These 3 Things Help Excrete Microplastics, BPA, & Phthalates | Rhonda Patrick
Summary
TLDRThe video script discusses how our bodies handle microplastics and associated chemicals like BPA, BPS, phthalates, and PFAS. It highlights the liver's role in processing these substances and the challenges of constant exposure. The script suggests strategies to aid detoxification, such as incorporating sulfurane-rich foods, increasing dietary fiber, and engaging in physical activities that promote sweating. However, it notes the limitations in eliminating 'forever chemicals' due to their long half-life, emphasizing the importance of reducing plastic exposure.
Takeaways
- 𧏠The body processes chemicals like BPA, BPS, phthalates, and PFAS through the liver using Phase 2 detoxification enzymes.
- â±ïž BPA is cleared relatively quickly within about 6 hours, while phthalates take between 12 to 24 hours.
- đ PFAS, or 'forever chemicals', have a half-life of 2 to 5 years, making them difficult to eliminate and leading to accumulation in organs.
- đ Microplastics vary in size; larger particles can be excreted through feces, but smaller nanoplastics can cross biological barriers and enter the bloodstream.
- đ„Š Sulfurane, found in cruciferous vegetables, activates the Nrf2 pathway, enhancing the body's detoxification enzymes and potentially helping to clear harmful chemicals.
- đ„Š Animal studies show sulfurane can reduce BPA-related toxicity by boosting Phase 2 detoxification enzymes.
- đ„Š Incorporating sulfurane-rich foods or supplements could be a strategy for detoxifying harmful chemicals.
- đ„Š Dietary fiber can bind to harmful chemicals in the GI tract, reducing absorption and promoting excretion through feces.
- đŠ Physical activity and sweating can also help eliminate harmful chemicals, as trace amounts of BPA and phthalate metabolites are found in sweat.
- đ« Avoiding exposure to PFAS is the best strategy due to their resistance to breakdown and long half-life in the body.
Q & A
How do microplastics and associated chemicals enter the human body?
-Microplastics and associated chemicals can enter the human body through ingestion, inhalation, or skin contact.
What role does the liver play in processing these chemicals?
-The liver processes these chemicals using various enzymes, particularly Phase 2 detoxification enzymes, which convert them into more water-soluble forms for easier excretion.
How quickly is BPA typically cleared from the body?
-BPA is cleared relatively fast, within about 6 hours under normal conditions.
What is the difference between how BPA and phthalates are excreted compared to PFAS (forever chemicals)?
-BPA and phthalates are excreted relatively quickly, whereas PFAS have a half-life of 2 to 5 years, making them harder to eliminate and more likely to accumulate in organs.
How do microplastics of different sizes affect excretion?
-Larger microplastics can pass through the gut and be excreted in feces, while smaller nanoplastics can cross biological barriers and enter the bloodstream.
What is a promising dietary strategy to help the body clear out chemicals like BPA, BPS, and phthalates?
-Incorporating sulfurane-rich foods or supplements into the diet can activate the Nrf2 pathway, boosting Phase 2 detoxification enzymes that help clear out toxins.
How does dietary fiber help in the elimination of harmful chemicals?
-Dietary fiber can bind to lipophilic chemicals in the GI tract, reducing their absorption and promoting excretion via feces.
What is the potential role of physical activity in eliminating microplastic-associated chemicals?
-Physical activity and practices that induce sweating can help eliminate harmful chemicals and compounds from the body, as sweat contains trace amounts of BPA and phthalate metabolites.
Why are the excretion strategies less effective for PFAS chemicals?
-Excretion strategies are less effective for PFAS because they are resistant to metabolic breakdown and have a long half-life in the body.
What is the best way to avoid the accumulation of PFAS chemicals in the body?
-The best way to avoid PFAS is to reduce exposure by avoiding plastics, especially those with high concentrations of PFAS, and by reducing overall plastic use.
How can a fiber-rich diet potentially aid in the excretion of microplastics?
-A fiber-rich diet might help encapsulate microplastics in the gut, facilitating their removal through regular bowel movements and reducing their residence time in the body.
