"I F***ING LOVE STEROIDS" - Ryan Garcia ABSOLUTELY Took Ostarine (positive B sample) | My Analysis

Summary

The video revisits the controversy surrounding boxer Ryan Garcia, who tested positive for the banned substance Ostarine on the day of his fight with Devon Haney. The script discusses the likelihood of Garcia's innocence or guilt based on B sample test results and urine concentrations. It explores the possibility of contamination, the submission of a hair test, and the implications of the findings. The video delves into the science behind Ostarine, its detectability, and the minimal effective dosage, concluding that Garcia's positive test is likely due to inadvertent contamination rather than intentional doping, but still resulting in significant scrutiny for his career.

Takeaways

• 🥊 Ryan Garcia tested positive for Ostarine, a selective Androgen receptor modulator (SARM), on the day of his fight with Devon Haney.
• 🚫 Ostarine is a synthetic compound not supposed to be present in an athlete's system and is considered a performance-enhancing substance.
• 🔬 Both A and B sample tests for Garcia came back positive, indicating the presence of Ostarine and 19-Norandrosterone.
• 💡 The speaker hypothesizes that Garcia may have been a victim of supplement contamination, as his legal team claims he never intentionally used a banned substance.
• 🔍 Garcia's hair sample analysis came back negative, suggesting no long-term ingestion of Ostarine, which could indicate contamination.
• 📉 The negative hair test result, however, cannot overrule the positive urine test and is not considered a gold standard for SARM ingestion assessment.
• 🚫 The 6 nanograms per milliliter reported for Garcia is 60 times over the allowable limit for Ostarine, which raises questions about his intentions.
• 🧬 Clinical trials suggest that a dose of around 3 milligrams of Ostarine is the minimum to see increases in power and lean body mass.
• 🤔 The speaker questions the likelihood of Ostarine being used intentionally for performance enhancement in boxing, given its high detectability and limited benefits.
• 🧐 The speaker concludes that while Garcia may have inadvertently ingested a contaminated supplement, the dose was too low to provide significant performance enhancement.
• 📚 The video script emphasizes the importance of athletes being responsible for what they ingest and the potential consequences of positive drug tests.

Q & A

What was the initial reason for Ryan Garcia's positive drug test?

Ryan Garcia tested positive for ostarine, a selective Androgen receptor modulator (SARM), and also screened positive for 19-norandrosterone, which is an endogenously produced metabolite that required confirmation via isotope ratio mass spectrometry.

What does the B sample test result indicate for Ryan Garcia?

The B sample test result also came back positive, indicating the presence of the banned substance ostarine in Ryan Garcia's system.

What is the significance of the hair test that Ryan Garcia's legal team mentioned?

The hair test was conducted to provide evidence of potential contamination and to show that Ryan Garcia did not ingest ostarine over a period of time, suggesting that any positive test result may not be due to intentional use.

What does the negative hair sample result suggest about Ryan Garcia's case?

The negative hair sample result is consistent with the claim of contamination and suggests that Ryan Garcia did not have a long-term ingestion of ostarine, which could support the argument that the positive test was not due to intentional use.

What is the allowable limit for ostarine in urine tests, and how did Ryan Garcia's test result compare to this limit?

The allowable limit for ostarine in urine tests is 0.1 nanogram per milliliter. Ryan Garcia's test result showed six nanograms per milliliter, which is 60 times over the limit.

What is the general consensus on the effectiveness of ostarine for performance enhancement?

Ostarine is considered a research chemical and is not FDA approved. While it can enhance lean muscle growth and strength to some extent, it is not very effective for performance enhancement, especially in sports like boxing.

What is the minimum efficacious dose of ostarine according to the clinical trials mentioned in the script?

The minimum efficacious dose of ostarine, where noticeable increases in power and lean body mass begin, is around three milligrams.

How does the dosage that Ryan Garcia tested positive for compare to the minimum efficacious dose of ostarine?

Ryan Garcia tested positive for six nanograms per milliliter, which is significantly lower than the minimum efficacious dose of three milligrams, suggesting that even if the ostarine was ingested, it would not have provided a significant performance-enhancing benefit.

