IgG4 after 5X shots (min 2X mRNA) - 1st direct evidence of immune refocusing - good or bad? (Ep#149)

Summary

In this update on IgG4 phenomena, Dr. Michael Rashik discusses a study on the effects of mRNA vaccines on IgG4 antibodies. The research indicates that updated vaccines targeting the XBB 1.5 variant lead to increased neutralization of various strains. However, it also suggests that these vaccines may cause antibodies to target different areas of the spike protein, potentially leading to immune refocusing and the risk of autoimmune conditions. The video provides a detailed analysis of the study's implications on public health.

Takeaways

• 🌟 Dr. Michael Rashik discusses a new paper on the impact of mRNA vaccines on IGG4 antibodies, particularly after additional vaccinations.
• 🔍 The study is the first to show that updated vaccines targeting the XBB 1.15 variant can lead to antibodies targeting different areas of the spike protein compared to the original vaccine.
• 📊 The paper reports an increase in neutralization of all variants post-immunization with the updated vaccine, which is marketed as a positive outcome.
• 🧬 The research indicates a phenomenon called 'immune steric refocusing', where the immune system starts targeting other areas of the spike protein besides the receptor binding domain with successive vaccinations.
• ⚠️ There are concerns that targeting more conserved areas of the spike protein could potentially lead to autoimmune conditions or other health issues.
• 📈 The study shows an increase in IGG4 antibodies post-vaccination, but these antibodies are not as effective against new variants as they are against the original Wuhan variant.
• 🤒 The protection from antibodies, particularly IGG4, seems to wane over time, which could be problematic for long-term immunity.
• 🧬💉 The study involved 24 individuals with varying vaccination histories, including some who had been infected with the virus between vaccine doses.
• 🔬 Memory B cells were analyzed to understand which variants they targeted before and after vaccination, revealing a shift in targeting post-vaccination.
• 🌐 The concept of 'cross-reactivity' is highlighted, where antibodies can target multiple variants, but this may not necessarily be beneficial.
• 👨‍⚕️ Dr. Rashik emphasizes the need for caution in interpreting the results of increased neutralization, considering the potential risks of targeting conserved spike protein areas.

Q & A

What is the main topic of Dr. Michar Rashik's video?

The main topic of Dr. Michar Rashik's video is an update on the IgG4 phenomenon, specifically discussing a published paper on IgG4 post mRNA vaccinations.

What does IgG4 antibodies targeting specific spike protein suggest according to the video?

The video suggests that the increase in IgG4 antibodies targeting the specific spike protein might have implications for an individual's immune response, which could be good or bad depending on the context.

How many papers have discussed the connection between mRNA shots and IgG4 antibodies according to the video?

According to the video, this is the 15th paper discussing the observation that mRNA shots increase IgG4 antibodies targeting the spike protein.

What is the XBB 1.15 variant mentioned in the video, and why was the mRNA shot specifically made for it?

The XBB 1.15 variant is a strain of the virus that was prevalent before the vaccines were made available. The mRNA shot was specifically made for it due to waning immunity observed in mRNA vaccinated individuals against infections.

What does 'cross-reactivity' mean in the context of the video?

In the context of the video, 'cross-reactivity' refers to the ability of an antibody to target multiple variants of the virus, not just the one specifically that the individual has been immunized against.

What was the study's observation regarding the antibodies produced with the updated variant vaccines?

The study observed that the antibodies produced with the updated variant vaccines were causing the antibodies to target different areas of the spike protein than the original shot.

What is 'immune steric refocusing' as mentioned in the video?

In the video, 'immune steric refocusing' refers to the concept that the immune system is being forced to target different areas of the spike protein with each successive immunization, potentially leading to less effective neutralization and increased risk of autoimmune conditions.

How many individuals were involved in the study discussed in the video?

The study involved 24 individuals who were measured for their antibodies and the performance of those antibodies before and after immunization with the XBB 1.5 variant mRNA shot.

What was the study's finding regarding the memory B cells and their targeting of the spike protein after immunization with the updated vaccine?

