New research shows grey hair will soon be cured
Summary
TLDRIn this insightful video, the presenter explores the science behind gray hair, debunking the myth that it's irreversible. Highlighting a study published in Nature, the video delves into melanocyte stem cells and their crucial role in hair pigmentation. The research reveals that these cells can revert from melanocytes back to stem cells, suggesting that gray hair is not a permanent condition. The presenter discusses the potential for future treatments that could reactivate these cells, offering hope for a cure to gray hair and the possibility of it becoming a reversible phenomenon.
Takeaways
- đ§â𩳠Gray hair is a common concern, but it is not as impactful as hair loss in terms of appearance.
- đŹ The traditional theory suggests that gray hair results from melanocyte cells wearing out and no longer producing melanin.
- đ° A recent study published in Nature has sparked interest in the possibility of reversing gray hair.
- 𧏠Melanocyte stem cells are unspecialized cells that can differentiate into melanocytes, responsible for hair color.
- đ The study used mice with an altered genome to track melanocyte stem cells during the hair growth cycle.
- đ Melanocyte stem cells were found to migrate and change shape during the hair cycle, with the ability to revert to stem cells from melanocytes.
- đ The Wnt signaling pathway was identified as a key regulator of melanocyte stem cell behavior.
- đ« The aging process can cause melanocyte stem cells to get 'stuck' in the hair bulge area, leading to gray hair.
- đĄ The discovery suggests that gray hair is not due to a loss of stem cell function but rather a problem with cell mobility.
- đ ïž Basic scientific research like this is crucial for understanding the mechanisms behind gray hair before a cure can be developed.
- đ The study's findings are promising, indicating that gray hair could potentially be reversed with the right intervention.
Q & A
What is the primary focus of the content on the channel mentioned in the script?
-The primary focus of the content on the channel is hair loss, but it also addresses other hair-related concerns such as stopping gray hair.
Why is the concern of stopping gray hair considered less important than stopping hair loss according to the script?
-Stopping gray hair is considered less important than stopping hair loss because gray hair just makes one look older and doesn't dramatically change one's appearance as hair loss does.
What is the scientific basis for the potential breakthrough in treating gray hair discussed in the script?
-The scientific basis for the potential breakthrough in treating gray hair is a study published in the journal Nature, which suggests that gray hair might be reversible due to the behavior of melanocyte stem cells.
What role do melanocyte stem cells play in the hair growth cycle?
-Melanocyte stem cells differentiate into melanocytes that produce melanin, giving hair its color. They are also involved in the hair growth cycle by moving between the hair germ area and the bulge and outer root sheath of the hair follicle.
What is unique about melanocyte stem cells compared to other stem cells in the body?
-Melanocyte stem cells are unique because they can reverse the process of differentiation, meaning they can change from a stem cell to a melanocyte and then back to a stem cell again.
What is the role of the Wnt pathway in the life cycle of melanocyte stem cells?
-The Wnt pathway is crucial in regulating the movement and differentiation of melanocyte stem cells. It activates in the hair germ region, stimulating hair growth and melanocyte stem cell differentiation, and is suppressed in areas where the stem cells revert back to their stem cell state.
What does the research suggest is the reason for gray hair development?
-The research suggests that gray hair development is due to melanocyte stem cells getting stuck in the hair bulge area and not returning to the hair germ area, where they need to be to differentiate into melanocytes and produce pigment.
What did the investigators do to artificially induce aging of hair follicles in the mice used in the study?
-The investigators artificially induced aging of hair follicles by plucking out hair prematurely, causing new hair cycles to begin repeatedly.
Outlines
𧏠The Science of Gray Hair and a Potential Breakthrough
The script discusses the common concern of gray hair and its relation to hair loss. It introduces the topic with a light-hearted approach, mentioning the Hair Cafe Institute of hair loss research. The main focus is on a study published in Nature that suggests gray hair might be reversible. The script delves into the science behind hair color, explaining the role of melanin and melanocyte stem cells. It describes how these cells are typically thought to wear out over time, leading to gray hair. The new research challenges this theory, suggesting that melanocyte stem cells may not be the issue but rather their movement and reactivation within the hair follicle cycle.
đŹ Melanocyte Stem Cells' Movement and Differentiation
This paragraph continues the exploration of the melanocyte stem cells and their behavior during the hair cycle. It details the study's findings on the cells' migration from the hair germ area to the bulge area and back, and their ability to differentiate into melanocytes and revert back to stem cells. The role of the Wnt signaling pathway in regulating this process is highlighted, along with its suppression in certain areas of the hair follicle. The paragraph also discusses the consequences of melanocyte stem cells becoming stuck in the bulge area due to repeated hair cycles, leading to gray hair formation.
