Does glutamine feed cancer? How to block glutamine safely
Summary
TLDRDr. Igor Atabekov, a clinical oncologist, discusses the metabolic approach to cancer treatment, focusing on glutamine, a key energy source for tumors. He explores natural remedies and drugs like metformin that could potentially block glutamine uptake, thereby starving cancer cells. The video also touches on substances like arisin, resveratrol, curcumin, berberine, and green tea extracts, which show promise in enhancing chemotherapy sensitivity and blocking glutamine metabolism. Dr. Atabekov emphasizes the need for further research, as these treatments are not yet standard but are grounded in scientific evidence.
Takeaways
- 👨⚕️ Dr. Igor Atabekov is a clinical oncologist with experience since 2010, practicing in Russia and exploring natural treatments for cancer.
- 🌿 He discusses the metabolic theory of cancer and the potential of keto diets and ketone bodies to starve cancer cells.
- 🚫 Dr. Atabekov emphasizes the need to reduce and block glutamine, a source of energy for many tumors, alongside sugar reduction.
- 🌿 Santonin, derived from plants used in beer making, can block glutamine transport into cells, though supplements are not known to him.
- 💊 Metformin, a common diabetes drug, may decrease insulin resistance, block glutamine, and affect cancer stem cells, but its effectiveness varies by tumor type.
- 🌿 Artemisinin, found in the sweet wormwood plant, has antimalarial properties and can block glutamine, though its sensitivity across tumors is not uniform.
- 🍇 Resveratrol, an antioxidant in grapes, can increase tumor sensitivity to chemotherapy drugs and affect glutamine metabolism, but its impact can be context-dependent.
- 🍵 Curcumin, found in turmeric, and substances in green tea like EGCG, can improve chemotherapy drug sensitivity and block glutamine transport in cancer cells.
- 🌿 Berberine, known for its anti-tumor activity, can decrease glutamine uptake by cancer cells.
- 🔬 The substances mentioned are not official treatments but have theoretical and scientific bases that require further research.
Q & A
Who is Dr. Igor Atabekov and what is his profession?
-Dr. Igor Atabekov is a clinical oncologist who has been practicing since 2010. He works in Russia, both in governmental clinics and is interested in exploring natural types of treatment and adjunctive treatments for cancer.
What is the metabolic theory of cancer that Dr. Atabekov mentioned?
-The metabolic theory of cancer refers to the concept of starving cancer cells by manipulating their metabolic pathways, such as the keto diet and reducing glucose intake, to limit the energy sources available to the tumor cells.
Why is glutamine significant in cancer treatment according to Dr. Atabekov?
-Glutamine is significant because it serves as a source of energy for many tumors. Reducing its availability can potentially starve the cancer cells and hinder their growth.
What is the role of metformin in cancer treatment as discussed by Dr. Atabekov?
-Metformin, primarily used for type 2 diabetes, may also have anti-cancer properties. It can block glutamine, decrease insulin resistance, and blood glucose levels, and it may also block autophagy, which is a survival mechanism for cells during starvation.
How does autophagy relate to cancer cell survival?
-Autophagy is a process where cells survive starvation by consuming their own cellular components. In cancer, blocking autophagy can prevent tumors from using this survival mechanism, potentially making them more vulnerable to treatment.
What is the significance of cancer stem cells in recurrence and drug resistance?
-Cancer stem cells are considered the source of recurrence and drug resistance. They can lie dormant and then reactivate to form new tumors, which is why targeting these cells is crucial in cancer treatment.
What is the potential role of arisin in cancer treatment?
-Arsinic, found in the herb Artemisia annua, has antimalarial and antiparasitic effects and may also block glutamine, potentially making tumors more sensitive to treatment.
How does resveratrol affect glutamine metabolism in cancer cells?
-Resveratrol, an antioxidant found in grapes, can increase the sensitivity of tumors to chemotherapy drugs and decrease the absorption and transport of glutamine, thus potentially inhibiting tumor growth.
What is the effect of curcumin on chemotherapy drug sensitivity?
-Curcumin, found in turmeric, can improve the sensitivity of tumors to chemotherapy drugs and decrease glutamine metabolism, suggesting it may be beneficial in combination with other treatments.
How does berberine impact cancer cells' glutamine uptake?
-Berberine, known for its anti-tumor activity, can decrease the uptake of glutamine by cancer cells, which may help in limiting the energy supply to the tumor.
What is the potential role of green tea components in blocking glutamine?
-Components in green tea, such as EGCG, can antagonize glutamine, potentially helping to block its use by cancer cells and thus inhibiting their growth and spread.
Outlines
👨⚕️ Dr. Igor's Introduction to Metabolic Cancer Treatment
Dr. Igor Atabekov, a clinical oncologist with over a decade of experience, introduces himself and his interest in exploring natural and adjunctive treatments for cancer. He acknowledges the limitations of conventional oncological treatments and expresses his commitment to finding additional ways to assist patients. Dr. Igor discusses the metabolic theory of cancer, emphasizing the role of keto diets and ketone bodies in starving cancer cells of glucose. He also highlights the importance of managing glutamine, a significant energy source for many tumors, and proposes methods to reduce and block its availability to cancer cells. The doctor apologizes for the casual setting due to being on vacation but emphasizes his dedication to continuing his work to help those in need.