Outlines
đ Detoxification of Microplastics and Chemicals
The script discusses how our bodies handle microplastics and associated chemicals like BPA, BPS, phthalates, and PFAS (forever chemicals). These chemicals are absorbed by the liver, which uses Phase 2 detoxification enzymes to convert them into more water-soluble forms for excretion, primarily through urine. However, the constant exposure to these chemicals means our bodies are in a continuous state of processing them. The script highlights that PFAS chemicals are particularly concerning due to their long half-life and resistance to breakdown, leading to accumulation in organs. Microplastics, especially nanoplastics, can cross biological barriers and enter the bloodstream, with their excretion mechanisms still not fully understood. The paragraph suggests that boosting the body's natural detoxification systems through dietary interventions, such as consuming sulfurane-rich foods like broccoli sprouts, could help increase the excretion of harmful chemicals.
đ„Š Dietary and Lifestyle Interventions for Detoxification
The second paragraph focuses on strategies to help the body clear out harmful chemicals and microplastics more efficiently. It emphasizes the role of sulfurane, a compound found in cruciferous vegetables, which activates the Nrf2 pathway and boosts Phase 2 detoxification enzymes. The script also explores the potential of dietary fiber to aid in the excretion of larger microplastics by binding to lipophilic chemicals in the gut and promoting their excretion through feces. Physical activity and practices that induce sweating, like exercise and sauna use, are mentioned as additional methods to eliminate harmful chemicals from the body. The paragraph concludes by noting that while these strategies can be effective for chemicals like BPA and phthalates, they are less so for PFAS due to their resistance to metabolic breakdown. It advises reducing exposure to plastics as the best way to avoid PFAS.
Mindmap
Keywords
đĄExcretion methods
đĄMicroplastics
đĄChemicals
đĄPhase 2 detoxification enzymes
đĄBPA
đĄPhthalates
đĄForever chemicals (PFAS)
đĄSulfurane
đĄDietary fiber
đĄPhysical activity
đĄNrf2
Highlights
The body processes microplastics and associated chemicals like BPA, BPS, phthalates, and PFAS through the liver.
Phase 2 detoxification enzymes help convert harmful chemicals into more water-soluble forms for excretion.
BPA is cleared relatively fast within about 6 hours under normal conditions.
Phthalates take longer to clear, ranging between 12 to 24 hours depending on the compound.
Our bodies are in a near continuous state of processing these chemicals due to constant exposure.
PFAS, or 'forever chemicals', have a half-life of 2 to 5 years and accumulate in organs.
Microplastics vary in size; larger particles can be excreted in feces, while smaller nanoplastics enter the bloodstream.
The long-term health implications of microplastics accumulation in organs are a growing concern.
Sulfurane, found in cruciferous vegetables, activates the Nrf2 pathway, a master regulator of detoxification.
Sulfurane can increase the excretion of toxins like Benzene and acryline by up to 60%.
Incorporating sulfurane-rich foods or supplements can help detoxify BPA, BPS, and phthalates.
Dietary fiber can bind to lipophilic chemicals in the GI tract, reducing absorption and promoting excretion via feces.
A fiber-rich diet may help encapsulate and remove larger microplastics through regular bowel movements.
Physical activity and practices that induce sweating can help eliminate harmful chemicals from the body.
Sweat contains trace amounts of BPA and phthalate metabolites, suggesting it as a viable route for excretion.
Consistent sweating through exercise or sauna use can play a role in reducing the body's toxic burden.
Excretion strategies are less effective for PFAS due to their resistance to metabolic breakdown.
Avoiding exposure to plastics is the most effective way to reduce the burden of PFAS chemicals.
