Understanding The Role Of Polynucleotides In Aesthetic Medicine #polynucleotides

Summary

This video script delves into the use of polynucleotides in aesthetic treatments, contrasting them with hyaluronic acid for skin quality improvement and volume restoration. It highlights the unique benefits of polynucleotides for treating crepey skin, stretch marks, and hair growth, while emphasizing that for volume loss, fillers or fat transfer are essential. The script also discusses the versatility of polynucleotides, their mechanism of action, and the concept of priming with polynucleotides before other treatments for enhanced results.

Takeaways

• 💉 Fillers or fat transfer are recommended for volume loss, while polynucleotides are for skin quality improvement.
• 🧬 Polynucleotides are polymers made from trout gonads, used as wound healing accelerators and for their lubricating properties.
• 🚫 Not suitable for vegans, vegetarians, or those allergic to fish due to the fish-derived nature of polynucleotides.
• 🔬 Studies suggest polynucleotides may have a greater biostimulatory effect than hyaluronic acid.
• 💧 Hyaluronic acid provides immediate glossiness and plumpness, whereas polynucleotides offer a more dermal effect.
• 👵 Polynucleotides are effective for treating crepey skin texture and stretch marks, but not for providing long-lasting plumping.
• 🔄 They act on different fibroblast receptors compared to hyaluronic acid, leading to distinct clinical outcomes.
• 🌱 Polynucleotides can also stimulate hair growth and improve scar appearance.
• 🛠️ Other treatments for stretch marks include laser, light therapies, micro needling, and carboxytherapy.
• 🧪 Polynucleotides can be used in various concentrations and can be mixed with other products for customized treatments.
• 📈 The concept of 'polynucleotide priming' suggests better results when used before other treatments like dermal fillers or laser resurfacing.

Q & A

What is the primary solution for volume loss according to the transcript?

The primary solution for volume loss is to have fillers or fat transfer.

What is the main topic discussed in the video script?

The main topic discussed is polynucleotides, their use in the clinic, and their effects on skin quality improvement.

What are the common misconceptions about biostimulators mentioned in the script?

The misconception is that people are happy to have biostimulators injections but are reluctant to have fillers, especially cross-linked ones, which doesn't make sense because many biostimulators are indeed cross-linked.

What are polynucleotides and what are they made from?

Polynucleotides are polymers consisting of double-stranded deoxyribonucleotides, essentially the building blocks of DNA, and they are typically made from trout gonads.

Why might someone not be suitable for polynucleotides treatment?

Someone might not be suitable for polynucleotides treatment if they are vegan, vegetarian, or allergic to fish, as polynucleotides are derived from fish.

How do polynucleotides differ from hyaluronic acid biostimulators in their clinical effects?

Polynucleotides give a more dermal effect, suitable for treating crepey skin texture or stretch marks, while hyaluronic acid provides immediate glossiness, plumpness, and hydration to the skin.

What are some alternative treatments for stretch marks mentioned in the script?

Alternative treatments for stretch marks include laser and light therapies, micro needling, radiofrequency microneedling, and carboxytherapy.

How do polynucleotides affect fibroblasts and what receptors do they act on?

Polynucleotides act on fibroblasts by providing them with necessary components like nitrogen bases and nucleotide precursors, increasing their viability. They act on receptors 39 and 40.

What is the concept of 'polynucleotide priming' as discussed in the script?

Polynucleotide priming is the use of polynucleotides prior to performing other treatments to get a larger and faster onset of response from the second treatment type.

What are the side effects of polynucleotides mentioned in the script?

The only side effects mentioned are potential bruising and downtime, with expense also being a consideration.

How can polynucleotides be applied in treatments and what is the recommended treatment frequency?

Polynucleotides are normally injected using a fine needle, either in a few big papules or smaller injections over a larger area. It is suggested to have one treatment every 14 to 21 days, for a total of four treatments.