đĄ Understanding the Cause of Gray Hair and the Path to a Cure
The final paragraph summarizes the implications of the study's findings, emphasizing that the cause of gray hair is not a loss of stem cell function but rather a problem with their mobility and reactivation. It suggests that by understanding the mechanisms behind gray hair, it may be possible to develop treatments that enhance stem cell motility or remove age-related impediments within the hair follicle. The script ends on an optimistic note, speculating that a cure for gray hair could be on the horizon, with the potential for reversal even in those who have been gray for many years.
Mindmap
Keywords
đĄHair Loss
đĄGray Hair
đĄMelanin
đĄMelanocyte Stem Cells
đĄDifferentiation
đĄTelogen Phase
đĄWnt Signaling Pathway
đĄReversible Differentiation
đĄReporter Mice
đĄStem Cell Motility
đĄPharmaceutical Company
Highlights
Maintaining hair's youthful color is a pressing concern and a lucrative industry, with many scams.
New scientific data lays the groundwork for a potential breakthrough in treating gray hair.
The recent study published in Nature suggests that gray hair might be reversible.
Melanin, created by melanocytes, is responsible for the color of hair and skin.
Previous theories suggested that melanocytes wear out after a few hair cycles, leading to gray hair.
New findings show that melanocyte stem cells (MSC) play a crucial role in hair pigmentation.
MSC can differentiate into melanocytes and then revert back to stem cells, a unique characteristic.
MSC migration from the hair germ to the bulge area and back is essential for hair pigmentation.
Aging and repeated hair cycles can cause MSC to get stuck in the bulge area, leading to gray hair.
The Wnt pathway is crucial for MSC activation and migration during the hair cycle.
Artificially inducing hair cycles in mice showed that repeated cycles lead to MSC getting stuck and hair turning gray.
Understanding MSC movement and differentiation could lead to treatments for gray hair.
Future research could focus on upregulating MSC mobility genes or addressing factors in the hair follicle that slow down MSC.
Gray hair appears to be reversible by reactivating MSC and their movement back to the hair germ region.
Theoretical reversal of gray hair is possible, even for those gray for decades, by reactivating dormant MSC.
Potential breakthrough treatments for gray hair could emerge from this research, changing the future of hair pigmentation.
Transcripts
sup tombs how y'all living hope
everything is Nova and you're all having
a preem week so most of my hair related
content on this channel pertains to hair
loss but obviously there are other hair
related concerns people have besides
just stopping hair loss probably the
second biggest concern after hair loss
is how to stop gray hair now I don't
think stuffing gray hair is nearly as
important as stopping hair loss gray
hair it just makes you look older but it
doesn't dramatically change your
appearance the way hair loss does if I
were to ever go gray I'd probably just
tell people it was because of my Witcher
mutations so no big deal or maybe I
could just dye my hair if I really
wanted to nevertheless
maintaining our hair's youthful color is
a very pressing concern for many people
not to mention a very lucrative industry
with many scams so this is definitely a
subject that is worth covering it isn't
the first time I've covered this I did
another video over a year ago where I
covered the state of the art in treating
gray hair but things have changed since
then because there is new scientific
data that lays the groundwork for a
potential breakthrough in treating gray
hair so an article was published in the
science journal Nature in April of this
year that caused a lot of excitement in
the Press even the magazine Popular
Mechanics had an article on it all the
headlines imply that there was a new
discovery that showed that gray hair
might be reversible if this is true then
it is a really big deal and some people
are about to get very very rich here at
the Hair Cafe Institute of hair loss
research located at The Witcher Fortress
of care more and we like to go beyond
the headlines and figure out what the
research really shows so let's go balls
deep into this new article on gray hair
is this a real breakthrough or is this
just more broccoli well let's go ahead
and do a little background though on the
science of gray hair before we continue
the reason our hair has color is the
same reason our skin has color it's
because of melanin in the hair melanin
is a dark pigment created by the cells
called melanocytes in the past the
theory for why we develop gray hair is
that these melodocytes only last for a
few hair cycles and then they wear out
and stop producing melanin hair without
melanin is gray or even white in color
well here's the article that has upended
this Theory like most articles that
appear in the journal Nature it is a
very dense and difficult article filled
with a lot of scientific jargon however
it is not necessary to go through every
single detail of the article's
methodology to understand what these
investigators did what the investigators
were interested in primarily is what are
known as melanocyte stem cells I think
most people understand that stem cells
are unspecialized cells in the body that
are capable of forming into specialized
cells such as blood cells or muscle
cells or nerve cells or in cells stem
cells have the ability to divide an
unlimited number of times which isn't
true of other cells in the body that
have a limited ability to reproduce
themselves normally stem cells can only
do two things they can either reproduce