The study found that after immunization with the updated vaccine, there was an increase in memory B cells targeting other areas of the spike protein besides the receptor binding domain, suggesting a shift in immune targeting.

What is the potential risk of targeting more conserved areas of the spike protein, as mentioned in the video?

The potential risk of targeting more conserved areas of the spike protein is that these areas might mimic something in our own bodies, which could lead to the development of autoimmune conditions or other health issues.

What is the video's conclusion about the updated vaccines and their effects on the immune system?

The video concludes that while the updated vaccines may show increased neutralization against all variants, they might also be inducing the immune system to target other areas of the spike protein, which could have unforeseen health consequences.

Outlines

00:00

🌿 Dr. Rashik's Update on IGg4 Phenomenon Post-Vaccination

Dr. Michar Rashik introduces a discussion on the IGg4 phenomenon following mRNA vaccinations, specifically focusing on a paper that examines the effects of an updated vaccine targeting the XBB.1.15 variant. The doctor mentions observing horses by the river, adding a personal touch to the video. The summary of the paper indicates that the updated vaccine leads to greater neutralization of various virus variants, but also shows that the antibodies target different areas of the spike protein compared to the original vaccine, suggesting a change in the immune system's targeting strategy.

05:02

🔬 Study on Antibody Performance Before and After XBB 1.5 Variant Vaccination

This section details a study involving 24 individuals, examining their antibody responses before and about a month after receiving an mRNA shot designed to combat the XBB 1.5 variant. The study includes individuals with different vaccination histories, some with previous infections that may influence IGg4 antibody formation. The study's findings show a significant drop in neutralization against other variants besides the original, highlighting the concept of imprinting in immune response. The doctor also discusses the possibility of waning immunity and the study's implications on cross-reactivity and immune refocusing.

10:02

📊 Analysis of Memory B Cells and Variant Targeting Post-Vaccination

The paragraph delves into the study's findings on memory B cells and their targeting of spike protein variants. Before the updated vaccination, memory B cells predominantly targeted the original Wuhan variant, with minimal targeting of other variants like XBB 1.5. After the updated vaccination, there was an increase in antibodies targeting various variants, including XBB 1.5, and a significant enhancement in neutralization. However, the study also reveals that the antibodies are now targeting other areas of the spike protein besides the receptor binding domain, which could potentially lead to autoimmune issues.

15:04

🧬 Exploring the Risks of Targeting Conserved Spike Protein Areas

Dr. Rashik discusses the potential risks associated with targeting conserved areas of the spike protein, which might mimic structures in the human body and could lead to autoimmune conditions. The doctor emphasizes that while the vaccines show increased neutralization against various variants, this enhanced response might come at the cost of targeting more conserved and potentially harmful areas of the spike protein. The summary underscores the need for further research to understand the long-term implications of these findings.

20:06

🌄 Reflections on the Study's Implications and a Call to Action

In the concluding remarks, Dr. Rashik wraps up the discussion by reflecting on the study's implications and the potential for vaccines to induce antibodies that target conserved spike protein areas. The doctor encourages viewers to consider the information presented, subscribe to the channel, share the video, and engage in the conversation. The picturesque backdrop of horses by the river serves as a serene end to the video, inviting viewers to appreciate the natural world while contemplating the complex issues at hand.

Keywords

💡IgG4 phenomenon

IgG4 phenomenon refers to a condition where the immune system produces an excess of IgG4 antibodies. In the context of the video, it is discussed in relation to mRNA vaccines and their impact on the immune system, particularly how they may increase IgG4 antibodies targeting the spike protein of the virus. The script mentions several papers observing this phenomenon post-vaccination.

💡mRNA vaccines

mRNA vaccines are a type of vaccine that uses a small piece of the virus's genetic code called messenger RNA (mRNA) to stimulate an immune response. The video discusses how these vaccines, specifically the updated ones targeting the XBB 1.15 variant, may affect the production of IgG4 antibodies and memory B cells, potentially leading to immune refocusing.

