Dutasteride or Finasteride for Hair Loss (ENGLISH)💊

Summary

تناقش المقالة الصوتية المقدمة عن علاج الفقدان الرأسي، وتناقش الفرق بين دواء فيناستيريد والدواء دو توستريد، وتأثيرهما على مستويات DHT في الجسم. يناقش النص الاستخدام الشائع للأدوية وDosage المقترحة للمرضى، ويذكر الاختلاف في التأثير السلبي للأدوية على المرضى. ويشدد على أن الأدوية قد تكون آمنة وفعالة، ولكن يجب التعامل معها بحذر واختيار الDosage التي تتناسب مع حالة كل مريض على حدة.

Takeaways

• 😀 تناقش النص النص ال録ي المتابعة لمناقشة الフィットنس التي جرت أمس، حول الاختيار بين الأدوية المنتهية للاستخدام أم لا.
• 🏥 سيناقش اليوم الاستخدام للأدوية التي ت称作 'butas' وكيفية تحطيم المقارنة مع 'finasteride'.
• 💊 سيناقش النص الDosage للـ 'finasteride' و 'dutasteride' وكيف تتقارن الDosages في النهاية.
• 🔗 يُذكر أن الرابط لمناقشة البارحة متوفر في الوصف أسفل النص.
• 📚 يُناقش النص التأثير السلبي لـ 'dutasteride' والتأثير الإيجابي على تقليل مستويات DHT في الجسم.
• 🚫 يُذكر أن 'dutasteride' لم يحصل بعد على الموافقة من FDA لاستخدامها في الفقدان الرأسي.
• 📈 يُناقش النص الاختلاف في الDosage التي يستخدمها المرضى بشكل منفصل، وتأثير ذلك على النتائج.
• 👨‍⚕️ يُذكر أن الأدوية يجب أن تكون مخصصة لكل مريض بناءً على احتياجاته وتحمل المخاطر.
• 📊 يُذكر أن الدراسات يمكن أن تكون مربكة وتجعل المرضى يشعرون بالارتباك حول الDosage التي يجب اتخاذها.
• 🌙 يُنصح بالأخذ من 'finasteride' في المساء قبل العشاء بسبب دورة حياة الهرمونات في الجسم.
• 💡 يُذكر أن زيادة مستويات التستوستيرون في الجسم قد لا تؤدي إلى تحسن أداء الرياضة أو بناء العضلات.
• 📚 يُنصح بأخذ استشارة طبيب متخصص قبل اتخاذ أي قرارات طبية جديدة.

Q & A

ما هي المناقشة التي جرت في النص حول دوا التناسب؟

النص يناقش دوا التناسب التي تسمى فينشستريد (تسمى أيضاً بروسكار أو بروفشيا) و دوا دو توستريد (تسمى تحت الاسم التجاري أ摸着 آرك). كلا الأدوية هما من عزل الـ DHT ويستخدمان في حالات الهزال الرأسي.

ما هي الفرق بين فينشستريد و دو توستريد؟

فينشستريد يمنع نوع 2 من 5 alpha reductase، في حين أن دو توستريد يمنع جميع الأنواع 1، 2، و 3 مما يقلل من مستويات DHT أكثر من فينشستريد.

لماذا يفضل بعض المرضى استخدام دو توستريد على فينشستريد؟

بعض المرضى يفضلون دو توستريد لأنه يقلل من مستويات DHT أكثر، مما قد يؤدي إلى زيادة نمو الشعر أكثر من فينشستريد.

لماذا لم يحصل دو توستريد على الموافقة الرسمية في الولايات المتحدة؟

الموافقة الرسمية لم ت被授予 لأن شركات الأدوية التي تصنع فينشستريد (مرك) و دو توستريد (جلاسكو سميث كلاين) تشعران بالحذر بسبب القضايا القانونية التي تواجهها.

