the idea that drinking coffee first thing in the morning is detrimental due to cortisol levels. Caffeine works by blocking adenosine receptors, and the timing of coffee consumption may not significantly impact its effectiveness.
Can caffeine negatively impact sleep regardless of an individual's perception?
-Yes, caffeine can have a negative impact on sleep by blocking adenosine receptors, which play a role in the sleep-wake cycle. Studies suggest that individuals may underestimate the negative effects of caffeine on their sleep, even if they feel they sleep well after consuming caffeine.
What role does caffeine play in enhancing exercise performance?
-Caffeine is considered a very effective supplement for enhancing exercise performance. It can improve muscle strength, power, and endurance, allowing individuals to lift heavier loads and perform more repetitions.
Is there a specific time to stop drinking coffee to avoid sleep disruption?
-Research suggests that to minimize caffeine's effects on sleep, it's best to avoid consuming coffee about nine hours prior to sleep for regular doses and 13 hours prior for larger doses, such as those found in pre-workout supplements.
Can coffee or caffeine consumption be beneficial for health outcomes?
-Data generally suggests that moderate caffeine consumption can be beneficial for various health outcomes, including potential benefits for gut health, cardiovascular health, and liver protection due to antioxidants present in coffee.
What is the potential impact of caffeine on adenosine receptors and how might this relate to tolerance?
-Caffeine, being structurally similar to adenosine, can bind to adenosine receptors and block their inhibitory effects. Over time, with regular caffeine consumption, the body may increase the number of adenosine receptors as a compensatory mechanism, which could lead to tolerance and reduced stimulatory effects of caffeine.
Is there a significant placebo effect associated with drinking coffee?
-Yes, there is evidence of a significant placebo effect with coffee consumption. The expectation of receiving caffeine and the ritual of drinking coffee can contribute to increased arousal and alertness, even beyond the direct physiological effects of caffeine.
Can the benefits of caffeine for exercise performance be negated by habitual consumption?
-Some studies suggest that habitual caffeine consumption may reduce the performance-enhancing effects of caffeine, while others show no significant difference. The exact impact may depend on the dose of caffeine provided before exercise and individual differences.
What is the recommended dosage of caffeine for enhancing exercise performance?
-The literature suggests a dosage of three to six milligrams per kilogram of body mass for enhancing exercise performance. For a 70-kilogram individual, this equates to about 210 to 420 milligrams of caffeine.
Can the timing of caffeine ingestion before a workout impact its effectiveness?
-While there is no definitive data suggesting an optimal timing for peak performance, caffeine typically takes about 30 to 60 minutes to enter the bloodstream and start taking effect. For short workouts, ingesting caffeine about an hour before may be beneficial.
What are some potential side effects of consuming caffeine beyond the recommended safe dose?
-Exceeding the safe dose of caffeine can lead to increased blood pressure, heart rate, anxiety, sweating, palpitations, and gastrointestinal issues such as diarrhea or stomach upsets. Extremely high doses can be toxic and, in rare cases, fatal.
Outlines
🚫 Caffeine Misconceptions Debunked
This paragraph addresses common misconceptions about caffeine, such as the belief that it should not be consumed first thing in the morning due to cortisol levels. It introduces Dr. Brian Saunders, a caffeine expert, who discusses the benefits of caffeine for health and exercise performance. The paragraph emphasizes that while there is a lot of misinformation about caffeine, scientific research generally supports its positive effects, especially when consumed in reasonable amounts.
🕒 Clarifying Caffeine Timing Myths
The paragraph delves into the myth about the ideal time to consume caffeine, specifically the idea that drinking coffee first thing in the morning is less effective due to cortisol levels. Dr. Saunders explains the role of adenosine and how caffeine works as an antagonist to it, leading to increased arousal and wakefulness. The paragraph concludes that there is no strong evidence to support the idea that caffeine consumption should be timed with cortisol peaks to avoid an afternoon crash.
🔍 The Science of Caffeine Tolerance
This section explores why some people may feel sleepy or tired after consuming caffeine, possibly due to genetic differences in liver enzymes that metabolize caffeine. It discusses the possibility of upregulation of adenosine receptors in the brain with habitual caffeine consumption, leading to a reduced response to caffeine over time. The paragraph highlights the need for more research to understand individual reactions to caffeine fully.
☕️ Coffee's Cognitive and Ritualistic Benefits
The paragraph examines the potential placebo effect of coffee and the ritualistic aspects of drinking it, suggesting that these factors might contribute to the perceived alertness and energy boost. It discusses a study that compared the effects of caffeine in water versus coffee on brain activity, indicating that coffee might have a broader impact on cognitive functions, possibly due to the sensory experience and anticipation associated with its consumption.
💪 Caffeine's Impact on Exercise Performance
This section highlights caffeine's role as an effective supplement for enhancing various types of exercise performance, from short-duration sprints to long-endurance activities. It explains the mechanisms by which caffeine improves performance, such as increasing adrenaline and noradrenaline, blood flow, and glucose availability to muscles, as well as reducing the perception of effort during exercise.
⏰ Optimal Timing for Caffeine Ingestion
The paragraph discusses the timing of caffeine ingestion in relation to workout schedules. It suggests that while there is no definitive peak time for caffeine to enhance performance, it generally takes 30 to 60 minutes for caffeine to enter the bloodstream and start taking effect. The paragraph advises consuming caffeine an hour before a workout for short sessions and considering the half-life of caffeine for longer workouts.
⚠️ Warning Signs of Caffeine Overconsumption
This section warns of the potential side effects of excessive caffeine consumption, such as increased heart rate, blood pressure, anxiety, and gastrointestinal issues. It emphasizes the importance of adhering to safe caffeine limits to avoid negative health impacts and suggests that individuals be aware of the total caffeine intake from various sources, including energy drinks and pre-workout supplements.
