Reverse Aging: Dr David Sinclair on NMN & Anti Ageing supplements (including their side effects)

Summary

El guion habla sobre la importancia de NMN y NAD para la longevidad y la salud. Se menciona que los genes de longevidad, conocidos como sirtuins, se activan durante el ejercicio y la dieta, pero su eficacia disminuye con la edad. Para combatir esto, se puede aumentar el nivel de NAD en el cuerpo, lo que mejora la salud y puede prevenir enfermedades. El NMN es un precursor que ayuda a aumentar los niveles de NAD. Además, se discuten otros métodos de mantener la salud, como el ayuno intermitente y la toma de metformina bajo supervisión médica, y se aboga por la importancia de la autovigilancia en la salud.

Takeaways

• 🧬 La investigación realizada en el laboratorio del entrevistado en la década de 2000 descubrió que ciertos genes de longevidad, conocidos como sirtuinas, protegen el cuerpo contra enfermedades como Alzheimer y diabetes.
• 🔄 Los sirtuinas son siete genes presentes en el cuerpo humano que, con el tiempo, se activan menos a medida que envejecemos, afectando negativamente nuestro estado de salud.
• 💊 El NAD (Nicotinamida adenina dinucleótido) es una molécula esencial para la vida humana, implicada en reacciones químicas y como sensor del cuerpo ante la adversidad.
• 📉 Los niveles de NAD disminuyen con la edad y la falta de actividad, lo que se asocia con un mayor riesgo de enfermedades.
• 💊 El NMN (Nicotinamida mononucleótido) es un precursor que el cuerpo utiliza para producir NAD, y su ingesta puede aumentar los niveles de NAD en el cuerpo humano.
• 🧪 Existen datos de ensayos clínicos que sugieren que aumentar los niveles de NAD puede mejorar la salud humana y potencialmente tratar enfermedades como la insuficiencia renal y la supervivencia a COVID-19.
• 🏃‍♂️ Otras formas de aumentar los niveles de NAD incluyen el ejercicio, la dieta y el uso de sauna, pero el NMN ofrece una alternativa de suplemento para lograr el mismo objetivo.
• 🚫 A pesar de que el entrevistado es un defensor del NMN, él desmiente cualquier involucramiento en la venta de productos relacionados y enfatiza la importancia de la ciencia detrás de su uso.
• 👨‍⚕️ Se sugiere que, bajo la supervisión de un médico, es posible prevenir enfermedades como la diabetes y la enfermedad cardiovascular a través del uso de medicamentos seguros como la metformina y la resveratrol.
• 🌐 La revolución en el enfoque de la salud y el bienestar del público, impulsada en parte por la pandemia, ha llevado a un mayor interés en la autovigilancia de la salud y la adopción de estilos de vida antienvejecimiento.
• 🍽 La práctica del ayuno intermitente se ha convertido en una tendencia ampliamente aceptada, con un impacto significativo en la salud y la longevidad, y se espera que esta tendencia se fortalezca en los próximos años.

Q & A

¿Qué es NMN y por qué es importante según el guion?

NMN es un precursor que el cuerpo utiliza para producir NAD, una molécula esencial para la vida que se requiere para reacciones químicas y actúa como sensor del cuerpo ante la adversidad. El consumo de NMN ha demostrado aumentar los niveles de NAD, lo que es beneficioso para la salud humana según estudios clínicos.

¿Cuál es la relación entre los genes de longevidad y NMN?

Los genes de longevidad, como los sirtuins, requieren NAD para su actividad. A medida que envejecemos, los niveles de NAD disminuyen, lo que reduce la actividad de estos genes. NMN ayuda a aumentar los niveles de NAD, potencialmente mejorando la función de estos genes.

¿Cómo pueden los niveles de NAD disminuir con el tiempo y la edad?

Los niveles de NAD disminuyen cuando no hay adversidad, como cuando se come en exceso y se está inactivo, y también disminuyen con la edad. Un adulto de 50 años tiene aproximadamente la mitad de los niveles que un joven de 20 años.

¿Qué es la importancia de mantener los niveles de NAD en niveles juveniles?

Mantener los niveles de NAD en niveles juveniles puede ayudar a mejorar la salud humana, imitar el ejercicio, la dieta y potencialmente mejorar esos modalidades, y se espera que en el futuro pueda tratar enfermedades como la insuficiencia renal y la supervivencia a COVID-19.

