How to Reverse Fatty Liver Disease Naturally | Jason Fung
Summary
TLDRThis video discusses non-alcoholic fatty liver disease (NAFLD), its increasing prevalence, and the role of dietary sugars in its development. It explains how excessive fructose and glucose intake lead to fat accumulation in the liver, causing inflammation and potentially cirrhosis. The script highlights studies showing that reducing sugar intake, through low-carb or fasting diets, can significantly decrease liver fat and reverse NAFLD, offering a natural and drug-free solution to this growing health crisis.
Takeaways
- 📚 Fatty liver, also known as non-alcoholic fatty liver disease (NAFLD), is characterized by an excessive accumulation of fat in the liver, which is not its normal function.
- 🔍 The issue arises when triglycerides, which should be stored in adipocytes (fat cells), are instead stored in the liver, leading to inflammation and potentially severe liver damage like cirrhosis.
- 🌐 NAFLD has become a global health problem, with up to 25% of people in the United States estimated to have the condition, and it has increased significantly since the 1980s.
- 📈 The liver naturally produces some fat, but in NAFLD, there is a dramatic increase in de novo lipogenesis, the process of creating new fat from sugars, particularly fructose.
- 🍬 Fructose is a key molecule in the development of fatty liver because it is exclusively metabolized by the liver and contributes to the creation of new fat.
- 🥖 High carbohydrate diets, especially those rich in glucose, can lead to increased conversion of glucose into new triglycerides, contributing to fatty liver.
- 🧪 Studies have shown that overfeeding carbohydrates, especially in the form of glucose and fructose, leads to increased body weight and liver fat.
- 💉 The hormone insulin, stimulated by high glucose intake, promotes fat storage, including the creation of new fat in the liver.
- ✂️ Reducing sugar intake, both glucose and fructose, has been shown to be an effective strategy in reversing fatty liver disease.
- 🍽️ Recent research supports the effectiveness of low sugar diets and fasting or low carbohydrate diets in significantly reducing liver fat and potentially reversing NAFLD.
- 🌟 The video suggests that by understanding the development of fatty liver and applying this knowledge through dietary changes, it is possible to naturally and effectively combat this growing health issue.
Q & A
What is fatty liver and why does it occur?
-Fatty liver, also known as non-alcoholic fatty liver disease (NAFLD), is a condition where there is an excessive accumulation of fat in the liver. It occurs when the liver stores fat molecules called triglycerides instead of adipocytes (fat cells), leading to problems such as inflammation and potential liver damage.
What is the progression of non-alcoholic fatty liver disease?
-The progression of NAFLD starts with the simple accumulation of fat in the liver, which can lead to non-alcoholic steatohepatitis (NASH), a more severe form characterized by inflammation. This inflammation can destroy the liver, potentially leading to cirrhosis, a condition that may require a liver transplant.
Why is non-alcoholic fatty liver disease becoming a global epidemic?
-Non-alcoholic fatty liver disease is becoming an epidemic due to its rapid increase in prevalence, affecting up to 25% of people in the United States alone. It was barely known in 1980 but has since grown significantly, with hospitalizations for fatty liver disease increasing almost 10-fold from 1998 to 2010.
What is the role of fructose in the development of fatty liver?
-Fructose plays a significant role in the development of fatty liver because it is metabolized by the liver and can lead to the creation of new fat, or triglycerides, through a process called de novo lipogenesis. Since fructose cannot be metabolized by other cells in the body, it contributes to the accumulation of fat in the liver.
How does a high carbohydrate diet contribute to fatty liver?
-A high carbohydrate diet can contribute to fatty liver by increasing the amount of glucose available to the liver. The liver can convert this excess glucose into new triglycerides, leading to an increase in liver fat.
What is de novo lipogenesis and why is it significant in fatty liver?
-De novo lipogenesis is the process by which the liver creates new fat from non-fat sources, primarily sugars like glucose and fructose. It is significant in fatty liver because it leads to an excessive accumulation of fat in the liver, contributing to the disease's development.
How does insulin relate to the development of fatty liver?
-Insulin is a hormone that signals the body to store energy. When there is a high intake of glucose, insulin levels rise, promoting the storage of energy, including the creation of new fat in the liver, which can contribute to fatty liver.
What dietary changes can help reverse fatty liver disease according to the research mentioned in the script?
-Research suggests that reducing the intake of sugars, both glucose and fructose, can help reverse fatty liver disease. This can be achieved through very low carbohydrate diets or fasting, which have shown to decrease liver fat by over 50 percent.
What was the outcome of the study involving teenage boys with fatty liver who followed a low sugar diet?
-The study showed that after following a low sugar diet, the average liver fat in the teenage boys decreased from 25 percent to 17 percent, indicating a significant reduction in liver fat.
How did the fasting and low carbohydrate diets compare in terms of reducing liver fat in a 2021 study?
-Both the fasting and low carbohydrate diets resulted in over 50 percent reduction in liver fat, showing that dietary interventions focusing on reducing sugar intake can be effective in treating fatty liver disease.
What is the potential impact of reversing fatty liver disease naturally without drugs?