💡Cross-reactivity

Cross-reactivity in immunology refers to the ability of an antibody to bind to multiple variants of a pathogen, not just the specific one it was generated against. The script discusses how the updated mRNA vaccines may induce cross-reactivity, which could have implications for the breadth of immune protection but also the specificity of the immune response.

💡Memory B cells

Memory B cells are a type of white blood cell that 'remembers' a specific pathogen and can quickly produce antibodies upon re-exposure. The video explains how the study in question analyzed the behavior of memory B cells before and after vaccination, noting changes in what variants of the spike protein they target.

💡Neutralization

Neutralization is the process by which antibodies render a pathogen harmless by binding to it and preventing it from infecting cells. The script describes how the study measured the neutralization capacity of antibodies produced in response to vaccination, showing increased protection against various virus variants post-vaccination.

💡Imprinting

Imprinting in the context of vaccines refers to the initial exposure to a pathogen variant shaping the immune response, making subsequent responses less effective against different variants. The video discusses how the initial mRNA vaccines may have caused imprinting, affecting the efficacy of later booster shots.

💡Sterile immune refocusing

Sterile immune refocusing is a concept discussed by Dr. Gerd Ven Bosch, which suggests that repeated immunizations may force the immune system to target different areas of a pathogen. The video presents evidence from the study that this refocusing may be occurring, with memory B cells targeting areas of the spike protein other than the receptor binding domain.

💡Receptor binding domain (RBD)

The receptor binding domain is a part of the spike protein that interacts with the human cell's ACE2 receptor, facilitating viral entry. The video emphasizes the importance of antibodies targeting the RBD for effective neutralization and discusses how updated vaccines may affect this targeting.

💡Autoimmune conditions

Autoimmune conditions occur when the immune system mistakenly attacks the body's own tissues. The script raises a concern that targeting conserved areas of the spike protein, which may mimic structures in the human body, could potentially induce autoimmune reactions.

💡Variants

In the context of the video, variants refer to different strains of the virus with distinct genetic mutations. The discussion revolves around how vaccines and the immune response may vary in effectiveness against different variants, such as the original Wuhan strain, XBB 1.5, and JN1.

Highlights

Dr. Michar Rashik discusses a new paper on IgG4 phenomena post mRNA vaccinations, exploring the impact of additional shots on IgG4 antibodies targeting the spike protein.

The paper is the 15th to observe an increase in IgG4 antibodies post mRNA shots, with a focus on the cross-reactivity of antibodies targeting multiple variants.

The study examines the effects of an mRNA shot specifically made for the XBB 1.15 variant, highlighting the changes in immune response post-immunization.

The research shows that post-immunization with the updated variant, there is greater neutralization of all variants, not just the XBB 1.5 variant.

The updated vaccines cause antibodies to target different areas of the spike protein than the original shots, indicating a change in the immune system's targeting.

The concept of 'steric immune refocusing' is introduced, suggesting that mRNA shots may be causing antibodies to target less ideal areas of the spike protein.

A study of 24 individuals measures antibody performance before and after immunization with the XBB 1.5 variant-specific shot.

The study reveals a decrease in protection against IgG4 antibody formation with increasing numbers of mRNA shots.

Infection between shots is shown to act like another shot, stimulating more IgG4 antibody formation, but this protection may wane.

The study demonstrates imprinting effects, where initial immunization influences the type of antibodies produced against future variants.

After immunization with the updated vaccine, almost everyone produced antibodies targeting all variants, including XBB 1.5 and JN1.

The paper shows an increase in IgG4 antibodies post-immunization, but not targeting the updated variants as effectively as the original.

Memory B cells' targeting of the receptor binding domain of the spike protein decreases with successive immunizations.

The study indicates that continued immunization may force antibodies to target other areas of the spike protein, away from the receptor binding domain.

There is a risk that targeting conserved areas of the spike protein could lead to autoimmune conditions or other health issues.

The paper raises concerns about the long-term effects of vaccines on the immune system's targeting of the spike protein.

Dr. Rashik emphasizes the importance of understanding what antibodies are targeting and the potential health implications of vaccines.