ما هي التأثيرات الجانبية التي يمكن أن تحدث من استخدام فينشستريد؟

من التأثيرات الجانبية التي يمكن أن تحدث من فينشستريد انخفاض الشهوة، ومشاكل في الوظيفة الجنسية، وانخفاض كمية الejaculate.

هل الزيادة في مستويات التستوستيرون يؤدي إلى زيادة أداء الرياضة؟

لا، لأن فينشستريد يزيد من مستويات التستوستيرون بـ15% فقط، مما لا يؤدي إلى زيادة أداء الرياضة أو بناء العضلات.

ما هي الDosage التي ينصح بها النص لـ فينشستريد؟

النص ينصح بـ 1 ملغم من فينشستريد يومياً لمدة ستة أشهر بعد العمليات الجراحية.

ما هي الDosage التي ينصح بها النص لـ دو توستريد؟

النص ينصح بـ 1 ملغم من دو توستريد يومياً، مع تجاهل الDosage بأسبوع واحد وأخذ 0.5 ملغم من دو توستريد في ذلك اليوم.

لماذا يجب تناول فينشستريد في المساء؟

لأن مستويات التستوستيرون في الجسم ترتفع في الليل، والنصف النشط لفينشستريد قصير، لذا يجب تناوله في المساء لتغطية فترة الذروة التستوستيرونية.

هل الأدوية الطبية لمنع الهزال الرأسي آمنة؟

نعم، الأدوية الطبية لمنع الهزال الرأسي تعتبر آمنة، مع أن التأثيرات الجانبية تكون نادرة وتختفي بعد التوقف عن الدواء.

لماذا يفضل بعض الأطباء تجنب تجنب الأدوية الجديدة مثل دو توستريد؟

بعض الأطباء يفضلون الحذر وتجنب تجنب الأدوية الجديدة لأن لديها تاريخ استخدام قصير ولا يمكن التقييم النهائي للتأثيرات الجانبية الطويلة الأجل.

Outlines

00:00

💊 Hair Loss Medication Discussion

The script begins with a discussion on the continuation of a previous conversation about fitness trade, which is likely a mispronunciation of finasteride, a medication used to treat hair loss. The speaker addresses whether one should take finasteride or not and introduces the topic of dutasteride, another DHT blocker. The speaker clarifies the difference in the mechanism of action between the two drugs, with dutasteride being more potent in reducing DHT levels. The historical context of both drugs is provided, including their FDA approval for different uses. The speaker also touches on the controversy surrounding the FDA approval of dutasteride for hair loss and the potential legal implications. The paragraph concludes with a note on the importance of individualized dosage and the role of anecdotal evidence and clinical experience in treatment decisions.

05:01

📊 Dosage Variations and Patient Experiences

This paragraph delves into the complexities of dosage variations for finasteride and dutasteride, highlighting the lack of standardized dosages and the prevalence of patient self-experimentation. The speaker discusses the challenges of maintaining consistent dosage when cutting tablets and the potential inaccuracies this introduces. The paragraph also addresses the economic factors that influence patient decisions, such as the cost of brand-name versus generic medications. The speaker shares anecdotal evidence of patients who have reported better results with variable dosages and those who take the medication on alternate days or in reduced doses. Key points about the effectiveness and side effects of both drugs are summarized, emphasizing the differences in DHT reduction and the longer half-life of dutasteride compared to finasteride. The speaker concludes by emphasizing the importance of a doctor's advice and the need for a personalized treatment plan based on the patient's needs and safety.

10:05

🕒 Optimal Timing and Dosage Recommendations

The final paragraph focuses on the optimal timing for taking finasteride and dutasteride, with a specific recommendation for finasteride to be taken at night due to its shorter half-life and the body's peak testosterone levels. The speaker also discusses the impact of these medications on testosterone levels, with dutasteride causing a more significant increase. The potential benefits and limitations of increased testosterone levels are explored, including the role of estrogen levels and the use of aromatase inhibitors for muscle mass enhancement. The paragraph concludes with the speaker's recommended dosages at their clinic, emphasizing the importance of long-term safety and the cautious approach to prescribing dutasteride due to its shorter history of use and less understood long-term side effects. The speaker acknowledges the higher rate of side effects associated with dutasteride and the preference for finasteride based on extensive patient experience and studies.