🛑 Paradoxical Effects of Caffeine Intake
The paragraph investigates the paradoxical effect of caffeine, where some individuals feel more tired after consumption. It discusses the role of genetics in caffeine metabolism and the potential for upregulation of adenosine receptors with habitual use, which could diminish the stimulating effects of caffeine over time.
🔄 Resetting Caffeine Tolerance
This section explores the concept of caffeine tolerance and the potential benefits of a caffeine fasting period to reset the body's sensitivity to caffeine. It presents conflicting research findings on the impact of habitual caffeine consumption on the effectiveness of caffeine for exercise performance, suggesting that a higher dose before exercise might be necessary for those with higher daily caffeine intake.
🌙 Caffeine's Effect on Sleep Quality
The paragraph discusses caffeine's impact on sleep, noting that it can negatively affect sleep quality regardless of an individual's perception. It references a meta-analysis suggesting that avoiding caffeine intake approximately nine to 13 hours before sleep can minimize its effects on sleep, emphasizing the importance of being mindful of caffeine consumption, especially in the afternoon.
☕️ The Coffee Nap: Fact or Fiction?
This section examines the concept of the 'coffee nap,' where individuals consume coffee and then nap before the caffeine fully takes effect. The paragraph suggests that while this practice seems logical, there is a lack of scientific evidence to support its effectiveness, and personal experiences may vary.
🌱 Factors Affecting Coffee's Caffeine Content
The paragraph explores the factors that influence the caffeine content in coffee, such as the type of beans, their source, and the brewing process. It highlights the variability in caffeine levels between different coffee preparations and the difficulty in standardizing caffeine content, even in commercial coffee shops and pre-packaged coffee pods.
🌍 Global Impact of Coffee Consumption
The final paragraph emphasizes the widespread consumption of coffee as the second most consumed drink worldwide after water. It acknowledges the lack of awareness among consumers about the complex effects of caffeine on the body and the importance of understanding these effects for everyday health and well-being.
Mindmap
Keywords
💡Caffeine
💡Adenosine
💡Exercise Performance
💡Cortisol
💡Caffeine Tolerance
💡Caffeine Metabolism
💡Caffeine Dosage
💡Caffeine Half-Life
💡Caffeine Side Effects
💡Coffee Brewing
💡Health Outcomes
Highlights
Caffeine is a highly effective supplement for enhancing exercise performance.
Coffee and tea are the most consumed beverages worldwide, after water.
There is a lot of misinformation about caffeine's impact on health; the data generally suggests positive health outcomes from moderate coffee consumption.
Caffeine works by blocking adenosine receptors, increasing arousal and wakefulness.
The timing of caffeine consumption in the morning may not affect its effectiveness as much as believed.
Caffeine may cause an increase in circulating adenosine levels, potentially leading to a post-caffeine crash.
Habitual caffeine consumers may develop tolerance, requiring more caffeine to achieve the same effects.
Caffeine can improve mood and reduce the perception of effort during exercise.
The ideal dose of caffeine for performance enhancement is between three to six milligrams per kilogram of body mass.
Caffeine's effects can last for several hours, even after six hours post-ingestion.
High doses of caffeine can lead to negative side effects such as increased heart rate, anxiety, and digestive issues.
Caffeine metabolism can vary between individuals, but it doesn't strongly correlate with perceived effects.
Some people may feel sleepier after caffeine due to habitual consumption and reduced physiological response.
Caffeine can have long-term health benefits, including potential protection for the liver and cardiovascular system.
The ritual of coffee drinking, including its sensory experience, may contribute to cognitive and performance benefits beyond caffeine alone.
There is significant variation in caffeine content between different coffee preparation methods and even between pods from the same brand.
Caffeine's impact on sleep is significant, regardless of an individual's perception of its effects.
Avoiding caffeine intake approximately nine hours before sleep can help minimize its negative effects on sleep.
The concept of a 'coffee nap' may have some merit, but more scientific research is needed to confirm its effectiveness.