Transcripts

hey everyone it's Dr michar rashik of

mar genomics today I'm doing another

update on

igg4 phenomena this is the first video

I'm going to talk about a published

paper on ig4 post five Mr vaccinations

so this is a new territory we're going

to be entering but before I get started

if you look really closely behind me

there at the bottom of the river I think

you might see some horses out of the

river it's very very

cool so check it out before I walk away

from from that see if you can spot it

there should be just like little dots

all right so let's continue with this IG

for Saga I've been neglecting this

territory lately because I've done so

many videos on this topic but because

this is uh based on now

additional additional vaccinations extra

shots I thought I would give you the

latest information on on this topic

today and

basically apart from this being the this

now the 15 paper that I'm going to be

discussing when it comes to the

observation that mRNA shots increase

igg4 antibodies targeting specific uh

Spike specifically spikes Spike protein

now check out my other videos on on why

that might or might not be good uh for

an individual in terms of igg4

antibodies however this is now I believe

uh probably fifth paper now that talks

about IGG for antibodies plus four M

mRNA shots I think this is a third one

third one talks about the B cells

producing IGG for antibodies

and um I think it's at least fifth paper

that talks about cross reactivity cross

reactivity means how an basically an

antibody can Target multiple variants

not just the one specifically that

you've been immunized against but it can

now Target other variants and this

publication talks about what happens to

an

individual after the f shot but

specifically this was a uh mRNA shot

that was specifically made for

xbb

1.15 variant that variant's been uh

around a while

back even before these vaccines were

made available and the vaccines were

made available at the latter half of

2023 so less than a year ago and the

reason why the these vaccines were

updated as such is because of the waning

immunity observed in mRNA vaccinated

individuals um against

infections and the take home message

here is hey look post postimmunization

with this updated

variant um basically you see greater

neutralization of all variants not just

xb1 or the ancestral variant which is

the Wuhan variant um and the authors

concluded hey this is great news this is

exactly what we want to see however this

is also the first paper that

shows what that the antibodies that are

produced with the updated

variants are causing the antibodies to

Target different areas of the spike

protein than the original shot

and this is basically change shows you

that how the immune immune system is

targeted is changes or basically what

the antibodies Target is changing oh I

don't know if you can see these horses

right behind me and there's a baby I can

all right well there's some more right

there they're coming back up maybe from

the from the river this is great I'll

stick around here in case we see more

because there's a whole heart of them

anyway

but this basically is the concept of

steric immune refocusing that Dr Kur ven

Bosch has been talking about as to what

is happening with what these what these

mRNA shots are are doing and this also

explains why we might see increased

neutralization but it might not

necessarily be a good thing while it's

being sold as a good thing to us I'm

going to zip this up as well in case we

have a gust of wind there's been

horrendous wind here anyway so let's uh

let's get started with this so what

happened here is they took 24

individuals and they measured uh their

antibodies and the performance of the

antibodies before immunization with with

the shot that was start specifically um

the shot that was supposed to make

antibodies against xbb 1.5 variant and

after about a month after and um they

had a variety of different people here

so they had people who were and you know

what I had a really really hard time

interpreting the language of the of the

scientists um of these scientists I

believe this was also from from uh

us uh my conclusion that conclusion is

that we're talking about people who had

either four up or five mRNA shots some

had four some had five but really the

description was so poor that that I

wasn't sure maybe it might have been

even six shots but I I'm concluding that

it is five shots so 12 people or I

believe it was actually 11 people had

only mRNA shots one person had two Novak

shots followed by two mRNA shots and

then for the remainder for the remainder

12 the prior to the xbb 1.5 mRNA shot

there what vaccines they even took

wasn't wasn't known to to the

investigators oh I better get out of

here I do not want have an encounter

with a wild

horse just uh better be safed and

sorry and

um and uh so the the the description is

a little was a little bit vague to me uh

more importantly four of those

individuals who had U prior to had any

mRNA shots they uh were infected now

remember from past videos I was

mentioning that it looked like infection

can protect against igg4 antibody

formation now why is this important oh

there's more of them look how beautiful

they are H why is this important is

because

um this study shows that with increasing