What is the role of Dr. Pascal Kint in Ryan Garcia's case?

Dr. Pascal Kint is a foremost expert in toxicology and hair sample analysis. Ryan Garcia's hair sample was sent to him for testing, which returned a negative result for ostarine.

What does the script suggest about the likelihood of Ryan Garcia's positive test being due to supplement contamination?

The script suggests that it is likely that Ryan Garcia's positive test was due to inadvertent contamination from a supplement, given the ultra-low levels found in his samples and the negative hair test result.

What are the implications of Ryan Garcia's positive test result for his boxing career and reputation?

The positive test result, even if not intentional, could lead to significant scrutiny and potentially negative consequences for Ryan Garcia's boxing career and reputation, including the possibility of having his win taken away.

Outlines

00:00

🥊 Ryan Garcia's Positive Drug Test Controversy

The paragraph discusses the controversy surrounding Ryan Garcia, who tested positive for the banned substance Ostarine on the day of his fight with Devon Haney. The script details the initial positive test, the confirmation through isotope ratio mass spectrometry, and the subsequent positive B sample test. It also mentions Garcia's claim of innocence, suggesting contamination from a supplement. The paragraph explores the possibility of Garcia cheating, the results of his hair follicle test which came back negative, and the argument that the detected levels of Ostarine could be due to contamination rather than intentional use. It concludes with the high likelihood that Garcia was a victim of supplement contamination, despite the potential for this to be a strategic excuse.

05:03

🧪 Analyzing Hair Sample Reliability in Doping Cases

This paragraph delves into the reliability of hair sample analysis as a method to refute urine analysis in doping cases. It explains that, as of 2022, hair testing cannot be considered a substitute for urine analysis because a negative hair result does not exclude the use of the detected drug. The paragraph also discusses the limitations of hair testing for sarms and notes that it cannot overrule the results of urine analysis. It suggests that while hair testing might support Garcia's claim of inadvertent contamination, it does not eliminate the positive urine test results. The paragraph also touches on the potential consequences for Garcia's boxing career and gambling winnings.

10:04

🧬 The Science Behind Ostarine Dosage and Detection

The script examines the science behind Ostarine, a selective androgen receptor modulator (SARM), discussing its clinical trials, efficacy, and detection in drug testing. It explains that Ostarine is not an approved FDA drug and has shown limited effectiveness for performance enhancement. The paragraph explores the minimum efficacious dose of Ostarine and its potential benefits for lean muscle growth and strength. It also discusses the elimination profiles of Ostarine and the likelihood that Garcia's positive test result was due to inadvertent contamination rather than intentional use, given the low levels detected in his system.

15:04

🏆 The Impact of a Positive Drug Test on a Boxer's Career

In this paragraph, the focus is on the potential impact of a positive drug test on a boxer's career, using Ryan Garcia's situation as an example. It emphasizes the importance of being cautious with substances consumed by athletes, especially those at the top of their sport. The paragraph suggests that even if Garcia can prove his positive test was not intentional, the fact that he competed with a banned substance in his system will likely lead to significant scrutiny and could result in the loss of his win. It concludes by highlighting the need for athletes to be more careful with what they ingest to avoid such controversies.

Keywords

💡Ryan Garcia

Ryan Garcia is a professional boxer who is the central figure in the video's discussion. He is mentioned in the context of testing positive for a prohibited substance, which has led to controversy and scrutiny. The video explores the implications of this event on his career and the debate surrounding whether his positive test was due to intentional cheating or inadvertent contamination.

💡Ostarine

Ostarine is a selective Androgen receptor modulator (SARM), which is a synthetic compound that is not allowed in sports due to its performance-enhancing capabilities. In the video, it is revealed that Ryan Garcia tested positive for ostarine, leading to the main conflict discussed throughout the script. The video delves into the details of ostarine's effects, detection, and the possible reasons for its presence in Garcia's system.

💡ADR (19-Norandrosterone)

19-Norandrosterone, or ADR, is an endogenously produced metabolite that can be detected in drug testing. While it is naturally occurring, it can also be an indicator of steroid use when present in abnormal levels. The video mentions that Garcia screen positive for ADR, which adds to the complexity of the case and the need for further testing to confirm the presence of prohibited substances.