Transcripts
this is everything you need to know
about caffeine is it really true you
shouldn't drink coffee first thing in
the morning is there an ideal time to
stop drinking coffee I think everybody
knows that kind of person who takes has
a cup of coffee before bed and
supposedly sleeps great caffeine's
having a negative impact on your sleep
regardless of whether or not you think
it is or not and is your coffee habit
hurting your health in the long term if
you enjoy coffee just go and enjoy
coffee and the data in general suggests
that actually caffeine or coffee CA
consumption overall is very beneficial
for a number of different Health
outcomes Dr Brian Saunders is a caffeine
expert armed with the latest research
and Science and his lab specializes in
caffeine's role in enhancing exercise
performance caffeine is a pretty
effective supplement if not the most
effective supplement for enhancing
exercise performance that's out there
you can improve muscle strength muscle
power muscle endurance so you can lift
heavier loads and you can do more
repetitions of that there's a lot of
coffee fear and misinformation out there
so today we're clearing that up is there
evidence for this not really any that I
know of I'm Dr Curran an NHS surgeon and
this podcast we cut through the BS of
Modern Health advice and tackle the
biggest issues in science health and
Medicine both coffee and tea are
estimated to be the most consumed drinks
worldwide second only to water but
caffeine consumption is massively
polarizing some some people celebrate
its health benefits others demonize it
and blame it for all sorts of poor
health outcomes so if you're someone
that feels guilty about your morning
coffee habit or you're stressing about
what time to drink your morning cuper
you're hearing that you should have
periods without caffeine or you're
wondering whether you need to stop
completely this one's for you Dr Brian
Saunders from the University of sa Paulo
is here to tell us the truth behind the
online claims and what the scientific
research actually says I've heard a lot
a couple of years back about this whole
thing about if you're consuming caffeine
or coffee or any beverage which contains
caffeine you shouldn't have it first
thing in the morning because you're not
getting you know the full bang for your
buck because your cortisol is already
elevated and caffeine is going to
elevate your cortisol even more and
actually it's better if you take it an
hour and a half after you wake up when
it can boost you even more when your
cortisol slightly dips which sort of
mechanistically I thought it made sense
but recently there's more research which
came out suggesting that not even a
thing it doesn't really matter when you
take your coffee or that potentially
caffeine acts on your desing system
which it does and another reason why you
shouldn't consume in the morning is
there any truth behind morning timing of
caffeine at all yeah it's uh it's it's
become quite big hasn't it this one uh a
lot of people sort of in my day-to-day
have come up to me and asked about this
and you see a lot of promotion about
online as you kind of briefly mentioned
I think sort of the one thing to to take
a step back is thinking about you know
how does caffeine actually work so as
you mentioned caffeine Works has a
structure similar to adenosine in our
body um and adenosine Rises um
throughout the day and has an
important uh role in the sleep wake
cycle So within our brain it actually is
quite inhibitory so it kind of promotes
sleepiness suppresses arousal so if we
block adenosine from doing that role we
then can increase arousal increase
wakefulness and alertness so essentially
that's uh what what caffeine can do in
the body so when it comes down to should
I drink caffeine should I drink my
coffee which contains caffeine first
thing in the morning I've heard a few
slightly different versions of why we
supposedly should avoid this which you
touched upon so essentially when we wake
our circulating adenosine levels should
be the lowest that they will be that day
because during sleep adenosine uh is
gradually cleared from from the brain
but you know if we have a poor night's
sleep we don't get enough sleep these
levels might be higher than um desirable
and so to block this most people will
then take caffeine you know thinking
okay that this will properly start my
day properly wake my day but the
argument I've seen then is that this
adenosine that's in your body then still
kind of hangs around and several hours
later when the caffeine levels in our
system start to drop then the adenosine
that's hung around essentially can go
back to doing its job and we get um an
afternoon crash again kind of supposedly
and so the theory is apparently to avoid
this we should wait for our cortisol
levels to Peak naturally so that
cortisol can have some role in this
clearance of that residual adeny
caffeine stimulates cortisol levels and
apparently the morning increase in
cortisol levels due to caffeine
ingestion is sort of
undesirable because then apparently it
doesn't allow cortisol to do its job so
that's why people say wait 90 minutes to
120 minutes before consuming caffeine it
means that cortisol Peaks naturally can
do its job clearing out adenosine and
you feel naturally alert and then
afterwards you can kind of bump that up
with caffeine so I guess the question
like going back to the actual question
you asked is sort of is there evidence
for
this not really any that I know
um I can't find any evidence even to
kind of suggest that cortisol plays a
role in adenosine clearance so I don't
know why increasing this morning Peak
would interfere with cortisol performing
that role if it did that role anyway you
know it might be relevant adenosine
levels are low immediat as when we
immediately wake up so maybe caffeine
will have its least impact at that
moment but I would say there's certainly
no dat to to suggest that caffeine
interferes with this cortisol Peak and
how adenosine is processed and that this
all causes an an an afternoon crash so
the the evidence is weak or not even
there in my opinion so when you
suggested that caffeine has a similar
structure to adenosine and therefore can
bind to the adenosine receptors is
caffeine bound to the adenosine
receptors preferentially than adenosine
or are they both got the same Affinity
towards those receptor so my main
question here is can caffeine work
better to really get rid of that
sleepiness in the morning when adenosine
is still being cleared from the system
after that night's sleep as for the
specific Affinity I'm uh I'm not
entirely sure something to to check into
but what we do see um in in studies that
actually measure the amount of adenosine
or circulating adenosine is that when we
provide an individual with caffeine that
adenosine in the circulation then Rises
which suggests that it potentially even
removes that adenosine that's bound to
the receptor so it certainly um seems to
get in the way it is an an antagonist of
those receptors and potentially even um
