MK 677 Only Cycle? | Everything You Need To Know About MK 677 | Ibutamoren | Nutrobal

Summary

In this informative video, Dr. Downey delves into the details of MK-677, a growth hormone secretagogue that boosts ghrelin levels and IGF-1, promoting lipolysis and muscle growth. He discusses its benefits for bodybuilders, its high oral bioavailability, and safety trials in beagles. The video covers dosage protocols, effects on anabolic states, and long-term trials in elderly individuals, highlighting MK-677's potential for preserving muscle mass, improving bone health, and enhancing sleep quality. It also addresses potential side effects like increased appetite, water retention, and decreased insulin sensitivity, providing a comprehensive guide for those considering MK-677.

Takeaways

• 🌟 MK677, also known as Ibutamoren, is a growth hormone secretagogue that works as a ghrelin receptor agonist, increasing levels of growth hormone and IGF-1.
• 💊 It's used for its lipolytic effects and ability to increase muscle mass, which is beneficial for bodybuilders looking to stay lean while gaining size.
• 🔍 MK677 was developed to be more selective and safer than traditional growth hormone, with fewer side effects and better oral bioavailability.
• 🐕 Initial safety and pharmacokinetic studies were conducted on beagles, showing a half-life of 4-6 hours for MK677 and a 24-hour elevation of IGF-1 levels.
• 📊 Dosage should be daily for optimal IGF-1 elevation; alternate day dosing was ineffective in studies.
• 👦 In children, MK677 was shown to raise growth hormone and IGF-1 levels without affecting other hormones, but growth was not the focus of the adult-oriented video.
• 🏋️‍♂️ A study on catabolic individuals demonstrated MK677's ability to maintain muscle mass during fasting, with a positive nitrogen balance.
• 🦴 It has positive effects on bone remodeling, beneficial for the elderly or those with osteoporosis, as shown by improved osteoporosis markers in fracture patients.
• 💤 MK677 has been shown to improve sleep quality, particularly deep sleep and REM sleep, with more pronounced effects in elderly individuals.
• ⚠️ Side effects include increased appetite due to ghrelin stimulation, elevated blood sugar levels due to decreased insulin sensitivity, and potential for heart issues in elderly individuals with pre-existing conditions.
• 🚫 MK677 does not require a post-cycle therapy (PCT) for hormones like testosterone as it does not inhibit the pituitary or hypothalamus, nor does it cause negative feedback on growth hormone production.

Q & A

What is MK-677 and how does it function differently from traditional growth hormone?

MK-677 is known as a growth hormone secretagogue, but it works differently by being a ghrelin receptor agonist. It increases the level of ghrelin, which in turn secretes growth hormone, rather than directly stimulating growth hormone production.

Why is growth hormone beneficial in terms of bodybuilding?

Growth hormone is beneficial for bodybuilding as it promotes lipolysis, the breakdown of fat, and increases muscle mass, allowing bodybuilders to maintain a lean physique while gaining size.

What role does IGF-1 play in the effects of growth hormone?

IGF-1, or Insulin-like Growth Factor 1, is stimulated by growth hormone and is measured to assess the effectiveness of growth hormone. It has a longer half-life in the bloodstream and is responsible for many of the anabolic effects seen in bodybuilders.

Why were growth hormone releasing peptides like MK-677 developed?

Growth hormone releasing peptides were developed to provide a more selective alternative to traditional growth hormone, which had safety concerns and side effects, such as increased risk of bone cancer.

What is the significance of MK-677's high oral bioavailability?

MK-677's high oral bioavailability means it can be effectively absorbed when taken by mouth, which is a favorable characteristic as it reduces the need for frequent injections and improves compliance with dosing regimens.

What was the half-life of MK-677 observed in beagle studies?

In beagle studies, MK-677 was found to have a half-life of about four to six hours, which is important for understanding proper dosing protocols.

How does the dosing frequency of MK-677 affect IGF-1 levels?

Studies in beagles indicated that for IGF-1 levels to remain elevated, MK-677 should be dosed daily. Alternate day dosing did not result in a significant increase in IGF-1 levels.

What was the effective dose of MK-677 in a study involving children?

In a study involving children, an effective dose of MK-677 was up to 0.8 milligrams per kilogram per day, which significantly raised growth hormone and IGF-1 levels without affecting other hormones.

How does MK-677 affect muscle mass in catabolic states?

