Reversing Fibrosis in Male Pattern Baldness

Summary

In this video, Danny R explores the complex issue of fibrosis, particularly its connection to hair loss. He discusses the cellular processes, the role of mitochondria, and the importance of glucose oxidation. Danny highlights the impact of oxidative stress and mitochondrial dysfunction on hair follicle health, introducing substances like appenine, naringenin, aspirin, and gelatin (specifically glycine) as potential protective agents against fibrosis and hair loss. The video aims to provide a multifaceted approach to understanding and addressing hair loss, emphasizing the need for a comprehensive strategy.

Takeaways

• 📚 Danny R offers a free book titled 'Organizing the Panic' on his website, which is a 2-hour presentation based on the ideas shared on his YouTube channel.
• 🎙️ The channel features a podcast with a variety of topics, focusing on a bioenergetic or thyroid-driven approach to health and life.
• 🗣️ Danny emphasizes the importance of daily content on his Facebook page, covering a wide range of topics, with a particular interest in hair loss due to the prevalence of misinformation.
• 🧬 The script delves into the cellular level, discussing the role of mitochondria and the oxidation of glucose, which is crucial for hair follicle health.
• 🚫 Excessive glutamine can inhibit the use of glucose, leading to oxidative stress and potentially the onset of fibrosis in hair follicles.
• 🔬 Oxidative stress and mitochondrial dysfunction are linked, with research suggesting a role in hair cell death and male pattern baldness.
• 🔄 The transforming growth factor beta 1 (TGFB1) is identified as a key player in fibrosis, being activated by oxidative stress and associated with hair loss.
• 💊 The script suggests a multi-layered approach to treating hair loss, referencing research that indicates a single cure is unlikely due to the complexity of the condition.
• 🍇 Apigenin, found in guavas and mushrooms, is highlighted for its antioxidant, anti-inflammatory properties, and its potential role in stimulating hair growth by downregulating TGFB1.
• 🍊 Naringinin, present in sweet oranges and marmalade, is discussed for its hepatoprotective and anti-fibrogenic effects, suggesting its potential in preventing fibrosis.
• 💊 Aspirin is presented as a controversial substance with potential benefits for fibrosis due to its various unique qualities, including its role as an aromatase inhibitor.
• 🥣 Gelatin, or more specifically glycine, is mentioned as beneficial for fibrosis, with research indicating its protective role in liver injury and its anti-inflammatory properties.

Q & A

Who is the speaker in the video and what is the main topic discussed?

The speaker is Danny R from DannyR.com, and the main topic discussed is fibrosis, particularly in relation to hair loss and how to potentially reverse it.

What is the book mentioned by Danny R and where can it be found?

The book mentioned is called 'Organizing the Panic,' which is a 2-hour presentation based on ideas from the YouTube channel. It can be found on Danny R's website, dan.com.

What is the role of glucose in hair follicles as discussed in the video?

Glucose is essential for hair follicles because they are extremely glucose-dependent tissues. Fatty acids cannot substitute for glucose, and when glucose isn't used properly, it can lead to oxidative stress and the beginning of fibrosis.

What is the connection between oxidative stress and hair follicle death according to the 2012 paper mentioned?

The 2012 paper suggests that recurring oxidative stress or inhibition of mitochondrial function significantly enhances hair cell death, which is associated with male pattern baldness.

What is the role of TGFB1 in fibrosis and hair loss?

TGFB1, or transforming growth factor beta 1, is considered a hair follicle inhibitory factor that is turned on by oxidative stress. It is associated with the degree of fibrosis in various problems and is referred to as the 'master switch of fibrosis.'

What is the significance of the 1985 paper's statement that 'androgenic alopecia is probably a series of diseases with a common end pathway'?

This statement implies that male pattern baldness is not a single disease but a collection of related conditions that result in the same outcome, suggesting that a multifaceted approach is needed for treatment.

What are the four components suggested for an anti-fibrotic therapy according to the book on fibrosis mentioned in the video?

The four components suggested for an anti-fibrotic therapy are the removal of causative agents, cytoprotection or cell protection, anti-inflammatory agents, and anti-transforming growth factor beta 1 (TGFB1) agents.

What is apigenin and how is it related to hair growth?