number of mRNA shots that protection M

Wayne and then uh 12 of those

individuals got infected in between

those shots typically infection between

shots act act like another shot to

stimulate more IG for antibody formation

and

uh yeah so the reason why this is

unfortunate is because it seems that all

of these individuals that we'll be

discussing ended up producing igg4

antibodies so that means that protection

might Wayne now remember I also

mentioned that those individuals who had

who were immunized first with Nonna

shots nonm

vaccines were and Then followed were

followed by mRNA shots but they seem to

also be protected against igg4

antibodies again from this paper we'll

see that that one individual who had two

Nova wax and had subsequently two mRNA

shots afterwards they were no longer

protected as well they're all basically

all individuals in this in this study

were producing um igg4 antibodies so but

anyway what the what the authors did in

this in this study the first thing that

did is they looked at neutralization so

what is that mean basically you create a

a pseudovirus construct with a spike

protein of Interest so you can place any

variant of Spike protein into this

construct and then you can see how this

virus construct that is synthesized in

the lab so this is not real virus like

that is infecting us but something that

you can manipulate in a lab how that

virus can infect bacteria and how the

antibodies collected or basically the

antibodies in the blood collected from

these individuals might be might be

preventing that pseudo virus from

infecting the bacteria and this is how

basically you can see how well the

antibodies are protecting um so this is

what is me measured as

neutralization and basically what

they're showing is that prior to the

immunization with that updated xbb 1.5

variant what uh all these um individuals

and bodies were protecting them very

well against the original variant Wuhan

uh Spike protein variant but that

protection Wan rapidly and precipitously

against all other variants and

ironically they measured it all the way

up to jn1 variant so that's the variant

that not long ago was taking over the

basically took over the entire world now

that is changing so basically you no

longer see that that variant is now

disappearing it's being replaced but

until recently that was the variant that

was dominating the world but they were

able to show that neutralization against

something like xbb 1.5 was the worst it

was about 29 times worse than

neutralization against the against the

original variant now this is called

imprinting we've talked about that in

some of the past videos as well and

basically the idea here is that whatever

you immunized against

first and therefore the antibodies that

you will produce against that specific

first variant you ever come into contact

with those are the antibodies that

you're going to be producing again next

time you encounter the pathogen even if

it's a different variant and because the

antibodies are now supposed to Target

we're targeting the original variant

there these antibodies are not going

going to be as good targeting the future

new evolved variant with new mutations

right so that's imprinting and and

clearly this study shows that there is

an imprinting effect right um at least

uh with these four four to five

immunizations that were done done in

these individuals um some of these

immunizations when it came to mRNA that

included the um included

the updated booster as

well but uh xbb 1.5 is basically the lat

latest one when it came to attempt to

manipulate the the results for for what

can your antibodies do all right so then

that's basically be before the the

immunization with the updated xbb 1.5

variant so you can see neutralization

drops that's because of this imprinting

these antibodies are no longer doing the

the best ideal job

possible let me show a little bit of the

mountains as well and

basically uh also what they measured is

also how many of the individuals they

tested were even producing any

antibodies targeting specific variants

so you could see for example pretty much

everyone was producing antibodies

targeting

the original Wuhan variant but when it

came to xv1.5

variant uh not even half the individuals

were producing any type of antibodies

that could Target Target that variant

okay so and another thing is that they

looked at is of course is the makeup of

these antibodies that that were uh

targeting these variants and basically

they measured um igg1 2 3 and four and

the idea here is

that the idea here is that about a on

average about a quarter of all of these

antibodies that were targeting these

Spike proteins were igg4 okay but the

vast majority of those igg4 antibodies

were targeting um the original Wuhan

Spike variant and only a small fraction

of these of these um prior to

immunization with the updated updated

vaccine were even targeting

xbb 1.15 variant in fact 30% of these

individuals didn't produce any

igg4 antibodies against xbb 1.5 varand

at all so now what happened after the

immunization of course this is now what

we want to want to see and and this is

what continual boosting is how is why

it's being sold to the public over and

over because after the after they

actually these individuals were

immunized with these updated vaccines

