These Molecules Reversed Aging by... YEARS! [TRIIM Study Explained - Study 216]

Summary

A 2019 study from Stanford Medical School, known as the 'TRIM' study, explored the effects of a molecular cocktail on 10 healthy men aged 50-65. The intervention aimed to reverse thymic involution, a sign of aging affecting immune health. Results showed a 30-40% drop in C-reactive protein levels, improved kidney function, and an increase in thymic fat-free mass in 80% of participants. Most notably, the study indicated a 6.5-year reversal in epigenetic age, correlating with improved clinical health measures. The cocktail included human growth hormone, DHEA, Metformin, vitamin D, and zinc. The study is now in phase two, with results expected by the end of 2024.

Takeaways

• 🔬 A 2019 study from Stanford Medical School showed promising signs of reversing aging through a cocktail of molecules.
• 🧬 The study, known as the TRIM study, involved 10 healthy men aged 50-65 and focused on immune health and epigenetic aging.
• 📉 Participants experienced a 30-40% drop in C-reactive protein levels and improved kidney function after 9-12 months of treatment.
• 💊 The treatment cocktail included human growth hormone, DHEA, Metformin, vitamin D, and zinc.
• 📈 The study observed a significant reduction in pro-inflammatory markers, such as CD38-positive monocytes.
• 🧠 The thymus, responsible for T cell maturation, showed signs of regeneration, reversing the age-related thymic involution.
• 🧬 Epigenetic clocks, which track age-related changes in gene tags, indicated a 6.5-year reversal in biological age for participants.
• ⚠️ Despite concerns about potential cancer promotion with DHEA, the study found improved markers for prostate cancer.
• 🔍 The study's results are being further investigated in a phase two clinical trial expected to conclude by the end of 2024.
• 📚 The speaker encourages viewers to explore more anti-aging content and stay updated for the results of the ongoing trials.

Q & A

What was the main focus of the study conducted at Stanford Medical School?

The study aimed to investigate the effects of a cocktail of molecules on immune health and epigenetic aging in healthy men aged 50 to 65.

What was the duration of the study?

The study ran for approximately 18 months, with some endpoints measured up to 12 months.

What changes were observed in C-reactive protein levels during the study?

There was a significant drop in C-reactive protein levels, around 30 to 40 percent, at the 12-month mark.

How did kidney function change as per the study?

Kidney function, measured as glomerular filtration rate, showed improvement starting at the nine-month mark.

What is thymic involution and how does it relate to aging?

Thymic involution is the process where the thymus, an organ responsible for maturing immune cells, gets replaced with fat tissue as we age, leading to a less functional organ.

What was the intervention's impact on thymic tissue as observed in the study?

The intervention led to a reduction in thymic fat mass and an increase in fat-free thymic tissue in about 80 percent of the participants.

How did the study measure changes in the immune profile?

The study measured changes in immune profile by looking at the levels of CD38 positive monocytes, which are markers of inflammation.

What are epigenetic clocks and how were they used in this study?

Epigenetic clocks are based on changes in epigenetic tags across the genome that correlate with age. The study used four different epigenetic clocks to measure biological age.

What was the most significant change observed in epigenetic age during the study?

The most significant change was a six and a half year reversal of epigenetic age from month 9 to 12 of the intervention.

What was the cocktail of molecules given to the participants in the study?

The cocktail included human growth hormone, DHEA, Metformin, vitamin D, and zinc.

What were the results regarding cancer markers in the study?

Markers for prostate cancer were found to be improved, while there was a slight increase in serum alkaline phosphatase, a liver enzyme.