Keywords

💡Fitness trade

تشير 'Fitness trade' إلى التبادل المتعلق بالصحة الجسدية، حيث يُناقش في النص النص الuya في السياق المناقش للعلاجات التي يمكن أن تساعد على تحسين الصحة الجسدية. في النص، يُناقش ما إذا كان من المفترض أن يتناول المرء 'finished rate' أو لا، مما يُشير إلى الأدوية التي يُستخدمها لعلاج الفقدان الرأسي.

💡Finasteride

'Finasteride' هو دواء يُستخدم عادة في علاج الفقدان الرأسي، يُعرف أيضًا بـ 'Propecia' أو 'Proscar'. يُذكر في النص أنه من الأدوية التي تمنع توليد DHT (الديهيدروستيرويدosterone)، وهو هورمون يُشتبه أنه يؤدي إلى الفقدان الرأسي.

💡DHT blockers

'DHT blockers' هي مجموعة من الأدوية التي تمنع توليد DHT، ويتم النقاش في النص حول دورها في تقليل مستويات DHT في الجسم لعلاج الفقدان الرأسي.

💡5 alpha reductase inhibitors

'5 alpha reductase inhibitors' هي فرع من الأدوية التي تمنع أنماط معينة من الهرمونات التي تؤدي إلى توليد DHT. يُذكر في النص أن 'finasteride' و 'dutasteride' هي من هذه الأدوية.

💡Benign prostatic hyperplasia

'Benign prostatic hyperplasia' هي حالة تطور طبيعي في البروستاتة مع تقدم السن، يُذكر في النص أن 'finasteride' تم اكتشافها أولاً كدواء لعلاج هذا النوع من المشاكل.

💡FDA approval

'FDA approval' يُشير إلى الموافقة الرسمية من قبل إدارة الأدوية والغذائية في الولايات المتحدة (Food and Drug Administration). يُناقش في النص كيف لم تحصل بعض الأدوية على الموافقة الرسمية لاستخدامها في علاج الفقدان الرأسي.

💡Dosage

'Dosage' هي كمية الدواء التي يُنصح بها للمريض. يُناقش في النص كيف أن الجرعات الفعلية للأدوية قد تكون معقدة ومختلفة من فرع لآخر، وكيف أن المرضى يجربون معدلات مختلفة من الأدوية.

💡Side effects

'Side effects' هي التأثيرات السلبية قد تظهر بعد تناول الأدوية. يُناقش في النص كيف أن 'finasteride' و 'dutasteride' لديهما تأثيرات جانبية مختلفة.

💡Circadian rhythm

'Circadian rhythm' هي نظم الجسد التي تتغير في دورة 24 ساعة. يُذكر في النص أنه يُنصح بالأخذ من 'finasteride' في المساء بسبب دورة حياة الهرمونات في الجسم.

💡Aromatase inhibitors

'Aromatase inhibitors' هي الأدوية التي تمنع تحويل الستيرويدون إلى استراديون. يُذكر في النص أنها تُستخدم لزيادة كثافة الشعر أو لتحسين أداء الرياضة.

💡Anecdotal evidence

'Anecdotal evidence' هي الأدلة الشخصية أو الشخصية الشخصية التي لا تعتمد على الدراسات العلمية الرسمية. يُذكر في النص كيف أن بعض المرضى يعتمدون على تجارب الآخرين أو تجارب شخصية لاختيار جرعات الأدوية.

Highlights

Discussion on whether to take finasteride or not for fitness trade.

Comparison of finasteride and dutasteride in terms of their effects on DHT levels.

Finasteride, also known as Proscar or Propecia, and dutasteride, under the trade name Avodart, are the most commonly used DHT blockers.

Difference in the mechanism of action between finasteride and dutasteride.