displaces adenosine that is already um
connected so is that a possible
mechanism as to why people experience
such a profound crash and tiredness
after ingesting a lot of caffeine when
this caffeine bumps away the bound
adenosine to its receptors and
eventually once the caffeine wears off
you suddenly get a flurry of all of that
free adenosine now rebinding to their
receptors and suddenly causing a massive
surge in tiredness or Lethy yeah it's
it's it's certainly a potential um you
know some people have suggested that it
increases the sensitivity of these
receptors to the adenosine then that
then connect once um the caffeine sort
of uh is metabolized essentially but
again I I I think it's it's far more of
a personal thing um rather than this is
exactly what happens I don't think that
the scientific evidence is particularly
strong to suggest that um there's a
bigger crash because of this um but
certainly some people do seem to
subjectively feel this yeah is there any
for example there's some phenomenon when
some people become habituated to
drinking a certain amount of coffee and
progressively they need to increase the
amount of coffee they drink to get the
same effect what drives that is is there
something which the body physiologically
upregulates the amount of adenosine
receptors to compensate for this
caffeine blocking adenosine what what's
going on that Mak someone tolerant
towards caffeine a lot of people
subjectively do feel that that you know
the the more they drink caffeine the
less they get that sort of um buzz from
it and certainly in our lab when when we
get people who are caffeine naive into
the lab you know you can we we try to do
double blind studies where we don't know
and they don't know what they're taking
but sometimes you know it's caffeine
that they've taken that day because the
the the buzz the change in their um
Dynamic is is is clear to see but it
does seem to be um less when an IND
idual consumes caffeine whether it be
via coffee or teas um chronically so
it's difficult to say exactly what
happens in humans because we don't have
that data but when we look at uh Mouse
models which is a far easier model to
look at especially when considering we
want to look at what happens in the
brain and and and we can literally take
the brain out and and look what's going
on what we see is that in mice with
regular caffeine
consumption uh their brain brains
actually increase the number of
adenosine receptors as a kind of
compensatory mechanism so that could
diminish that kind of stimulatory effect
over time because essentially the same
amount of caffeine won't bind or you
know won't bind to as many receptors
they'll be more receptors free for the
adenosine to bind and then again that
adenosine to have its kind of depressive
inhibitory
effects I think a big caveat again would
be number one this is in mice uh number
two this is with caffeine doses kind of
100 times that we use in humans or you
know usually consuming a coffee or a tea
Etc so we don't really know if the same
is happening in humans but you know you
can extrapolate a little and suggest
that this this is maybe the mechanism
that's happening so in terms of people
drinking any sort of caffeine in the
morning or ingesting any sort of
caffeine in the morning is there a
significant Placo effect at play more
than just the caffeine having these
physiological effects which obviously it
does but is there also a huge uh role
for the placebo effect in making people
feel more alert and more energized I
think short answer yes uh I love this
kind of placebo stuff and and and our
lab has some on
studies uh looking at this topic maybe a
bit more specific to um the caffeine and
looking its influence on cognition and
performance and the mechanisms behind it
but I think um a lot of it overlaps so
there's there's more and more data
coming out suggesting that there's a
huge potential placebo effect of that
morning coffee and that might be linked
to um kind of the expectation of getting
that caffeine and that caffeine hit but
also so sort of that whole ritual behind
drinking your coffee your tea your your
drink of choice when we look at maybe
the expectation behind caffeine when
somebody believes that they're getting
caffeine but maybe they're actually just
getting a placebo we already see
increased arousal increased
expectation um there's in terms of sort
of my main area of of work we can see
that it can improve exercise performance
that's simply the expectation of or
believing that I've received caffeine
I'm going to get caffeine you can
already see changes in mood changes in
exercise performance but there was a
recent really interesting study um that
looked at taking caffeine as simply sort
of a a supplement so I believe diluted
in water versus caffeine in a coffee and
so what they did they used some sort of
complex measurement technique
of the brain called resting state
functional MRI so a highly complex
analysis of brain activity but in this
study so they made several measures of
brain activity before and shortly after
either consuming just caffeine so as a
kind of supplement or an actual coffee
and so they found that both caffeine and
coffee did cause some changes in brain
activity that were related to kind of um
a greater preparing ESS to switch from
resting to to working processes so it
suggests that the caffeine maybe made
people more ready for action um but some
changes in brain activity were only seen
when coffee was consumed and that like
there was increased sort of connectivity
in areas with um implicated in visual
processing uh higher level cognitive
functions such as working memory goal
directed Behavior so it seems coffee
produced a far more wide ranging effect
on cognitive activity which suggests
that actually the ritual of having a
coffee May trigger kind of brain areas
that's not only sort of due to the um
effects of caffeine but maybe due to you
know the stimulatory effects the the
sensory experience of having that coffee
maybe the smell the taste and
anticipation so really really
interesting data from uh from this study
do you think the added benefits of
consuming caffeine in the form of coffee
in addition to those ritualistic habits
and that conditioned Behavior it's also
maybe could be due to all the you know
the fermented beans the coffee beans the
antioxidants the polyphenols and the
sort of Prebiotic fibers from that
adding to all of those cognitive and
physical benefits yeah I I think um and
that's potentially a limitation of this
study to extrapolate that it's entirely
Placebo effects here you know I guess
what they probably needed was uh
decaffeinated coffee as another control
to be able to potentially eliminate
other compounds within coffee that maybe
generated these effects you know even if
it is these other compounds and maybe
not sort of only um Placebo effects that
are generating these these um changes in
brain activity you know it still does
suggest that yeah maybe having that cup
of coffee is more beneficial than
somebody who prefers just to take a