-Reversing fatty liver disease naturally without drugs can help reduce the risk of liver failure and the need for liver transplants, contributing to better overall health and potentially reducing healthcare costs associated with liver diseases.
Outlines
🍲 Understanding Fatty Liver and Its Dietary Causes
This paragraph introduces the concept of fatty liver, explaining that it is an accumulation of fat, specifically triglycerides, in the liver where it doesn't belong. It contrasts the normal storage of fat in adipocytes with the problematic storage in the liver, leading to inflammation and potential liver damage. The speaker outlines the progression from non-alcoholic fatty liver disease (NAFLD) to non-alcoholic steatohepatitis (NASH), which can result in cirrhosis and the need for a liver transplant. The paragraph also discusses the increasing prevalence of NAFLD globally and the role of de novo lipogenesis, the production of new fat from sugars, particularly fructose, in the development of fatty liver. The importance of fructose, found in high fructose corn syrup and table sugar, is highlighted, as it is exclusively metabolized by the liver and contributes to fat accumulation.
🍏 Reversing Fatty Liver Disease Through Diet Modification
The second paragraph delves into the dietary interventions that can reverse fatty liver disease. It discusses how overconsumption of glucose and fructose leads to increased insulin production and de novo lipogenesis, resulting in liver fat accumulation. The speaker cites studies that demonstrate the effectiveness of reducing sugar intake, including both glucose and fructose, to decrease liver fat. A study involving teenage boys with fatty liver is highlighted, showing significant reduction in liver fat with a low sugar diet. Additionally, another study from 2021 is mentioned, which found that both fasting and low-carbohydrate diets can reduce liver fat by over 50 percent. The paragraph concludes by emphasizing the natural and cost-free approach to reversing fatty liver disease through dietary changes, suggesting the use of very low carbohydrate diets and fasting as potential solutions.
Mindmap
Keywords
💡Fatty Liver
💡Non-Alcoholic Fatty Liver Disease (NAFLD)
💡Cirrhosis
💡De Novo Lipogenesis
💡Fructose
💡Glucose
💡Insulin
💡Fasting
💡Low Carbohydrate Diet
💡Triglycerides
💡Foie Gras
Highlights
Fatty liver disease is a condition where the liver accumulates too much fat, leading to potential health problems.
Non-alcoholic fatty liver disease (NAFLD) can progress to non-alcoholic steatohepatitis (NASH), causing inflammation and potential liver damage.
NAFLD has become an epidemic, affecting up to 25% of people in the United States.
Hospitalizations for fatty liver disease have increased significantly, with a 10-fold increase from 1998 to 2010 in the UK.
De novo lipogenesis, the creation of new fat from sugar, is a key process in the development of fatty liver disease.
Fructose, found in high fructose corn syrup and table sugar, is particularly harmful as it is metabolized by the liver and contributes to fat production.
High carbohydrate diets can lead to increased glucose conversion into triglycerides, contributing to fatty liver.
Insulin, a hormone stimulated by glucose, promotes fat storage and is linked to increased liver fat.
Overfeeding of fructose in humans has been shown to increase de novo lipogenesis and liver fat significantly.
A low sugar diet has been proven effective in reducing liver fat in teenagers with fatty liver disease.
Both fasting and low carbohydrate diets have shown to reduce liver fat by over 50%, suggesting a dietary approach to treating fatty liver.
Cutting back on sugar, both glucose and fructose, is a logical intervention for reversing fatty liver disease.
Fatty liver disease can be reversed naturally without drugs, through dietary changes.
Intermittent fasting and low carbohydrate diets are potential methods for managing and reversing fatty liver disease.
The video provides educational content on understanding and addressing fatty liver disease through lifestyle changes.
Transcripts
today i'm going to talk about fatty
liver
what it is how we get it and what new
research is telling us
about how we can reverse it naturally
without any drugs
just a change in our diet
this is a picture of what fatty liver
looks like it's
pretty much what it sounds like too much
fat
in the liver what's wrong with that well
fat which is the molecule called
triglycerides
should be stored in fat cells which are
called adipocytes
if you store fat in fat cells well it
doesn't cause a lot of problems
but if you store fat in the liver where
it's not supposed to be stored
then you're going to get a lot of
problems so
when you look at non-alcoholic fatty
liver disease
and the first stages what you can see is
that the cells are swollen up
with all this extra fat as it progresses
to non-alcoholic steatohepatitis
or nash you start to develop
a lot of inflammation and this
inflammation in the liver
can actually destroy the liver and
completely wipe it out
leading to destruction which is called
cirrhosis
and at that point you might even need a
liver transplant
non-alcoholic fatty liver disease is
becoming
a bigger and bigger problem in north
america and now
all over the world in fact it was barely
known in 1980 when the first cases were
described
from a virtually unknown disease in 1980
it's become an epidemic up to 25 percent
of people in the united states are
thought to have
non-alcoholic fatty liver disease and
it's not just a problem with the fat
in fact it's causing a lot of liver
problems overall
this is data from the united kingdom
which shows that
hospitalizations for fatty liver disease
have increased almost
10-fold from 1998 to 2010
as a cause of liver transplantation it's
doubled
from 2007 to 2013.