Finasteride was originally discovered to treat benign prostatic hyperplasia and later used for hair loss.

Dutasteride has not received FDA approval for hair loss treatment due to legal concerns.

The importance of personal experience and anecdotal evidence in hair loss treatment.

Confusion regarding dosage due to various patient experiments and lack of clinical trials.

Individual differences in metabolism, risk tolerance, and mental robustness affecting treatment compliance.

Some patients prefer the word of the doctor over statistics for treatment decisions.

Issues with cutting tablets and the resulting dosage variations.

Different patient strategies for taking finasteride and dutasteride, such as alternate days or half tablets.

Key points differentiating finasteride and dutasteride in terms of DHT blockage and side effects.

Long-term use of finasteride showing a decrease in effectiveness after 2 to 5 years.

Combination of dutasteride with finasteride can enhance the effects of each other.

Dutasteride's shorter history on the market makes it harder to assess long-term side effects.

Recommended dosages for finasteride and dutasteride at the speaker's clinic.

The importance of caution when prescribing dutasteride due to its higher rate of side effects.

Discussion on the impact of finasteride and dutasteride on testosterone levels and athletic performance.

The use of aromatase inhibitors in conjunction with finasteride for muscle mass benefits.

The speaker's approach to advising patients on treatment plans based on safety and individual needs.