¿Cuáles son algunos de los beneficios que ha experimentado el entrevistado al tomar NMN durante ocho a diez años?

El entrevistado ha experimentado solo beneficios al tomar NMN, como mejoras en la salud general, y no ha mencionado ningún efecto secundario negativo.

¿Qué es Metformin y por qué lo toma el entrevistado?

Metformin es una medicación utilizada para tratar la diabetes tipo 2. El entrevistado la toma como medida preventiva para evitar enfermedades como la diabetes y la enfermedad cardiovascular, a pesar de que algunos médicos pueden recomendarla solo para personas mayores de 60 años.

¿Cómo aborda el entrevistado las preocupaciones sobre los efectos secundarios de Metformin?

El entrevistado sugiere que los efectos secundarios de Metformin, como la disminución del tamaño de los músculos, son reversibles y que los riesgos son pequeños en comparación con los beneficios de la prevención de enfermedades.

¿Qué cambios en el comportamiento y estilos de vida antienvejecimiento cree que veremos en el futuro?

El entrevistado es optimista sobre la adopción de estilos de vida antienvejecimiento y prácticas como el ayuno intermitente, que ya es popular. Cree que la revolución en la atención de la salud por parte de la población continuará y se volverá más prevalente.

¿Qué papel juegan los dispositivos y las pruebas caseras en la revolución de la salud mencionada?

Los dispositivos y las pruebas caseras están facilitando que las personas se activen en su propia salud, permitiéndoles realizar pruebas en casa y monitorear su salud de manera más fácil y accesible.

¿Por qué el entrevistado cree que la práctica del ayuno intermitente es popular y posiblemente subestimada?

El entrevistado cree que el ayuno intermitente es popular porque es relativamente fácil de hacer y tiene un bajo riesgo percibido. Además, la preocupación por la salud y la muerte debido a la pandemia ha incrementado el interés en prácticas de salud como el ayuno intermitente.

Outlines

00:00

🧬 La importancia de NMN y la salud

El primer párrafo aborda la importancia de NMN (Nicotinamide mononucleotide) en el contexto de la investigación sobre la longevidad. Se menciona que en los estudios de la década de 2000, se descubrió que ciertos genes de longevidad, conocidos como sirtuinas, protegen el cuerpo contra enfermedades como Alzheimer y diabetes. Estos genes se activan durante situaciones adversas como el ejercicio, la dieta y el sauna, pero su actividad disminuye con la edad. La NAD (Nicotinamide adenine dinucleotide) es un componente esencial en el cuerpo que se utiliza para la producción de estos enzimas y su nivel disminuye con la edad. El NMN es un precursor que el cuerpo utiliza para producir NAD, y su ingesta puede aumentar los niveles de NAD en el cuerpo, lo que ha demostrado ser beneficioso en estudios clínicos. Aunque no se ha demostrado que NMN extienda la vida, ha mostrado mejoras en la salud y el rendimiento, y se está investigando su potencial para tratar enfermedades como la insuficiencia renal y la supervivencia a COVID-19.

05:00

💊 Consideraciones sobre el uso de Metformina y Resveratrol

El segundo párrafo discute el uso temprano de Metformina, una medicación comúnmente utilizada para tratar la diabetes tipo 2, y Resveratrol, un compuesto polifenólico encontrado en la uva y otros productos naturales. Se aborda la preocupación de los efectos secundarios de la Metformina, como la disminución de la masa muscular, y cómo el doctor del entrevistado lo instó a usarla a los 29 años debido a altos niveles de colesterol. Se argumenta que, bajo supervisión médica, es razonable comenzar a usar medicamentos para prevenir enfermedades en edades tempranas, especialmente cuando estos son seguros y reversibles. Además, se cuestiona la percepción pública sobre los riesgos de los medicamentos basada en información incompleta o malinterpretada, y se enfatiza la importancia de revisar los datos científicos originales y medirse a uno mismo bajo supervisión médica antes de tomar decisiones sobre el uso de medicamentos.