Apigenin is a chemical found in guavas and mushrooms with antioxidant, anti-inflammatory, and anti-tumor properties. It stimulates hair growth by downregulating the transforming growth factor beta 1 (TGFB1).

What is naringenin and how does it exhibit anti-fibrogenic effects?

Naringenin is found in sweet non-sour orange juice and marmalade. It has been shown to have hepatoprotective and anti-fibrogenic effects, suggesting its potential use in preventing the development of hepatic fibrosis.

How does aspirin potentially contribute to the prevention of fibrosis?

Aspirin has been shown to decrease the extent of fibrosis by acting as an aromatase inhibitor, increasing carbon dioxide, and supporting mitochondrial respiration, which may help prevent the progression of fibrosis and stimulate liver regeneration.

What is the role of gelatin or glycine in preventing fibrosis and its benefits?

Gelatin, which contains glycine, has been shown to have a positive influence on the properties of hepatic collagen and protect against various types of injury. Glycine is also considered a novel anti-inflammatory that can protect against shock and reperfusion injury to several tissues and organs.

Outlines

00:00

📚 Introduction to Fibrosis and Health Conversation

Danny R introduces the video, expressing gratitude for viewer engagement and promoting his free book 'Organizing the Panic' available on his website. He outlines the video's focus on fibrosis, suggesting an approach starting from cellular and mitochondrial perspectives. The discussion emphasizes the role of glucose oxidation in hair follicles and the oxidative stress resulting from its failure, linking it to hair loss and the role of TGFB1 as a fibrotic factor. The video promises an exploration of potential anti-fibrotic strategies, hinting at a multifaceted solution to complex health issues like hair loss.

05:01

🍊 Natural Compounds for Fibrosis and Hair Loss Prevention

The second paragraph delves into specific natural compounds that may help prevent fibrosis and hair loss. Apigenin, found in guavas and mushrooms, is highlighted for its antioxidant, anti-inflammatory, and anti-tumor properties, with studies suggesting it can stimulate hair growth by downregulating TGFB1. Narigenin, present in sweet oranges and marmalade, is noted for its hepatoprotective and anti-fibrogenic effects, with potential applications in treating cancer and fibrosis. Aspirin's role as an aromatase inhibitor and its ability to decrease inflammation and fibrosis is discussed, alongside its benefits for mitochondrial respiration. Gelatin, or more specifically glycine, is mentioned as beneficial for fibrosis due to its anti-inflammatory properties and its protective effects on various tissues and organs.

10:02

🛡️ Protective Measures Against Fibrosis and Inflammation

In the final paragraph, the speaker wraps up the video by summarizing the discussed protective measures against fibrosis and inflammation. He mentions the potential of appenine, naringenin, aspirin, and gelatin (glycine) to not only address hair loss but also to support the health of various organs. The speaker invites viewers to engage in the comments section and expresses appreciation for the viewership, encouraging likes for the video as a sign of support for continued content creation.

Keywords

💡Fibrosis

Fibrosis refers to the thickening and scarring of connective tissue usually due to the accumulation of collagen. In the context of the video, fibrosis is discussed in relation to hair loss, where it is suggested that the failure to oxidize glucose into carbon dioxide can lead to oxidative stress and fibrosis, which is associated with hair follicle death and male pattern baldness.

💡Mitochondria

Mitochondria are the organelles within cells that produce energy in the form of ATP through the process of oxidative phosphorylation. The video discusses the importance of mitochondria in the context of hair follicle health, suggesting that mitochondrial dysfunction can lead to oxidative stress and contribute to the development of fibrosis.

💡Glutamine

Glutamine is an amino acid that plays a role in various metabolic processes. The video mentions glutamine as a potential inhibitor of glucose use, which, when glucose is not utilized properly, can lead to the onset of fibrosis by affecting the cell's energy production and causing oxidative stress.

💡Oxidative Stress

Oxidative stress occurs when there is an imbalance between the production of free radicals and the ability of the body to counteract or detoxify their harmful effects through neutralization by antioxidants. The video connects oxidative stress with the failure to oxidize glucose and the subsequent damage to proteins and fats within the cell, which is linked to hair follicle death.