Transcripts

hello now the race talk is in

continuation of yesterday's talk we were

discussing fitness trade yesterday and

whether you should take finished rate or

not and today we're going to talk about

butas today and how to destroy compares

with finished ride and today I'm also

going to discuss with you the dosage of

finis right and the dosage of do toss

tonight and how they compare in the end

I will go through the dosage that I

recommend for my patients the link for

yesterday's talk is in the description

below

and you can see it if you want to

electrons to yesterday stock I keep

receiving so many emails from my

patients regarding what is the dosage

whether they should take notice trade

off in a strain and the Mail's are so

many that I decided that I must publish

this video and since because of the

Kovach close down I have all the time to

do it so here I am presenting to you

whatever knowledge that I have

though many missions today are advocates

of finestra and some are advocates off

to destroyed there is a second category

of patients who a little cautious they

do not want to use a blow torch to

extinguish a candle finished right which

is also referred to as proscar or

propecia and to toss right which comes

under the trade name of a mood arc are

the most commonly used DHT blockers

which are used in hair loss today both

of them are 5 alpha reductase inhibitors

so therefore the testosterone levels in

the body increase whereas the DHT levels

decrease there is a fine difference

between the mechanism of action of

finasteride on one hand and to trust

ride on the other where is finished

right inhibits type 2 5 alpha reductase

to thirst right inhibits all three ice

low signs that is type 1 type 2 and type

3 so in so doing it reduces the amount

of DHT much more than finasteride does

but on the downside you have more side

effects from Reuters right then from

finished finished trade was originally

discovered as a drug to treat benign

prostatic hyperplasia that is prostatic

disorders in 1976 it was only 1992 that

it was its use started in hair loss

patients but it was only as laid back as

in 1997 that it was FDA approved as an

exception

therapy for hair loss patients the

approval of goethe stride for benign

prostatic hypertrophy follow the same

route Dukas trade was FDA approved for

prostatic disorders in 2001 but till now

it has not been able to get FDA approval

for its use in hair loss medicine it is

very likely that it will never get in

the near future

why because with so many laws for

against Merck there's makers of propecia

Glasco Smith Kline the makers of avid

art that is do tough terrain are

cautious now to get this approval FDA

will think twice before recommending

another hair loss medication after so

many cold cases 1000 and 100 against

Merck the makers of propecia so it is

not likely in the near future that you

destroyed it is going to get FDA

approval

however it has got government sanction

in countries like Japan and Korea not

having FDA approval does not mean that

you trust right is not effective in hair

loss there are so many papers today on

the use of in Australia in Australia TT

treating hair loss that one it leaves

one confused so at the end it is only

the experience the anecdotal evidence

the experience in a clinical setting

what the doctor has to feel a doctor who

has been practicing here historic

surgery and who has been prescribing to

destroyed and fenestrated for a long

time and a patient who has been taking

these medicines these people count more

than any scientific study the field of

dosage II is equally confusing why

because patients have been experimenting

with various combinations and

permutations and over a period of time

there are certain laid down dosage

combinations which are nowhere in

clinical trial which never have been

studied in a paper which have been

established by hearsay so to say in the

mind of hair loss sufferers it is very

interesting that many clinics also

follow certain dosage regimes which are

not corroborated by any study as such

this is very interesting how crowd

behavior has evolved with the use of

data spread and finished fried over a

period of time patients interact with

one another and there are so many media

on which they interact social platforms

one-to-one basis through the doctors and

this is involved a very peculiar

strategy to handle hair loss and the

dosages of

finis

and distress trade are equally very

quaint we need to note here that every

patient is different every patient has

different metabolisms everybody does not

have the same risk tolerance

people have different mental robustness

and this is very important to understand

because for compliance is very crucial

too many patients have observed 90%

maintenance of hair and some amount of

regrowth with 5% chances of side-effects

is more acceptable than just 70% of

maintenance of hair and regrowth and 1%

side-effects and the reverse is also

true

so everybody is made up differently

everybody has different risk tolerance

and so every medicine every regime that

we make one patient his tailor cut to

that patient's requirement and that

patient's risk tolerance and how the

particular drug is having an effect on

him one dosage for every patient will

not work it has never worked till now

and there is a majority of patients who

don't even look towards statistics for

them the word of the doctor is enough

and these are the patients who are the

happiest amongst all these people there

many people who are taking proscar

taking the 5 milligram tablet cutting it

into 4 pieces and using them when you

cut a tablet there's breakage of the cut

module and powder formation the sum

amount of the tablet is lost so people

think that they are making 1.25

milligram pieces but they actually not

like that one day they will be taking

1.25 milligram the other day they're

taking 1 milligram and some other days

they are taking 1.5 milligram as well so

there is a wide variation when you cut a

tablet a 5 milligram tablet into four

pieces

now how this started when propecia came

into the market it was exorbitantly

priced because the company had rights to

this medicine and nobody else could

maybe genetic forms for 5 years after 5

years of a lot of generic formulations

came into the market and the costing of

finesse trial

reduced to a great extent but still

there is a category which cannot afford

propecia and still divides 5 milligram

proscar into 4 parts and use it with

this considerable variation of dosage of

1.25 milligram of cross scar there was

considerable variation but there are

some patients who have reported that

they do better with this variation on a

daily basis then if they took one