💡Isotope Ratio Mass Spectrometry

Isotope ratio mass spectrometry is a technique used to analyze the isotopic composition of elements in a sample. In the context of the video, it is mentioned as a method for confirming the presence of ostarine, which is an endogenously produced metabolite. This technique is crucial for determining whether the presence of ostarine is due to natural production or the use of a prohibited substance.

💡B Sample

In the realm of drug testing, the 'B Sample' refers to a second sample of urine or blood that is collected and stored for testing in the event that the 'A Sample' tests positive. The video discusses how Ryan Garcia's B sample also tested positive for ostarine, which further confirms the initial positive test and intensifies the controversy surrounding the case.

💡Hair Sample Analysis

Hair sample analysis is a method used to detect the presence of drugs over a longer period of time compared to urine tests. In the video, it is mentioned that Ryan Garcia's hair sample tested negative for ostarine, which his team argues supports the claim of contamination rather than intentional use. However, the video also explains the limitations of hair testing in such cases.

💡Contamination

Contamination in the context of the video refers to the accidental presence of a prohibited substance, such as ostarine, due to external factors like supplements or environmental exposure. Garcia's team suggests that contamination from a supplement is the most likely explanation for the positive test, which is a key point in the debate over whether his actions were intentional or accidental.

💡Performance-Enhancing Drugs (PEDs)

Performance-enhancing drugs, or PEDs, are substances that athletes use to improve their physical abilities and performance. The video discusses ostarine as a PED and explores the levels at which it could potentially enhance performance. The script also debates whether the levels found in Garcia's system could have provided any performance benefits.

💡Supplement Contamination

Supplement contamination refers to the unintentional presence of prohibited substances in dietary supplements. The video suggests that one of the natural supplements Ryan Garcia was using could have been contaminated with ostarine, leading to the positive test. This is a common issue in sports, as athletes must be cautious about the supplements they consume to avoid positive drug tests.

💡Nanogram per Milliliter

A nanogram per milliliter is a unit of measurement used to express the concentration of a substance in a solution. In the video, it is mentioned that the allowable limit for ostarine is 0.1 nanogram per milliliter, and Garcia's test result was 60 times over this limit, which is a significant point in the discussion about the severity of the positive test.

💡Clinical Trials

Clinical trials are research studies that help determine the safety and effectiveness of medical treatments, such as drugs. The video refers to clinical trials involving ostarine to establish the minimum effective dose and to understand its potential benefits and drawbacks. This information is relevant to the discussion of whether the detected levels of ostarine in Garcia's system could have had any performance-enhancing effects.

Highlights

Ryan Garcia tested positive for ostarine on the day of his fight with Devon Haney.

The B sample test results also came back positive for ostarine.

Hair test results for Ryan Garcia were negative, suggesting contamination.

Legal team argues for contamination causing a positive test, not intentional use.

Ostarine is a selective Androgen receptor modulator and not naturally produced.

Garcia's urine concentrations were 60 times over the allowable limit for ostarine.

Hair sample analysis cannot overrule urine test results for SARMs.

The negative hair test is consistent with contamination but does not exclude drug use.

Garcia had no previous history of positive tests leading up to the fight.

The minimum effective dose of ostarine for performance enhancement is around 3 milligrams.

Clinical trials show ostarine is not very effective for performance enhancement.

The detected amount of ostarine in Garcia's system is unlikely to provide a significant advantage.

Ostarine is considered a poor choice for performance enhancement in boxing.

Garcia's legal team is working to identify a contaminated supplement as the source.

The incident has led to significant scrutiny and potential consequences for Garcia.

Garcia's case highlights the importance of being cautious with supplements and substances ingested by athletes.