In a study involving individuals in a catabolic state, MK-677 was shown to preserve muscle mass by maintaining a positive nitrogen balance even during fasting periods.

What was the impact of MK-677 on bone health in elderly individuals with fractures?

MK-677 demonstrated positive effects on bone remodeling in elderly individuals with fractures, improving markers of osteoporosis, although functional outcomes were not greatly improved.

What are some potential side effects of MK-677?

Potential side effects of MK-677 include increased appetite due to ghrelin stimulation, elevated blood sugar levels due to decreased insulin sensitivity, increased prolactin levels, and water retention which could potentially lead to heart issues in susceptible individuals.

Does MK-677 require a post-cycle therapy (PCT) for hormones such as testosterone?

No, MK-677 does not require a PCT for hormones like testosterone as it does not significantly impact these hormones or cause negative feedback on the pituitary and hypothalamus.

What was the observed impact of MK-677 on sleep quality in studies?

Studies showed that MK-677 increased deep sleep (stage four sleep) and REM sleep duration, with more pronounced effects in elderly individuals.

How did MK-677 affect LDL cholesterol levels in a two-year trial with elderly individuals?

In the two-year trial, the MK-677 group showed a decrease in LDL cholesterol levels compared to the placebo group.

What dosage of MK-677 is commonly used in studies?

The dosage of MK-677 commonly used in studies is 25 milligrams per day, which was found to have minimal adverse effects.

Outlines

00:00

😀 Introduction to MK677 and Its Effects

Dr. Downey introduces the video on MK677, a growth hormone secretagogue, explaining its role as a ghrelin receptor agonist that increases growth hormone levels. He discusses the benefits of growth hormone for bodybuilders, such as lipolysis and muscle mass increase, and the importance of IGF-1, which is stimulated by growth hormone and serves as a long-term indicator of its effects. The video promises a comprehensive overview of MK677, including its creation, safety trials, and pharmacokinetics, with a focus on its oral bioavailability and dosing protocols based on studies in beagles.

05:03

💉 MK677 Studies and Anabolic Effects

This paragraph delves into the studies conducted on MK677, including its effectiveness in raising growth hormone and IGF-1 levels without interfering with other hormones. It highlights a study showing MK677's anabolic properties by maintaining a positive nitrogen balance in a catabolic state. The benefits for elderly individuals, such as positive bone remodeling and improved markers for osteoporosis, are also discussed. Additionally, a study on healthy men indicates a significant increase in fat-free mass with no change in fat mass, while noting the increase in prolactin levels and the necessity for daily dosing for optimal IGF-1 elevation.

10:06

💤 Sleep Improvement and Side Effects

The third paragraph focuses on the positive impact of MK677 on sleep quality, with studies showing increased deep sleep and REM sleep duration in both young and elderly individuals. However, it also addresses potential side effects, such as the risk of heart failure in elderly individuals with pre-existing conditions, increased appetite due to ghrelin stimulation, and the impact on blood glucose levels and insulin sensitivity, which may be concerning for diabetics or the elderly. The paragraph also mentions other side effects like increased prolactin levels and water retention, advising caution and monitoring for individuals at risk.

15:07

🚫 Safety, Side Effects, and Considerations for Use

In the final paragraph, Dr. Downey discusses the long-term safety of MK677 based on trials with elderly individuals, noting no adverse effects in many studies. However, he also highlights the common side effect of increased appetite and the need for caution regarding blood pressure and water retention. The paragraph addresses concerns about growth hormone suppression and the need for post-cycle therapy, concluding that MK677 does not inhibit the pituitary or hypothalamus and does not require a hormone recovery protocol. Recommendations for dosage and cycle length are provided, with a reminder to monitor blood pressure and consider the impact on blood glucose levels.

Keywords

💡MK-677

MK-677, also known as Ibutamoren, is a growth hormone secretagogue that works as a ghrelin receptor agonist. It increases the levels of ghrelin, which in turn stimulates the release of growth hormone. In the video, it is discussed as a substance that can increase muscle mass and promote fat breakdown, which is beneficial for bodybuilders and fitness enthusiasts. The script mentions MK-677 as the central topic of the video, emphasizing its effects on growth hormone and IGF-1 levels.