💡Transforming Growth Factor Beta 1 (TGFB1)

TGFB1 is a protein that plays a role in regulating cell growth, apoptosis, and tissue repair. The script describes TGFB1 as a hair follicle inhibitory factor that is turned on by oxidative stress and is associated with the degree of fibrosis, indicating its role as a 'master switch' in the fibrotic process.

💡Androgenic Alopecia

Androgenic alopecia is a common type of hair loss characterized by male pattern baldness, which is influenced by genetic and hormonal factors. The video suggests that oxidative stress and TGFB1 are associated with this condition, and it implies a multi-layered approach to treatment.

💡Aromatase Inhibitors

Aromatase inhibitors are substances that reduce the conversion of androgens to estrogens. The video mentions apin and aspirin as aromatase inhibitors, which may have potential benefits in treating hair loss by reducing the impact of hormones on hair follicles.

💡Aspirin

Aspirin is a medication commonly used to treat pain, fever, and inflammation. The video discusses aspirin as a controversial substance for its potential to prevent the progression of fibrosis and stimulate liver regeneration, as well as its role as an aromatase inhibitor.

💡Gelatin

Gelatin is a protein derived from collagen, which is found in animal tissues. The script suggests that gelatin, or more specifically glycine, which is a component of collagen, may have protective effects against fibrosis and could be beneficial in treating hair loss by supporting tissue health.

💡Naringenin

Naringenin is a flavonoid found in citrus fruits, which has antioxidant, anti-inflammatory, and antifibrotic properties. The video mentions naringenin as a substance that could be useful in preventing the development of hepatic fibrosis and has potential therapeutic effects on hair loss.

💡Glycine

Glycine is the simplest amino acid and a component of collagen. The video highlights glycine's role in protecting against various types of tissue damage and its potential as an anti-inflammatory, which could be beneficial in treating conditions like fibrosis and hair loss.

Highlights

Danny R offers a free book 'Organizing the Panic' on his website, which is a 2-hour presentation based on ideas from his YouTube channel.

The video discusses fibrosis, aiming to explain how it occurs and potential ways to reverse it.

Fibrosis is linked to the failure to oxidize glucose into carbon dioxide, leading to oxidative stress.

Oxidative stress and mitochondrial dysfunction are connected, enhancing hair cell death.

Transforming growth factor beta 1 (TGFB1) is identified as a key hair follicle inhibitory factor associated with fibrosis.

Baldness is considered a complex problem that may not have a single cure due to its multifaceted nature.

Anti-fibrotic therapy may include cytoprotective agents, anti-inflammatory agents, and TGFB1 inhibitors.

Aspirin is suggested as a controversial but potentially useful substance for its anti-inflammatory and anti-fibrotic properties.

Gelatin, rich in glycine, is highlighted for its potential protective effects against fibrosis and inflammation.

Glycine is noted for its positive influence on liver collagen and protection against various types of tissue injury.

Naringenin, found in sweet oranges, is discussed for its hepatoprotective and anti-fibrogenic effects.

Aromatase inhibitors, such as apin and aspirin, are mentioned for their potential role in treating hair loss.

The video emphasizes the importance of a multi-layered approach to treating complex conditions like baldness.

Research suggests that androgenic alopecia may be a series of diseases with a common end pathway.

Aspirin and exox aarin are found to decrease the extent of fibrosis, indicating the importance of anti-thrombotic effects.

Low-dose aspirin is indicated to prevent the progression of fibrosis and stimulate liver regeneration.

Glycine's anti-inflammatory properties are highlighted, suggesting its potential in treating various tissue and organ injuries.