every day so this is just an anecdotal

incident and there is no research that

has gone into it neither is a paper

being published

there is another subset of patients who

takes these medicines on alternate days

there's another one who splits the

tablet into half the one milligram

tomato to half and takes 0.5 milligram

tablets every day there are others also

who have discovered that their hair is

maintained even if they take one tablet

every third or fourth day important

points to note about do toss right and

finished right are number one that

finasteride blocks 70% of the DHT

whereas bucha strike rocks 94% of the

DHT on a milligram 2 milligram is so it

has obtained that to destroy promotes

more hair growth also Dukas try has a

longer half-life of 4 to 5 months as

compared to that of finasteride which is

only 5 to 6 hours this is very important

side effects whereas in the case of

finasteride 1.9 percent of the page

complain of decreased libido and 1.3

percent of the patients complain of

erectile dysfunction 1.2% patients

complain of decreased ejaculate now in

the case of 2 destroyed this is much

higher so while taking finasteride a lot

of papers have proof that it is a safe

drug the side effects are rare they are

transient that is they disappeared after

you discontinued the drugs all the

papers also prove that the drug is due

passed right on double-blind trial on

self-assessment and on clinical

observations provides more hair

thickness after menu ating global

photograph so in my experience of using

finasteride alone I have seen that most

patients when they take it for a long

time after 2 to 5 years it is variable

the effects of finasteride start to wane

away and this is when I discovered that

a combination of rooters to ride with

finished friend both these drugs were

used together and they complement one

another and enhance the effect of each

other then the medicine to destroyed has

been in vogue only for the last 10 to 15

years and more so it has been popular

only in the last about 5 years of 7

years I'm going to say so this period of

time in the history of a drug is not a

time period in which you can assess the

long-term side effect

that you can get by constant long-term

use use of Medicine in asteroid has been

in the market for a long time and

there's a long history of its use so we

feel that it is a safer drug and it's

safer to recommend to the patient and a

patient in the long term may not have

significant side therefore this is the

reason why some doctors like me too are

hesitant in prescribing do test aligned

to the patient it is always better to

earn on the side of caution than to be

sorry so studies can be very confusing

there is one study of 1999 which

confuses the maximum this study

concludes that finished ride is almost

as effective at 0.05 milligram per day

dosage as it is at 1 milligram per day

or 5 milligram per day when it comes to

scalp skin DHT levels and point 2

milligram per day is almost as effective

as 1 milligram per day or 5 milligram

per day when it comes to serum DHT

levels now this study is not helpful at

all and there is a host of studies which

are so confusing and therefore patients

who are unfinished right they don't know

what to do at the end of the day after

this searched and searched and searched

the internet they get a reading so that

is where the doctor has to step in and

advise a treatment plan best suited to

the needs of the patient and the safety

of the patient now what time should

finished right or just right we take now

as far as to destroyed is concerned it

has a long half-life you can take it any

time of the day but finesse trial should

be only taken at night before dinner why

because the peak testosterone level in

the body happens at 1:00 a.m. this is

the circadian rhythm and since the

half-life of finasteride is only six to

eight hours or even lesser so it may not

cover that period when the peak of

testosterone takes place if we are

taking the drug in the morning another

fact about finasteride versus do

destroyed that you should know is that

finish tried increases the testosterone

levels by only 15%

whereas in the case of root Australia it

is much more so many because to student

levels go up estradiol levels also go up

by 15% increase of testosterone

by 15% is not very alarming as it is we

take testosterone supplementation after

the age of 50 but complete research has

not been done to establish that use of

finasteride for increased testosterone

levels is beneficial for supplementation

and can be used in place of testosterone

supplementation many patients also ask

since testosterone levels have gone up

will it boost my athletic performance

will it boost my muscle building no it

is not so because it also increases the

level of e star dial in your body so to

have the benefits of muscle mass

increase or the other added benefits of

testosterone you also have to have an

East retire inhibit so some patients

know this and the doctors advise them to

take aromatics aromatics is a drug which

decreases the level of Easterner in the

body and if you are retreat it improves

your muscle mass because the eastern our

level is degree but if you have to take

it you have to consult an

endocrinologist or your physician before

embarking on this journey so the

recommended dose at my clinic causes

starting one milligram finished right

immediately after the hair transplant

once the five-day medicines of

antibiotics etcetera over and this one

milligram finasteride is taken every day

for a duration of six month which is

mandatory beyond this period it is up to

the patient in consultation with me if

he wants to continue further as native

thinning hair do toss to ride in my

clinic is used very sparingly but I have

had good results in patients who take

one milligram tablet of philostrate

everyday but once a week they omit that

dose and take

0.5 milligram of crude rose tonight this

is a combination which is increasingly

proving beneficial to me till now

on one hand 3 million people have taken

finish tried so we are fully aware of

the side effects the possible side

effects that finish trade has given to

some patient whereas in the case of

utah's tried not more than hundred

thousand patients have been on route us

tonight so to evaluate the possibility

of long-term side effects is a little

bit difficult in the case of the test

track so based on many studies and

anecdotal evidence it is guaranteed that

do describe Bill Cosby

on the other hand it is also true that

it has higher rate of side-effects than

a proven drug which is finasteride or

propecia thank you very much

[Music]

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