10:01

🌐 La revolución en la autovigilancia de la salud

El tercer párrafo explora el aumento en la autovigilancia de la salud y la adopción de estilos de vida antienvejecimientos, como la ayuno intermitente, en respuesta al despertar de la conciencia sobre la salud causada por la pandemia. Se menciona que el uso de pruebas caseras se ha vuelto más común y que, aunque hay riesgos asociados con la falta de supervisión médica, la toma de control de la propia salud es esencial. Se destaca la importancia de los cambios en el estilo de vida, como la reducción de las comidas diarias y el aumento de los horarios de ayuno, y cómo estos pueden ser más efectivos que los medicamentos en la promoción de la longevidad y la salud. Finalmente, se expresa optimismo sobre la futura adopción de estas prácticas por parte de la mayoría de la población.

Keywords

💡NMN

NMN, o nicotinamida mononucleótido, es un precursor del NAD, una molécula esencial para las funciones celulares y la longevidad. En el video, se menciona que al ingerir NMN, los niveles de NAD en el cuerpo pueden aumentar, lo que podría mejorar la salud y prolongar la vida. NMN es promovido como un suplemento potencial para combatir el envejecimiento y mejorar la resistencia física y mental.

💡NAD

El NAD, o dinucleótido de nicotinamida y adenina, es una molécula clave en el metabolismo celular que participa en las reacciones químicas necesarias para la vida y actúa como un sensor de adversidad en el cuerpo. A medida que las personas envejecen, los niveles de NAD disminuyen, lo que puede conducir a una disminución de la actividad de los genes sirtuinas, vinculados a la longevidad. El aumento de los niveles de NAD mediante suplementos como NMN podría ayudar a mejorar la salud y retrasar los efectos del envejecimiento.

💡Sirtuinas

Las sirtuinas son un grupo de genes relacionados con la longevidad que protegen el cuerpo contra enfermedades como el Alzheimer y la diabetes. Estos genes se activan durante períodos de adversidad, como el ejercicio o el ayuno, para ayudar al cuerpo a sobrevivir. En el video, se menciona que las sirtuinas requieren NAD para su actividad, y al aumentar los niveles de NAD, se podría mantener la función protectora de las sirtuinas a medida que envejecemos.

💡Longevidad

La longevidad se refiere a la extensión de la vida humana y a la mejora de la salud en la vejez. En el video, se discute cómo la investigación en el laboratorio del orador se centra en comprender y promover la longevidad mediante el uso de suplementos como NMN para aumentar los niveles de NAD, activar genes protectores y emular los efectos beneficiosos del ejercicio y la dieta.

💡Adversidad

La adversidad, en el contexto del video, se refiere a situaciones que desafían al cuerpo, como el ejercicio intenso, la restricción calórica o la exposición a temperaturas extremas. Estas condiciones activan mecanismos de supervivencia en el cuerpo, incluidos los genes sirtuinas, que ayudan a proteger contra enfermedades y envejecimiento. Al aumentar los niveles de NAD, se puede simular esta adversidad, activando dichos mecanismos sin necesidad de someterse físicamente a estas condiciones.

💡Ensayos clínicos

Los ensayos clínicos son estudios de investigación realizados en humanos para evaluar la eficacia y seguridad de nuevos tratamientos o intervenciones. En el video, el orador menciona que ya se han llevado a cabo ensayos clínicos con NMN, mostrando resultados prometedores en la mejora de la salud humana al aumentar los niveles de NAD, aunque reconoce que todavía es temprano para determinar su impacto en la extensión de la vida.

💡Metformina

La metformina es un medicamento comúnmente utilizado para tratar la diabetes tipo 2. Sin embargo, en el video, se discute su uso potencial para la longevidad debido a su capacidad para mejorar la sensibilidad a la insulina y reducir la inflamación. El orador considera que, aunque la metformina puede tener efectos secundarios menores, como la reducción de la masa muscular, sus beneficios en la prevención de enfermedades a largo plazo podrían superar estos inconvenientes.

💡Restricción calórica

La restricción calórica implica reducir la ingesta de calorías sin malnutrición para mejorar la salud y aumentar la longevidad. En el video, se menciona que la restricción calórica es una forma natural de aumentar los niveles de NAD en el cuerpo, lo que activa genes protectores y promueve la salud. Esta práctica se considera una forma efectiva de emular condiciones de adversidad que benefician al organismo.

💡Fasting intermitente

El fasting intermitente es una práctica dietética que alterna períodos de ayuno con períodos de alimentación. En el video, se menciona que esta práctica se ha vuelto popular porque es fácil de adoptar, tiene bajos riesgos y puede tener beneficios significativos para la salud, incluyendo la mejora de los niveles de NAD y la activación de procesos de longevidad en el cuerpo. Es visto como un método accesible para la mayoría de las personas para mejorar su bienestar general.