Transcripts

hey everybody Danny R of Danny r.com

thank you so much for clicking on this

video thank you for liking subscribing

commenting Etc I know I say this all the

time but uh these videos are always

really fun to do because of the

conversation that is generated around

them so thank you so much I sincerely

appreciate it and before we get into

today's video I wanted to just quickly

mention I have a free book that's

available on my website dan.com uh you

can watch organizing the Panic which is

like a 2hour presentation based on these

ideas on this YouTube channel

I have a podcast on this YouTube channel

with tons of different topics of like a

bioenergetic or thyroid driven approach

to health and just life in general I

make uh daily content on my Facebook

Monday through Friday and the topics

vary from all over so I'm most

interested in hair loss because I think

there's so much bad information out

there but that's just my opinion and

feel free to disagree with me so today I

want to talk about fibrosis and I wanted

to go through a easy maybe an easy way

of understanding how fibrosis happens

and then what things you can do about it

that I think would help uh reverse

fibrosis maybe an easy way to start and

a easy way to approach every problem is

what's going on in the cell and how

what's happening with the mitochondria

and is carbon dioxide being produced and

as we know the hair follicle is an

extremely glucose dependent tissue like

fatty acids can't be subbed in and when

there's too much uh I think glutamine

mean it actually inhibits the use of

glucose and so when glucose isn't used

bad things are going to start happening

and that is actually what the first part

of fibrosis is actually the the failure

to oxidize glucose into carbon dioxide

and so uh in every type of tissue the

failure to oxidize glucose creates

oxidative stress and so if you look at

the cell as uh reductants like protein

fat and carbohydrate as being being uh

being reduced into electrons and

electrons being pulled through the cell

to oxygen when Oxygen's not there which

is mainly governed by carbon dioxide the

electrons start creating uh going off

and damaging proteins and fats within

the cell creating oxidative stress the

oxygen is also becoming a problem the

Rea reactive oxygen species because it's

not being disposed of properly or

quickly and so uh oxid stress and then

mitochondrial D function are basically

synonymous with each other so this paper

from 2012 says reoccurring oxitive

stress or inhibition of mitochondrial

function significantly enhance hair cell

death and of course we know that

oxidative stress is associated with male

pattern boldness and they say uh these

invitro findings suggest that there may

be a role for oxitive stress in the

pathogenesis of androgenic alpia both in

relation to cell cence and migration but

also secretion of known hair follicle

inhibit hiitory factors that was in

2015 so one of those known hair follicle

inhibitory factors is transforming

growth factor beta 1 or

tgfb1 and so oxa stress turns on

tgfb1 and tgfb1 is just

uncontroversially associated with the

degree of fibrosis in many different

problems so they say therefore we

suggest that the induction of tgfb1 by

Androgen is mediated by reactive oxygen

species and hair follicle dermal papia

cells the progression of androgenic

alopecia is closely related to Androgen

inducible transforming growth factor

tgfb1 secretion by hair follicle dermal

papia cells in the bald scalp tgfb1 has

been called the master switch of

fibrosis and this is just one example

they say an inhibitor of invitro hair

growth and a master switch of the

fibrotic program so just to reiterate

baldness uh is a complex problem

obviously and it many people have been

hoping that there will be a cure

released or a single pill or or

something like that and I even said in

one of my articles I didn't think a cure

would ever come out just because there

won't be a cure for osteop osteoporosis

or a cure for PCOS or things like that

because they're so ridiculously

complicated that they take a I think a

multi-layered approach is really the

best approach and that's I I think

there's some suggestions in the research

that are actually uh diive with that

point of view so this one paper from

1985 said androgenic alpia is probably a

series of diseases with a common end

pathway then another paper in 2014 said

it is unlikely that a single targeted

agent will be sufficient for treating

androgenic alpia and therefore it would

be a challenge to obtain compounds with

multiple activities and so to tag along

on that there was a book on fibrosis and

just the the pathology of fibrosis and

they thought that an anti fibrotic

therapy would include things that uh One

removing causitive agents agents for

cyto protection or cell protection

anti-inflammatory agents and

anti-transforming growth factor beta 1

agents or

tgfb1 and so considering we already know

that progesterone is helpful you need

enough thyroid to produce normal amounts

of progesterone in both men and women

and so I could talk about milk I could

talk about cheese their calcium content

and protein ability to increase igf1 and

those Foods having igf-1 in them already

fructose strong coffee a diet low in the

polyunsaturated fats vitamin D vitamin