🌿 Natural Remedies and Metformin for Cancer Treatment
Dr. Igor discusses various natural substances and the drug metformin as potential treatments to block glutamine, a key nutrient for cancer cells. He mentions Santonin, derived from plants used in beer production, which can inhibit glutamine transport within cells. Metformin, a first-line drug for type 2 diabetes, is noted for its potential to decrease insulin resistance and blood glucose, and its ability to block glutamine and autophagy in cancer cells, thereby hindering their survival mechanisms. Additionally, metformin's impact on cancer stem cells is highlighted, which are linked to recurrence and drug resistance. The doctor also touches on the development of targeted therapies to deliver metformin more effectively to tumor sites.
🍇 Antioxidants and Natural Compounds in Cancer Metabolism
Dr. Igor continues by exploring the effects of natural compounds like artesunate, resveratrol, curcumin, and berberine on glutamine metabolism in cancer cells. He explains how these substances can increase the sensitivity of tumors to chemotherapy drugs or decrease glutamine uptake, thus potentially enhancing the effectiveness of cancer treatments. He also discusses the potential of EGCG from green tea to block glutamine, which could theoretically help prevent tumor growth and metastasis. The doctor emphasizes that while these treatments show promise, they are not yet standard protocol and require further scientific investigation. He concludes by encouraging viewers to engage with the content and support the channel for more informative videos.
Mindmap
Keywords
💡Clinical Oncologist
💡Metabolic Theory of Cancer
💡Keto Diet
💡Glutamine
💡Metformin
💡Autophagy
💡Cancer Stem Cells
💡Resveratrol
💡Curcumin
💡Berberine
💡EGCG
Highlights
Dr. Igor Atabekov is a clinical oncologist with an interest in natural and adjunctive treatments for cancer.
Metabolic theory of cancer and the potential of keto diets to starve cancer cells are discussed.
Glutamine is identified as a significant energy source for many tumors.
Santoo, derived from plants used in beer making, can block glutamine transport into cells.
Metformin, a drug for type 2 diabetes, may also block glutamine and decrease tumor cell growth.
Metformin's potential to block autophagy, a survival mechanism for tumors during starvation.
The importance of targeting cancer stem cells to prevent recurrence and drug resistance.
Arsenic, found in Arisaema annua, has antiparasitic effects and may block glutamine.
Resveratrol, an antioxidant in grapes, can increase tumor sensitivity to chemotherapy drugs.
Curcumin, found in turmeric, can improve sensitivity to chemotherapy and decrease glutamine metabolism.
Berberine, known for its anti-tumor activity, can decrease glutamine uptake by cancer cells.
Green tea's EGCG is a known blocker of glutamine, which may help in cancer treatment combinations.
Epigallocatechin gallate (EGCG) from green tea may play a role in blocking glutamine and preventing tumor growth and metastasis.
The need for further research to understand which tumors are sensitive to these glutamine-blocking substances.
The potential of targeted therapies to deliver metformin directly to tumors for more effective treatment.
Dr. Atabekov emphasizes that the discussed treatments are not official protocols and require more investigation.
Transcripts
hello dear friends my name is Dr Igor
atabekov I'm clinical oncologist
practicing since 2010 I'm doctor in
Russia and I'm working in the official
governmental clinic but also very
interested in different natural um
natural types of treatment in some
adjunctive treatments in metabolic
treatment of cancer because our official
official oncological treatments are very
limited and uh often lack efficacy we
cannot cure many patients that's why I'm
always seeking for some additional ways
to help the patients and um before I was
talking about the metabolic theory of
cancer about the ways to starve the
cancer about the keto diet Ketone bodies
about glutamine the source of many of
the energy for many tumors and today I
will talk about the possible methods how
you can reduce and block glutamine
because with sugar it's quite easy okay
don't eat the food that is full of carbs
uh do keto diets and you will decrease
your sugar maximally you will decrease
your insulin and you'll have a lot of
ketones but what can you do with
glutamine let's figure it out
I'm sorry for this view I'm in vacation
now but still I need to continue my work
to help people who are in need that's
why let's start from the first natural
uh remedy this is
santoo what is that that is the
substance from the plants that you use
to make a beer so it's good used for all
beer lovers but no of course you don't
need to drink more beer to cure cancer
and this substance can block the
transport of glutamine inside the cell
so the cell can use it afterwards
unfortunately I don't know any
supplements
nowadays that you can buy to have this
Santa humo but some people do their
tinctures from this plant next one
metformin metformin is a well-known drug
it's number one drug against against
diabetes Mill of second type from one
side it decreases insulin resistance it
decreases blood glucose so it's already
good against tumors right from the other
side it appears that it can block the
glutamine and really we the scientists
observed that it can decrease the cell
growth of many tumor cell lines many
types of cancer it can block the enzyme
glutaminase that converts glutamine to
glutamate and the tumor cannot use it
anymore also it appears to block
autophagy autophagy is the process of um
survival during starvation that mean if
we block glucose we block glutamine and
the tumor still can survive by autophagy
by eating the junk by using Lums by
eating junk around the tumor cells this
junk will be disassembled into small