caffeine pill in the morning to to get
their Buzz yeah so if someone were using
some source of caffeine for boosting
their exercise
performance what benefits can someone
Achieve Beyond just increase alertness
and focus when they're consuming
caffeine to boost their exercise
performance whether they're a marathon
runner or just lifting weights in the
gym or cycling somewhere what can they
expect well in general I think they can
expect to probably improve their
exercise performance yeah um the general
consensus is certainly that caffeine um
is a pretty effective supplement
probably one of the if not the most
effective kind of uh supplement for
enhancing exercise performance that's
out there and that's you know you
mentioned there across a wide range of
exercise types that's that's the really
kind of fantastic and interesting thing
with caffeine you know you see from the
shortest duration activities you know
kind of um those explosive
high-intensity Sprints that maybe lasts
up to one minute you know 100 meter
running 200 meter running 50 m swimming
a a cycling Sprint at the end of a race
there's evidence that caffeine can
improve performance if you sort of
prolong that exercise duration a bit
more um you know a middle duration
Activity 4 kilometer cycling that might
last anywhere from 4 to 8 minutes if you
know depending on Elite to a
recreational 2,000 meter rowing sort of
six to nine minutes um maybe longer
endurance activities 10 kilm 16 40 kilm
cycling time trial performance cross
country swimming skiing sorry Marathon
running as you said there's data to show
that caffeine can improve this kind of
activity um you've got resistance
exercise so you know when you when you
get in the gym and you're performing
contractions of of isolated or multiple
muscle groups um there's evidence to
show that you can improve uh muscle
strength muscle power muscle endurance
so you can lift heavier loads and you
can do more repetitions of that and then
even kind of team sports which is a
whole mix of you know agility repeated
Sprints and changes of direction there's
so much evidence to show that caffeine
can also improve various aspects of
performance during this kind of activity
so if you look at the entirety of the
data you know there's probably 300 400
uh studies out there in general the
average shows a pretty pretty decent
performance enhancing potential of Cafe
you know I think some people might think
that they you know a recreational Runner
I'll take some caffeine and now all of a
sudden I might be S of chasing down
Usain Bolt during that 100 meter it's
not a miracle worker you know the
effects that we see in these studies are
generally kind of small to moderate okay
it doesn't mean it doesn't matter um
especially if you're a competitive
athlete but I think um it's certainly a
caveat that I always like to mention to
people yeah the these are small to
moderate performance improvements it's
not a miracle worker yeah I guess it's
going to optimize you as much as your
threshold allows given your current
physical limitation so if you're already
an ultr level athlete it's going to give
you the extra 1 two% if you're you know
a casual Runner it will give you an
extra 1 to two% but won't make you a
professional uh and really what I wanted
to query was how exactly does it exert
these benefits what's the mechanism
underpinning these exercising boosting
abilities of caffeine is it increase
blood flow is it enhance recovery
increased uh you know glucose usage by
muscles what's going on it's effects on
mood and on um uh arousal
motivation is part of its influence for
sure so as as we've already mentioned by
uh interfering with adenosine receptors
it can enhance mood and all these um
factors but then essentially um what we
see is an increase in in a in a lot of
um hormones that can lead to direct
benefits on the muscle so um we see an
increased in increas in uh adrenaline
noradrenaline you know that kind of
fight or flight
response um that kind of leads leads to
hyperarousal and you see an increase in
circulating glucose cardiac output blood
flow to the working muscles as you
mentioned um so that's definitely sort
of one method by which it works there's
also a large literature that we see that
um caffeine can decrease the perception
of effort during exercise so it feels
easy easier so that same say pace might
feel easier or you could kind of flip
that and you could run faster for the
same kind of perception of effort and
that's likely also due to the fact that
there's adenosine receptors present in
um nerve endings that are involved in
pain signal transduction wow so if you
antagonize these receptors you could
potentially reduce the signal of pain
reducing that perception of pain and
effort during exercise which I think is
an important stimulus to how hard and
how how much effort an individual um is
putting in and then there's also some
some suggestion um that there are Direct
effects on muscle that it can increase
kind of the the sensitivity of the
muscle to calcium release which is
really important for muscle contraction
there's a bit of debate about how much
caffeine is necessary for that but it
seems quite sort of all all-encompassing
of a variety of potential mechanisms
which is probably why caffeine Works
kind of across the board for so many
different exercise types so if someone
was an average caffeine consumer what
sort of dose of caffeine would provide
these increased benefits the literature
suggests caffeine relative to your body
mass so um most research out there has
probably used um doses between three and
six milligrams per kilogram of body mass
now I always like to highlight to people
it's milligrams and not grams you know
there's there's there's been some
horrendous mistakes made um so for say
70 kilo individual that's about 210
milligrams of caffeine wow and that that
already seems to be um performance
enhancing it is a lot it is a lot it's
you know depending on the source of
coffee or where you get it from it's
it's two to three espressos essentially
wow so you know given that the kind of I
guess safe limit in a day for a human is
roughly around 400 Mig maybe so you know
getting 200 Mig upwards is good going
for you know exercise boosting potential
for caffeine oh yeah oh yeah and and
again if if you look at those
recommendations they are quite wide if
you think about it for like from
doubling from 3 to six milligram so I
would always recommend as maybe a
starting point go for that lower end and
kind of see if it works for you see how
you react see if you know if you're
actually measuring your performance if
it's boosted your performance lower than
3 milligrams per kilo of body mass has
been shown to be effective so you could
even go towards the lower end um maybe
less of an effect um but certainly to go
above 6 milligrams per kilo you then
entering potentially trickier water
potentially some side effects and the
general data doesn't suggest that it's
more beneficial and actually might not
be um beneficial so i' kind of stick to
the lower end of of those ranges I just
