methods for determining particle size by different methods counting and separation method #sgsir

Summary

The lecture discusses various methods for determining particle size in pharmaceuticals, including Optical Microscopy and Sedimentation Methods. It explains the importance of particle size in suspensions and emulsions, and how different techniques like Optical Microscopy can reveal particle shape and size. The script also covers the Seiving Method, highlighting its advantages such as cost-effectiveness, simplicity, and rapid results, as well as its limitations with particles smaller than 50 micrometers. The Anderson Petting method is introduced for particles as small as 1 micrometer, emphasizing the significance of gravity in sedimentation and the process of sample collection for analysis.

Takeaways

• 🔬 The lecture discusses methods for determining particle size in various contexts, including protection and subscription to a video for more details.
• 🧪 The Optical Microscopy technique is explained, which helps in determining the shape and logical appearances of particles with the help of physical microscopy.
• 📏 The script mentions specific size ranges for particles that can be analyzed using Optical Microscopy, such as 0.2 to 210 micrometers.
• 👀 The importance of subscription and following the channel for updates on methods like the Anderson Sedimentation Method, also known as Sedimentation Method, is highlighted.
• 📚 The process of using Optical Microscopy to distinguish between different particle sizes in a suspension is described, including the use of projected diameters.
• 🔍 The script touches on the limitations of certain methods, such as the inability to analyze particles smaller than 50 micrometers with the Sedimentation Method.
• 📉 The disadvantages of the Sedimentation Method are outlined, including the need for a large sample size and the potential for sample degradation.
• 💡 The script suggests that the Sedimentation Method is useful for particles ranging from 50 to 15,000 micrometers, but not for smaller particles.
• 🧴 The process of preparing a suspension for analysis is detailed, including the use of a cylindrical vessel and the importance of maintaining specific levels for accurate results.
• 🕒 The influence of gravity on the sedimentation process is explained, with particles settling at the bottom over time due to gravitational forces.
• 📝 The script concludes with instructions on how to collect and analyze samples at different time intervals to determine the molecular weight of polymers and the valuation of suspension animation.

Q & A

What is the main topic of the lecture?

The main topic of the lecture is the method of determining particle size in pharmaceutical suspensions and sedimentation.

What are the three methods discussed in the lecture for determining particle size?

The three methods discussed are Optical Microscopy, Sieving Method, and Sedimentation Method, also known as the Anderson Pett.

What is the range of particle size that can be determined using Optical Microscopy?

Optical Microscopy can determine the size of particles ranging from 0.2 micrometers to 210 micrometers.

What is the importance of knowing the particle size in pharmaceutical formulations?

Knowing the particle size is crucial for ensuring the effectiveness, stability, and uniformity of pharmaceutical formulations.

What are the limitations of the Sieving Method?

The Sieving Method is limited to particles larger than 50 micrometers and may not be suitable for smaller particles.

How does the Sedimentation Method work for determining particle size?

The Sedimentation Method works by allowing particles to settle under the influence of gravity, with smaller particles settling more slowly than larger ones.

What is the significance of the 'favorite diameter' mentioned in the script?

The 'favorite diameter' refers to the projected area diameter, which is a measure used in Optical Microscopy to determine the size of particles in a suspension.

What are the advantages of the Sieving Method?

The advantages of the Sieving Method include its simplicity, cost-effectiveness, and the ability to provide accurate results quickly.

What is the role of the 'Sieving Method' in the development of tablets and capsules?

The Sieving Method plays an important role in ensuring that the particle size distribution is suitable for the manufacturing process of tablets and capsules, affecting their disintegration and dissolution rates.

What is the impact of particle size on the solubility of a pharmaceutical substance?

Smaller particles have a larger surface area, which generally leads to increased solubility and faster dissolution rates, which is important for the bioavailability of the drug.

How does the script mention the importance of subscription in learning about pharmaceutical processes?

The script encourages subscription to receive updates and learn more about pharmaceutical processes, such as particle size determination methods.