💡Growth Hormone

Growth hormone is a peptide hormone that stimulates growth, cell reproduction, and cell regeneration in humans. In the context of the video, it is highlighted for its role in lipolysis (fat breakdown) and increasing muscle mass, which are desirable effects for bodybuilders. The script explains that MK-677 increases growth hormone levels, contributing to its popularity among athletes.

💡Ghrelin

Ghrelin is a hormone that stimulates appetite and growth hormone release. The video script describes MK-677 as a ghrelin receptor agonist, meaning it mimics the action of ghrelin, leading to an increase in growth hormone secretion. This is a key mechanism by which MK-677 is believed to promote muscle growth and fat loss.

💡IGF-1

Insulin-like growth factor 1 (IGF-1) is a hormone highly correlated with growth hormone levels. It plays a crucial role in growth and development. The video emphasizes that IGF-1 is stimulated by growth hormone and is a longer-lasting indicator of the hormone's effects. MK-677 is shown to elevate IGF-1 levels, which is important for its anabolic effects.

💡Lipolysis

Lipolysis refers to the breakdown of lipids or fats in the body. In the video, it is mentioned that growth hormone, which is increased by MK-677, facilitates lipolysis, aiding in fat loss while preserving or increasing muscle mass, a highly sought-after effect in bodybuilding and fitness.

💡Pharmacokinetics

Pharmacokinetics is the study of how a drug moves through the body, including its absorption, distribution, metabolism, and excretion. The script discusses the pharmacokinetics of MK-677, noting its half-life and the duration for which IGF-1 levels remain elevated, which is crucial for understanding dosing protocols.

💡Anabolic

Anabolic refers to the process of building up or increasing in size, often associated with muscle growth. The video script uses the term 'anabolic' to describe the effects of MK-677, indicating that it promotes muscle protein synthesis and can help preserve muscle mass in catabolic states.

💡Catabolism

Catabolism is the set of metabolic pathways that break down molecules in cells, resulting in the release of energy and the breakdown of complex molecules into simpler ones. In the context of the video, MK-677 is shown to have a positive effect on individuals in a catabolic state, helping to maintain muscle mass during fasting or periods of muscle breakdown.

💡Side Effects

Side effects are any undesirable effects caused by a medication or substance. The video script discusses various side effects associated with MK-677, including increased appetite, water retention, and potential impacts on blood glucose levels and heart health. Understanding these side effects is important for individuals considering the use of MK-677.

💡Hormone Replacement Therapy (HRT)

Hormone replacement therapy involves the administration of hormones to replace those that the body no longer produces in adequate amounts. The script mentions MK-677 in the context of HRT, particularly for elderly individuals, to improve muscle mass and bone health, although it does not significantly impact testosterone levels.

💡Prolactin

Prolactin is a hormone responsible for milk production in females and has various other functions in both sexes. The video script notes that MK-677 can significantly increase prolactin levels, which may have individual-specific effects and could require monitoring through blood tests.

💡PCT (Post Cycle Therapy)

Post Cycle Therapy refers to the treatment or supplementation taken after a cycle of anabolic steroids or other performance-enhancing drugs to restore the body's normal hormonal balance. The script clarifies that MK-677 does not require a PCT because it does not cause negative feedback on the pituitary and hypothalamus, thus not suppressing intrinsic growth hormone production.

Highlights

Dr. Downey releases a comprehensive video on MK-677, summarizing extensive research.

MK-677 is a growth hormone secretagogue, not working via the traditional growth hormone pathway but as a ghrelin receptor agonist.

Growth hormone benefits include lipolysis and increased muscle mass, appealing to bodybuilders for maintaining leanness while gaining size.

IGF-1, stimulated by growth hormone, is crucial for bodybuilding effects and is used to measure the hormone's efficacy.

MK-677 was developed for increased selectivity and safety compared to traditional growth hormone, with fewer side effects.

MK-677 has high oral bioavailability, a significant advantage over earlier growth hormone releasing peptides.

Pharmacokinetic studies in beagles show MK-677's half-life is 4-6 hours, with IGF-1 levels elevated for about 24 hours.

Daily dosing of MK-677 is necessary for consistent IGF-1 elevation, as alternate day dosing does not significantly increase IGF-1 levels.

In children, MK-677 at 0.8 mg/kg/day was found effective in raising growth hormone and IGF-1 without interfering with other hormones.

A 1998 study showed MK-677 preserved muscle mass in catabolic states, beneficial for the elderly and those with wasting conditions.

