Ostarine Only Cycle? | Doctor's Analysis

Summary

In this video, Dr. [__] explores Ostarine, a selective androgen receptor modulator (SARM), discussing its pharmacokinetics, mild anabolic effects, and potential use in cutting cycles. The script reviews studies on rats and humans, noting Ostarine's selectivity, minimal suppression of LH and FSH, and liver toxicity concerns. It suggests a daily dosage not exceeding six milligrams and a cycle duration of eight weeks to avoid side effects, emphasizing the importance of liver support and the limited benefits of higher doses.

Takeaways

• 🚫 Dr. [__] does not condone the use of illegal substances or PEDs but provides an opinion based on research.
• 🔬 Ostarine, also known as S22 or a nobo song, is a well-researched SARM with mild effects, suitable for cutting cycles.
• 💊 Ostarine is highly bioavailable, meaning it is well absorbed when taken orally and peaks within an hour of intake.
• 📊 Pharmacokinetic studies suggest daily dosing, with 3-30 mg daily for 8 weeks being common, though the highest studied dosage is 3 mg for 12 weeks.
• 🐁 In rat studies, Ostarine was found to be highly selective, increasing muscle mass without affecting the prostate or suppressing LH and FSH levels.
• 🔄 Ostarine is a weak antagonist of the progesterone receptor, which may lead to elevated prolactin levels and potential issues with gyno.
• 👵👴 A phase one trial in postmenopausal women showed lean mass gain without significant changes in strength.
• 👴👵 A phase two trial in elderly individuals found a significant increase in lean mass with a dosage as low as 3 mg, along with improved insulin sensitivity and decreased triglycerides.
• ⚠️ Ostarine can cause liver enzyme elevations at low dosages, indicating liver toxicity that is more potent than traditional oral steroids.
• 🏥 Another phase 2 trial in cancer patients with cachexia showed similar lean mass gains with 1 mg being as effective as 3 mg, with common side effects being nausea and diarrhea.
• 💪 Ostarine is not reported to be great for gaining size but is anecdotally known to help maintain size during cutting cycles.
• ⚠️ Dr. [__] suggests that going over 6 mg daily may be pointless due to a lack of additional anabolic benefits and increased risk of side effects and toxicity.

Q & A

What is the main topic of the video?

The main topic of the video is discussing Osterine and an Osterine-only cycle, including its effects, dosages, and research findings.

What is Osterine also known as?

Osterine is also known by names such as S22 and Anobosong.

Why is Osterine considered mild among anabolic agents?

Osterine is considered mild because it is highly selective, attaching to muscles to increase size without affecting other tissues like the prostate, and it doesn't cause significant suppression of LH and FSH in rats.

What is the bioavailability of Osterine when taken as a tablet?

Osterine is very bioavailable, meaning it is highly absorbed in the stomach when taken as a tablet.

What is the recommended dosing frequency for Osterine based on pharmacokinetics?

Daily dosing is recommended for Osterine due to its presence in the system for around 14 to 21 hours after intake.

What dosages were used in the studies mentioned in the video?

The highest dosage used in the studies was 3 milligrams for 12 weeks, but forum reports suggest dosages of 5 to 30 milligrams daily for eight weeks.

What was the outcome of the phase one trial involving healthy menopausal women?

The phase one trial showed a lean mass gain without a significant change in strength.

What were the findings from the phase two trial involving healthy elderly women and men?

The phase two trial found that individuals taking 3 milligrams of Osterine gained about 1.3 kilograms in lean mass, improved insulin sensitivity, and decreased triglycerides, but also experienced a decrease in HDL.

Why might Osterine cause an elevation in prolactin levels?

Osterine is a weak antagonist of the progesterone receptor, and antagonists to progesterone can sometimes cause an elevation in prolactin levels.

What liver-related side effect was observed in some patients during the trials?

Elevations in liver enzymes were observed in a few patients, with one having to discontinue therapy due to drug-induced liver toxicity.

What is the speaker's hypothesis regarding the optimal dosage of Osterine for anabolic effects?

The speaker hypothesizes that the optimal dosage of Osterine for anabolic effects is around 0.1 milligrams per day in rats, which converts to approximately 6 milligrams daily for an average 70 kg human, suggesting that going over this dosage may not provide additional benefits.

Why is the speaker concerned about the use of Osterine in higher dosages?

The speaker is concerned because higher dosages of Osterine may not provide additional anabolic benefits but could increase the risk of side effects and toxicity, especially liver-related issues.

What is the speaker's recommendation regarding the duration of an Osterine cycle?

The speaker recommends limiting the duration of an Osterine cycle to eight weeks to minimize the risk of suppression and toxicity.

What precautions does the speaker suggest for liver health when using Osterine?

The speaker suggests taking extra precautions for liver health, such as using liver support supplements, due to the liver toxicity associated with Osterine.

What is the speaker's view on the use of Osterine for muscle mass gain?

The speaker believes that while Osterine can help maintain lean mass during cutting, using it at higher dosages for muscle mass gain is not beneficial and may lead to unnecessary side effects.