Is Ostarine STRONGER than Anavar? | Ostarine VS Anavar | Doctor's Analysis

Summary

In this video, Dr. Downey compares the anabolic capacities of Ostarine (MK-2866) and Anavar (Oxandrolone), two popular performance-enhancing drugs. Through animal and human studies, he finds Ostarine to be more potent per milligram but with a 'sealing effect' that limits its benefits at higher doses. Anavar, while less potent, is deemed safer and more tolerable at its maximum therapeutic dose, leading to better clinical outcomes. The video also discusses side effects, suppression levels, and the importance of considering clinical efficacy over milligram-to-milligram comparisons.

Takeaways

• 🌟 Dr. Downey's video compares the anabolic capacities of Ostarine (MK-2866) and Anavar (Oxandrolone).
• 🔍 Ostarine is also known as S22, and the video discusses its effects on the levator ani muscle in rats, which is a common model for assessing anabolic effects.
• 📊 In the rat model, Ostarine at a high dose of 1mg/day showed a plateau effect on muscle growth, with the levator ani being 136% of the control.
• 💊 A similar dose of Anavar resulted in a 193% increase in the levator ani muscle weight, suggesting a stronger anabolic effect at a similar dosage.
• ⚠️ The Anavar study used in the comparison did not involve castrated rats, which could affect the outcome due to hormonal differences.
• 🧬 Human studies on Ostarine and Anavar are limited, with differences in dosages and study populations making direct comparisons challenging.
• 💪 Ostarine showed a lean mass gain of 1.2 kg in a study with 3mg/day dosage for 12 weeks, while Anavar showed a 3 kg gain at 20mg/day for the same duration.
• 🔄 Despite the difference in dosages, both Ostarine and Anavar showed similar incidences of adverse effects, suggesting a maximal therapeutic dose for each.
• 🚫 Ostarine appears to have a 'sealing effect' where increasing the dose beyond a certain point does not increase anabolic benefits but does increase side effects.
• 🆚 On a milligram-per-milligram basis, Ostarine is more potent than Anavar, but Anavar is favored for its clinical safety and efficacy at higher doses.
• 🧬 Anavar has more research supporting its use, making it more predictable, while Ostarine is less suppressive and has potential benefits that will be explored in a future video.

Q & A

What is the main topic of the video by Dr. Downey?

The main topic of the video is a comparison between the anabolic capacities of Ostarine (also known as MK-2866 or S22) and Anavar (Oxandrolone), including their side effects and efficacy in both rats and humans.

What is the purpose of using the levator ani muscle in rat models?

The levator ani muscle is used in rat models to assess the anabolic effects of a substance, as it is a muscle of the pelvic floor in rats that can show significant growth in response to anabolic agents.

What was the highest dose of Ostarine used in the rat study mentioned in the script?

The highest dose of Ostarine used in the rat study was one milligram per day, which corresponded to about five milligrams per kilogram in a rat.

How did the levator ani muscle respond to the highest dose of Ostarine in the rat study?

At the highest dose, the levator ani muscle was found to be 136% of that of the control group, indicating significant growth in response to Ostarine.

What was the percentage increase in the levator ani muscle weight in response to a similar dose of Anavar in the study with castrated rats?

In the study with castrated rats, a dose of 10 milligrams per rat resulted in a percentage increase in the levator ani muscle weight that was more or less similar to that of Ostarine.

Why is it difficult to compare Ostarine and Anavar studies directly in humans?

It is difficult to compare Ostarine and Anavar studies directly in humans because the dosages, study populations (e.g., elderly men vs. postmenopausal women), and study durations often differ significantly between the two.

What was the lean mass gain observed in the Ostarine study involving elderly men and postmenopausal women?

In the Ostarine study, the lean mass gain observed was 1.2 kilograms at a dosage of three milligrams per day for 12 weeks.

What was the lean mass gain in the Anavar study involving older men?

In the Anavar study, the lean mass gain was three kilograms at a dosage of 20 milligrams per day for 12 weeks.

Why does Dr. Downey suggest that Ostarine might be more potent milligram per milligram than Anavar, despite the different outcomes in the human studies?

Dr. Downey suggests that Ostarine might be more potent milligram per milligram because the dosages used in the studies were different, and the adverse effects were similar at the maximal therapeutic doses for both substances.

What is the concept of 'sealing effect' mentioned in the script?

The 'sealing effect' refers to a plateau in the anabolic response to a substance, beyond which increasing the dose does not yield additional benefits but only increases side effects. This effect appears to occur at lower dosages with SARMs like Ostarine compared to traditional oral steroids.

What are the potential clinical implications of the comparison between Ostarine and Anavar?

The clinical implications suggest that while Ostarine may be more potent on a milligram per milligram basis, Anavar is favored for its safety profile and clinical tolerability at higher doses, as well as having more research supporting its use.

What is the benefit of Ostarine mentioned in the script that Anavar does not have?

The benefit of Ostarine mentioned in the script is that it is not as suppressive as Anavar, meaning it may have a lower impact on the body's natural hormone production.