Formulasi Sediaan Likuida part 2 PDK 2022 UMG-UNIMUDA

Summary

The video lecture discusses the formulation technology of non-sterile and semi-solid dosage forms. It emphasizes the importance of solubility, stability, and homogeneity in drug preparation to ensure effectiveness. Key considerations include avoiding sedimentation, preventing solidification, and ensuring the ease of redispersion. It also highlights the role of excipients such as preservatives, deflocculating agents, and antioxidants in maintaining the stability and efficacy of the formulations. The lecture further covers the need for pH balance, compatibility between active and inactive ingredients, and techniques for creating stable suspensions with good therapeutic properties.

Takeaways

• 🔬 Homogeneous solutions are critical to prevent uneven mixing and ineffective therapeutic effects.
• ⚖️ Migrating formulations must avoid sedimentation that can solidify, making redispersion difficult.
• 🧪 Aggregation should be managed to ensure that particles are easily separated in water, promoting uniform dispersion.
• 💊 Additives are important to enhance the stability of suspensions and prevent hardening, like cementing, which cannot be redispersed.
• 👃 Suspensions should minimize unpleasant odors and tastes for better patient compliance.
• 📏 Particle size of active ingredients should not exceed 5 micrometers to ensure optimal formulation.
• 🔗 Compatibility between active ingredients and excipients is essential to maintain the effectiveness of the formulation.
• 🧫 Preservatives are necessary to prevent contamination, especially in liquid formulations that include water.
• 💧 Electrolytes and other additives like NaCl can help stabilize suspensions and improve dispersion.
• 🧴 Antioxidants are crucial in preventing oxidation of active ingredients, which can reduce potency and stability.

Q & A

What is the first consideration when preparing non-sterile suspensions?

The first consideration is homogeneity. The suspension must be stable and not separate easily, ensuring that when shaken, the suspension remains homogeneous and the therapeutic effect is consistent.

Why is it important to prevent sedimentation in a suspension?

Preventing sedimentation ensures that the solid particles do not clump or become difficult to resuspend. If sedimentation occurs, it can result in uneven dosing, reducing the therapeutic effect of the suspension.

What is aggregation in the context of suspension formulation?

Aggregation refers to the strong bonding between particles within the suspension, which can make the suspension difficult to resuspend after it has been stored. The goal is to create weak particle bonds, making resuspension easier when the suspension is shaken.

How can the unpleasant taste or odor of a suspension be mitigated?

Unpleasant taste or odor can be addressed by using flavoring agents or sweeteners in the formulation to make the suspension more palatable, especially for patients like children.

What are the key physicochemical properties to consider in suspension stability?

The key physicochemical properties include particle size, solubility, compatibility of active ingredients with water, and the chemical stability of the components. All these factors influence the overall stability and effectiveness of the suspension.

Why is it essential to consider the particle size in a suspension?

Particle size must be small enough to ensure a homogeneous mixture, with the ideal particle size being less than 5 micrometers. Larger particles can cause sedimentation and uneven distribution of the active ingredient.

What is the role of deflocculating agents in suspension formulations?

Deflocculating agents prevent the formation of dense, hard-to-resuspend sediments by keeping the particles in the suspension in a dispersed state. However, these agents are rarely used due to safety concerns.

How do electrolytes like NaCl help in suspension formulations?

Electrolytes like NaCl help by coating the surface of particles, making them more compatible with the liquid medium, which aids in stabilizing the suspension and preventing aggregation.

What is the significance of buffering agents in suspensions?

Buffering agents maintain the pH of the suspension, ensuring the stability of the active ingredients. The pH can affect both the chemical stability of the drug and the suspension's effectiveness.

How do antioxidants contribute to the stability of suspensions?

Antioxidants prevent the oxidation of active ingredients, which can lead to a reduction in potency, changes in color, or loss of effectiveness. By adding antioxidants, the suspension remains stable for a longer period.