themselves or they can convert into more
specialized cells which is called
differentiation so the function of stem
cells is to replenish the Aging cells in
the body as you might imagine stem cells
are important for hair growth too let's
look at the end of the hair growth cycle
which is called the telogen resting
phase this is the phase where the hair
has stopped growing and the hair
follicle has shrunken and become
inactive usually within three months
this hair will shed and then a new
antigen growth phase will begin
during the telegen resting phase at the
bottom of the hair follicle there's a
small area of cells called the hair germ
this is one of the areas of the hair
follicle that Harbors the hair follicle
stem cells when the antigen phase begins
these hair follicle stem cells
differentiate into the hair follicle
cells and these hair follicle cells
produce the Keratin that causes our hair
to grow so mixed in with these hair
follicle stem cells are also melanocyte
stem cells that differentiate into
melanocytes that produce melanin that
gives our hair color but as the nature
article points out for some unknown
reason the melanocyte stem cells fail
earlier than other stem cell systems
resulting in gray hair well the
investigators in this study set out to
discover what exactly was going on with
these melanocyte stem cells they use
pretty amazing technology to track these
cells down now this is a mouse study but
this is still a pretty incredible study
nevertheless the investigators were
actually able to track what was going on
with individual blotocyte stem cells in
Living Mice during the hair cycle to do
this they were able to breed mice with
an altered genome that produce
fluorescent marker proteins that allow
them to see these stem cells in Living
Mice using 3D imaging these mice are
called reporter mice and I have to say
it's pretty miraculous that this is even
possible at all anyways the researchers
found that most of the balotocyte stem
cells were located in the hair germ area
during the telogen resting phase as you
can see in this figure here the Blue
Area shows the melanocyte stem cells
concentrated in the HG or hair germ area
of the follicle so they were able to
image the same hair follicle every one
to four days to see what was happening
to these hair bolotocyte stem cells
during the hair cycle well the first
surprising thing they found was the
melanocyte stem cells actually took off
and migrated upward during the hair
cycle they went from the hair germ area
to the area known as the Bulge area and
the outer root sheath this image here
shows this migration the orange dot or
the melanocyte stem cells that start out
at the bottom of the hair follicle they
then migrate to the top of the hair fall
follicle during the ancient growth phase
they then migrate back to the bottom of
the hair follicle in the next halogen
resting phase well even weirder during
the ancient growth phase the melanocyte
stem cells change their form most stem
cells are just oval featureless cells
melanocyte stem cells start out that way
too but during the early antigen phase
they actually change shape and grow
little tentacles called dendrites these
dendrites persist while the cells move
up to the Bulge and outer root sheath of
the hair follicle then they disappear
again so do these dendrites help the
cells move like little feet I don't know
and the investigators don't speculate
about that but it's still interesting
nevertheless the next surprise that the
investigators found was that unlike any
other known stem cells melodicide stem
cells can reverse the process of
differentiation that means that they can
change from a stem cell to a melanocyte
and then change from a melodocyte back
to a stem cell again so the life cycle
of a melanocyte stem cell is something
like this during early antigen the stem
cells are mostly located in the hair
germ area but they grow dendrites and
migrate to the Bulge and outer root
sheath of the hair follicles where they
convert to melanocytes and produce
melanin by late in the antigen phase the
melanocytes convert back to stem cells
and migrate back to the hair germ area
where they hang out during the telogen
phase then the whole process repeats
with each hair cycle the investigators
looked at what was regulating all this
and it turns out it was the wnt wind
pathway I've talked about this pathway
many times before and this is because
the trash hormone DHT down regulates the
pathway which leads to the shortening of
the ancient growth phase this is one of
the mechanisms of androgenic alopecia it
is a downstream effect of DHT which
results in the destruction of the hair
follicle as such some companies like
kintor who are most famous for
developing gt20029 in pure lutabide are
also working on treatments like
ky19382 which is a wind pathway
simulator I'll link some videos on these
treatments below if you are interested
in learning more about this specific
pathway but anyways the wind pathway is
a activated in the hair germ region at
the beginning of the antigen phase and
this stimulates hair growth but it also
stimulates the melanocyte stem cells to
migrate and differentiate into actual
pigment producing melanocytes however
once they have migrated upwards they
reach an area where the wind pathway is
suppressed this causes them to revert
back to their stem cell state in order
to complete the cycle they then need to
migrate back to the hair germ region
again so that they can differentiate
again into melanocytes during the next
hair cycle when they are stimulated by
the wind proteins well here's where
things get very interesting gyms the
investigators noticed that some of the