K2 antibiotics but I'm not going to talk

about those things I'm going to talk

about some other things uh things that I

talk about less often so uh the first

one I wanted to talk about was appenine

and I'm not really sure if I'm saying

that right I've never heard anybody say

it but appenine is a chemical found in

guavas and mushrooms and it is a really

interesting chemical it has a direct

relation to hair loss so they say taken

together these findings suggest that

appenine which is known to have an

antioxidant anti-inflammatory and

anti-tumor properties stimulates hair

growth through the downregulation of

transforming growth factor beta 1

Gene that was done in

2009 and apin is also an aromatase

inhibitor so they say several naturally

occurring and syn synthetic flavones

were found to inhibit aromatization

these flavones include apin back to the

first apin reference it's a powerful

anti-inflammatory so they say the study

suggests that the modulation of Cox 2

and inducible Nitric o oxide synthes by

apin and related flavonoids may be

important in the prevention of

carcinogenesis and inflammation so the

next substance I wanted to talk about

was nenenin and this is found in things

like sweet non sour orange juice and

marmalade and I'll actually link like a

marmalade recipe that uh on my Facebook

from Emma the nutrition coach and I love

marmalade It's seems so cheap and it

seems to be extremely useful they say

that in conclusion these results

demonstrate that naringenin exhibited

invivo hepo protective and anti-

fibrogenic effects it suggests that

ningen may be useful in preventing the

development of hepatic

fibrosis that was in 2004 another paper

says ninin could be an ideal therapeutic

agent in the treatment of both cancer

and fibrosis in

2009 and neine decreases a variety of

inflammatory factors involved in

boldness and they say these results

indicate that neurogenin could attenuate

diabetic neuropathy via VIA its

anti-inflammatory and antifibrotic

activities and similar to appenine it

decreases nitric oxide in pylenin

synthesis so the third thing I want to

talk about is aspirin and this is a

controversial subst uh substance so I

encourage everybody to read Ray Pete's

article on Aspirin because that reading

that a few times was the thing that kind

of changed my mind but it's so cheap you

can dissolve it in water and avoid the

recipients uh and it's an aromatase

inhibitor so it just it just seems

really useful and it's good for fibrosis

so we let's talk about that and so they

say few treatments have been proposed to

alter the hepatocytic activity in the

cerotic liver today none have been

proven effective aspirin and exox aarin

decreased the extent of fibros fibrosis

by 43% and

36% respectively suggesting that the

anti-thrombotic effect has an important

role in preventing the progression of

fibrosis the results of this present

study indicate that lowd dose aspirin

both prevents the progression of

fibrosis and stimulates liver

regeneration in a ratp model of therosis

aspirin just has a bunch of unique

qualities it increases carbon dioxide

increases cyclic amp it decreases the

conversion of oranic acid to prandin and

it uh just is supportive of

mitochondrial respiration in general so

last thing I wanted to talk about that I

think probably gives the most bang for

the buck and I know there was a MD that

was really fond of using gelatin for

male pattern baldness and I'll link that

somewhere up here but uh gelatin so

gelatin is a protein it's like the other

half of the animal if you consider

muscle meat and then gelatinous uh

protein and the in the west at least we

get very limited amounts of gelatin and

the protein and gelatin glycine among

other proteins is uniquely benefit icial

especially for fibrosis so one study

said in conclusion an administration of

glycine had a positive influence on both

quantitative and qualitative properties

of hepatic collagen and alcoholic liver

injury and I think in that study they

were dosing the rats with alcohol and

giving them uh Glycine and it was

protective even when they were Contin

continually administering alcohol and

then just in general glycine has been

called a novel anti-inflammatory and

they say glycine protects against shock

caused by Hemorrhage endotoxin and

sepsis prevents

AIA reperfusion and Cold Storage

reperfusion injury to a variety of

tissues and organs including liver

kidney heart intestine and skeletal

muscle and diminishes liver and renal

injury caused by hepatic and renal

intoxicants and drugs so that was it I

just wanted to talk about appenine

naringenin aspirin and gelatin or and

more specifically glycine as being

protective things that you might not

encounter in on on baldness forms as

being protective uh and possibly

reversing fibrosis and not only the the

the balding area of the scalp which is

enduring lots of inflammatory effects

but also other organs so that was it for

me I know like uh that was a lot to chew

on but if you have any questions I'll

try to be hanging out in the comments

thank you so much for watching hit the

like button if you enjoyed the video

that really encourages me to keep on

doing them and again I have an amazing

viewership and I sincerely appreciate it

and I'll talk to you guys soon take care