normally the liver can produce some fat
and it does take in
fat from other sources such as the
plasma
which is the bloodstream their fatty
acids the evening meal contains fatty
acids as well
and it will go into the liver and the
liver will export it out
the difference between normal livers and
non-alcoholic fatty liver disease
is that there's a massive increase in
the amount of fat
that is produced by this process called
de novo lipogenesis
this is the creation of new fat
but what is it created from it's not
from old fat
it's from sugar when we talk about
sugars
there's two main molecules we're talking
about glucose
which is the main sugar that you find in
starches
like bread flour rice potatoes
those are long chains of glucose the
other simple sugar
is fructose and that's what's found in
high fructose corn syrup
and also table sugar or sucrose that is
one molecule of glucose and one molecule
of fructose
fructose is a very important molecule
for de novo lipogenesis
because the fructose cannot be
metabolized by
any cell other than the liver whereas
most of the cells of your body that is
your heart your muscles your kidneys
your liver
can use glucose for energy none of those
can use the fructose so all the fructose
that you eat
essentially goes straight into the liver
and from this diagram you can see
that it gets turned into triglycerides
or new fat and from there it's supposed
to be exported out but if you're
producing
too much of this new fat then it's going
to accumulate
in the liver the other main molecule we
have to worry about is glucose
if you're eating a very high
carbohydrate diet
then you're going to take this glucose
and you're going to turn it into
new triglycerides this is a diagram
of how it happens and it seems very
complicated
but essentially you can see that you're
taking the feedstock which is glucose
putting it through this metabolic
pathway
in the liver which is the hepatocyte and
out comes
triglycerides or new fat we know how
this process
works in animals for example in the
production of foie gras
well this is a very controversial food
because
of potential animal cruelty it is the
fatty liver of a goose
and it's made by putting a tube down
and feeding these ducks large amounts of
not
fat but starches corn mash in this case
they take all this corn which is high in
glucose
and their liver creates more fat you get
fatty liver
which is the the food that we call foie
gras
and it works in humans too in this study
what they did
was they overfed humans carbohydrates
and from baseline when they fed them a
lot of
glucose and fructose they increased
their body weight but only by two
percent
however when they measured their liver
fat it went up
by 27 and when they measured how much
de novo lipogenesis was happening they
found an identical
27 percent when they took them off of
their
high starch diets they lost all that
liver fat
when you eat a lot of glucose
this is going to stimulate the
production of the hormone insulin
which is a storage hormone it tells our
body to store
some of this energy that's coming in and
one of the ways that our body does that
is through the creation of new fat these
studies show that there's a clear
correlation
between giving people insulin and how
much
fat is in their liver the same effect
is seen in overfeeding of fructose
things like
sugar or high fructose corn syrup when
they did this to humans what they found
was that the amount
of de novo lipogenesis that was
being done in the liver increased the
amount
of new fat by 79 the rate
of de novo lipogenesis increase from
baseline
by six times so the liver is responding
to this high load of fructose by turning
it into
fat in the liver once we understand
how this fat is created and stored in
the liver
that leads us naturally to how we're
going to treat it
since fatty liver is caused by too much
sugar
both glucose and fructose the logical
solution
is simply to cut them down and that's
what recent research has shown us to be
highly effective in the reversal of
fatty liver disease
this study published in 2019 looked at
teenage boys who had developed fatty
liver
and what they did was they randomized
them to
a normal diet versus a very
low sugar diet less than three percent
of calories compared to
a normal diet which was less than 10
percent of calories
what were the results this is a graph
of what happened on the low sugar diet
the dotted line is the amount of fat in
the liver prior to the diet
and the circle is how much liver fat
there was
after following this low sugar diet and
on
average the liver fat decreased from 25
percent to 17 percent
you can see that most of the circles
drop below the original dotted line
compared to the usual diet where there
really wasn't much change
and the average liver fat moved from 21
only to 20 or no change at all this
study
from 2021 randomized
people to two different types of dietary
intervention
either a fasting type diet which is a
five to two diet or a low carbohydrate
high fat
diet in the fasting diet their diet
didn't change much although on two of
the days
they ate very few calories the low carb
diet
severely restricted the amount of
carbohydrates that they ate
so what happened both the fasting and
the low carb diets
resulted in better weight loss compared
to the usual diet
but more importantly when they looked at
the liver fat they could reduce the
amount of fat in the liver
by over 50 percent both with fasting
and low carbohydrate diets
this makes a lot of sense if fatty liver
is really just caused by too much sugar
that is too much glucose and too much
fructose
then the logical intervention is to
simply cut them back
by using very low carbohydrate diets
and or fasting we can reverse
fatty liver disease a blossoming
epidemic
and one that's contributing to a lot of
liver failure
and we can do it completely naturally
and
completely free we just have to take the
knowledge of
how it develops and apply it to our
lives if you want to learn more
about how to use intermittent fasting
you can check out the other videos
in my playlist somewhere here
thanks for watching if you learned
something maybe share it with a friend
they might learn something too and if
you enjoyed this video
make sure you hit the like button
somewhere down below
i'll see you next week
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