Transcripts

sup guys Derek more plates.com today we

are revisiting the Ryan Garcia debacle

this guy has tested positive for

Austrian on the day of his fight with

Devon Haney so we got the B sample test

results in we also apparently know the

urine concentrations and I think I have

a pretty good idea if he was indeed

trying to cheat or not based on the data

we have I can discern a reasonable

hypothesis so anyways May 1st VOD sends

him the letter that basically says he

tested positive for ostering as well as

screen positive as well for 19 Nor

androsterone but it needed confirmation

via isotope ratio Mass Spec analysis

because it's an endogenously produced

metabolite however ostarine a selective

Androgen receptor modulator is not it is

something that's not supposed to be

there at all so as you would expect when

you have a sarm in your system your B

sample is probably going to come back

positive as well and indeed it has so

his test results for the B sample come

back positive as well and to make

matters worse for him if there was any

ambiguity as to if this you know win is

going to get turn into a no contest or

whatever like it's not good that he was

literally in the ring fighting on the

day of with drugs in his system

regardless if it's a micro do regardless

if it was inadvertent regardless if it

was contamination at the end of the day

he had a amount that exceeded the

acceptable threshold for a synthetic

compound that is not supposed to be

there that has seen his performance

enhancing on the day he's punching a guy

in the head so not good however he has

also gotten his hair tested apparently

and his legal team has said you know

it's come up Negative they believe

there's contamination causing a positive

test King Ryan I beat the case like

orange juice let's go the glove didn't

fit okay unfollow LP Logan is still gay

button 29,000 likes Jesus Christ here we

go you use ostering to help you retain

muscle while cutting weight you had a

bad cycle and got caught it's over bro

I'm slowly losing respect for Ryan this

is a perfect example of people who are

just like your be sample came back CL

[ __ ] you that's basically the extent of

what's going to happen here for a lot of

people regardless of how much

information comes out that is positively

reinforcing his case as a pro athlete

you should not especially the top of

your sport like this was

absolutely un ran at the end of the day

regardless if there was inadvertent

contamination or whatever like you are

responsible for what goes into your body

is what people will say regardless so

for Ryan he has this hair test

supposedly and his lawyers legal team

says Ryan Garcia's committed to clean

and Fair competition has never

intentionally used any bad substance

soon after being notified of his

positive test Ryan voluntarily had his

hair collected and shipped to Dr Pascal

kin the foremost expert and toxic iology

and hair sample analysis the results of

Ryan's hair sample came back negative

this is consistent with contamination

and demonstrably proves that Ryan had

not ingested ostrin over a period of

time the only way he would have had any

advantage whatsoever in the ring Ryan

has voluntarily submitted to tests

throughout his career which have always

shown negative results he also tested

negative multiple times leading up to

the fight against Haney all of these

factors combined with his ultra low

levels it's interesting legal jargon

ultra low levels from samples taken on

April 19th and 20th in the billionth of

a gram range point to Ryan being a

victim of supplement contamination and

never receiving any performance

enhancing benefit from the microscopic

amounts in his system we are certain

that one of the natural supplements Ryan

was using in the lead up to the fight

will prove to be contaminated or in the

process of testing the supplements to

determine the exact source so you know I

think it's likely that something he did

cause

contamination um whether it ends up

being one of the supplements that he

took or not you know it's probably the

most likely source of it however the

dose that he got was it performance-

enhancing after all and was he you know

because even if it wasn't his

supplements you could easily argue oh I

just so happen to be taking this thing

it spiked and that's why it's in my

system but this is not a unusual

strategy for some people who are looking

to use a particular compound having a

product that is knowingly contaminated

as a cop out to be able to use that

compound and then say it was your

supplement that said would you do that

with austerine

intentionally probably not so here we

know the amount apparently that was

actually in his urine so Garcia's tweet

also LED Renown Sports nutritionist

Victor Ki to write Austrian has a 0.1

nanogram per milliliter allowable limit

and Ryan Garcia had six nanograms per

milliliter reported for April 19th which

is 60 times over the limit history of B

sample test is 99% confirmation of a so

60 times over the limit it sounds like a

lot you know it sounds like oh wow you

were clearly trying to like retain

muscle while cutting weight or whatever

you know like a lot of people jump to

these conclusions as you can see here I

can see why somebody would think that

let talk about the hair sample analysis

so he says he got you know hairs on his

head an analyze to assess some sort of

further back time scale of ostran

ingestion and would show that indeed he

didn't take any is it a reliable way to

actually you know refute a urine

analysis not really unfortunately for

him so human hair testing for sarms

current knowledge and limitations as of

2022 in case of an adverse analytical

finding hair testing can be a compliment

to document the claim of the athlete but

of course the result should not be

considered as an alternative to urine

analysis this is because a negative hair

result cannot exclude the use of the

detected drug drug and cannot overrule

the urine result so at the end of the

day like you taking hair out of your

head and sending it for analysis to some

experts like that's great it could help

your case maybe but it's like this isn't

a validated method of sarm ingestion

assessment really at the end of the day

like this is still new and

developing uh methodologies around hair

testing which may be viable but it is

not a gold standard right now and as

noted cannot be used to act as an

alternative for the actual urine

analysis that is um facilitated through

the actually governing the actual

governing body so despite the fact that

he might have done this himself like you

know chain of custody on the actual

sample who knows like what went into

this did he just [ __ ] take it off his

head himself and send it in the mail who

knows but at the end of the day it's

like this isn't going to just eliminate

the you know the test results that he's

had in his urine it is just something to

build a case against how it was not

intentional is what he's trying to do

which is fair but it's still ultimately

not going to get rid of it it just might

reduce the scrutiny to some extent but

it is certainly not beating you know I

beat it like he suggest he says I beat

the case like no you're still [ __ ]