MK-677 demonstrated positive effects on bone remodeling, potentially beneficial for the elderly with osteoporosis or fractures.

In a trial with healthy men, MK-677 at 25 mg/day resulted in a 3 kg increase in fat-free mass compared to placebo.

Long-term trials with elderly individuals showed MK-677's safety and efficacy over two years, with increased fat-free mass and decreased LDL cholesterol.

MK-677 has been shown to improve sleep quality, particularly increasing deep sleep and REM sleep stages.

Some studies suggest a potential risk of heart failure with MK-677 use in elderly individuals with pre-existing conditions.

MK-677 causes elevated blood sugar levels by decreasing insulin sensitivity, a consideration for diabetics or the elderly.

Increased prolactin levels are a common side effect of MK-677, but individual symptomatology may vary.

MK-677 does not cause growth hormone suppression and does not require a post-cycle therapy for hormones like testosterone.

Transcripts

hi guys welcome back to the channel i'm

dr downey and today

i am finally releasing the video on

mk677

so i've spent many hours looking at the

research around

mk677 so that i could put it together in

a summarized format for you all to

inform you about everything that there

is or almost everything that there is so

essentially this video is everything you

need to know about mk677

or almost everything you need to know

because i'm sure i've missed out on a

few things

so the title of the video is just an

mk677 only cycle

that's more to draw in attention but i

will briefly touch on that

but for the most part i'm just going

over everything about mk 677 so that you

guys know what you're taking

so mk 677 is known as a growth hormone

secretary however it doesn't really work

via that pathway it's more of a ghrelin

receptor agonist and it increases the

level of ghrelin which secretes growth

hormone

but essentially all you need to know is

that it does increase the levels of

growth hormone and why is growth hormone

so beneficial well it causes lipolysis

or breakdown of fat as well as

increasing muscle mass and a lot of big

bodybuilders like this drug because it

keeps them lean while putting on size

so there are many growth hormone

receptors but the main actions i don't

want to say main actions but a lot of

the effects that we see in bodybuilders

come mainly from igf-1 now igf-1 is

stimulated by growth hormone and we

measure igf-1 to see if the growth

hormone is working so growth hormone

essentially stimulates these receptors

on the liver and this creates igf-1

so growth hormones half-life is quite

short and it's secreted in like a

pulsatile manner because of this short

half-life however igf-1 stays in the

bloodstream a lot longer and when

looking at these drugs it's important

for us to look at how long the igf-1

levels are elevated not growth hormones

since igf-1 is more important if from a

bodybuilding aspect why were things like

mk677 created

well we have been using growth hormone

for a long time especially in children

with short stature however there were

concerns about the safety around growth

hormone especially with regards to the

increase in mortality and older studies

that they found however nowadays they

found that that may not be the case but

there are a lot of side effects like

bone cancer prominence was increasing so

they wanted to see if they could make

something a bit more selective

so essentially they started making these

growth hormone releasing peptides that

was initially made and the issue with

them is whilst they were a tad bit more

selective

they required frequent injections and

another issue was that it was poorly

orally bioavailable

but over time and over a lot of

experimentation they eventually found

this substance that could stimulate the

growth hormone releasing peptide 6

receptor

and this was a derivative of a

a benzolactin

and it had a very long name but

essentially this came to be what we know

as mk677

and the favorable thing about mk677 is

it had very high oral bioavailability so

they started off safety trials in

beagles and unfortunately a lot of our

studies on the pharmacokinetics are

based on beagles and we haven't really

done many in humans but essentially in

this two-week trial they found it to be

safe and then it proceeded to go into

further development so i always like

touching on the pharmacokinetics so you

can understand proper dosing protocols

and it is stated but remember this is in

beagles that mk 677 has a half-life of

about four to six hours so that's mk 677

itself but in these studies they noted

that the important factor which is igf-1

is seems to be elevated for about 24

hours

so what this means is that if you want

that igf-1 level to be constantly

increased you need to do it every day or

dose it every day they found that if you

did every other day dosing in these

beagles that you would not get the

significant increase in igf-1 levels and

this increase was about

124 percent or 26 sorry so just remember

there was no increase noted on alternate

day dosing which means it has to be

dosed every day so let's look at the

safety of this drug and obviously you

want to see if it's safe in children

because that's why it was kind of

designed

obviously there are other purposes of it

too for

elderly individuals and people like that

so in one of the first studies on