Transcripts
okay lastly I want to cover some
excretion methods I want to talk about
how our bodies handle the influx of
microplastics and the chemicals
associated with them including BPA BPS
phalates and the forever chemicals the
pasas so once these chemicals enter the
body whether it's through ingestion or
inhalation or through skin contact they
are quickly absorbed and processed
primarily by the liver the liver is
equipped with a variety of enzymes part
of these enzymes are called Phase 2
detoxification enzymes these are enzymes
that convert these chemicals into more
water soluble forms making them easier
for our body to excrete them mostly
through urine for example BPA is cleared
relatively fast within about 6 hours
under normal conditions ballades take a
bit longer ranging between 12 to 24
hours depending on the specific compound
while that might sound reassuring the
problem is we are exposed to these
chemicals almost constantly so our
bodies are in a near continuous state of
processing them but this is where it
gets even more complicated so past again
these are forever chemicals do not break
down easily so unlike BPA or phalates
the past have a halflife of 2 to 5 years
meaning they accumulate in our organs
like the liver and the kidneys and their
persistence in the body makes them much
harder harder to eliminate they stick
around and they build up over time then
there's microplastics themselves
microplastics do vary in size larger
particles could pass through the gut and
be excreted in feces but the smaller
nanoplastics these are the really really
tiny particles these are crossing
biological barriers and they're entering
the bloodstream once they get into
circulation systemically we don't really
fully understand how or if they're ever
excreted efficiently what we do know is
that they are accumulating in our organs
in our tissues and this is a growing
concern when we talk about long-term
Health implications so how do we help
our bodies clear out chemicals like BPA
BPS and phalates more efficiently one
promising strategy revolves around
tapping into our body's natural
detoxification systems and we can do
that through dietary and lifestyle
interventions one compound that really
stands out here is sulfur F you've
probably heard me talk about this before
it's a powerful molecule found in
broccoli sprouts and other cruciferous
vegetables sulfurane activates a key
pathway called
Nrf2 think of Nrf2 as a master regulator
of
detoxification it controls the
production of enzymes that helps our
body clear out many many toxins it
boosts The Phase 2 detoxification
enzymes these are enzymes that bind to
harmful chemicals and make them more
water soluble so we can excrete them
through our urine animal Studies have
shown that when rodents are exposed to
BPA and given sulfurane their Phase 2
detoxification enzymes go into overdrive
and they experience less overall BPA
related toxicity now while there's not a
lot of direct evidence on sulfurane
ability to clear BPA and phalates
specifically I think the mechanism here
is very solid and we do have compelling
human data in other areas for instance
studies show that sulfurane can increase
the excretion of toxins like Benzene and
acryline which we get exposed through
through air pollution and food by up to
60% so in my view incorporating
sulfurane rich foods into our diet like
broccoli Sprouts which contain up to a
100 times more sulfurane than mature
broccoli or considering a highquality
supplement of stabilized sulfurane or
its precursor glucoraphenin could be a
viable strategy for helping detoxify BPA
BPS and phalates and by doing so we do
Boost our body's natural detoxification
Pathways that has been shown in human
studies that could help us more
effectively eliminate some of these
microplastic Associated chemicals
another Avenue Worth exploring is the
role of dietary fiber in helping our
bodies eliminate chemicals associated
with plastics and perhaps even even some
microplastics themselves consuming fiber
rich foods can bind to lipophilic
chemicals like BPA and phalates in the
GI tract and reduce their absorption
into the bloodstream promoting their
excretion via feces so feces is another
way our bodies detoxify BPA phalates and
even microplastics some animal studies
support this mechanism indicating that
higher fiber intake leads to increased
fecal extre of these compounds but what
about microplastics themselves while
research is still emerging here I think
there's a reason to believe that dietary
fiber could Aid in the excretion of some
larger microplastics so since
microplastics can be trapped within the
gut Lumen a fiber rich diet could
potentially help encapsulate these
particles and facilitate their removal
through regular bowel movements
essentially fiber might help sweep the
gut clean and reduce the residence time
of microplastic
therefore limiting their chances of
causing harm and getting into the
bloodstream this means incorporating
foods that are high in fiber like
legumes fruits vegetables whole grains
could serve a dual purpose not only do
they provide essential nutrients and
micronutrients and phytochemicals and
fermentable fiber that supports overall
health and gut health but they also
could enhance the elimination of both
harmful chemicals and microplastic
particles let's talk about another
powerful tool for eliminating some of
these microplastic Associated chemicals
physical activity and practices that
induce sweating so exercise things like
sauna hot tubs even Hot Yoga sweat it's
not just about cooling down the body
it's also a way to eliminate harmful
chemicals and compounds from the body so
sweat does can trace Trace Amounts of
BPA and phalate metabolites Now While
most of these chemicals are excreted
through urine Studies have shown that
sweat can help too one study published
in the Journal of environmental and
public health found measurable levels of
phalates in sweat of participants I
think this tells us that regular
sweating whether through exercise or
sauna or hot yoga can be a viable root
for excreting some of these harmful
substances so while the amounts of BPA
and BPS and phalates that are excreted
in sweat are smaller compared to urine I
think consistent sweating could really
still play a meaningful role in
lightening the toxic burden load on our
body and lastly I do want to make one
last mention that these excretion
strategies that we've been discussing
are less effective for the forever
chemicals the past because of their
resistance to metabolic breakdown
because their Half-Life in the body is 2
to five years so really the best way to
avoid past is to avoid the exposure in
the first place and reducing our
exposure to Plastics does Remain the
most effective way to reducing our
burden of past chemicals so this means
avoiding plastic chemicals avoiding
mineral Waters with high concentrations
of past and really just trying hard to
reduce our use of plastics
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