The IDEAL RATIO Between Testosterone & DHT-Derivatives? Vigorous Q&A

Summary

The video script discusses the ideal ratio of testosterone to non-aromatizing compounds like Primobolan or Masteron to minimize the need for an aromatase inhibitor (AI). The speaker suggests starting with a one-to-one ratio, which is easy to follow and accounts for different esters of testosterone and the two esters of Masteron and the single ester of Primobolan. The script delves into the mechanisms of different AIs, including the suicide inhibitor Aromasin and reverse-binding inhibitors like Arimidex or Letrozole. It emphasizes the importance of blood work to adjust the ratio based on individual serum estrogen levels. The video also mentions oral DHT derivatives and their potential effects on aromatization. The speaker provides a starting point for the one-to-one ratio based on the Avogadro's constant but stresses that personal blood work is crucial for determining the optimal ratio. The video concludes with a recommendation for regular blood work and the use of Diindolylmethane (DIME) to help metabolize estradiol and reduce the estrogenic burden.

Takeaways

• 📊 A one-to-one ratio of testosterone to a non-aromatizing compound like Primobolan or Masteron is suggested as a starting point to potentially avoid the need for an aromatase inhibitor (AI).
• 🧬 Testosterone comes in various esters, whereas Primobolan has two and Masteron has one, making the one-to-one ratio easy to follow regardless of the ester.
• 🔍 Dihydrotestosterone (DHT) derivatives like Boldenone, Dihydrobaldone, and some of their metabolites act as reverse-binding aromatase inhibitors, similar to Arimidex or Letrozole.
• ⚖️ Aromasin is a steroidal, suicide inhibitor that irreversibly binds to the aromatase enzyme, rendering it inactive and preventing the conversion of testosterone into estrogen.
• 📉 The one-to-one ratio is based on the logic that for each molecule of testosterone that can convert into estradiol, an equal molecule of a DHT derivative is needed to block this conversion.
• 💊 Oral DHT derivatives may not work as effectively as injectable ones in inhibiting aromatization, though they can still provide some effect.
• 🧪 Blood work is crucial to determine if the chosen ratio is effective for an individual, and adjustments may be needed based on serum estrogen levels.
• 📉 Body fat levels can influence the amount of aromatase enzymes and thus the potential for aromatization, which should be considered when determining dosages.
• 🔄 If blood work indicates high estrogen levels, the dosage of the steroid inhibiting conversion may need to be increased, or the ratio of testosterone to the inhibiting steroid may need to be altered.
• 🧮 For a more precise calculation, the Avocados constant can be used to determine the exact milligrams of testosterone and the non-aromatizing compound needed for a one-to-one molecular ratio.
• 💡 Dinomethione (DMN) can be used to help metabolize estradiol into estrogen and reduce the overall estrogenic burden from exogenous testosterone.

Q & A

What is the suggested starting ratio of testosterone to a non-aromatizing compound to minimize the need for an aromatase inhibitor?

The suggested starting ratio is one-to-one, meaning for every milligram of testosterone, you would use an equal milligram of a non-aromatizing compound like Primobolan or Masteron.

Why is blood work important when using a one-to-one ratio of testosterone to a non-aromatizing compound?

Blood work is crucial to determine if the chosen ratio is effective for an individual, as it can reveal serum estradiol levels and the need for further adjustments to the hormone balance.

How do dihydrotestosterone (DHT) derivatives act as aromatase inhibitors?

DHT derivatives like Boldrone, Dihydrobaldinone, and their metabolites act as reversely binding aromatase inhibitors, temporarily inhibiting the aromatization of aromatizable compounds.

What is a suicide inhibitor and how does Aromasin work as one?

A suicide inhibitor is a compound that becomes permanently inactivated after reacting with its target enzyme. Aromasin works as a steroidal suicide inhibitor by getting stuck in the aromatase enzyme, rendering it inactive and preventing the conversion of testosterone into estradiol.

Why might the one-to-one ratio not work as effectively with oral DHT derivatives?

The one-to-one ratio might not be as effective with oral DHT derivatives because their relative binding affinities for the aromatase enzyme have not been established, and they may not provide the same aromatase inhibiting effects as injectable compounds.

What is the significance of the Avocados constant in calculating the ideal one-to-one ratio of molecules?

The Avocados constant allows for the calculation of the exact milligrams of testosterone and a non-aromatizing compound needed to achieve an equal number of molecules, providing a precise one-to-one ratio as a starting point.

What is the role of sex hormone-binding globulin (SHBG) in the context of the one-to-one ratio?

SHBG binds to sex hormones, affecting their availability. Although the relative binding affinities for SHBG are known, the exact impact on the one-to-one ratio and its adjustments based on blood work is not explicitly detailed in the script.

How often should one check their blood work after starting a hormone protocol?

It is recommended to check blood work about a month into the protocol to assess the serum estradiol levels and make any necessary adjustments to the hormone ratios.

What are some factors that can influence the need for an aromatase inhibitor?

Factors such as body fat levels, diet, and the amount of adipose tissue can influence the expression of aromatase enzymes and, consequently, the need for an aromatase inhibitor.

What is the alternative approach if blood work indicates that the one-to-one ratio is not effective?

If blood work indicates that the one-to-one ratio is not effective, one can adjust the ratio of testosterone to the non-aromatizing compound, or consider using a different approach such as daily micro administrations of testosterone without an aromatase inhibitor.

What is the role of Diindolylmethane (DIM) in managing estrogen levels?

DIM can help with the metabolism of estradiol into estrogen, thereby reducing the overall estrogenic burden of the exogenous testosterone being used.

How can one get a discount on health panels that include estradiol testing?

One can get a 10 percent discount on health panels from merrickhealth.com by using the vigorous discount codes provided in the video description.