targeting BB 1.5 variant they were able

to show a couple things pretty number

one almost everyone now produce

antibodies

targeting targeting um all of these

different variants including xbb 1.5

including jn1 and the neutralization

increased

dramatically as well so an increase

something around say between to eight

fold for all of these for all of these

variants on average right like different

variants s s different impact but

basically the take message of of the

authors was like Hey look at look what's

happening here these vaccines are

overcoming the imprinting problem

encountered before and now these V

updated vaccines what they allowed is

they allowed to neutralize all of the

variants um a month after vaccination

and that's good this is what why the

vaccines are being sold to us because

everyone seem to be producing now

antibodies targeting all of the

different variants that's great that's

by the way is what we call cross

neutralization when same antibody can

Target variety of different variants but

what's also very Mark about this paper

and this is where it can really tell us

valuable new informations they also

looked at what type of memory B cells

these individuals were were producing

meaning memor what were those memor B

cells responsible for targeting what

type of variants these memor B cells

would be targeting meaning B cells

remember B cells are the type of cells

that are responsible eventually to

produce antibodies once they start

producing antibodies they're not called

B cells they're called plasma cells but

I always refer to them as B cells for

sake of simplicity so what and then of

course memory means they are they are

kept around in our body memorizing what

they're supposed to Target and when you

reactivate them with the next infection

they will come back on and immediately

start producing the antibodies you want

so they basically looked at what do

these memor abuses actually Target with

their antibodies right so that's where

it's really really interesting and why

this the preferred narrative might not

actually work because what they what

they showed is that just have to uh

forgive me for the hair but it's really

windy

here but hey look at the beautiful

scenery behind me um so it's just

gorgeous and basically what they're

showing is

that they look at the memor B cells

targeting either receptor binding domain

of the spike protein which is basically

ideally if you want to achieve

neutralization is what you want to

Target the most okay because why because

receptor binding domain of the spike

protein as its name suggests is the area

of the spike protein that is responsible

for interacting with the A2 receptor

which is how the the virus gains entry

into our cells okay so then if that's

the

case then of course those will be some

of the most neutralizable antibodies

those are some of the best ones they and

they contrasted that against looking at

what type of memor cell are targeting

Spike protein anywhere else so besides

the receptor binding domain and let's

just say on on

average on average oh and I don't know

if I mentioned this by the way after

immunization um they also saw increase

in igg4 antibodies as well not a

surprise we've seen this but that

increase that they saw in igg4 after

immunization was not

targeting the updated variants uh as

well as um the original antibodies there

was an increase um in igg4 antibodies

targeting other variants as

well but uh again the bulk was a it was

still targeting the original Wuhan

variant

but when they look at memory B cells

when they when uh when uh they looked at

the memor B cells prior to immunization

let's say there was just over 2% % of

memor B cells just over 2% of memor B

cells targeting uh either receptor

binding domain of the spike protein or

Spike protein anywhere else but when it

came

to receptor binding domain all of these

memor obeses were pretty much targeting

the original Wuhan strain very little

were targeting xb1 and original Wuhan or

xb1 when it came to receptor binding

domain almost nothing it was like let's

say on average

05% less than .1% of any of these memor

cells prior to immunization we're

targeting targeting receptor binding

domain of other

variants and then uh slightly different

story when it came to what else was was

being targeted by these memor B cells

anywhere else on the spike protein and

here is already interesting component

because let's say about 2% just 2.2 2.3%

of these memor Bells were targeting

Spike protein anywhere else besides me

the receptor binding

domain and again half of that was maybe

around targeting the original Wuhan

strain maybe say. 3 to. 4% of these

memor of B cells were targeting the xbb

1.5 variant and just under 1% 8% was

targeting xbb 1.5 and the original Wan

strain together meaning those memor B

cells had were producing antibodies that

were able to Target something specific

that was able to recognize both the

original Wuhan strain and the XP 1.5

variant that already indicates that

there had to be some immune re uh re

refocusing and the reason why is because

this clearly shows you that eventually

these memory B cells they no longer can

Target receptor binding domain towards

the new variants but they're targeting

other areas of the Spike protein that

allow to

