CARA PEMBUATAN SUPPOSITORIA PARACETAMOL

Summary

This video discusses the formulation of Paracetamol suppositories, covering key aspects such as the definition, benefits, and drawbacks of suppositories as a dosage form. The speaker explains the process of preparing Paracetamol suppositories, detailing the role of ingredients like white wax and cocoa butter. Various tests such as melting point, melting time, and hardness are conducted to evaluate the quality of the suppositories. The presentation highlights how the concentration of white wax affects the physical properties, such as melting point and hardness, ultimately influencing the effectiveness of the product.

Takeaways

• 😀 Suppositories are solid dosage forms given rectally, vaginally, or urethrally, which melt or soften at body temperature.
• 😀 They can act as local or systemic therapeutic agents, providing benefits like faster effects compared to oral medications.
• 😀 The main advantages of suppositories include avoiding stomach irritation, preventing drug degradation by digestive enzymes, and providing quick effects.
• 😀 Suppositories are beneficial for patients who are unconscious or prone to vomiting.
• 😀 The disadvantages include being unpleasant for the user and having unpredictable drug absorption rates.
• 😀 Absorption of the drug in suppositories is influenced by physiological factors (e.g., diffusion, metabolism) and physical factors (e.g., drug solubility, suppository base).
• 😀 Paracetamol suppositories are used to reduce fever and relieve pain, with characteristics such as a molecular weight of 151.16 and solubility in water, ethanol, and glycerol.
• 😀 The main equipment required for suppository preparation includes a beaker, mortar, pestle, suppository molds, weighing scales, and a UV spectrophotometer.
• 😀 The manufacturing process involves melting white wax, adding cocoa butter, mixing with Paracetamol, pouring into molds, and cooling the mixture to solidify it.
• 😀 Physical testing of suppositories includes measuring their melting point, melting time, and hardness to ensure proper functionality and consistency in release.
• 😀 The results indicate that increasing the white wax concentration raises the melting point, increases the time to melt, and makes the suppository harder, which influences its release and effectiveness.

Q & A

What is suppository, and how is it administered?

A suppository is a solid dosage form that is administered through the rectum, vagina, or urethra. It melts, softens, or dissolves at body temperature to deliver its therapeutic effects.

What are the benefits of using suppositories?

Suppositories offer several advantages: they avoid stomach irritation, protect the drug from digestive enzymes, allow for faster absorption into the bloodstream, and are beneficial for patients who are vomiting or unconscious.

What are the disadvantages of suppositories?

The main disadvantages of suppositories include their unpleasant usage for some patients and unpredictable absorption rates, which can vary.

What physiological and physical factors affect the absorption of drugs from suppositories?

Factors affecting drug absorption from suppositories include the release of the drug from the base, diffusion through the mucosa, detoxification or metabolism, distribution in body fluids, and protein binding in the blood.

What is Paracetamol suppository, and what are its uses?

Paracetamol suppository is a medication used to reduce fever and relieve pain, such as headaches, toothaches, and mild aches. It contains paracetamol, which acts as an antipyretic and analgesic.

What are the characteristics of Paracetamol?

Paracetamol has a molecular weight of 151.16 and a molecular formula of C8H9NO2. It is soluble in 70 parts water, 7 parts 95% ethanol, 13 parts acetone, 40 parts glycerol, and 9 parts propylene glycol.

What tools and materials are used to make Paracetamol suppositories?

The tools required include glassware, a mortar and pestle, suppository molds, water bath, refrigerator, analytical balances, a melting point apparatus, and a UV spectrophotometer. The materials used are Paracetamol, cocoa butter (or chocolate fat), white wax, and Aqua Pro Injection.

What is the procedure for preparing Paracetamol suppositories?

The preparation involves determining the formula with varying percentages of white wax, melting white wax at 65°C, adding cocoa butter, then mixing in Paracetamol, and finally pouring the mixture into pre-oiled molds. The molds are cooled, and suppositories are weighed and tested.

What physical properties of Paracetamol suppositories are tested?

The physical properties tested include melting point, melting time, and hardness. These tests assess the suppository's ability to melt at body temperature, dissolve quickly, and maintain its structural integrity during handling.

How does the addition of white wax affect the suppository's properties?

Adding white wax increases the melting point and hardness of the suppository. White wax has a melting point higher than cocoa butter, which stabilizes the suppository and results in a firmer consistency.