💡Salud preventiva

La salud preventiva se refiere a las medidas y acciones tomadas para prevenir enfermedades y mejorar la salud antes de que surjan problemas graves. En el video, se enfatiza la importancia de adoptar un enfoque proactivo hacia la salud, utilizando métodos como la suplementación con NMN, el fasting intermitente y la monitorización de la salud personal para prevenir enfermedades relacionadas con la edad y mejorar la calidad de vida a largo plazo.

Highlights

NMN is a precursor that the body uses to make NAD, which is required for life and involved in chemical reactions.

As we age, NAD levels decrease, which can be mitigated by boosting NAD back to youthful levels.

Raising NAD levels can improve human health and potentially treat diseases like kidney failure and COVID-19.

Ingesting NMN has been shown to raise NAD levels by about two to threefold in humans.

The speaker has been taking NMN for approximately eight to ten years and has only seen benefits.

Exercise, fasting, and sauna can boost NAD levels, but NMN supplementation is another way to achieve this.

NAD boosters have been shown to improve performance, endurance, and overall health.

There are no known adverse events in human clinical trials for NMN supplementation.

The speaker emphasizes the importance of consulting with a doctor before starting any supplementation.

Metformin is discussed as a medication that can prevent heart disease and diabetes, even for those in their 30s.

The speaker counters misconceptions about the side effects of metformin and its impact on muscle mass.

The importance of verifying scientific claims by reading the original research papers is highlighted.

Intermittent fasting is becoming a popular health practice, with many people already practicing it.

The pandemic has been a wake-up call for many to take a more active role in their health and wellness.

The speaker is optimistic about the future of personal health monitoring and lifestyle changes for the better.

The speaker predicts that in 20 years, the majority of people will be actively monitoring their health.

The speaker discusses the ease of adopting intermittent fasting as a health practice.

The speaker notes a shift away from the conventional three-meals-a-day pattern towards more flexible eating schedules.