mk677 in children they used a dose or

they dusted up to 0.8 milligrams per kg

a day and they found that this rain this

dose was effective to significantly

raise growth hormone as well as igf-1

and it did not interfere with any of the

other hormones like prolactin or messing

around with the thyroid hormones however

in the study they did not look at growth

specifically

i'm not going to look at growth either

because this is for adults not this

video is for adults not children

so let's see if mk 677 is anabolic as

everyone says it is

so in this one study in 1998 they looked

at individuals in a catabolic state so

in a state where they were essentially

in a deficit and muscle protein

synthesis was or muscle protein

breakdown was greater than that of

synthesis

so in this trial they were given 25

milligrams they were compared to placebo

and what they found was that in this

trial

the individuals who were taking mk 677

had a positive daily nitrogen balance

even though they were fasting so the

individuals were forced to fast during

this period to put them in a catabolic

state

and it found that the mk-677 group

actually had a positive nitrogen balance

which means that they had a positive

protein balance or muscle balance

not

not really but that's essentially what

it means and in the placebo group they

actually had quite a significant

negative nitrogen balance

so this essentially demonstrated that

mk677

preserve muscle mass or tissue in

catabolic states which is a good sign

for the elderly and people with wasting

conditions furthermore not much

important to any of you guys since um i

doubt any of you have osteoporosis or

osteopenia but it did show that it was

very favorable in bone positive bone

remodeling so good for the elderly

especially if they had fractures

and when they looked at individuals with

fractures it did improve the markers of

osteoporosis however functional outcomes

were not that greatly improved

what was interesting though was in the

study igf-1 levels were significantly

increased in comparison to placebo and

this again was in 20 using a dose of 25

milligrams

so in the

in the mk-677 group of 25 milligrams a

day

the increase in igf-1 levels were 84

percent and in placebo 17

and the 84 did reach statistical

significance

but the two studies i just mentioned

were in elderly individuals what about

in healthy men

so there aren't many studies on this but

there was a double blind randomized

control trial which we do like because

we get to see if there's causation as

opposed to correlation

and in this study they had 24 men and

they found that in the mk 677 group when

compared to placebo they gained three

kilograms of fat-free mass more than the

placebo group

and this was again at 25 milligrams a

day however they did not show any change

in abdominal or visceral fat mass which

you'll see often reported since growth

hormone is actually

has actually been shown to decrease

visceral and abdominal fat mass

of note and what many people will

mention is that in the study the serum

prolactin so prolactin levels were

greatly or significantly increased just

like the growth hormone levels

but we'll touch on that again later

and we in fact do have long-term trials

which is good from a safety point of

view so there was a double blind

randomized control trial which is good

on 65 healthy elderly individuals and

they lasted two years and they found

that in the group using 25 milligrams of

mk-677 a day growth hormone as well as

igf levels were equal to that of their

healthy of healthy individuals and

you'll see a lot of people reference the

study

of note also is that fat free mass

increased in the mk 677 group they all

gained

on average a kilogram of lean muscle

mass

in contrast to the placebo group which

actually lost fat free mass

of interest also is that their ldl

cholesterol the bad cholesterol also

decreased

however this fat free mass increase was

not accompanied by any increase in

strength

or fat loss now a side effect or

positive that many individuals will note

when taking mk 677 and that is sleep and

this has been demonstrated in trials in

a smaller crossover study in eight young

males they found that

in this study those taking 25 milligrams

of mk67 the seven a day had a 50

increase in stage four sleep duration

and if i'm not mistaken stage four sleep

is essentially

deep sleep the sleep before rem sleep

and these individuals also had a 20

increase in rem sleep but what was

interesting is that in older individuals

there was a massive increase in the

benefit that it had on sleep and that

was demonstrated by elderly individuals

having a 50

increase in rem cycle sleep but let's

look at the side effects

so

many may look at these studies and see

that mk 677 in the one study increased

the risk of congestive heart failure or

heart failure however not many people

understand what heart failure is firstly

these individuals in the group were

already

elderly not young and healthy

furthermore they had high baseline blood

pressure

and lastly heart failure is not really

an acute condition

people commonly think heart failure and

heart attacks are synonymous but

essentially heart failure is more of a

disease

of chronic conditions such as

chronically high blood pressure

previous

heart attacks can lead to heart failure

which is where the heart just doesn't

have enough strength to pump a heart