pieces small components and the tumor
will use them that's how the tumor Will
Survive their full starvation but here
if we block autophagy if we block lomes
by the way I was talking about it in the
third video of this playlist about I
mean about mitochondrial theory if you
block lomes then this is the one more
heat to the tumor also it is known that
metformin can affect also the stem cells
of the cancer that is most very
important because stem cells um are
considered to be the source of all
recurrencies of drug resistance and um
if we see for example the person who was
cured from cancer we think he was cured
by all this radiation by chemotherapy
and then after many years the tumor
grows again this is because of these
stem cells sleeping somewhere um
controlled by immunity and then after
stress after immunity fail the tumor
will grow again and spread and give a
lot of metastasis
that's why killing these to stem cells
is a major task for us but as we see
here not all the tumors were um
sensitive to metformin treatment and it
depends on um which processes this tumor
uses for its life what is its metabolism
characteristics the problem nowadays is
we don't know how to understand which
tumor will be sensitive to this remedy
which tumor will be sensitive to this
remedy we're trying to develop this
targeted therapies now but still it's an
a Very starting level here they are
trying to make the special little
carriers for met forming uh to put it
maximally into the tumor not into the
other cells uh this is more targeted
therapy so the metformin will be
accumulated inside the tumor to cause a
good concentration and to block
glutamine block all the other things
there loagy so good luck for them and
let's move forward one more natural
substance is arisin that is found in
aresia anua it's a herb it has
antiparasitic effect it has antim
malarian effect also it can cause
glutamine blockage and many people who
use this alternative approach for cancer
treatment they use arisin also note all
tumors will be sensitive to the this
substance next substance is Resveratrol
this is a well-known antioxidant found
in grapes mostly and it also affects the
metabolism of glutamine it can really
increase the sensitivity of tumor to
some chemotherapy drugs like CIS platin
and um increase it many times and even
if the tumor already lost its
sensitivity to this C platin the res
veral May renew it as you can see here
decreases the absorption of glutamine
and its transporting systems but there
is another article on Goma or neural
cell tumor which shows that yes really R
veratrol in constant concentrations can
decrease the tumor growth but in very
short uh when it's acting very shortly
uh it will actually in increase
glutamine so it's it needs to be
investigated more kurkumin found in
kurkuma longa this is a very famous
substance which can also improve their
sensitivity to many chemotherapy drugs
there are by the way a lot of different
investigations of kurkumin on
oncological patients showing quite good
results Improvement of their treatment
results of their survival of course
there is no 100% remedy that will cure
all the cancers in every tumor there may
be some substances that will work or not
work and we don't know which will and it
also attenuates the metabolism of
glutamine in cells the same here there
is a tumor of B ducts that is very
aggressive it's not sensitive to any
drugs we use some drugs like gabin but
the tumor gains resistance very fast and
here we show that kurkumin can really
increase the sensitivity of tumor to
this gam cabin that is very interesting
we need to uh study in future which
combinations will be good for this tumor
or that tumor and here we see also that
cumine can decrease glutamine in cancer
cells and decreases the the transport of
glutamine to the cells so it they it can
be used by these cells one more
substance berberine berberine is a good
coltic and also it has anti-tumor
activity here you can see that it can
also decrease the uptake of glutamine by
cancer cells next green tea s is the
first substance that is found in green
tea that can that antagonize this
glutamine and the second substance is of
course wellknown epig kin galade that is
seen in many supplements and this is a
very interesting study where they shows
that when the embryo after conception
embryo Tri tries to implant uh it's
called Invasion when the cells grow into
the other cells in the tissues like that
that's what we see in tumor tors the
tumor borders are usually if you see the
tumor it doesn't mean this are borders
it has invasive growth meaning like like
it grows through and it's difficult to
see the bord that's why often we try to
cut out more the surgeons Tres to cut
out more uh because of that and the same
here and this process is dependent on on
the immune cells and glutamine because
these immune cells will use the
glutamine and maybe the glutamine is the
substance that helps the tumors also to
grow like that to spread and to
metastasize if theoretically we block
glutamine maybe it will help to stop
tumors from growing and from
metastasizing and the substance
egcg from green tea is a well-known
Blocker of glutamine of course alone it
won't stop any cancer but it has a good
potential role in combinations dear
friends that's all for today about
glutamine blockers I want to highlight
again that all I talk I'm talking about
is not official for now it's not in
protocols but it has some good the
theoretical plus some scientific basis
and needs to be investigated more wish
you good luck have a good day and I
would appreciate if you write any
comments under this video or support
this channel by the links down in the
description see you in the next videos
good bye be
afid
e
else down the music start DR E's going
to heal your broken heart
[Music]
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