Uji Preformulasi Tablet Paracetamol

Summary

This video demonstrates a tablet reformulation experiment, covering preformulation testing procedures such as flow rate, angle of repose, and moisture content. The process includes measuring granule flow, determining the density and cohesion of materials, and testing moisture levels using specialized equipment. The experiment aims to assess whether the materials can be effectively formulated into tablets with optimal properties. The procedure is performed with careful measurement and repeated trials to ensure accuracy, highlighting the importance of preformulation tests in pharmaceutical manufacturing.

Takeaways

• 😀 Preformulation testing of granules is essential to evaluate their suitability for tablet formulation.
• 😀 The first test conducted is the Index Test, which measures the density of granules using a 25 cm³ measuring cylinder.
• 😀 The granules are shaken 20 times in the Index Test to ensure accurate measurement, and the test is repeated three times for reliability.
• 😀 The Angle of Repose Test assesses the internal cohesion of the granules and any frictional resistance by measuring the angle between the powder pile and a horizontal surface.
• 😀 The Angle of Repose Test is repeated three times to ensure accurate and consistent results.
• 😀 The Flow Time Test evaluates the flowability of the granules by measuring the time it takes for them to pass through a funnel.
• 😀 The Flow Time Test is also repeated three times for precision and consistency in the results.
• 😀 Moisture content is tested using a moisture balance, set to 120°C for three minutes to determine the granules' moisture level.
• 😀 The moisture content test involves weighing the granules in an aluminum dish and calculating the moisture content after three minutes.
• 😀 The practical tests help predict whether the granules can be successfully compressed into tablets with optimal properties.
• 😀 The entire process involves careful preparation, measurement, and repetition of tests to ensure reliable and valid results.

Q & A

What is the purpose of the tablet reformulation test?

The purpose of the tablet reformulation test is to evaluate whether the formulated materials can be compressed and produce tablets with good characteristics. This involves testing aspects like the flowability, density, and moisture content of the materials.

What are the main tests conducted in the preformulation stage?

The main tests conducted in the preformulation stage include the index test, angle of repose test, flow time test, and moisture content test.

What does the index test measure?

The index test measures the flowability of the granules by determining the ratio of the volume before deformation to the volume after deformation. It provides insight into the density of the materials or granules being tested.

What does the angle of repose test reveal?

The angle of repose test reveals the cohesion of the material and the internal friction between particles, indicating the material's flowability. It helps determine the level of resistance to external forces during mixing or compaction.

How is the angle of repose measured?

The angle of repose is measured by placing granules in a funnel and allowing them to flow freely, forming a cone. The angle formed between the base and the sloped surface of the pile is calculated to determine the flowability of the granules.

What does the flow time test assess?

The flow time test assesses the time it takes for the granules to flow through a funnel, which provides information about the material’s ability to flow and its cohesiveness.

What is the significance of the moisture content test in tablet formulation?

The moisture content test is crucial as it determines the amount of moisture in the granules, which affects the stability and quality of the final tablet. Excess moisture can impact the tablet’s hardness and shelf life.

How is the moisture content of the granules measured?

The moisture content is measured using a moisture balance. Granules are placed on an aluminum pan, and the device uses heat to remove moisture, displaying the percentage of moisture present in the sample.

Why is the preformulation process important in tablet manufacturing?

The preformulation process is important because it helps predict whether the chosen materials will behave as expected during tablet compression, ensuring that the final product will have the desired properties such as good flowability, stability, and correct moisture content.

What is the ideal range for the index in the index test?

The ideal range for the index in the index test is a value that does not exceed 20%, ensuring that the granules have appropriate flow properties for the tablet compression process.