attack is where muscle in that

in the myocardium dies

and what happens is when you get older

the increase you have an increased risk

of getting a weaker heart and something

like

mk677 which will increase your water

retention as well as possibly your blood

pressure can precipitate

can precipitate

decompensation of an already weakened

heart

however in the study

they noted that the prevalence was about

6

in these elderly individuals and if you

look at the prevalence of heart failure

in elderly individuals as a whole

it's six percent

so i think it is important to note it

however although you won't get heart

failure unless it's chronic like over

the course of many years

you won't get heart failure using mk677

but the side effects can precipitate

heart failure or

or lead you to having an enlarged heart

over the course of

a few years how it does this we're not

too sure it's probably similar to that

of growth hormone by increasing the ras

system water retention increasing your

blood pressure things like that can lead

to a weakened or enlarged heart which

leads to

heart failure

however in many other studies and

healthy elderly individuals one with 161

elderly individuals over six months

noted no adverse effects

as well as in another smaller trial with

32 healthy in elderly individuals they

also noted no adverse effects

however in the two-year trial that we

mentioned previously one of the effects

that was noted quite commonly or 67

percent of the individuals actually

noted this is that they had an increased

appetite and this isn't surprising since

it stimulates ghrelin the hunger hormone

of interest there were fewer deaths in

the mk-677 group but when confounding

variables were controlled for it didn't

appear to seem to be related to the

mk677

now one side effect that is demonstrated

in all studies and i would recommend or

i think is important to know and that is

what it does to your blood glucose or

sugar

so it causes elevated sugar levels

and it does this through decreasing your

insulin sensitivity

so it's quite commonly demonstrated that

in these studies that the individuals

taking mk-677 had higher fasting glucose

levels

and this led to an increase in hba1c

levels so hba1c is your glycated

hemoglobin and essentially is a marker

for

long-term glucose control

and that was increased in the

individuals taking mk-677

it did reach statistical significance

and this was at a dose of 25 milligrams

so i think it is important to note

whilst i don't think

it would have much of an impact on a

healthy younger individual if you are

diabetic or our elderly i would take

this into account and take precautionary

measures whether it be through dietary

manipulation the use of anti-glycemic

agents such as metformin i think that's

important to take into consideration

other side effects include increased

prolactin levels which we mentioned

it is a significant increase but whether

or not it will be significant in you and

you will become symptomatic is really

individual dependent i would recommend

getting blood tests if you do think you

have symptoms of high prolactin levels

a big issue is water retention so i

would limit your salt intake and ensure

your blood pressure is controlled as

this was probably the main reason for

those cases of heart failure in those

studies people have mentioned that free

testosterone decreases which has been

shown in a study and it did reach a

level of significance however it did not

make the participants hypogonadal the

decrease just reached statistical

significance it didn't decrease it to

the point of becoming hypogonadal

does it cause growth hormone suppression

well actually these secretogs were

created in order not to inhibit the

pituitary and hypothalamus they they

work at the pituitary and hypothalamus

but don't cause negative feedback

so after stopping the secretogs there is

no need to do a growth hormone pct

as they do not cause negative feedback

and do not cause your intrinsic growth

hormone production levels to decrease do

you need a pct for your hormones such as

testosterone no since it does not

significantly impact

those hormones some recommend a pct with

metformin that is really up to you and

whether or not you feel your fasting

glucose levels were impacted greatly but

again you'd have to get that checked you

can't go off feeling

so that is almost all there is on mk677

so far i tried my best to get all the

data on humans as i don't like looking

at data in rats and animals

as a lot of the time it's not really

applicable to humans but it's a it

starts off as a good basis but once we

have human trials we'll use those

instead

so if you are looking to run this as a

mk677 only cycle the dosages they seem

to use are 25 milligrams again i'm a

doctor so i don't recommend this but 25

milligrams seems to be the doses that

was used with minimal adverse effects

the length of your cycle is really up to

you as we have demonstrated that

up for up to two years it was used

safely with not many adverse effects and

it did have an increase in fat-free mass

but the increase in strength and

decrease in abdominal fat wasn't really

demonstrated in these studies

but just keep an eye on your blood

pressure as water retention is quite

commonly reported so let me know what

you think about this video in the

comments down below and i will see you

in the next one