provided is there an ideal time to
ingest caffeine so it peaks in your
bloodstream before the workout say 30
minutes 60 Minutes 90 minutes before you
work out to consume a certain dosage
there's no good data to suggest we need
to reach our Peak or that Peak caffeine
in the blood equals Peak performance um
but obviously you know it does take
about you know depending on the
ingestion type maybe sort of 30 to 60
Minutes for it to really enter the
bloodstream and start taking effect so
yeah if if you're you know going for a
short workout I I would say you know
maybe an hour before your workout um
ingest caffeine if you're going to be if
you're doing longer workouts I mean the
wash out the halflife of caffeine the
time it takes to be metabolized and
excreted is long so if you're if you're
taking say that 3 milligrams per
kilogram dose in 5 hours you're still
going to have about half of what that
peak in your blood was so in general I
think timing isn't too much of an issue
but again if your workout is short you
know if you're only going to do half an
hour one hour maybe then make sure that
you're taking the caffeine one hour
before that but those effects are then
going to last for for for a few hours
and I think there's one study that shows
even sort of six hours after ingestion
caffeine is still having uh performance
enhancing effects yeah so assuming
someone blow past the 400 mgram ceiling
that's safy consumed for a human in a
24-hour period you know presumably you
know you're going to have those really
emphasized effects of caffeine that
would have been okay at a physiological
safe dose of increased blood pressure
increased heart rate which is all
exercise boosting but they start to
become negative influencers and you may
get anxiety increased sweating um
palpitations maybe some GI side effects
some you know diarrhea or you know tummy
upsets what other quite dangerous side
effects can you come if you're really
pushing that you know safe 24-hour
dosage I think you've you've kind of hit
the nail on the head there those are
those are all potential side effects
when we we increase the the dose of
caffeine um aside from
Simply potentially toxic doses now again
in general we we we we're not going to
hit those toxic uh um doses with say a
cup of coffee or or even like a one
little capsule of caffeine but um
sometimes there's there's there's
caffeine and say pre-workout supplements
that people um ingest and and they don't
think about the amount of caffeine
that's in there they're looking to
increase I don't know the amount of
carbohydrate or creatin and so they
increase that dose accidentally
increasing the amount of caffeine um
which then could lead to really quite
High toxic doses of of caffeine which at
the really high end could could lead to
death and unfortunately there are kind
of case reports of this in the
literature it is rare and it is um
really a lot a lot of caffeine you know
that you would have to ingest sort of in
into the grams into the several you know
10 to 20 kind of grams of of of caffeine
but again even going above six
milligrams per per kilo you can increase
you know potential GI discomfort you can
increase anxiety anxiety is a big one
you know if if you're a person who
already potentially suffers from anxiety
is more prone to panic panic attacks you
know increasing again we've said it kind
of uh caffeine can increase uh
adrenaline noradrenaline so that
increases heart rate blood pressure
symptoms that are similar to uh anxiety
and so that can exacerbate that anxiety
you're increasing cortisol the stress
hormone so that can heighten feelings of
stress and anxiety and so that could
potentially negate any potential
benefits um of taking that caffeine so
we certainly have to look to limit um
look to take the minimal beneficial dose
in my opinion sometimes you know more is
is generally not better go stick towards
that lower end and and and see what
happens I think a lot of people fail to
appreciate that end of the day you know
caffeine is a potent drug whether we
like that word or not it is a drug and a
lot of these leading energy drinks in
the market a full can may contain upward
of 150 160 milligram of caffeine and I
know several people who chug through
three or four of those a day so they're
regularly consuming more than the safe
dose and not even really thinking about
it and then you wonder you know they're
feeling stressed probably because of
that you know heightened phal flight
response and the cortisol and the
adrenaline and all those effects of
caffeine which is consistently going
Beyond you know a safe metabolic dose
people don't realize the like the true
potential it's always that kind of with
like with many things that kind of
inverted you you know of course in in
small little doses it can be great it
can be fantastic I I I love my cup of
coffee in the morning I love a cup of
tea in the afternoon um I I I enjoy a
bit of caffeine sometimes pre-workout
but once you start to sort of overdo it
hit the excess that's when it can become
too much can become um
deleterious and then it's it's no longer
positive it's negative and it can cause
all kinds of negative impacts really so
the stereotypical view of caffeine is
that you take it and you feel alert and
you feel focused but paradoxically there
are a lot of people who take caffeine or
any sort of coffee or anything like that
and they actually feel more tired and
this always struck me as quite strange
and I suspected maybe they are you know
genetically faster metabolizers of
caffeine and they just you know Chow
through it their liver enzymes just Chow
through the caffeine a lot quicker but
apart from genetic variances in the
liver enzymes metabolizing caffeine and
reducing the halflife of it is there any
other mechanism as to why some people
might paradoxically feel sleepy or tired
of after consuming caffeine well I think
the caffeine metab metabolism stuff is
quite interesting because although yes
we have people who are faster
metabolizers and slower
metabolizers the extent to which this
actually modifies kind of perception of
of mood perception of arousal doesn't
seem to link to that genetic makeup so
um in collaboration with some colleagues
uh at the University of Brazilia we
actually looked at you know does an
individual's genotype for caffeine
metabolism um link to how they in
general respond to caffeine a
questionnaire based um assessment of you
know how they whether they get the
Jitters whether they feel anxious
whether they feel um an upward liftting
mood Etc and there doesn't actually seem
to be that strong a link between um
caffeine metabolism or or or and and
genetics and how an IND an individual
actually perceives or feels following
ingestion and um just on a side note as
well I think the data in terms of kind
of caffeine metabolism and exercise
performance following
caffeine it's a tenuous Link at best at
the minutes so I think we need certainly
more more data on the topic but I
wouldn't say that there's strong
evidence to suggest that caffeine
