Alur Industri Farmasi Sediaan Tablet

Summary

In this presentation, Irene Lawrence from the D3 Pharmacy Study Program explains key aspects of pharmaceutical industry tablet preparations. She covers the definition of tablets as solid preparations with active ingredients, and highlights important evaluation criteria like uniformity of weight, hardness, disintegration time, friability, and size uniformity. Irene discusses tablet-making methods such as wet granulation, dry granulation, and direct printing. Additionally, she explains the role of filler, binder, disintegrant, and lubricants in tablet formulations, emphasizing their importance in the manufacturing process.

Takeaways

• 😀 Tablets are solid pharmaceutical preparations containing active ingredients and excipients in various forms.
• 😀 The first step in tablet evaluation is uniformity of weight, which depends on granule size and distribution.
• 😀 Poor granule flow properties can cause uneven powder distribution, resulting in inconsistent tablet weights.
• 😀 Hardness refers to a tablet's resistance to pressure, stress, fracture, rolling, rubbing, and falling.
• 😀 Disintegration time is the time needed for a tablet to break apart in a suitable medium, typically no more than 15 minutes for uncoated tablets.
• 😀 Friability measures a tablet's resistance to shock and abrasion, important for tablet durability.
• 😀 Uniformity of size includes the diameter and thickness of the tablet, which affects ease of packaging, transfer, and storage.
• 😀 Wet granulation is a method of tablet preparation where fine powder is transformed into granules using a binder solution.
• 😀 Dry granulation involves adding binders to a drug powder mixture and compacting it into larger masses.
• 😀 Direct compression is a faster method of tablet manufacturing that eliminates the need for granulation, reducing production time.
• 😀 Common tablet excipients include fillers (to increase volume and weight), binders (to aid particle adhesion), disintegrants (to facilitate disintegration in the digestive tract), and lubricants (to reduce friction during the compression process).

Q & A

What are tablets in the pharmaceutical industry?

Tablets are solid pharmaceutical preparations that contain active ingredients and additional substances in various forms, designed to deliver a specific dose of medication.

What factors influence the uniformity of tablet weight?

The uniformity of tablet weight is influenced by the size and distribution of granules, as well as the flow properties of the granules. Poor granule flow can lead to non-uniform weight distribution.

How does poor granule flow affect tablet production?

Poor granule flow can result in non-uniformity in the amount of powder entering the compression chamber, leading to tablets with varying weights.

What is tablet hardness, and why is it important?

Tablet hardness refers to the tablet's resistance to pressure, stress, fracture, rolling, rubbing, and falling. It is important for ensuring the tablet's structural integrity during handling and use.

What is the disintegration time for uncoated tablets?

The disintegration time for uncoated tablets is the time required for the tablet to break down in a suitable medium, typically no more than 15 minutes unless otherwise specified.

What is the purpose of evaluating tablet friability?

Friability measures the tablet's resistance to shock and abrasion, helping to assess its durability during packaging, handling, and transport.

Why is uniformity of size important in tablet production?

Uniformity of size, including diameter and thickness, ensures consistency in tablet packaging, transfer, and storage, contributing to efficiency and quality control.

What is the wet granulation method in tablet manufacturing?

Wet granulation involves converting fine powders into granules using a suitable binder solution. This method helps in improving the flow and compression properties of the tablet formulation.

How does dry granulation differ from wet granulation?

In dry granulation, granules are formed by compacting a mixture of drug powder with binders, without the need for liquid. This method is typically used when the drug is sensitive to moisture.

What are the advantages of direct tablet printing?

Direct tablet printing offers the advantage of shorter production time, improving efficiency and reducing the overall manufacturing time.

What role do fillers play in tablet formulations?

Fillers are added to increase the volume and weight of the tablet, ensuring that the correct dosage of the active ingredient is delivered while maintaining a manageable tablet size.

What is the function of binders in tablet preparation?

Binders help in particle adhesion, allowing the formation of granules and ensuring the integrity of the tablet. They contribute to the tablet's strength and stability.

How do disintegrants work in tablet formulations?

Disintegrants facilitate the breaking or disintegration of the tablet when it comes in contact with liquids in the digestive tract, ensuring that the active ingredients are released for absorption.

What is the purpose of lubricants in tablet production?

Lubricants are used to reduce friction between the tablet's surface and the tablet press, preventing sticking and ensuring smooth tablet formation during the production process.