MK 677 Only Cycle? | Everything You Need To Know About MK 677 | Ibutamoren | Nutrobal

Summary

In this informative video, Dr. Downey delves into the details of MK-677, a growth hormone secretagogue that boosts ghrelin levels and IGF-1, promoting lipolysis and muscle growth. He discusses its benefits for bodybuilders, its high oral bioavailability, and safety trials in beagles. The video covers dosage protocols, effects on anabolic states, and long-term trials in elderly individuals, highlighting MK-677's potential for preserving muscle mass, improving bone health, and enhancing sleep quality. It also addresses potential side effects like increased appetite, water retention, and decreased insulin sensitivity, providing a comprehensive guide for those considering MK-677.

Takeaways

• 🌟 MK677, also known as Ibutamoren, is a growth hormone secretagogue that works as a ghrelin receptor agonist, increasing levels of growth hormone and IGF-1.
• 💊 It's used for its lipolytic effects and ability to increase muscle mass, which is beneficial for bodybuilders looking to stay lean while gaining size.
• 🔍 MK677 was developed to be more selective and safer than traditional growth hormone, with fewer side effects and better oral bioavailability.
• 🐕 Initial safety and pharmacokinetic studies were conducted on beagles, showing a half-life of 4-6 hours for MK677 and a 24-hour elevation of IGF-1 levels.
• 📊 Dosage should be daily for optimal IGF-1 elevation; alternate day dosing was ineffective in studies.
• 👦 In children, MK677 was shown to raise growth hormone and IGF-1 levels without affecting other hormones, but growth was not the focus of the adult-oriented video.
• 🏋️‍♂️ A study on catabolic individuals demonstrated MK677's ability to maintain muscle mass during fasting, with a positive nitrogen balance.
• 🦴 It has positive effects on bone remodeling, beneficial for the elderly or those with osteoporosis, as shown by improved osteoporosis markers in fracture patients.
• 💤 MK677 has been shown to improve sleep quality, particularly deep sleep and REM sleep, with more pronounced effects in elderly individuals.
• ⚠️ Side effects include increased appetite due to ghrelin stimulation, elevated blood sugar levels due to decreased insulin sensitivity, and potential for heart issues in elderly individuals with pre-existing conditions.
• 🚫 MK677 does not require a post-cycle therapy (PCT) for hormones like testosterone as it does not inhibit the pituitary or hypothalamus, nor does it cause negative feedback on growth hormone production.

Q & A

What is MK-677 and how does it function differently from traditional growth hormone?

MK-677 is known as a growth hormone secretagogue, but it works differently by being a ghrelin receptor agonist. It increases the level of ghrelin, which in turn secretes growth hormone, rather than directly stimulating growth hormone production.

Why is growth hormone beneficial in terms of bodybuilding?

Growth hormone is beneficial for bodybuilding as it promotes lipolysis, the breakdown of fat, and increases muscle mass, allowing bodybuilders to maintain a lean physique while gaining size.

What role does IGF-1 play in the effects of growth hormone?

IGF-1, or Insulin-like Growth Factor 1, is stimulated by growth hormone and is measured to assess the effectiveness of growth hormone. It has a longer half-life in the bloodstream and is responsible for many of the anabolic effects seen in bodybuilders.

Why were growth hormone releasing peptides like MK-677 developed?

Growth hormone releasing peptides were developed to provide a more selective alternative to traditional growth hormone, which had safety concerns and side effects, such as increased risk of bone cancer.

What is the significance of MK-677's high oral bioavailability?

MK-677's high oral bioavailability means it can be effectively absorbed when taken by mouth, which is a favorable characteristic as it reduces the need for frequent injections and improves compliance with dosing regimens.

What was the half-life of MK-677 observed in beagle studies?

In beagle studies, MK-677 was found to have a half-life of about four to six hours, which is important for understanding proper dosing protocols.

How does the dosing frequency of MK-677 affect IGF-1 levels?

Studies in beagles indicated that for IGF-1 levels to remain elevated, MK-677 should be dosed daily. Alternate day dosing did not result in a significant increase in IGF-1 levels.

What was the effective dose of MK-677 in a study involving children?

In a study involving children, an effective dose of MK-677 was up to 0.8 milligrams per kilogram per day, which significantly raised growth hormone and IGF-1 levels without affecting other hormones.

How does MK-677 affect muscle mass in catabolic states?

In a study involving individuals in a catabolic state, MK-677 was shown to preserve muscle mass by maintaining a positive nitrogen balance even during fasting periods.

What was the impact of MK-677 on bone health in elderly individuals with fractures?

MK-677 demonstrated positive effects on bone remodeling in elderly individuals with fractures, improving markers of osteoporosis, although functional outcomes were not greatly improved.

What are some potential side effects of MK-677?

Potential side effects of MK-677 include increased appetite due to ghrelin stimulation, elevated blood sugar levels due to decreased insulin sensitivity, increased prolactin levels, and water retention which could potentially lead to heart issues in susceptible individuals.

Does MK-677 require a post-cycle therapy (PCT) for hormones such as testosterone?

No, MK-677 does not require a PCT for hormones like testosterone as it does not significantly impact these hormones or cause negative feedback on the pituitary and hypothalamus.

What was the observed impact of MK-677 on sleep quality in studies?

Studies showed that MK-677 increased deep sleep (stage four sleep) and REM sleep duration, with more pronounced effects in elderly individuals.

How did MK-677 affect LDL cholesterol levels in a two-year trial with elderly individuals?

In the two-year trial, the MK-677 group showed a decrease in LDL cholesterol levels compared to the placebo group.

What dosage of MK-677 is commonly used in studies?

The dosage of MK-677 commonly used in studies is 25 milligrams per day, which was found to have minimal adverse effects.