Transcripts

now you're you're a big fan of nmn and

before I read your book I had never even

heard of nmn why why is that good

well now we're talking about research uh

from my lab in the early 2000s we found

that the certain longevity genes that

we've my team and well I should say my

mentors team Lenny guarante uh

discovered certain so let me tell you

about sirtuins these are seven genes in

our body some of us have better versions

than others and in general it's it's

found that they protect the body against

diseases ranging from um Alzheimer's to

diabetes now these genes I'll get

Switched Off over time

the the main role is to make enzymes

that tell the body how to survive during

adversity so when you're exercising and

dieting and in sauna they come on

protect the body but the problem is as

we get older they become less active and

one of the biggest problems is that for

their activity they require a a little

molecule in the body a very abundant one

called NAD NAD is required for life it's

involved in chemical reactions but it's

also used as a sensor for the body of

adversity when we have no adversity

we're eating a lot and sitting around

NAD levels go down that's true as we get

older as well so a 50 year old has half

the levels of a 20 year old for NAD

um

and what we like to do is to boost the

levels of NAD back up to youthful levels

and mimic exercise mimic dieting or even

enhance those modalities now we've even

got

um human clinical trial data I was

mentioning one of my companies has done

clinical trials already for the last few

years and by raising NAD levels we can

actually improve human health

and we hope that this will be a drug one

day to treat diseases ranging from

kidney failure to even

covid-19 survival

so what about nmn well nmn is a

precursor that the body uses to make NAD

and by ingesting nmn we've shown in

humans that you can raise your NAD

Levels by about two to threefold and

that's beneficial in humans based on

clinical studies

um you know when I say I'm a fan you

know I'm not selling this stuff a lot of

companies claim that I'm involved with

uh selling it that's not true I spend

fair amount of legal fees on trying to

stop that

um but yeah any NAD boosters as they're

called seem to be really beneficial I

take nmn um and I've been doing so for

probably about eight to ten years and uh

so far so good I've only seen benefits

some people ask about and so basically

you're saying the goal is to increase

your NAD

um one way to do that is through

exercise you know you can do that by

fasting sauna um but there's this other

way to do is to is to take this nmn

um essentially it's a supplement and you

and and that can also boost your NAD

uh yes that's what the science is saying

and others have shown to improve six

minute walk so it's being used for

performance uh endurance and overall

health

it's not proving that it extends

lifespan in fact we've only just

recently founded extensor mouse's

lifespan haven't published that yet

so it's early days we still have a lot

to go on um or to do at least but other

side effects for taking it or their

um or does doing one thing make it

harder to do something else or

doesn't seem to be I mean mice in mice

there's a couple of studies in some rare

cases of genetically inbred mice that

don't have an immune system uh that they

there's hints that cancer might spread

slightly more frequently in a very small

study but these are mice that are in

bread and have no immune system so

it's still full steam ahead with human

clinical trials there's been no Adverse

Events in any of the patients that have

been tested

or the subjects I should call them

um and yeah so I'm I'm not yet ready to

say that there's any known uh or at

least a tangible provable risks that uh

you know I want to be the first person

to know if there's a risk because yeah

father takes it my friends and family

take it I take it

um so I'm not I'm not selling it I just

want to know the science but I do know

that my father is too old to wait till

100 proof that this extends lifespan you

and I are getting to that point where we

can't wait

um and so that's really what I'm doing

is I'm educating the public about the

risks and rewards there are a couple of

male studies that I want to point out

but you know all weight up I think that

uh the risk right now for me and my

family is it's worth taking that risk

until until further notice now you also

take Metformin

um and um and

um like I don't even know how to

pronounce it but sorry always virtual

where's virtual yeah yeah

um and you know uh and often I'll you

know when I talk to my doctor he's like

well I I feel like you know maybe you're

a bit too young to take metformin and

maybe you know I I often encourage my

patients who are let's say 60 or over

but it has some side effects and that it

makes it a little bit less likely to

build muscle mass and stuff like that

like how do you weigh some of those

things

uh well let's start with when should you

start

um I had a a real

um heart to heart with my doctor when I

was 29. I had super high cholesterol

levels and he said I don't want to put

you on a medicine because you're too

young and I said dude

it I don't want to wait till I get heart

disease to go on a medicine put it on

put me on it now

so I've I've always been

of the philosophy that

it doesn't matter what age somebody is

you treat everybody the same way you

know within reason of course 20 year

olds are a bit young for this kind of

stuff but if you're in your 30s and you

want to uh prevent heart disease prevent

diabetes I think that it's perfectly

fine uh under Dr supervision taking

medicines that will prevent disease

especially when does these medicines are

extremely safe you do it under doctor

Supervision in case there's a problem

but with metformin for example and

certainly Resveratrol very very very

rare that somebody uh gets so sick that

it's a problem and it's it's always

reversible as well you just stop taking

it if you get sick so these are risks I

think are worth taking I don't prescribe

anything I don't even recommend anything

publicly so I would say talk to your

doctor you know it's if they say you're

too young

I would keep fighting it I would show

you the data and if if you want there's

always alternative doctors

um I just I think that the the argument

that when you're young it's too early I

you know there's a there's a at least

when I heard that there's this trade-off

of like okay it's hard to build muscle

mass building muscle mass is very

important as you get older

um and so

um and so you know so you have to figure

the trade

well it's frustrating to me as a

scientist that

when somebody says something in public

or someone a podcaster says it's a

problem it becomes locked into the

Public's Consciousness and unfortunately

nobody ever goes back

and reads the actual paper that this

came from and that that was also true

for the women's health initiative and

breast cancer people still believe that

HRT causes breast cancer and uh that

turns out it doesn't same for metformin

and exercise when you look at the data

uh and it's really easy to see it's not

difficult you can look at it the graph

that says there's a difference uh first

of all is being manipulated in a way

that is deceiving they cut off the

y-axis so that you're just seeing the

very tippy top of the bars and the

actual difference is about five percent

um and it turns out that that five

percent is almost certainly due to

people just not doing the extra couple

of reps in the exercise because they

feel a bit more tired so what's the

solution well if you don't mind having

muscles that are five percent

smaller then no big deal those muscles

are just as strong and healthier

um and have less inflammation

I don't care if my muscles are still 95

there I'm not trying to win any contests

for bodybuilding but I can also I can

avoid metformin on days I work out no

big deal or force myself to do a couple

more reps when I feel tired that's all

it is I wouldn't say that that's a

reason not to take Metformin there are

other reasons such as gastric uh

gastrointestinal issues that's more of a

an issue but I think it the point here

that I want to make is

make sure that the science is true and

the data that you're getting is true

don't just believe pundits or even uh

you know doctors who are saying this

stuff try to go to the paper read it or

listen to scientists who do read papers

and also just measure yourself do it

under Dr supervision make sure that it's

not harming you make sure you feel fine

and then by all means in my view it's

worth starting in your 40s to maximize

your lifespan because we're aging every

day it doesn't just begin after the age

of 50 or 60.