metabolism matters all that much I I
think I might be proven wrong at the
lower doses but I think sometimes when
you know like I said a 3 milligram per
kilo dose is already so much that we're
probably already
saturating um most things and so
metabolism of caffeine doesn't actually
make um that much of a difference as to
what's going on when um somebody takes
caffeine and actually um feels sleepier
personally um I haven't sort of
encountered too many of these
individuals I've certainly encountered
individuals who don't perceive an effect
they they they take caffeine and uh they
don't actually feel the effects and I
would say that's probably more to do
with them likely being a habitual
consumer so what we do see um with
habitual consumption is that those phys
ological effects again likely or
potentially due to an upregulation of
the adenosine receptors in the brain um
the physiological effects are reduced so
um with with um kind of
lowlevel lowish level habitual
consumption maybe up to about 200
milligrams per day we can see a a
blunting in the cortisol response um
whereas sort of really higher end um
habitual consumption kind of maybe above
that 400 milligrams per day um
recommendation that may even abolish
that cortisol response after caffeine
ingestion similarly kind of adrenaline
or adrenaline response can be blunted in
in chronic caffeine users so in those
individuals I think that would probably
explain why they don't feel as much Buzz
as um as other people so those people
who are habitual caffeine consumer
humors and maybe they've experienced
some blunted physiological response
objectively and maybe even subjectively
to themselves they perceive that same
dose of caffeine to have less of an
effect is there any value in those
people still consuming their same dose
of caffeine to get any benefits will
they get any benefits or should they
undertake a period of I don't know
caffeine fasting to almost reset their
tolerance our lab has been studying this
and so a few years ago we we we came out
with some research where we we got
people with different levels of Habitual
caffeine consumption you know ranging
from pretty caffeine naive all the way
up to you know in excess of the 400
milligrams per day and we showed that
caffeine provided acutely before
exercise improved their exercise
performance regardless of there was no
association you know there wasn't a
blunting in those individuals with
higher use there wasn't a greater effect
in in those with um lower use so our
data and and we have more data coming
out um suggests that maybe your habitual
caffeine intake doesn't matter that much
in terms of EX benefits for exercise
performance but you know science is
science and you you can find so many
studies showing the opposite and so
pretty much at the same time as we we
our study came out another study did
suggest a blunting in the effect so this
study was was controlled in a different
way they they got caffeine naive
individuals so with very low caffeine
consumption they provided caffeine prior
to exercise and showed it improved
performance but then half the group went
away and took caffeine every day for for
a month so then when they came back they
were now kind of Habitual or chronic
caffeine users and then when they were
tested again that caffeine prior to
exercise was less efficient it didn't
eliminate the performance benefits of
caffeine but it was reduced and so you
know that suggests that maybe caffeine
um chronic caffeine consumption
does uh inhibit a little bit um its
effects the key difference is maybe in
the dose provided before exercise so in
the other group study they provided 3
Mig per kilogram of body mass daily and
then provided the same amount pre
exercise whereas the amount we gave to
our participants was on the whole
greater than their daily dose um so it
was 6 milligrams per kilo that we
provided so maybe the key is if you're
an individual who you know drinks say
approximately three milligrams of of per
kilo um of caffeine per day then maybe
prior to exercise you need a a bit more
than that to then truly get the benefits
now that's a little bit extrapolating
the data we're actually testing that
right now in our lab so hopefully um
that'll come out in the next few months
but um you know I think I think there is
some logic to it I guess if you look at
the literature you'll see different
numbers quoted for the halflife of
caffeine and I guess that will also vary
depending on the individual as well I
guess maybe anything from 5 hours to 8
hours or anything in between and
although caffeine has various
physiological benefits it also has that
negative effect on sleep and its
interaction being an antagonist of the
adenosine system as well which helps us
to sleep is there any way or sort of any
way to clear caffeine faster if you'd
consumed a large amount in the few hours
leading up to your bedtime and you
didn't want it to affect your sleep in
the way that it mechanistically does so
we've actually been looking trying to
look into this to see if there is say a
caffeine
antagonist but from our
searches um I don't believe there is one
so the unfortunate thing for those who
do want to take caffeine later in the
day or have taken more than they want
and are having trouble sleeping is that
in general
you're not you're just going to have to
wait for for lady time to do its job but
you know that I think the easiest way to
avoid that is to just limit your
afternoon intake of caffeine and kind of
see what works with you I think an
important point when it comes to sleep
there's a really nice study showing
differences in what we objectively
perceive or how we objectively perceive
caffeine to influence our sleep versus
what it objectively does so in this
study they provided caffeine sort of 63
and immediately before bedtime versus
not providing
caffeine and when you ask somebody to
objectively quantify sort of um how
quickly they fell asleep how much they
slept um uh Total Sleep Time generally
they underestimate
the effects or the negative effects that
caffeine has had on their sleep so
generally they underestimate or
overestimate their Total Sleep time they
overestimate the percentage time they're
actually asleep so caffeine's having a
negative impact on your sleep kind of
regardless of whether or not you think
it is or not you know I think everybody
knows that kind of person who takes has
a cup of coffee before bed and
supposedly sleeps great I'm one of those
but after reading this study I thought
well this this actually suggests that
despite my perception it might not be
the the true case there was a
metaanalysis that came out last year
kind of pooling so many different
studies that um suggests that if we want
to limit caffeine's effects on our sleep
we should look to avoid um consuming
kind of coffee about nine hours from
about nine hours prior to sleep and at
bigger doses so those kind of preworkout
doses is the data suggest that we want
to limit that to 13 hours before bed so
you know if you're going to bed at 10
that's kind of limiting it to 9:00 a.m.
