Pertimbangan Biofarmasetik dalam Rancang Bangun Produk Obat

Summary

This video explores biofarmaceutic considerations in drug formulation, focusing on factors like particle size and delivery methods. It highlights the importance of bioavailability and how different routes of administration, such as transdermal systems, affect drug release. Transdermal products, which offer controlled drug delivery over extended periods, are discussed in detail. The video also explains how different layers of these products, including adhesives and permeable films, manage drug release and maintain skin contact. The overall goal is to optimize drug performance and minimize side effects, with references provided for further understanding.

Takeaways

• 😀 Bioavailability is influenced by the drug's physicochemical properties, such as particle size and solubility.
• 😀 The preparation of solid dosage forms must consider the bioavailability of the active ingredient for effective therapeutic action.
• 😀 Formulation design plays a significant role in achieving desired drug release and absorption characteristics.
• 😀 Drug release mechanisms can be designed to ensure controlled delivery over a prolonged period.
• 😀 The physicochemical properties of the drug should align with the intended delivery route for optimal absorption and effectiveness.
• 😀 Transdermal drug delivery systems (TDDS) offer benefits such as sustained drug release and avoidance of gastrointestinal side effects.
• 😀 TDDS includes multiple layers like the drug layer, adhesive layer, release control membrane, and protective backing layer.
• 😀 The adhesive layer in TDDS is designed to ensure good contact with the skin, enabling efficient drug diffusion.
• 😀 The release control layer in TDDS regulates the rate of drug diffusion to ensure consistent systemic delivery.
• 😀 Formulating transdermal patches requires careful consideration of drug properties, skin permeability, and adhesive quality for optimal therapeutic effect.

Q & A

What is the significance of particle size in drug delivery systems?

The size of particles in a suspension plays a crucial role in drug delivery. It influences the bioavailability and absorption rate, ensuring effective therapeutic action of the drug.

How does bioavailability relate to drug formulation?

Bioavailability refers to the proportion of the drug that enters the bloodstream and reaches its target site. Drug formulations must consider factors like particle size to ensure efficient delivery and bioavailability.

What are the key considerations in bio-pharmaceutics for drug design?

Key considerations include particle size, route of administration, and the drug's ability to reach systemic circulation or target tissues effectively. These factors impact how the drug performs once administered.

What is transdermal drug delivery?

Transdermal drug delivery involves administering medication through the skin, allowing the drug to enter the bloodstream and circulate systemically. This method is designed for extended release over hours or days.

How does a transdermal patch control the release of the drug?

A transdermal patch typically contains layers such as a drug layer, a rate-controlling membrane, and an adhesive layer. The rate-controlling layer manages the diffusion of the drug, ensuring sustained release over time.

Why is the adhesive layer of a transdermal patch important?

The adhesive layer in a transdermal patch ensures continuous contact with the skin, which is crucial for the sustained diffusion of the drug through the skin and into the bloodstream.

What is the role of the semi-permeable film in a transdermal patch?

The semi-permeable film in a transdermal patch controls the drug's release rate by allowing only a specific amount of drug to pass through it, ensuring the drug is delivered at a controlled pace.

How does the controlled release in transdermal drug systems benefit patients?

Controlled release allows medication to be administered over a prolonged period, reducing the frequency of dosing and potentially improving patient compliance and therapeutic outcomes.

What is the importance of maintaining continuous skin contact in transdermal drug delivery?

Continuous skin contact is essential for ensuring that the drug is absorbed consistently over time, preventing fluctuations in drug levels and ensuring the therapeutic effect is sustained.

What are some advantages of using transdermal drug delivery systems?

Transdermal systems offer advantages such as bypassing the gastrointestinal system, providing a steady drug release, and improving patient compliance by reducing the need for frequent dosing.