now initially I was actually kind of

skeptical to the idea that like big

subsets of the population would adopt

any of these anti-aging Lifestyles but

then I saw a couple of studies that say

10 of Americans are already intermittent

fasting every single day over 25 percent

have already tried it maybe intermittent

fasting is is not the best one to

measure because it's kind of easy to do

you just kind of skip breakfast and so

it's kind of a simple relatively simple

thing to do but how optimistic that you

actually will see widespread Behavior

changes

well we are in in the midst of a

revolution in people's wellness and how

active they are in their own health

pandemic was a major wake-up call to

people who stared in the mirror and saw

their own mortality and then there was a

boom in home testing because people

didn't want to go into doctor's offices

for obvious reasons and so it's becoming

also easier for people to take home

tests now we don't want people you know

going rogue and testing themselves and

trying to interpret themselves with chat

gpt4 and Beyond I don't think that's the

only solution I think there's a risk

that uh we won't have enough doctor

supervision and some people overdo it

there's always that risk so there's a

caution here I do think though that

there's a place for people taking their

own health into their own hands you

can't always be supervised by your

doctor when you're at a restaurant

people do need to realize that most of

what affects their health in the future

is up to them not their doctor and what

you do every day in your life Echoes for

decades and that changing a lifestyle

is as important if not more important

than the medicines you will take and

that's why I think that this revolution

that we're seeing in

the population not just in the US but

around the world is a great thing and

will only become more prevalent and in

20 years it'll be the majority of people

will will be on board with monitoring on

health it's going to get easier and

easier with devices as well uh cheaper

and cheaper and we'll look back at

two years ago when almost nobody did

this and think that going to your doctor

once a year for an annual checkup and

having the doctor banging your knees and

cough uh will will seem medieval in fact

even to us today it seems medieval

yeah it's in intermittent fasting one

it's while it's you know maybe uh 10 of

the population it seems like it's it's

probably closer to 40 percent of my

friends oh yeah and

um and one I think one of the reasons is

well besides the fact that it's

relatively easy to do

um it's it's maybe one of the easiest

ones to to to to to do of of all the of

all the things that people prescribe

um it's also also pretty easy to to at

least for people to believe that has low

harm

um and because if you say to somebody

stop eating meat or something like that

first of all I think that's hard for

people to do because they they love they

might love their meat and second they

may they may show you 40 studies of how

that actually could do harm to them

um whereas and so so it's it's kind of

like this both things that come in of

why people may change behaviors

yeah absolutely and everybody's

different some people like hot and cold

therapy some people don't um yeah

exercises for some it's not for me

although I know it's important to do

um and the same goes for fasting I do

agree that there's a real uh I don't

know if it's fashion or a permanent

trend for people to not eat the three

meals a day that we were told to eat and

snack in between I think that's very

2010 we're beyond that now uh most

people realize that we're eating too

much obviously you can see it in

people's waistlines and I think that

that 10 is an underestimate that

certainly people who are taking notice

of

what's out the information that's out

there

um yeah in in my Circles of course it's

it's 95 but I think I meet enough people

from the general public that it's way

more than 10 that people are interested

in their health and I think that's also

largely driven by the pandemic people

worried about getting

sick and dying I mean what 30 or 40 year

old ever had to worry about that before

yeah and so after that in in the

aftermath people are just more

interested in seeing what they can do

now and fasting is a pretty easy way to

go to start skipping breakfast a lot of

people do that anyway trying to have a

very small lunch or skip lunch is

another way to go I like to eat within a

six hour window at night I'll have

dinner I often uh as I said snack a

little bit during the day but that's my

goal at least and I compensate by

drinking a lot of liquids that don't

have sugar in them and that helps yeah

you know it's it's an amazing thing to

see how just in in my career working on

aging and talking about aging and

talking about longevity and fasting went

from Total Fringe in science to now

mainstream in not just science but in

the General Public