neutralize at least in the end these

assays we don't know what happens inside

the body because no one is measuring

this allowed in these laboratory AES to

contact the spike protein somewhere else

besides receptor Bing domain it clearly

shows you that as you keep immunizing

what happens is you're forcing the

antibodies to start targeting Spike

protein somewhere else now where it gets

interesting is after what did they see

with these memory B cells after they

immunized after they immunized uh with

that updated xbb 1.5 variant and here

there was a little bit of increase in

when it comes to targeting the receptor

binding domain of the spike proein but

only for the again for the original

Wuhan variant did that there was no

increase in memory B cells basically

none to Target any other variants

and uh and when it but when it came to

other areas of the spike protein there

was an

increase there was an increase in being

able to Target other

variants other variants including say

xbb 1.5 after immunization with the

updated variant with the xbb

1.5 away from receptor binding domain

clearly this means that with each

successive shot what we're are achieving

is we are we are basically inducing our

body to start producing antibodies to

start attacking the spike protein in

other areas besides the receptor binding

domain this is basically what exactly

what Dr ger ven Bosch was showing or has

been describing as immune steric immune

refocusing meaning we're we are forcing

our body to start targeting other areas

of the of the spike

protein and and as far as I I'm I'm

concerned this is the first paper

actually demonstrating this via these

study of these memory B cells now why is

this actually important we are sold that

this is great news over and over because

look we're clearly showing that there is

a increased neutralization that's good

the only problem with this is that this

neutralization is very temporary and

studies show that it wains quite rapidly

as well right so that's issue number one

and issue number

two when you start targeting other areas

of the spike protein besides the

receptor binding domain you run the risk

that you might be targeting more and

more conserved areas of the spike

protein and why is that an issue is

because because the more

conserved areas of the spike protein

that you target the more likely you are

going to be

targeting elements of the spike protein

that could be mimicking something in our

own bodies and if you're producing

antibodies that actually are targeting

something in our might be also targeting

something in our bodies then of course

that's when you run the risk of

inducing autoimmune conditions

potentially right or or you might be um

helping uh helping produce other

problems so uh this is uh and and this

is why it's it's potentially a problem

we are being sold on the vaccines for

their enhanced neutralization against

all variants this is why you should

boost and so on and so on but we're

forgetting or ignoring the idea that

look with that same neutralization

enhanced

neutralization we might be inducing our

an

antibodies to start targeting something

else in our body and if that's true and

we cannot fully know if it's true

because the what these antibodies are

targeting is almost never studied so we

don't really look at what these

antibodies supposed to be targeting and

therefore How likely they might be

targeting something that is also found

in our body but if it is were to be true

we might be seeing development of

aimmune conditions down the road in some

of these individuals let's take a look

one more look at these Cool Heart of

horses so beautiful before I wrap it up

so basically that's it I wanted to give

you an update on that because I thought

this was super awesome very valuable

paper that finally shows you that look

we might be we might be uh doing uh

perhaps some harm with these updated

vaccines because of the fact that we

have this cross reactivity because cross

reactivity would suggest that we might

be targeting

important conserved areas of the spike

protein and if they're conserved they

also run the risk of mimicking something

in our own body this is why they're

conserved inside viruses because

normally they're not targeted and

they're not normally not targeted

because they mimic something in our body

so it's already been pre-selected

through through say our growth not to

Target these areas of our body precisely

so that we don't induce induce

autoimmune conditions and rather we want

to Target other more dominant more

obvious more easily targetable areas of

the spike protein such as the receptor

binding domain and as I was mentioning

to you clearly with these immunizations

targeting xbb 1.5

variant these memory B cells clearly

show that they do not lead to increase

of antibodies targeting receptor binding

domains of other variants but rather

these other areas of the spike protein

all right that's all I have for you

today well it's actually longer video

than I anticipated but hey I got

distracted and uh and please leave a

comment please uh let us know what you

what you think about this of course

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to seeing you in another installment and

future video all right bye everyone ciao

for now

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