in the morning so wow not that people
are necessarily going to do this but
just people should be aware that it can
interfere with your sleep and so you
know the more you take the more you take
in the afternoon the more it can
negatively impact upon your sleep how
much value can you place on these I
guess these trending things on social
media where people talk about having a
coffee nap where they consume some
coffee then have a nap almost before the
coffee really hits their system and then
as they wake up from their 45 60 Minute
power nap the coffee then hits and
they're now less groggy after their nap
but they've also got the added benefit
of the caffeine and the coffee peeking
and they feel good is it any scientific
underpinning as to Coffee naps if you
can immediately fall asleep following
that coffee um then and and have that
you know generally your nap should kind
of be I think around 20 minutes half an
hour max then you would wake up at the
moment that caffeine is kind of really
starting to rise and and and having an
effect I think it's one of those
that mechanistically
logistically it seems to make sense but
until we actually test it in my opinion
it's all just kind of hearsay and you
know it's it it's all about like your
first sort of uh question about you know
should we take it immediately upon
waking or 90 minutes to 120 Minutes
there might sometimes be some rationale
for doing this but until we actually
measure it properly in the lab if some
somebody goes out and does it then it's
all just
anecdotal but it doesn't mean to say
that if it works for you then great then
you know I I sometimes think that with
science sometimes we are too quick to
dismiss a person's personal
feelings but you know it is important
that we say oh here is the data on
average this is the
direction but of course there can be
some deviations from that direction
depending on
individuals yeah I guess you know
anecdotal data is still data and if you
get a series of anecdotal data points it
becomes a case Series so yeah guess it's
not straightforward just to wipe that
off and disregard it but what was
interesting is that previously you
mentioned that uh caffeine consumption
can sensitize the adenine receptors to
be you know more sensitive towards the
effects of adenosine and potentially
there may be some upper regulation of
the adenosine receptors as well is there
any long-term effect on the adenine
receptors when you habitually consume
caffeine in the very long term to the
point where it actually could cause
these longer term physiological changes
again I don't think we we have that data
I don't think we we we know what it does
especially in humans because it's pretty
difficult to take a brain biopsy so I I
don't think anybody's going to be
volunteering for that anytime soon again
all you can do is look at um what kind
of um long-term data suggests when we
look at Snippets of you know people's
long-term use so you know you can
evaluate that via questionnaire and then
look at their General Health and I think
in general the data do suggest that
caffeine or coffeine consumption overall
is very beneficial for a number of
different Health outcomes we look at oh
there might be a m a reduction in
exercise performance with habitual
consumption so we we we should really
sort of remove remove it from the diet
to avoid this but it's such a minor
thing when in the long term if you enjoy
coffee just go and enjoy coffee and the
data in general suggests that actually
caffeine consumption and coffee intake
in those you know reasonable doses again
as you mentioned before 400 milligrams
per day is kind of set as as as the
upper limit or
thereabouts then you're you're you're
likely to gain long-term benefits and
and you're not likely to get any um
unfavorable um issues in my opinion yeah
I think that some of the study I read
suggested up to three cups of coffee a
day could actually you know provide some
significant benefits for gut health
cardiovascular health even some liver
protection and the antioxidant effect of
um you know the chlorogenic acid and
various things in uh coffee and coffee
beans I mean Brazil and South America in
general has some pretty great coffee is
there any
thing you'd recommend in terms of the
preparation of coffee or the Brewing or
the even types of beans and locations
and how they're harvested that has any
effect as to really maximizing the
caffeine dosage and how great it is for
absorption depending on where it's
soured how it's soured and how it's made
yes so obviously there are there are you
know plenty of different kinds of or or
or sources of um caffeine um obviously
coffee beans is is one of the most
well-known but then you know you've got
cacao beans uh you've got Cola nuts from
Africa tea leaves obviously um at a
generally at a lower amount yba mate the
Guan Berry here in in Brazil which I
believe can actually kind of in general
per um Bean contains more caffeine than
a than a coffee bean so you know the
different types of beans the different
locations or where they're
grown probably even one coffee bean to
the next Coffee Bean right next to it
the amount of caffeine in there will
likely differ and then you know you've
got to factor in um the processing you
know Brazil I agree has some fantastic
coffee but it also has some pretty
abysmal coffee in my opinion I've been
to um a really nice uh coffee Farm here
where you know they fully explain the
process and you know the most popular
but most popular maybe because they're
quite cheap brands or or or or coffees
out there are generally the less good
beans that have kind of been filtered
away and also contain a bit of dirt and
a bit of stuff that you wouldn't
necessarily want in there and so they
over roast them to make it a bit more
flavorsome but you know you can kind of
see it in the color it's kind of more
black color whereas coffee shouldn't
really be that really dark black color
it should be a more light muddy Brown
and so that will already change or or
likely change the caffeine content how
much we don't really know but we do know
that you know processing preparation if
you do have a drip coffee if you use a
percolator if you have you know a
pressure espresso this can all influence
how much caffeine is actually in
uh your coffee but even you know trying
to standardize that will still lead to
different caffeine content so there's
some really nice studies showing that
again the different preparation types
lead to a different amount of caffeine
using the same kind of pack of coffee um
if you go to a coffee shop you might
think oh that might be more standardized
but no there's a there's really nice
data showing that the same coffee from
the same popular brand
coffee shop um on consecutive days the
actual caffeine content ranged kind of
between 250 and 550 milligrams within
that one coffee like obviously big big
coffee espresso pods there's a really
nice study from Ben des's group in um
Australia where you know you might think
that they'll probably be able to
standardize better the amount of
caffeine in each of these
pods but no they actually vary quite
wildly from one pod to the next and
don't exactly match up with What's um
actually written on the
label it's something I always mention to
people who want to use caffeine for
exercise
performance can you use caffeine in
coffee to improve performance of course
you can there's some nice studies that
show that but you don't know exactly how
much caffeine you're getting that's the
issue so if you're somebody who only
wants a little but on that one day you
get a huge impact you know you get that
550 milligrams that might not be
beneficial to you or or or it might be
that you get the wheat coffee today and
there's less caffeine so if you want to
know exactly how much caffeine you're
getting then you know maybe a supplement
um is is the better option for you for
your for your workout I think I heard I
hope this is correct but it's the second
most consumed drink in the world after
water and I think given that it's
certainly very widely consumed by a lot
of people you know millions billions of
people around the world most people
don't really appreciate the nuance and
the level of complexity as to what's
going on in their systems consuming this
quite potent drug so thank you very much
Brian for adding all of this nuance and
science to the world of coffee which is
you know incredibly important to
people's everyday lives thanks again to
Dr Brian Saunders next episode we meet
exercise scientist Dr Mike isrel who
tells us just how little you can work
out and still reap the benefits the most
effective way to lose weight and why
supplementing with creatine isn't just
for bodybuilders and much more subscribe
so you don't miss it and the weekly Dr K
explores podcast and I'll see you
curious croutons next week
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