unfortunately and when I say [ __ ] I

mean like he gets the scrutiny and even

if he proves that it's inadvertently

spiked in his supplements or whatever

like you were still responsible and

you're likely going to you have your win

taken away I would think and I have no

idea what this means for all of his

gambling winnings and stuff like that

must be wild I can't even imagine what

that is like right now where you bet on

yourself millions of dollars and then it

comes to light that you cheated and if

that gets held up is there gambling

entities chasing him now too you know

like I can't even imagine what this

guy's dealing with so the actual dosage

that he used six per milliliter what

does that actually equate to well first

what is the minimum efficacious dose for

ostarine so we look back at some of the

clinical trials I went over the

austerine pipeline I believe in my first

video by pipeline I mean the clinical

pipeline in which it is being assessed

for different indications it is a

research chemical at the end of the day

this is not an approved FDA approved

drug yet it is still in clinical trials

and has actually failed for lack of

efficacy see a few times notably so it's

not that effective of a drug for

performance enhancement but it does

enhance lean muscle growth and strength

to some extent but what is the lowest

dose you can actually get something out

of at least based on the literature

available we have studies assessing as

low as 0.1 milligrams all the way as

high as 100 milligrams in about 1,500

subjects and this was back in I don't

know when I wrote this article but it

was a while ago but it comprises most of

the notable austerine literature that

actually

assesses um dose increments and what

actually equates to an outcome worth

evaluating so percent change in lean

body mass is a metric of assessment of

efficacy in many of these studies but

also strength and of course these aren't

healthy populations but you have to

extrapolate what you can as to what is

better than like Baseline hormone

production and in general what we see

when we dig into the literature is that

ostarine at a dose of about three

milligrams is kind of where you start to

get into the territory of increases in

power something that could be chocked up

to useful in sport anything below that

you're not really getting especially as

a male highly unlikely to be getting

anything worth taking it to begin with

and to be honest as mentioned in the

first video Even if you were looking at

this thing seriously if you're an

athlete with even a like room

temperature IQ coach on your side would

hopefully tell you this is not the

compound you want to be using like there

is no sane not completely idiotic person

who would ever suggest using ostarine

for p as a peed in boxing this is a

completely absurd choice of a peed with

how highly detectable it is and just you

know the hordes of anecdotes at this

point of people who have been popped by

accident inadvertently most of the case

cuz it's such a stupid drug to take all

the people that want to hate on Ryan

will talk about how ostrin is great for

retaining muscle and blah blah blah and

it it can be helpful for that for sure

but at the end of the day like you would

pick a way way smarter drug to be taken

if you were trying to use an anabolic

agent than like one of the most highly

detectable

synthetic selective not neurologically

enhancing non- psychoactive like just

shitty [ __ ] anabolic drugs

realistically like this thing hasn't

even been FDA approved it is not the

go-to choice for boxing enhancement that

aside it is performance enhancing

probably at around 3 milligrams give or

take so 6 nanograms per milliliter 60

times over the allowable limit what does

that mean how much would you have to

ingest to actually get six nanog per

milliliter is the question cuz if he

actually had a contaminated supplement

is it possible that it had an enough

ostarine in it to actually give him

performance enhancing properties at this

3 mgram dose or is it possible that he

actually just [ __ ] took it at 3 mg

and it led to this 6 nanog per

milliliter test result well that's where

we look at this elimination profiles of

micro doed ostrin mimicking contaminated

products ingestion study so in here we

have individuals being administered