stem cells would get stuck in the hair
bulge area and not return to their home
base meaning the hair germ area you can
see that here where some of the orange
spots which are the melanocide stem
cells are still in the hair bulge area
during the telogen phase those stem
cells are stuck in an area with low wind
activation so they can't differentiate
into melanocytes anymore and also they
can't produce pigment anymore the
melanocyte stem cells have got to return
to the hair germ area at the bottom of
the hair follicle to be reactivated for
the next hair cycle the investigators
then did a clever thing they
artificially induced aging of the hair
follicles in these mice by plucking out
hair prematurely thus causing new hair
Cycles repeatedly what they found by
doing this is that the mice developed
gray hair but the recently developed
gray hair was that more and more of the
melanocyte stem cells were getting stuck
in the hair bulge and not returning to
the hair germ area you can see that in
this figure here at the top you see in
the SEC intelligent phase that the stem
cells have returned to the hair Germ at
the bottom of the follicle by the seven
intelligent phase the stem cells are
scattered in the Bulge area and are
stuck there none of them have gotten
back to the hair germ and so they are no
longer capable of differentiating back
into melanocytes the graph at the bottom
shows the stem cells are farther away
from the hair germ by the seven
intelligent phase and they are more
likely to be stuck in the Bulge area by
the seven intelligent phase compared
with the second intelligent vase so what
does all this mean well it means that
the reason we get gray hair is not
because melodicide stem cells lose the
ability to convert into melanocytes as
we age if anything this research shows
that melodicide stem cells are more
flexible than any other stem cells
unlike other stem cells melodocyte stem
cells can convert into melodocytes and
can also convert from melanocytes back
into stem cells again the problem is
that melanocytes have to move back and
forth from the hair germ area to the
Bulge and outer root area in order to
keep functioning unfortunately this
melanocyte stem cell movement slows down
with repeated hair Cycles which results
in an accumulation of these stem cells
in the Bold region where the wind
pathway activation is too low to
reactivate them we need to make sure the
stem cells return to the hair germ
region in order to prevent hair graying
as one of the investigators says in the
Popular Mechanics article quote it is
the loss of chameleon-like function in
melanocyte stem cells that may be
responsible for graying and loss of hair
color these findings suggest that Milan
outside stem cell motility and
reversible differentiation are key to
keeping hair healthy and colored unquote
so this isn't a cure for gray hair at
least not yet however it is basic
science like this that is important to
work out the mechanisms of gray hair
before we can find a cure now that we
know the problem is just a problem with
these cells moving around it should be
possible to see what genes are
responsible for this Mobility maybe it
would be possible to up regulate these
Mobility genes or maybe there is
something in the hair follicle itself
that is accumulating with age and
slowing down these stem cells and
keeping them from moving whatever the
case I am pleased to report that we now
know what causes gray hair and we also
know how to reverse it based on this
science at this point it is really just
a matter of which pharmaceutical company
is willing to make the investment needed
to properly develop and research a cure
for the mass Market the good news is
that it looks like this is already
happening the researchers who did the
study are already looking at developing
a cure so I think we are very close May
maybe even just a few years away from an
absolute breakthrough in treating gray
hair what is good about this gray hair
treatment is that it isn't like
androgenic alopecia where if you lose
your hair you can't really get it back
with gray hair it looks like it is
theoretically reversible even if you
have been gray for decades after all if
we can get these stem cells unstuck they
should be able to produce melanin again
in the very next hair cycle which would
mean that gray hair would disappear
forever it's just a simple matter of
getting a physiological process that
happens in our hair follicles to start
working again nothing is actually
destroyed when your hair goes gray it's
just the cells are inactive but there's
no reason they can't be reactivated
again and this research shows that it is
very much possible the old theory that
you just run out of melanin is just flat
out wrong and this new research shows
that hair grain is completely reversible
so we don't actually have any physical
products surrounding This research that
exists just yet but we didn't have
finasteride either back in the 1970s
when Julian imperato McGinley originally
conducted her research linking five AR
deficiencies to an absent sense of
androgenic alopecia this is how
treatments start through basic
scientific discoveries just like this
one so it stands to reason that it is
only a matter of time before gray hair
becomes a historical footnote and the
only people who will still have gray
hair will be people who do so by choice
and who knows maybe gray hair will even
become fashionable again because of how
rare it becomes due to it being so
treatable I mean not just me pondering
so I guess we'll see anyways I'll see
you all next time hair loss witchers God
bless
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