orally one and 10 and 50 microgr being

assessed and analyzed using liquid

chromatography with t mass

spectrometry now when you look at these

excretion profiles of the parent

compound as well as its metabolites

you'll note that in general to get to a

point where you are even reaching about

six nanog per milliliter in the urine

because you can see here Austrian

nanograms per milliliter you have uh

excretion profiles of metabolites as

well where are we hitting the 6 nanog

per Mill Mark you are in microgram

territory so keep keep in mind here

micrograms how many micrograms are in a

milligram 1,000 so to get to 3 millgram

which is probably the minimum

efficacious dose you're looking at 3,000

micrograms of ingested ostarine over the

span of multiple days like this is not

just one Administration you get an acute

performance outcome that you can use in

the ring like again this is not a

psychoactive neurologically enhancing

compound really it is something that

would be a purely tissue selective

anabolic with a lack of androgenic

activity you would use in a muscle

wasting scenario for like women to not

have viralized outcomes but have some

anabolic action in bone or muscle like

that is the typical desired outcome of a

compound like this again a reason why

it's not very helpful for boxing or the

ideal choice for a male but Peak

ostering concentrations range from 0.96

to 5.77 nanog per Mill L and were

observed 4 to 22 22 hours after

ingestion and the drug was detectable

for even at these low ass concentrations

for like multiple days like this is

ultimately pretty damn close to what he

was tested for at the 6 nanogram per

milliliter Mark so you have these

dosages being utilized as high as 50

micrograms so like 50 micrograms like

what is that you're like if you took 50

micrograms every day leading up to the

fight you would get absolutely nothing

out of it like to actually get to the 3

milligram dose you are like

astronomically higher than this and so

like to me that shows that this is very

likely inadvertent contamination via

something and even if it was

contaminated via something it is

essentially impossible for him to have

gotten a performance enhancing benefit

out of it and realistically even if he

got like the minimum acious dose how

much would it have really helped them at

the end of the day not very much like

this is not this is a drug that has

essentially failed its uh Target end

points like it is not an FDA approved

drug it is seen as like a primitive sarm

that may have some utility in like you

know elderly women for anti-catabolic

action but it is certainly not going to

be like the [ __ ] maker break for a

boxer like you would be using a much

higher dose as a male boxer to get like

a significant Advantage out of it now

perhaps that is a bit exaggerating 3 Mig

maybe it would do something for a

complete natural who's depleted and

weight cutting absolutely a case to be

made there but at the end of the day

like this isn't even close to that what

he ingested was an probably accidental

micro do to the tune of like double

digit micrograms at most and that is not

even close to imparting performance

enhancing advantages as per the clinical

literature as per the extrapolated

excretion profiles in these studies no

matter which way you spin it with this

guy

even if he was TR even if he was trying

to dope like like his dose was like way

too low and even if it was an in

inadvertent contamination there's no way

the dose he was using inadvertently

would have helped him so it's like you

know I feel like there's a strong case

for him to show that it was not

intentional However the fact remains

that he walked into the ring with a over

the like with a positive test result and

fought a guy so that is going to yet

unfortunately significant amounts of

scrutiny for years to come and that

[ __ ] sucks for him cuz it could have

been avoided entirely just by being a

little bit more careful with what he's

putting in his mouth so take from that

way you will uh thank you guys for

watching like subscribe if you want to

see more deep dived into pharmacology

human biology and other interesting [ __ ]

so um yeah I don't remember how to do my

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me so uh yeah I guess I'll talk to you

guys soon